UniProtKB - P58107 (EPIPL_HUMAN)
Epiplakin
EPPK1
Functioni
Caution
GO - Molecular functioni
- intermediate filament binding Source: UniProtKB
- keratin filament binding Source: GO_Central
- RNA binding Source: UniProtKB
- structural molecule activity Source: GO_Central
GO - Biological processi
- intermediate filament bundle assembly Source: GO_Central
- intermediate filament cytoskeleton organization Source: GO_Central
- intermediate filament organization Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of epithelial cell proliferation Source: UniProtKB
- negative regulation of keratinocyte migration Source: UniProtKB
- negative regulation of keratinocyte proliferation Source: UniProtKB
- negative regulation of wound healing Source: UniProtKB
- regulation of epithelium regeneration Source: UniProtKB
- wound healing Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P58107 |
Names & Taxonomyi
Protein namesi | Recommended name: Epiplakin1 PublicationAlternative name(s): 450 kDa epidermal antigen |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15577, EPPK1 |
MIMi | 607553, gene |
neXtProti | NX_P58107 |
VEuPathDBi | HostDB:ENSG00000261150.2 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 2 Publications
Plasma membrane
- Apicolateral cell membrane By similarity
- Basolateral cell membrane By similarity
Other locations
- hemidesmosome 1 Publication
- tight junction 1 Publication
- Cell projection 1 Publication
- Cell junction By similarity
Note: May move dynamically from bundling intermediate filaments in the cytoplasm or at the cell periphery and reinforcing them (PubMed:23398049). Decorates the keratin intermediate filaments (IF) network and partially that of vimentin (PubMed:15671067).2 Publications
Cytoskeleton
- cytoskeleton Source: UniProtKB
- keratin filament Source: UniProtKB
Nucleus
- perinucleolar compartment Source: UniProtKB
Plasma Membrane
- apicolateral plasma membrane Source: UniProtKB-SubCell
- basolateral plasma membrane Source: UniProtKB-SubCell
Other locations
- bicellular tight junction Source: UniProtKB
- cell junction Source: GO_Central
- cell periphery Source: UniProtKB
- cell projection Source: UniProtKB-SubCell
- cytoplasm Source: GO_Central
- hemidesmosome Source: UniProtKB
- membrane Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junctionPathology & Biotechi
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 83481 |
OpenTargetsi | ENSG00000261150 |
PharmGKBi | PA27835 |
Miscellaneous databases
Pharosi | P58107, Tdark |
Genetic variation databases
BioMutai | EPPK1 |
DMDMi | 300669637 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078145 | 1 – 5088 | EpiplakinAdd BLAST | 5088 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 34 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1543 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 2422 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2508 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2718 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2958 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3044 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3249 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3489 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3575 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3783 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4023 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4109 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4317 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4557 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4645 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4850 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P58107 |
jPOSTi | P58107 |
MassIVEi | P58107 |
PaxDbi | P58107 |
PeptideAtlasi | P58107 |
PRIDEi | P58107 |
ProteomicsDBi | 57049 |
PTM databases
iPTMneti | P58107 |
PhosphoSitePlusi | P58107 |
SwissPalmi | P58107 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000261150, Expressed in oviduct epithelium and 157 other tissues |
ExpressionAtlasi | P58107, baseline and differential |
Interactioni
Subunit structurei
Interacts with KRT5, KRT14 and KRT5/KRT14 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:15671067).
Interacts with KRT8 and KRT18 and KRT8/KRT18 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:15671067).
Interacts with KRT1, VIM and DES; interaction is stronger with KRT1 than with VIM or DES; interaction is dependent of higher-order structure of intermediate filament (PubMed:16923132).
