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UniProtKB - P58107 (EPIPL_HUMAN)

Entry version 166 (10 Feb 2021)
Sequence version 3 (28 Mar 2018)
Previous versions | rss
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Protein

Epiplakin

Gene

EPPK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity).By similarity3 Publications

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P58107

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epiplakin1 Publication
Alternative name(s):
450 kDa epidermal antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPPK11 PublicationImported
Synonyms:EPIPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15577, EPPK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607553, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P58107

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000261150.2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		83481

Open Targets

More...OpenTargetsi		ENSG00000261150

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27835

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P58107, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EPPK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669637

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781451 – 5088EpiplakinAdd BLAST5088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphothreonineCombined sources1
Modified residuei1543PhosphothreonineCombined sources1
Modified residuei2422PhosphoserineCombined sources1
Modified residuei2508PhosphoserineCombined sources1
Modified residuei2718PhosphoserineCombined sources1
Modified residuei2958PhosphoserineCombined sources1
Modified residuei3044PhosphoserineCombined sources1
Modified residuei3249PhosphoserineCombined sources1
Modified residuei3489PhosphoserineCombined sources1
Modified residuei3575PhosphoserineCombined sources1
Modified residuei3783PhosphoserineCombined sources1
Modified residuei4023PhosphoserineCombined sources1
Modified residuei4109PhosphoserineCombined sources1
Modified residuei4317PhosphoserineCombined sources1
Modified residuei4557PhosphoserineCombined sources1
Modified residuei4645PhosphoserineCombined sources1
Modified residuei4850PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P58107

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P58107

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P58107

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P58107

PeptideAtlas

More...PeptideAtlasi		P58107

PRoteomics IDEntifications database

More...PRIDEi		P58107

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57049

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P58107

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P58107

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P58107

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial cells of liver, small intestine, colon, salivary glands, stomach and appendix.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated upon calcium-mediated keratinocyte differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000261150, Expressed in oviduct epithelium and 157 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P58107, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KRT5, KRT14 and KRT5/KRT14 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:15671067).

Interacts with KRT8 and KRT18 and KRT8/KRT18 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:15671067).

Interacts with KRT1, VIM and DES; interaction is stronger with KRT1 than with VIM or DES; interaction is dependent of higher-order structure of intermediate filament (PubMed:16923132).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123666, 86 interactors

Protein interaction database and analysis system

More...IntActi		P58107, 32 interactors

Molecular INTeraction database

More...MINTi		P58107

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000484472

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P58107, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P58107

