Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inhibin beta E chain

Gene

INHBE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • hormone activity Source: UniProtKB-KW
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

ReactomeiR-HSA-209822 Glycoprotein hormones
SignaLinkiP58166

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta E chain
Alternative name(s):
Activin beta-E chain
Gene namesi
Name:INHBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139269.2
HGNCiHGNC:24029 INHBE
MIMi612031 gene
neXtProtiNX_P58166

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi83729
OpenTargetsiENSG00000139269
PharmGKBiPA134898991

Polymorphism and mutation databases

BioMutaiINHBE
DMDMi14285500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003373620 – 236Sequence analysisAdd BLAST217
ChainiPRO_0000033737237 – 350Inhibin beta E chainAdd BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi198N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi240 ↔ 248By similarity
Disulfide bondi247 ↔ 315By similarity
Disulfide bondi276 ↔ 347By similarity
Disulfide bondi280 ↔ 349By similarity
Disulfide bondi314InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP58166
MaxQBiP58166
PaxDbiP58166
PeptideAtlasiP58166
PRIDEiP58166
ProteomicsDBi57050

PTM databases

iPTMnetiP58166
PhosphoSitePlusiP58166

Expressioni

Gene expression databases

BgeeiENSG00000139269 Expressed in 73 organ(s), highest expression level in liver
CleanExiHS_INHBE
ExpressionAtlasiP58166 baseline and differential
GenevisibleiP58166 HS

Organism-specific databases

HPAiCAB034017
HPA016843

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123742, 17 interactors
STRINGi9606.ENSP00000266646

Structurei

3D structure databases

ProteinModelPortaliP58166
SMRiP58166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP58166
KOiK22689
OMAiGYQLNYC
OrthoDBiEOG091G09LW
PhylomeDBiP58166
TreeFamiTF318514

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001318 Inhibin_betaC
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PRINTSiPR00672 INHIBINBC
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P58166-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPDVQLWL VLLWALVRAQ GTGSVCPSCG GSKLAPQAER ALVLELAKQQ
60 70 80 90 100
ILDGLHLTSR PRITHPPPQA ALTRALRRLQ PGSVAPGNGE EVISFATVTD
110 120 130 140 150
STSAYSSLLT FHLSTPRSHH LYHARLWLHV LPTLPGTLCL RIFRWGPRRR
160 170 180 190 200
RQGSRTLLAE HHITNLGWHT LTLPSSGLRG EKSGVLKLQL DCRPLEGNST
210 220 230 240 250
VTGQPRRLLD TAGHQQPFLE LKIRANEPGA GRARRRTPTC EPATPLCCRR
260 270 280 290 300
DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS
310 320 330 340 350
LLKANNPWPA STSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS
Length:350
Mass (Da):38,561
Last modified:June 1, 2001 - v1
Checksum:iA49C1495677E3E6F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VNP4F8VNP4_HUMAN
Inhibin beta E chain
INHBE
274Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03619862R → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036199215Q → H in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412024 mRNA Translation: AAN03682.1
AK075285 mRNA Translation: BAC11521.1
BC005161 mRNA Translation: AAH05161.1
CCDSiCCDS8939.1
RefSeqiNP_113667.1, NM_031479.4
UniGeneiHs.632713

Genome annotation databases

EnsembliENST00000266646; ENSP00000266646; ENSG00000139269
GeneIDi83729
KEGGihsa:83729
UCSCiuc001snw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412024 mRNA Translation: AAN03682.1
AK075285 mRNA Translation: BAC11521.1
BC005161 mRNA Translation: AAH05161.1
CCDSiCCDS8939.1
RefSeqiNP_113667.1, NM_031479.4
UniGeneiHs.632713

3D structure databases

ProteinModelPortaliP58166
SMRiP58166
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123742, 17 interactors
STRINGi9606.ENSP00000266646

PTM databases

iPTMnetiP58166
PhosphoSitePlusiP58166

Polymorphism and mutation databases

BioMutaiINHBE
DMDMi14285500

Proteomic databases

EPDiP58166
MaxQBiP58166
PaxDbiP58166
PeptideAtlasiP58166
PRIDEiP58166
ProteomicsDBi57050

Protocols and materials databases

DNASUi83729
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266646; ENSP00000266646; ENSG00000139269
GeneIDi83729
KEGGihsa:83729
UCSCiuc001snw.4 human

Organism-specific databases

CTDi83729
DisGeNETi83729
EuPathDBiHostDB:ENSG00000139269.2
GeneCardsiINHBE
HGNCiHGNC:24029 INHBE
HPAiCAB034017
HPA016843
MIMi612031 gene
neXtProtiNX_P58166
OpenTargetsiENSG00000139269
PharmGKBiPA134898991
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP58166
KOiK22689
OMAiGYQLNYC
OrthoDBiEOG091G09LW
PhylomeDBiP58166
TreeFamiTF318514

Enzyme and pathway databases

ReactomeiR-HSA-209822 Glycoprotein hormones
SignaLinkiP58166

Miscellaneous databases

GenomeRNAii83729
PROiPR:P58166
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139269 Expressed in 73 organ(s), highest expression level in liver
CleanExiHS_INHBE
ExpressionAtlasiP58166 baseline and differential
GenevisibleiP58166 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001318 Inhibin_betaC
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PRINTSiPR00672 INHIBINBC
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINHBE_HUMAN
AccessioniPrimary (citable) accession number: P58166
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again