2 PublicationsProtein-protein interaction databases
BioGRIDi | 123666, 86 interactors |
IntActi | P58107, 32 interactors |
MINTi | P58107 |
STRINGi | 9606.ENSP00000484472 |
Miscellaneous databases
RNActi | P58107, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 34 – 71 | Plectin 1Add BLAST | 38 | |
Repeati | 72 – 109 | Plectin 2Add BLAST | 38 | |
Repeati | 110 – 147 | Plectin 3Add BLAST | 38 | |
Repeati | 148 – 185 | Plectin 4Add BLAST | 38 | |
Repeati | 192 – 225 | Plectin 5Add BLAST | 34 | |
Repeati | 278 – 315 | Plectin 6Add BLAST | 38 | |
Repeati | 316 – 353 | Plectin 7Add BLAST | 38 | |
Repeati | 355 – 391 | Plectin 8Add BLAST | 37 | |
Repeati | 392 – 429 | Plectin 9Add BLAST | 38 | |
Repeati | 546 – 583 | Plectin 10Add BLAST | 38 | |
Repeati | 603 – 640 | Plectin 11Add BLAST | 38 | |
Repeati | 641 – 678 | Plectin 12Add BLAST | 38 | |
Repeati | 679 – 716 | Plectin 13Add BLAST | 38 | |
Repeati | 717 – 754 | Plectin 14Add BLAST | 38 | |
Repeati | 758 – 792 | Plectin 15Add BLAST | 35 | |
Repeati | 865 – 903 | Plectin 16Add BLAST | 39 | |
Repeati | 923 – 960 | Plectin 17Add BLAST | 38 | |
Repeati | 961 – 998 | Plectin 18Add BLAST | 38 | |
Repeati | 999 – 1036 | Plectin 19Add BLAST | 38 | |
Repeati | 1037 – 1074 | Plectin 20Add BLAST | 38 | |
Repeati | 1239 – 1276 | Plectin 21Add BLAST | 38 | |
Repeati | 1277 – 1314 | Plectin 22Add BLAST | 38 | |
Repeati | 1315 – 1352 | Plectin 23Add BLAST | 38 | |
Repeati | 1353 – 1390 | Plectin 24Add BLAST | 38 | |
Repeati | 1391 – 1428 | Plectin 25Add BLAST | 38 | |
Repeati | 1564 – 1601 | Plectin 26Add BLAST | 38 | |
Repeati | 1602 – 1639 | Plectin 27Add BLAST | 38 | |
Repeati | 1640 – 1677 | Plectin 28Add BLAST | 38 | |
Repeati | 1678 – 1715 | Plectin 29Add BLAST | 38 | |
Repeati | 1719 – 1753 | Plectin 30Add BLAST | 35 | |
Repeati | 1890 – 1927 | Plectin 31Add BLAST | 38 | |
Repeati | 1928 – 1965 | Plectin 32Add BLAST | 38 | |
Repeati | 1966 – 2003 | Plectin 33Add BLAST | 38 | |
Repeati | 2004 – 2041 | Plectin 34Add BLAST | 38 | |
Repeati | 2042 – 2079 | Plectin 35Add BLAST | 38 | |
Repeati | 2217 – 2259 | Plectin 36Add BLAST | 43 | |
Repeati | 2260 – 2297 | Plectin 37Add BLAST | 38 | |
Repeati | 2298 – 2335 | Plectin 38Add BLAST | 38 | |
Repeati | 2336 – 2373 | Plectin 39Add BLAST | 38 | |
Repeati | 2377 – 2411 | Plectin 40Add BLAST | 35 | |
Repeati | 2753 – 2795 | Plectin 41Add BLAST | 43 | |
Repeati | 2796 – 2833 | Plectin 42Add BLAST | 38 | |
Repeati | 2834 – 2871 | Plectin 43Add BLAST | 38 | |
Repeati | 2872 – 2908 | Plectin 44Add BLAST | 37 | |
Repeati | 2913 – 2947 | Plectin 45Add BLAST | 35 | |
Repeati | 3284 – 3326 | Plectin 46Add BLAST | 43 | |
Repeati | 3327 – 3364 | Plectin 47Add BLAST | 38 | |
Repeati | 3365 – 3402 | Plectin 48Add BLAST | 38 | |
Repeati | 3403 – 3440 | Plectin 49Add BLAST | 38 | |
Repeati | 3444 – 3478 | Plectin 50Add BLAST | 35 | |
Repeati | 3818 – 3860 | Plectin 51Add BLAST | 43 | |
Repeati | 3861 – 3898 | Plectin 52Add BLAST | 38 | |
Repeati | 3899 – 3936 | Plectin 53Add BLAST | 38 | |
Repeati | 3937 – 3974 | Plectin 54Add BLAST | 38 | |
Repeati | 3978 – 4012 | Plectin 55Add BLAST | 35 | |
Repeati | 4352 – 4394 | Plectin 56Add BLAST | 43 | |
Repeati | 4395 – 4432 | Plectin 57Add BLAST | 38 | |
Repeati | 4433 – 4470 | Plectin 58Add BLAST | 38 | |
Repeati | 4471 – 4508 | Plectin 59Add BLAST | 38 | |
Repeati | 4512 – 4546 | Plectin 60Add BLAST | 35 | |
