Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acyl-coenzyme A thioesterase 8

Gene

Acot8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:11673457). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA) (PubMed:11673457). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:11673457). Catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA (PubMed:11673457). May be involved in the metabolic regulation of peroxisome proliferation (By similarity).By similarity1 Publication

Miscellaneous

Constitutes about 1% of total peroxisomal protein.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by CoASH (IC50=10-15 µM). Also inhibited by cysteine-reactive agents.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

In summary, KM for medium- to long-chain acyl CoAs is in the order 1.4-6.7 µM, and with short-chain acyl CoAs range from 8 to 30 µM. KM for bile acid-CoA esters is in the range 6-15 µM.1 Publication
  1. KM=29.4 µM for acetyl-CoA1 Publication
  2. KM=8.0 µM for propionyl-CoA1 Publication
  3. KM=22.6 µM for butyryl-CoA1 Publication
  4. KM=23.4 µM for hexanoyl-CoA1 Publication
  5. KM=6.9 µM for octanoyl-CoA1 Publication
  6. KM=2.9 µM for decanoyl-CoA1 Publication
  7. KM=2.5 µM for myristoyl-CoA1 Publication
  8. KM=1.7 µM for palmitoyl-CoA1 Publication
  9. KM=1.4 µM for palmitoleoyl-CoA1 Publication
  10. KM=1.6 µM for oleoyl-CoA1 Publication
  11. KM=4.2 µM for arachidoyl-CoA1 Publication
  12. KM=6.7 µM for arachidonoyl-CoA1 Publication
  13. KM=6.3 µM for trihydroxycoprostanoyl-CoA1 Publication
  14. KM=14.6 µM for choloyl-CoA1 Publication
  15. KM=8.8 µM for chenodeoxycholoyl-CoA1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei233Charge relay systemBy similarity1
    Active sitei255Charge relay systemBy similarity1
    Active sitei305Charge relay systemBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Serine esterase
    Biological processPeroxisome biogenesis

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.1.2.2 3474
    3.1.2.20 3474
    3.1.2.27 3474

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    R-MMU-2046106 alpha-linolenic acid (ALA) metabolism
    R-MMU-389887 Beta-oxidation of pristanoyl-CoA
    R-MMU-390247 Beta-oxidation of very long chain fatty acids
    R-MMU-9033241 Peroxisomal protein import

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000534

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Acyl-coenzyme A thioesterase 8 (EC:3.1.2.271 Publication)
    Short name:
    Acyl-CoA thioesterase 8
    Alternative name(s):
    Choloyl-coenzyme A thioesterase
    Peroxisomal acyl-CoA thioesterase 2
    Short name:
    PTE-2
    Peroxisomal acyl-coenzyme A thioester hydrolase 1
    Short name:
    PTE-1
    Peroxisomal long-chain acyl-CoA thioesterase 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Acot8
    Synonyms:Pte1, Pte2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2158201 Acot8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Peroxisome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002021531 – 320Acyl-coenzyme A thioesterase 8Add BLAST320

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P58137

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P58137

    PeptideAtlas

    More...
    PeptideAtlasi
    P58137

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P58137

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P58137

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P58137

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous.1 Publication

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Induced in the liver, by peroxisome proliferator or fasting via the peroxisome proliferator-activated receptors (PPARs). Diurnal regulation of its expression.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000017307 Expressed in 279 organ(s), highest expression level in embryo

    CleanEx database of gene expression profiles

    More...
    CleanExi
    MM_ACOT8

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P58137 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P58137 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    homodimer.1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    P58137, 1 interactor

    Molecular INTeraction database

    More...
    MINTi
    P58137

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000099383

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P58137

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P58137

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi318 – 320Microbody targeting signalSequence analysis3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the C/M/P thioester hydrolase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3016 Eukaryota
    COG1946 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000004207

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000246495

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG019167

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P58137

    KEGG Orthology (KO)