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 71Plectin 1Add BLAST38
Repeati72 – 109Plectin 2Add BLAST38
Repeati110 – 147Plectin 3Add BLAST38
Repeati148 – 185Plectin 4Add BLAST38
Repeati192 – 225Plectin 5Add BLAST34
Repeati278 – 315Plectin 6Add BLAST38
Repeati316 – 353Plectin 7Add BLAST38
Repeati355 – 391Plectin 8Add BLAST37
Repeati392 – 429Plectin 9Add BLAST38
Repeati546 – 583Plectin 10Add BLAST38
Repeati603 – 640Plectin 11Add BLAST38
Repeati641 – 678Plectin 12Add BLAST38
Repeati679 – 716Plectin 13Add BLAST38
Repeati717 – 754Plectin 14Add BLAST38
Repeati758 – 792Plectin 15Add BLAST35
Repeati865 – 903Plectin 16Add BLAST39
Repeati923 – 960Plectin 17Add BLAST38
Repeati961 – 998Plectin 18Add BLAST38
Repeati999 – 1036Plectin 19Add BLAST38
Repeati1037 – 1074Plectin 20Add BLAST38
Repeati1239 – 1276Plectin 21Add BLAST38
Repeati1277 – 1314Plectin 22Add BLAST38
Repeati1315 – 1352Plectin 23Add BLAST38
Repeati1353 – 1390Plectin 24Add BLAST38
Repeati1391 – 1428Plectin 25Add BLAST38
Repeati1564 – 1601Plectin 26Add BLAST38
Repeati1602 – 1639Plectin 27Add BLAST38
Repeati1640 – 1677Plectin 28Add BLAST38
Repeati1678 – 1715Plectin 29Add BLAST38
Repeati1719 – 1753Plectin 30Add BLAST35
Repeati1890 – 1927Plectin 31Add BLAST38
Repeati1928 – 1965Plectin 32Add BLAST38
Repeati1966 – 2003Plectin 33Add BLAST38
Repeati2004 – 2041Plectin 34Add BLAST38
Repeati2042 – 2079Plectin 35Add BLAST38
Repeati2217 – 2259Plectin 36Add BLAST43
Repeati2260 – 2297Plectin 37Add BLAST38
Repeati2298 – 2335Plectin 38Add BLAST38
Repeati2336 – 2373Plectin 39Add BLAST38
Repeati2377 – 2411Plectin 40Add BLAST35
Repeati2753 – 2795Plectin 41Add BLAST43
Repeati2796 – 2833Plectin 42Add BLAST38
Repeati2834 – 2871Plectin 43Add BLAST38
Repeati2872 – 2908Plectin 44Add BLAST37
Repeati2913 – 2947Plectin 45Add BLAST35
Repeati3284 – 3326Plectin 46Add BLAST43
Repeati3327 – 3364Plectin 47Add BLAST38
Repeati3365 – 3402Plectin 48Add BLAST38
Repeati3403 – 3440Plectin 49Add BLAST38
Repeati3444 – 3478Plectin 50Add BLAST35
Repeati3818 – 3860Plectin 51Add BLAST43
Repeati3861 – 3898Plectin 52Add BLAST38
Repeati3899 – 3936Plectin 53Add BLAST38
Repeati3937 – 3974Plectin 54Add BLAST38
Repeati3978 – 4012Plectin 55Add BLAST35
Repeati4352 – 4394Plectin 56Add BLAST43
Repeati4395 – 4432Plectin 57Add BLAST38
Repeati4433 – 4470Plectin 58Add BLAST38
Repeati4471 – 4508Plectin 59Add BLAST38
Repeati4512 – 4546Plectin 60Add BLAST35
Repeati4885 – 4927Plectin 61Add BLAST43
Repeati4928 – 4965Plectin 62Add BLAST38
Repeati4966 – 5003Plectin 63Add BLAST38
Repeati5004 – 5041Plectin 64Add BLAST38
Repeati5045 – 5079Plectin 65Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 1115Interaction with KRT5By similarityAdd BLAST1074
Regioni1572 – 5085Interaction with KRT5By similarityAdd BLAST3514
Regioni2761 – 2953Interaction with KRT14By similarityAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3687 – 3714Sequence analysisAdd BLAST28
Coiled coili4221 – 4248Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Plectin repeats are important for the binding to keratin and VIM and controls intermediate filament networks organization.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0516, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162855

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P58107

Identification of Orthologs from Complete Genome Data

More...OMAi		VWELLFY

Database of Orthologous Groups

More...OrthoDBi		2464at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P58107