Repeati | 4885 – 4927 | Plectin 61Add BLAST | 43 | |
Repeati | 4928 – 4965 | Plectin 62Add BLAST | 38 | |
Repeati | 4966 – 5003 | Plectin 63Add BLAST | 38 | |
Repeati | 5004 – 5041 | Plectin 64Add BLAST | 38 | |
Repeati | 5045 – 5079 | Plectin 65Add BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 42 – 1115 | Interaction with KRT5By similarityAdd BLAST | 1074 | |
Regioni | 1572 – 5085 | Interaction with KRT5By similarityAdd BLAST | 3514 | |
Regioni | 2761 – 2953 | Interaction with KRT14By similarityAdd BLAST | 193 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 3687 – 3714 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 4221 – 4248 | Sequence analysisAdd BLAST | 28 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0516, Eukaryota |
GeneTreei | ENSGT00940000162855 |
InParanoidi | P58107 |
OMAi | VWELLFY |
OrthoDBi | 2464at2759 |
PhylomeDBi | P58107 |
Family and domain databases
Gene3Di | 3.90.1290.10, 13 hits |
InterProi | View protein in InterPro IPR043197, Plakin IPR035915, Plakin_repeat_sf IPR001101, Plectin_repeat |
PANTHERi | PTHR23169, PTHR23169, 20 hits |
Pfami | View protein in Pfam PF00681, Plectin, 36 hits |
SMARTi | View protein in SMART SM00250, PLEC, 65 hits |
SUPFAMi | SSF75399, SSF75399, 13 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA
60 70 80 90 100
SGQAQSVYAA MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ
110 120 130 140 150
QGLVGLELKE KLLAAERATT GYPDPYGGEK LALFQAIGKE VVDRALGQSW
160 170 180 190 200
LEVQLATGGL VDPAQGVLVA PEPACHQGLL DRETWHKLSE LEPGTGDLRF
210 220 230 240 250
LDPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG AVSAAELLEV
260 270 280 290 300
GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS
310 320 330 340 350
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP
360 370 380 390 400
ELHEQLLVAE QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA
410 420 430 440 450
TGGLVCPARR LRLPLEAALR CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ
460 470 480 490 500
LLALCVTDPE TGLAFLPLSG GPRGGEPQGP PFIKYSTRQA LSTATATVSV
510 520 530 540 550
GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK LAAKLSATLE
560 570 580 590 600
QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA
610 620 630 640 650
SVQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT
660 670 680 690 700
GFIIDPKANK GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI
710 720 730 740 750
SLFQAMQKGL IVREHGIRLL EAQIATGGVI DPVHSHRVPV DVAYRRGYFD
760 770 780 790 800
QMLNLILLDP SDDTKGFFDP NTHENLTYLQ LLERCVRDPE TGLYLLPLSS
810 820 830 840 850
TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE YFSEGRRRQL
860 870 880 890 900
LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ
910 920 930 940 950
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM
960 970 980 990 1000
RQKLLGPRVA LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR
1010 1020 1030 1040 1050
LKRAEGAIAG FRDPFSGKQV SVFQAMKKGL IPWEQAARLL EAQVATGGII
1060 1070 1080 1090 1100
DPTSHHHLPM PVAIQRGYVD QEMETALSSS SETFPTPDGQ GRTSYAQLLE
1110 1120 1130 1140 1150
ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD GTSLWDLLSS
1160 1170 1180 1190 1200
CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR
1210 1220 1230 1240 1250
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG
1260 1270 1280 1290 1300
VLLQPSGAKA SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV
1310 1320 1330 1340 1350