    More...
    KOi
    K11992

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WLLYAMD

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0BLB

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P58137

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315124

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003703 Acyl_CoA_thio
    IPR029069 HotDog_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11066 PTHR11066, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF54637 SSF54637, 2 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00189 tesB, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    P58137-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSAPEGLGDA HGDADRGDLS GDLRSVLVTS VLNLEPLDED LYRGRHYWVP
    60 70 80 90 100
    TSQRLFGGQI MGQALVAAAK SVSEDVHVHS LHCYFVRAGD PKVPVLYHVE
    110 120 130 140 150
    RIRTGASFSV RAVKAVQHGK AIFICQASFQ QMQPSPLQHQ FSMPSVPPPE
    160 170 180 190 200
    DLLDHEALID QYLRDPNLHK KYRVGLNRVA AQEVPIEIKV VNPPTLTQLQ
    210 220 230 240 250
    ALEPKQMFWV RARGYIGEGD IKMHCCVAAY ISDYAFLGTA LLPHQSKYKV
    260 270 280 290 300
    NFMASLDHSM WFHAPFRADH WMLYECESPW AGGSRGLVHG RLWRRDGVLA
    310 320
    VTCAQEGVIR LKPQVSESKL
    Length:320
    Mass (Da):35,827
    Last modified:June 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94F6AFCFEEE2FA23
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    Q8BZR4Q8BZR4_MOUSE
    Acyl-coenzyme A thioesterase 8
    Acot8 Pte1
    268Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3UXJ8G3UXJ8_MOUSE
    Acyl-coenzyme A thioesterase 8
    Acot8
    113Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti284S → F in AAL35333 (PubMed:11673457).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF441166 mRNA Translation: AAL35333.1
    BC005792 mRNA Translation: AAH05792.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS17057.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_573503.2, NM_133240.2

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Mm.277878

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000103094; ENSMUSP00000099383; ENSMUSG00000017307

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    170789

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:170789

    UCSC genome browser

    More...
    UCSCi
    uc008nwf.2 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF441166 mRNA Translation: AAL35333.1
    BC005792 mRNA Translation: AAH05792.1
    CCDSiCCDS17057.1
    RefSeqiNP_573503.2, NM_133240.2
    UniGeneiMm.277878

    3D structure databases

    ProteinModelPortaliP58137
    SMRiP58137
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiP58137, 1 interactor
    MINTiP58137
    STRINGi10090.ENSMUSP00000099383

    Chemistry databases

    SwissLipidsiSLP:000000534

    PTM databases

    iPTMnetiP58137
    PhosphoSitePlusiP58137

    Proteomic databases

    EPDiP58137
    PaxDbiP58137
    PeptideAtlasiP58137
    PRIDEiP58137

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    170789
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000103094; ENSMUSP00000099383; ENSMUSG00000017307
    GeneIDi170789
    KEGGimmu:170789
    UCSCiuc008nwf.2 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10005
    MGIiMGI:2158201 Acot8

    Phylogenomic databases

    eggNOGiKOG3016 Eukaryota
    COG1946 LUCA
    GeneTreeiENSGT00390000004207
    HOGENOMiHOG000246495
    HOVERGENiHBG019167
    InParanoidiP58137
    KOiK11992
    OMAiWLLYAMD
    OrthoDBiEOG091G0BLB
    PhylomeDBiP58137
    TreeFamiTF315124

    Enzyme and pathway databases

    BRENDAi3.1.2.2 3474
    3.1.2.20 3474
    3.1.2.27 3474
    ReactomeiR-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    R-MMU-2046106 alpha-linolenic acid (ALA) metabolism
    R-MMU-389887 Beta-oxidation of pristanoyl-CoA
    R-MMU-390247 Beta-oxidation of very long chain fatty acids
    R-MMU-9033241 Peroxisomal protein import

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P58137

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000017307 Expressed in 279 organ(s), highest expression level in embryo
    CleanExiMM_ACOT8
    ExpressionAtlasiP58137 baseline and differential
    GenevisibleiP58137 MM

    Family and domain databases

    InterProiView protein in InterPro
    IPR003703 Acyl_CoA_thio
    IPR029069 HotDog_dom_sf
    PANTHERiPTHR11066 PTHR11066, 1 hit
    SUPFAMiSSF54637 SSF54637, 2 hits
    TIGRFAMsiTIGR00189 tesB, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOT8_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58137
    Secondary accession number(s): Q8VHM4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: December 5, 2018
    This is version 141 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again