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.1290.10, 13 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 20 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00681, Plectin, 36 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00250, PLEC, 65 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF75399, SSF75399, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P58107-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA 
        60         70         80         90        100
SGQAQSVYAA MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ 
       110        120        130        140        150
QGLVGLELKE KLLAAERATT GYPDPYGGEK LALFQAIGKE VVDRALGQSW 
       160        170        180        190        200
LEVQLATGGL VDPAQGVLVA PEPACHQGLL DRETWHKLSE LEPGTGDLRF 
       210        220        230        240        250
LDPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG AVSAAELLEV 
       260        270        280        290        300
GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS 
       310        320        330        340        350
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP 
       360        370        380        390        400
ELHEQLLVAE QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA 
       410        420        430        440        450
TGGLVCPARR LRLPLEAALR CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ 
       460        470        480        490        500
LLALCVTDPE TGLAFLPLSG GPRGGEPQGP PFIKYSTRQA LSTATATVSV 
       510        520        530        540        550
GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK LAAKLSATLE 
       560        570        580        590        600
QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA 
       610        620        630        640        650
SVQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT 
       660        670        680        690        700
GFIIDPKANK GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI 
       710        720        730        740        750
SLFQAMQKGL IVREHGIRLL EAQIATGGVI DPVHSHRVPV DVAYRRGYFD 
       760        770        780        790        800
QMLNLILLDP SDDTKGFFDP NTHENLTYLQ LLERCVRDPE TGLYLLPLSS 
       810        820        830        840        850
TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE YFSEGRRRQL 
       860        870        880        890        900
LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ 
       910        920        930        940        950
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM 
       960        970        980        990       1000
RQKLLGPRVA LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR 
      1010       1020       1030       1040       1050
LKRAEGAIAG FRDPFSGKQV SVFQAMKKGL IPWEQAARLL EAQVATGGII 
      1060       1070       1080       1090       1100
DPTSHHHLPM PVAIQRGYVD QEMETALSSS SETFPTPDGQ GRTSYAQLLE 
      1110       1120       1130       1140       1150
ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD GTSLWDLLSS 
      1160       1170       1180       1190       1200
CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR 
      1210       1220       1230       1240       1250
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG 
      1260       1270       1280       1290       1300
VLLQPSGAKA SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV 
      1310       1320       1330       1340       1350
EDAVKVGLVG RELSEQLGQA ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN 
      1360       1370       1380       1390       1400
EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC RLGLLDTQTS QVLTAVDKDN 
      1410       1420       1430       1440       1450
KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL EVDDHTAVAL 
      1460       1470       1480       1490       1500
RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ 
      1510       1520       1530       1540       1550
VVSAVTTLVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG 
      1560       1570       1580       1590       1600
TTTVKEVAEM DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT 
      1610       1620       1630       1640       1650
ALVLLEAQAA TGFIIDPVEN RKLTVEEAFK AGMFGKETYV KLLSAERAVT 
      1660       1670       1680       1690       1700
GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGI IDPVHSHRVP 
      1710       1720       1730       1740       1750
VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL QLLERCVEDP 
      1760       1770       1780       1790       1800
ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL 
      1810       1820       1830       1840       1850
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI 
      1860       1870       1880       1890       1900
RGEVTAADLF NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSGCIA 
      1910       1920       1930       1940       1950
GVTVPSTREV MSLHEASRKE LIPAAFATWL LEAQAATGFL LDPCTRQKLS 
      1960       1970       1980       1990       2000
VDEAVDVGLV NEELRERLLK AERAATGYRD PATGDTIPLF QAMQKQLIEK 
      2010       2020       2030       2040       2050
AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI YALISDQKHM 
      2060       2070       2080       2090       2100
RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW LLFPVNKAAR DSEHIDDETR 
      2110       2120       2130       2140       2150
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA 
      2160       2170       2180       2190       2200