EDAVKVGLVG RELSEQLGQA ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN
1360 1370 1380 1390 1400
EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC RLGLLDTQTS QVLTAVDKDN
1410 1420 1430 1440 1450
KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL EVDDHTAVAL
1460 1470 1480 1490 1500
RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ
1510 1520 1530 1540 1550
VVSAVTTLVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG
1560 1570 1580 1590 1600
TTTVKEVAEM DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT
1610 1620 1630 1640 1650
ALVLLEAQAA TGFIIDPVEN RKLTVEEAFK AGMFGKETYV KLLSAERAVT
1660 1670 1680 1690 1700
GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGI IDPVHSHRVP
1710 1720 1730 1740 1750
VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL QLLERCVEDP
1760 1770 1780 1790 1800
ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL
1810 1820 1830 1840 1850
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI
1860 1870 1880 1890 1900
RGEVTAADLF NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSGCIA
1910 1920 1930 1940 1950
GVTVPSTREV MSLHEASRKE LIPAAFATWL LEAQAATGFL LDPCTRQKLS
1960 1970 1980 1990 2000
VDEAVDVGLV NEELRERLLK AERAATGYRD PATGDTIPLF QAMQKQLIEK
2010 2020 2030 2040 2050
AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI YALISDQKHM
2060 2070 2080 2090 2100
RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW LLFPVNKAAR DSEHIDDETR
2110 2120 2130 2140 2150
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA
2160 2170 2180 2190 2200
LQTVAQLILE LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL
2210 2220 2230 2240 2250
ETGRSTTQEL MEDDRVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW
2260 2270 2280 2290 2300
KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEAVAAG VVGGEIQEKL
2310 2320 2330 2340 2350
LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID
2360 2370 2380 2390 2400
PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL
2410 2420 2430 2440 2450
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ
2460 2470 2480 2490 2500
SVSVWELLFY REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA
2510 2520 2530 2540 2550
RAEAEAGSPR PDPREALRAA TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR
2560 2570 2580 2590 2600
EELLAEFGSG TLDLPALTRR LTAIIEEAEE APGARPQLQD AWRGPREPGP
2610 2620 2630 2640 2650
AGRGDGDSGR SQREGQGEGE TQEAAAAAAA AAARRQEQTL RDATMEVQRG
2660 2670 2680 2690 2700
QFQGRPVSVW DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE
2710 2720 2730 2740 2750
TEERLSKVSF RGLRRQVSAS ELHTSGILGP ETLRDLAQGT KTLQEVTEMD
2760 2770 2780 2790 2800
SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS IYQAMWKGVL RPGTALVLLE
2810 2820 2830 2840 2850
AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE RAVTGYTDPY
2860 2870 2880 2890 2900
TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYQ
2910 2920 2930 2940 2950
RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM
2960 2970 2980 2990 3000
LQLAGRGSAV HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS
3010 3020 3030 3040 3050
EDRRQDLLSR YRAGTLTVEE LGATLTSLLA QAQAQARAEA EAGSPRPDPR
3060 3070 3080 3090 3100
EALRAATMEV KVGRLRGRAV PVWDVLASGY VSRAAREELL AEFGSGTLDL
3110 3120 3130 3140 3150
PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG DGDSGRSQRE
3160 3170 3180 3190 3200
GQGEGETQEA AAAARRQEQT LRDATMEVQR GQFQGRPVSV WDVLFSSYLS
3210 3220 3230 3240 3250