LQTVAQLILE LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL 
      2210       2220       2230       2240       2250
ETGRSTTQEL MEDDRVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW 
      2260       2270       2280       2290       2300
KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEAVAAG VVGGEIQEKL 
      2310       2320       2330       2340       2350
LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID 
      2360       2370       2380       2390       2400
PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL 
      2410       2420       2430       2440       2450
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ 
      2460       2470       2480       2490       2500
SVSVWELLFY REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA 
      2510       2520       2530       2540       2550
RAEAEAGSPR PDPREALRAA TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR 
      2560       2570       2580       2590       2600
EELLAEFGSG TLDLPALTRR LTAIIEEAEE APGARPQLQD AWRGPREPGP 
      2610       2620       2630       2640       2650
AGRGDGDSGR SQREGQGEGE TQEAAAAAAA AAARRQEQTL RDATMEVQRG 
      2660       2670       2680       2690       2700
QFQGRPVSVW DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE 
      2710       2720       2730       2740       2750
TEERLSKVSF RGLRRQVSAS ELHTSGILGP ETLRDLAQGT KTLQEVTEMD 
      2760       2770       2780       2790       2800
SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS IYQAMWKGVL RPGTALVLLE 
      2810       2820       2830       2840       2850
AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE RAVTGYTDPY 
      2860       2870       2880       2890       2900
TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYQ 
      2910       2920       2930       2940       2950
RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM 
      2960       2970       2980       2990       3000
LQLAGRGSAV HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS 
      3010       3020       3030       3040       3050
EDRRQDLLSR YRAGTLTVEE LGATLTSLLA QAQAQARAEA EAGSPRPDPR 
      3060       3070       3080       3090       3100
EALRAATMEV KVGRLRGRAV PVWDVLASGY VSRAAREELL AEFGSGTLDL 
      3110       3120       3130       3140       3150
PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG DGDSGRSQRE 
      3160       3170       3180       3190       3200
GQGEGETQEA AAAARRQEQT LRDATMEVQR GQFQGRPVSV WDVLFSSYLS 
      3210       3220       3230       3240       3250
EARRDELLAQ HAAGALGLPD LVAVLTRVIE ETEERLSKVS FRGLRCQVSA 
      3260       3270       3280       3290       3300
SELHTSGILG PETLRDLAQG TKTLQEVTEM DSVKRYLEGT SCIAGVLVPA 
      3310       3320       3330       3340       3350
KDQPGRQEKM SIYQAMWKGV LRPGTALVLL EAQAATGFVI DPVRNLRLSV 
      3360       3370       3380       3390       3400
EEAVAAGVVG GEIQEKLLSA ERAVTGYTDP YTGQQISLFQ AMQKDLIVRE 
      3410       3420       3430       3440       3450
HGIRLLEAQI ATGGVIDPVH SHRVPVDVAY RRGYFDEEMN RVLADPSDDT 
      3460       3470       3480       3490       3500
KGFFDPNTHE NLTYVQLLRR CVPDPDTGLY MLQLAGRGSA VHQLSEELRC 
      3510       3520       3530       3540       3550
ALRDARVTPG SGALQGQSVS VWELLFYREV SEDRRQDLLS RYRAGTLTVE 
      3560       3570       3580       3590       3600
ELGATLTSLL AQAQAQARAE AEAGSPRPDP REALRAATME VKVGRLRGRA 
      3610       3620       3630       3640       3650
VPVWDVLASG YVSRAAREEL LAEFGSGTLD LPALTRRLTA IIEEAEEAPG 
      3660       3670       3680       3690       3700
ARPQLQDAWR GPREPGPAGR GDGDSGRSQR EGQGEGETQE AAAATAAARR 
      3710       3720       3730       3740       3750
QEQTLRDATM EVQRGQFQGR PVSVWDVLFS SYLSEARRDE LLAQHAAGAL 
      3760       3770       3780       3790       3800
GLPDLVAVLT RVIEETEERL SKVSFRGLRR QVSASELHTS GILGPETLRD 
      3810       3820       3830       3840       3850
LAQGTKTLQE VTEMDSVKRY LEGTSCIAGV LVPAKDQPGR QEKMSIYQAM 
      3860       3870       3880       3890       3900
WKGVLRPGTA LVLLEAQAAT GFVIDPVRNL RLSVEEAVAA GVVGGEIQEK 
      3910       3920       3930       3940       3950
LLSAERAVTG YTDPYTGQQI SLFQAMQKDL IVREHGIRLL EAQIATGGVI 
      3960       3970       3980       3990       4000
DPVHSHRVPV DVAYRRGYFD EEMNRVLADP SDDTKGFFDP NTHENLTYVQ 
      4010       4020       4030       4040       4050
LLRRCVPDPD TGLYMLQLAG RGSAVHQLSE ELRCALRDAR VTPGSGALQG 
      4060       4070       4080       4090       4100
QSVSVWELLF YREVSEDRRQ DLLSRYRAGT LTVEELGATL TSLLAQAQAQ 
      4110       4120       4130       4140       4150
ARAEAEAGSP RPDPREALRA ATMEVKVGRL RGRAVPVWDV LASGYVSRAA 
      4160       4170       4180       4190       4200
REELLAEFGS GTLDLPALTR RLTAIIEEAE EAPGARPQLQ DAWRGPREPG 
      4210       4220       4230       4240       4250
PAGRGDGDSG RSQREGQGEG ETQEAAAATA AARRQEQTLR DATMEVQRGQ 
      4260       4270       4280       4290       4300
FQGRPVSVWD VLFSSYLSEA RRDELLAQHA AGALGLPDLV AVLTRVIEET 
      4310       4320       4330       4340       4350
EERLSKVSFR GLRRQVSASE LHTSGILGPE TLRDLAQGTK TLQEVTEMDS 
      4360       4370       4380       4390       4400
VKRYLEGTSC IAGVLVPAKD QPGHQEKMSI YQAMWKGVLR PGTALVLLEA 
      4410       4420       4430       4440       4450
QAATGFVIDP VRNLRLSVEE AVAAGVVGGE IQEKLLSAER AVTGYTDPYT 
      4460       4470       4480       4490       4500
GQQISLFQAM QKDLIVREHG IRLLEAQIAT GGVIDPVHSH RVPVDVAYRR 
      4510       4520       4530       4540       4550
GYFDEEMNRV LAHPSDDTKG FFDPNTHENL TYVQLLRRCV PDPDTGLYML 
      4560       4570       4580       4590       4600
QLAGRGSAVH QLSEELRCAL RDARVMPGSG ALQGQSVSVW ELLFYREVSE 
      4610       4620       4630       4640       4650
DRRQDLLSRY RAGTLTVEEL GATLTSLLAQ AQAQARAEAE AEAGSPRPDP 
      4660       4670       4680       4690       4700
REALRAATME VKVGRLRGRA VPVWDVLASG YVSGAAREEL LAEFGSGTLD 
      4710       4720       4730       4740       4750
LPALTRRLTA IIEEAEEAPG ARPQLQDAWR GPREPGPAGR GDGDSGRSQR 
      4760       4770       4780       4790       4800
EGQGEGETQE AAAAARRQEQ TLRDATMEVQ RGQFQGRPVS VWDVLFSSYL 
      4810       4820       4830       4840       4850
SEAHRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV SFRGLRRQVS 
      4860       4870       4880       4890       4900
ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP 
      4910       4920       4930       4940       4950
AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS 
      4960       4970       4980       4990       5000
VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR 
      5010       5020       5030       5040       5050
EHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YRRGYFDEEM NRVLADPSDD 
      5060       5070       5080 
TKGFFDPNTH ENLTYLQLLQ RATLDPETGL LFLSLSLQ
Length:5,088
Mass (Da):555,658
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED7799C641FA8FC5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B730A0A075B730_HUMAN
Epiplakin
EPPK1
5,063Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB40803 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC92750 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202D → N in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti544K → E in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti602V → A in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti1507T → A in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti1507T → A in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti1618V → A in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti1897G → D in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2081L → V in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2081L → V in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2286 – 2288AVA → PVP in BAB40803 (PubMed:11278896).Curated3
Sequence conflicti2286 – 2288AVA → PVP in BAC92750 (PubMed:14708632).Curated3
Sequence conflicti2294G → S in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2294G → S in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2592W → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2592W → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2624 – 2628Missing in BAC92750 (PubMed:14708632).5
Sequence conflicti2624 – 2625Missing in BAB40803 (PubMed:11278896).Curated2
Sequence conflicti2715R → C in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2900Q → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2900Q → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2977T → M in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3083R → G in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3083R → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3159E → EAAA in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3161A → AAAT in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3246C → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3246C → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3445D → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3614R → G in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3614R → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3695T → A in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3840R → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3979D → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4042T → M in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4079G → S in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4119R → RPS in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4148R → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4227 – 4229Missing in BAC92750 (PubMed:14708632).Curated3
Sequence conflicti4374H → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4374H → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4513H → D in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4513H → D in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4576M → T in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4576M → T in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4637 – 4638Missing in BAB40803 (PubMed:11278896).Curated2
Sequence conflicti4637 – 4638Missing in BAC92750 (PubMed:14708632).Curated2
Sequence conflicti4760E → EAAA in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4760E → EAAA in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4804H → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4804H → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti5066L → V in BAC92750 (PubMed:14708632).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0815331094S → N De novo variant found in a patient with childhood apraxia of speech; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB051895 mRNA Translation: BAB40803.1 Different initiation.
AB107036 Genomic DNA Translation: BAC92750.1 Different initiation.
AC109322 Genomic DNA No translation available.
AC234917 Genomic DNA No translation available.
AL137725 mRNA Translation: CAB70895.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS75800.1