EARRDELLAQ HAAGALGLPD LVAVLTRVIE ETEERLSKVS FRGLRCQVSA
3260 3270 3280 3290 3300
SELHTSGILG PETLRDLAQG TKTLQEVTEM DSVKRYLEGT SCIAGVLVPA
3310 3320 3330 3340 3350
KDQPGRQEKM SIYQAMWKGV LRPGTALVLL EAQAATGFVI DPVRNLRLSV
3360 3370 3380 3390 3400
EEAVAAGVVG GEIQEKLLSA ERAVTGYTDP YTGQQISLFQ AMQKDLIVRE
3410 3420 3430 3440 3450
HGIRLLEAQI ATGGVIDPVH SHRVPVDVAY RRGYFDEEMN RVLADPSDDT
3460 3470 3480 3490 3500
KGFFDPNTHE NLTYVQLLRR CVPDPDTGLY MLQLAGRGSA VHQLSEELRC
3510 3520 3530 3540 3550
ALRDARVTPG SGALQGQSVS VWELLFYREV SEDRRQDLLS RYRAGTLTVE
3560 3570 3580 3590 3600
ELGATLTSLL AQAQAQARAE AEAGSPRPDP REALRAATME VKVGRLRGRA
3610 3620 3630 3640 3650
VPVWDVLASG YVSRAAREEL LAEFGSGTLD LPALTRRLTA IIEEAEEAPG
3660 3670 3680 3690 3700
ARPQLQDAWR GPREPGPAGR GDGDSGRSQR EGQGEGETQE AAAATAAARR
3710 3720 3730 3740 3750
QEQTLRDATM EVQRGQFQGR PVSVWDVLFS SYLSEARRDE LLAQHAAGAL
3760 3770 3780 3790 3800
GLPDLVAVLT RVIEETEERL SKVSFRGLRR QVSASELHTS GILGPETLRD
3810 3820 3830 3840 3850
LAQGTKTLQE VTEMDSVKRY LEGTSCIAGV LVPAKDQPGR QEKMSIYQAM
3860 3870 3880 3890 3900
WKGVLRPGTA LVLLEAQAAT GFVIDPVRNL RLSVEEAVAA GVVGGEIQEK
3910 3920 3930 3940 3950
LLSAERAVTG YTDPYTGQQI SLFQAMQKDL IVREHGIRLL EAQIATGGVI
3960 3970 3980 3990 4000
DPVHSHRVPV DVAYRRGYFD EEMNRVLADP SDDTKGFFDP NTHENLTYVQ
4010 4020 4030 4040 4050
LLRRCVPDPD TGLYMLQLAG RGSAVHQLSE ELRCALRDAR VTPGSGALQG
4060 4070 4080 4090 4100
QSVSVWELLF YREVSEDRRQ DLLSRYRAGT LTVEELGATL TSLLAQAQAQ
4110 4120 4130 4140 4150
ARAEAEAGSP RPDPREALRA ATMEVKVGRL RGRAVPVWDV LASGYVSRAA
4160 4170 4180 4190 4200
REELLAEFGS GTLDLPALTR RLTAIIEEAE EAPGARPQLQ DAWRGPREPG
4210 4220 4230 4240 4250
PAGRGDGDSG RSQREGQGEG ETQEAAAATA AARRQEQTLR DATMEVQRGQ
4260 4270 4280 4290 4300
FQGRPVSVWD VLFSSYLSEA RRDELLAQHA AGALGLPDLV AVLTRVIEET
4310 4320 4330 4340 4350
EERLSKVSFR GLRRQVSASE LHTSGILGPE TLRDLAQGTK TLQEVTEMDS
4360 4370 4380 4390 4400
VKRYLEGTSC IAGVLVPAKD QPGHQEKMSI YQAMWKGVLR PGTALVLLEA
4410 4420 4430 4440 4450
QAATGFVIDP VRNLRLSVEE AVAAGVVGGE IQEKLLSAER AVTGYTDPYT
4460 4470 4480 4490 4500
GQQISLFQAM QKDLIVREHG IRLLEAQIAT GGVIDPVHSH RVPVDVAYRR
4510 4520 4530 4540 4550
GYFDEEMNRV LAHPSDDTKG FFDPNTHENL TYVQLLRRCV PDPDTGLYML
4560 4570 4580 4590 4600
QLAGRGSAVH QLSEELRCAL RDARVMPGSG ALQGQSVSVW ELLFYREVSE
4610 4620 4630 4640 4650
DRRQDLLSRY RAGTLTVEEL GATLTSLLAQ AQAQARAEAE AEAGSPRPDP
4660 4670 4680 4690 4700
REALRAATME VKVGRLRGRA VPVWDVLASG YVSGAAREEL LAEFGSGTLD
4710 4720 4730 4740 4750
LPALTRRLTA IIEEAEEAPG ARPQLQDAWR GPREPGPAGR GDGDSGRSQR
4760 4770 4780 4790 4800
EGQGEGETQE AAAAARRQEQ TLRDATMEVQ RGQFQGRPVS VWDVLFSSYL
4810 4820 4830 4840 4850
SEAHRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV SFRGLRRQVS
4860 4870 4880 4890 4900
ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP
4910 4920 4930 4940 4950
AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS
4960 4970 4980 4990 5000
VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR
5010 5020 5030 5040 5050
EHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YRRGYFDEEM NRVLADPSDD
5060 5070 5080