NCBI Reference Sequences

More...RefSeqi		NP_112598.3, NM_031308.3
XP_016869379.1, XM_017013890.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000615648; ENSP00000484472; ENSG00000261150

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83481

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83481

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051895 mRNA Translation: BAB40803.1 Different initiation.
AB107036 Genomic DNA Translation: BAC92750.1 Different initiation.
AC109322 Genomic DNA No translation available.
AC234917 Genomic DNA No translation available.
AL137725 mRNA Translation: CAB70895.1
CCDSiCCDS75800.1
RefSeqiNP_112598.3, NM_031308.3
XP_016869379.1, XM_017013890.1

3D structure databases

SMRiP58107
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123666, 86 interactors
IntActiP58107, 32 interactors
MINTiP58107
STRINGi9606.ENSP00000484472

PTM databases

iPTMnetiP58107
PhosphoSitePlusiP58107
SwissPalmiP58107

Genetic variation databases

BioMutaiEPPK1
DMDMi300669637

Proteomic databases

EPDiP58107
jPOSTiP58107
MassIVEiP58107
PaxDbiP58107
PeptideAtlasiP58107
PRIDEiP58107
ProteomicsDBi57049

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		74951, 32 antibodies

Genome annotation databases

EnsembliENST00000615648; ENSP00000484472; ENSG00000261150
GeneIDi83481
KEGGihsa:83481

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83481
DisGeNETi83481

GeneCards: human genes, protein and diseases

More...GeneCardsi		EPPK1
HGNCiHGNC:15577, EPPK1
MIMi607553, gene
neXtProtiNX_P58107
OpenTargetsiENSG00000261150
PharmGKBiPA27835
VEuPathDBiHostDB:ENSG00000261150.2

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000162855
InParanoidiP58107
OMAiVWELLFY
OrthoDBi2464at2759
PhylomeDBiP58107

Enzyme and pathway databases

PathwayCommonsiP58107

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83481, 10 hits in 143 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Epiplakin_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83481
PharosiP58107, Tdark

Protein Ontology

More...PROi		PR:P58107
RNActiP58107, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000261150, Expressed in oviduct epithelium and 157 other tissues
ExpressionAtlasiP58107, baseline and differential

Family and domain databases

Gene3Di3.90.1290.10, 13 hits
InterProiView protein in InterPro
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
PANTHERiPTHR23169, PTHR23169, 20 hits
PfamiView protein in Pfam
PF00681, Plectin, 36 hits
SMARTiView protein in SMART
SM00250, PLEC, 65 hits
SUPFAMiSSF75399, SSF75399, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPIPL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58107
Secondary accession number(s): A0A087X1U6, Q76E58, Q9NSU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 28, 2018
Last modified: February 10, 2021
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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