TKGFFDPNTH ENLTYLQLLQ RATLDPETGL LFLSLSLQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A075B730 | A0A075B730_HUMAN | Epiplakin | EPPK1 | 5,063 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 202 | D → N in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 544 | K → E in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 602 | V → A in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 1507 | T → A in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 1507 | T → A in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 1618 | V → A in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 1897 | G → D in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 2081 | L → V in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 2081 | L → V in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 2286 – 2288 | AVA → PVP in BAB40803 (PubMed:11278896).Curated | 3 | |
Sequence conflicti | 2286 – 2288 | AVA → PVP in BAC92750 (PubMed:14708632).Curated | 3 | |
Sequence conflicti | 2294 | G → S in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 2294 | G → S in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 2592 | W → R in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 2592 | W → R in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 2624 – 2628 | Missing in BAC92750 (PubMed:14708632). | 5 | |
Sequence conflicti | 2624 – 2625 | Missing in BAB40803 (PubMed:11278896).Curated | 2 | |
Sequence conflicti | 2715 | R → C in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 2900 | Q → R in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 2900 | Q → R in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 2977 | T → M in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 3083 | R → G in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 3083 | R → G in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 3159 | E → EAAA in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 3161 | A → AAAT in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 3246 | C → R in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 3246 | C → R in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 3445 | D → H in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 3614 | R → G in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 3614 | R → G in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 3695 | T → A in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 3840 | R → H in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 3979 | D → H in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 4042 | T → M in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 4079 | G → S in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 4119 | R → RPS in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 4148 | R → G in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 4227 – 4229 | Missing in BAC92750 (PubMed:14708632).Curated | 3 | |
Sequence conflicti | 4374 | H → R in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 4374 | H → R in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 4513 | H → D in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 4513 | H → D in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 4576 | M → T in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 4576 | M → T in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 4637 – 4638 | Missing in BAB40803 (PubMed:11278896).Curated | 2 | |
Sequence conflicti | 4637 – 4638 | Missing in BAC92750 (PubMed:14708632).Curated | 2 | |
Sequence conflicti | 4760 | E → EAAA in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 4760 | E → EAAA in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 4804 | H → R in BAB40803 (PubMed:11278896).Curated | 1 | |
Sequence conflicti | 4804 | H → R in BAC92750 (PubMed:14708632).Curated | 1 | |
Sequence conflicti | 5066 | L → V in BAC92750 (PubMed:14708632).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081533 | 1094 | S → N De novo variant found in a patient with childhood apraxia of speech; unknown pathological significance. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051895 mRNA Translation: BAB40803.1 Different initiation. AB107036 Genomic DNA Translation: BAC92750.1 Different initiation. AC109322 Genomic DNA No translation available. AC234917 Genomic DNA No translation available. AL137725 mRNA Translation: CAB70895.1 |
CCDSi | CCDS75800.1 |
RefSeqi | NP_112598.3, NM_031308.3 XP_016869379.1, XM_017013890.1 |
Genome annotation databases
Ensembli | ENST00000615648; ENSP00000484472; ENSG00000261150 |
GeneIDi | 83481 |
KEGGi | hsa:83481 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB051895 mRNA Translation: BAB40803.1 Different initiation. AB107036 Genomic DNA Translation: BAC92750.1 Different initiation. AC109322 Genomic DNA No translation available. AC234917 Genomic DNA No translation available. AL137725 mRNA Translation: CAB70895.1 |
CCDSi | CCDS75800.1 |
RefSeqi | NP_112598.3, NM_031308.3 XP_016869379.1, XM_017013890.1 |
3D structure databases
SMRi | P58107 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123666, 86 interactors |
IntActi | P58107, 32 interactors |
MINTi | P58107 |
STRINGi | 9606.ENSP00000484472 |
PTM databases
iPTMneti | P58107 |
PhosphoSitePlusi | P58107 |
SwissPalmi | P58107 |
Genetic variation databases
BioMutai | EPPK1 |
DMDMi | 300669637 |
Proteomic databases
EPDi | P58107 |
jPOSTi | P58107 |
MassIVEi | P58107 |
PaxDbi | P58107 |
PeptideAtlasi | P58107 |
PRIDEi | P58107 |
ProteomicsDBi | 57049 |
Protocols and materials databases
Antibodypediai | 74951, 32 antibodies |
Genome annotation databases
Ensembli | ENST00000615648; ENSP00000484472; ENSG00000261150 |
GeneIDi | 83481 |
KEGGi | hsa:83481 |
Organism-specific databases
CTDi | 83481 |
DisGeNETi | 83481 |
GeneCardsi | EPPK1 |
HGNCi | HGNC:15577, EPPK1 |
MIMi | 607553, gene |
neXtProti | NX_P58107 |
OpenTargetsi | ENSG00000261150 |
PharmGKBi | PA27835 |
VEuPathDBi | HostDB:ENSG00000261150.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0516, Eukaryota |
GeneTreei | ENSGT00940000162855 |
InParanoidi | P58107 |
OMAi | VWELLFY |
OrthoDBi | 2464at2759 |
PhylomeDBi | P58107 |
Enzyme and pathway databases
PathwayCommonsi | P58107 |
Miscellaneous databases
BioGRID-ORCSi | 83481, 10 hits in 143 CRISPR screens |
GeneWikii | Epiplakin_1 |
GenomeRNAii | 83481 |
Pharosi | P58107, Tdark |
PROi | PR:P58107 |
RNActi | P58107, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000261150, Expressed in oviduct epithelium and 157 other tissues |
ExpressionAtlasi | P58107, baseline and differential |
Family and domain databases
Gene3Di | 3.90.1290.10, 13 hits |
InterProi | View protein in InterPro IPR043197, Plakin IPR035915, Plakin_repeat_sf IPR001101, Plectin_repeat |
PANTHERi | PTHR23169, PTHR23169, 20 hits |
Pfami | View protein in Pfam PF00681, Plectin, 36 hits |
SMARTi | View protein in SMART SM00250, PLEC, 65 hits |
SUPFAMi | SSF75399, SSF75399, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPIPL_HUMAN | |
Accessioni | P58107Primary (citable) accession number: P58107 Secondary accession number(s): A0A087X1U6, Q76E58, Q9NSU9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM