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Entry version 145 (12 Aug 2020)
Sequence version 2 (18 Sep 2013)
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Protein

Ras GTPase-activating protein 2

Gene

Rasa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) and phospholipids.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri706 – 742Btk-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5658442, Regulation of RAS by GAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras GTPase-activating protein 2
Alternative name(s):
GAP1m
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rasa2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2149960, Rasa2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi626 – 628KKR → QQQ: No binding to IP4, reduced binding to phospholipids. 1 Publication3
Mutagenesisi628R → C: Greatly reduced binding to IP4 and to phospholipids. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000566392 – 847Ras GTPase-activating protein 2Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei554PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P58069

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P58069

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P58069

PeptideAtlas

More...
PeptideAtlasi
P58069

PRoteomics IDEntifications database

More...
PRIDEi
P58069

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P58069

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58069

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032413, Expressed in secondary oocyte and 279 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P58069, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P58069, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
227827, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034984

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P58069, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 137C2 1PROSITE-ProRule annotationAdd BLAST119
Domaini148 – 288C2 2PROSITE-ProRule annotationAdd BLAST141
Domaini355 – 549Ras-GAPPROSITE-ProRule annotationAdd BLAST195
Domaini603 – 704PHPROSITE-ProRule annotationAdd BLAST102

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21Ala-richAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri706 – 742Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158201

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008096_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P58069

KEGG Orthology (KO)

More...
KOi
K08053

Identification of Orthologs from Complete Genome Data

More...
OMAi
DICRERY

Database of Orthologous Groups

More...
OrthoDBi
145372at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105302

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13370, PH_GAP1m_mammal-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR037773, RASA2_PH
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001562, Znf_Btk_motif

The PANTHER Classification System

More...
PANTHERi
PTHR10194, PTHR10194, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00779, BTK, 1 hit
PF00168, C2, 2 hits
PF00169, PH, 1 hit
PF00616, RasGAP, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00402, TECBTKDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00107, BTK, 1 hit
SM00239, C2, 2 hits
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS51113, ZF_BTK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P58069-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAPAAAA SPEAPAVSGS ADPETGDEDS REVRVLQSLR GRIYEAKNLL
60 70 80 90 100
PYLGPNKMRD CFCTINLDQE EVYRTQVVEK SLSPYFSEEF YFEIPRTFQY
110 120 130 140 150
LSFYVYDKNV LQRDLRIGKV AIKKEDLCSH SGKETWFSLQ PIDSNSEVQG
160 170 180 190 200
KVHLELRLNE LITENGTVCQ QLVVHIKACH GLPLINGQSC DPYATVSLVG
210 220 230 240 250
PSRNDQKKTK VKKKTSNPQF NEVFYFEVTR SSSYSRKSQF QVEEEDIEKL
260 270 280 290 300
EIRIDLWNNE NLVQDVFLGE IKVPVNVLRS DSFHQAWYLL QPRDNGNKSS
310 320 330 340 350
KTDDLGSLLL TLCYTEDCVL PSEYYGPLKT LLLKSPDVQP VSASAAYILG
360 370 380 390 400
EICQDQKDAV LPLVRLLLHH NKLVPFITAV AELDLKDTPD ANAIFRGNSL
410 420 430 440 450
ATQCLTEMMK IVGGHYLKVT LKPVLDEICE SSKSCEIDPV KLKEGDNVEN
460 470 480 490 500
NKENLYYYVD KVFNTIVGSS VSCPTVMCDI FYSLRQMAAK KFPNHPHVQY
510 520 530 540 550
SAVSSFVFLR FFAVAILSPH AFHLRPHYPD TQTVRTLTLI SKTIQIIGNW
560 570 580 590 600
GCQSRKKSRF KKSVMCEFLK MFQEERYFTD VKKFLDEISS TETKESSGTS
610 620 630 640 650
EPVHLKEGEM YKRAQGRTRI GKKNFKKRWF CLTSRELTYH RQQGKDAIYT
660 670 680 690 700
IPVKNILAVE KLEEGSFNKK NMFQVIHTEK TLYIQANNCV EANEWIDVLC
710 720 730 740 750
RVSRCNHNRL SSFHPSAYLN GNWLCCQETS ESTPGCKPCT AGIPADIQID
760 770 780 790 800
IDEDRETERI YSIFTLSLLK LQKMEETCGS IAVYQGPQKE PGYSKFTIED
810 820 830 840
SVATFKTIQQ IKSTIEKLDE PHEKYRKKRS SSAKYGSKEN PIVGKIS
Length:847
Mass (Da):96,401
Last modified:September 18, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54C6C6A3FAACAB2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZE9D3YZE9_MOUSE
Ras GTPase-activating protein 2
Rasa2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11S → AS in BAB32975 (PubMed:8702543).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB056433 mRNA Translation: BAB32975.1
AC144935 Genomic DNA No translation available.
AC161257 Genomic DNA No translation available.
CH466560 Genomic DNA Translation: EDL20956.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23416.1

NCBI Reference Sequences

More...
RefSeqi
NP_444498.2, NM_053268.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034984; ENSMUSP00000034984; ENSMUSG00000032413

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114713

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:114713

UCSC genome browser

More...
UCSCi
uc009rcn.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056433 mRNA Translation: BAB32975.1
AC144935 Genomic DNA No translation available.
AC161257 Genomic DNA No translation available.
CH466560 Genomic DNA Translation: EDL20956.1
CCDSiCCDS23416.1
RefSeqiNP_444498.2, NM_053268.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi227827, 1 interactor
STRINGi10090.ENSMUSP00000034984

PTM databases

iPTMnetiP58069
PhosphoSitePlusiP58069

Proteomic databases

EPDiP58069
MaxQBiP58069
PaxDbiP58069
PeptideAtlasiP58069
PRIDEiP58069

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18019, 42 antibodies

Genome annotation databases

EnsembliENSMUST00000034984; ENSMUSP00000034984; ENSMUSG00000032413
GeneIDi114713
KEGGimmu:114713
UCSCiuc009rcn.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5922
MGIiMGI:2149960, Rasa2

Phylogenomic databases

eggNOGiKOG2059, Eukaryota
GeneTreeiENSGT00940000158201
HOGENOMiCLU_008096_1_1_1
InParanoidiP58069
KOiK08053
OMAiDICRERY
OrthoDBi145372at2759
TreeFamiTF105302

Enzyme and pathway databases

ReactomeiR-MMU-5658442, Regulation of RAS by GAPs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
114713, 6 hits in 21 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rasa2, mouse

Protein Ontology

More...
PROi
PR:P58069
RNActiP58069, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032413, Expressed in secondary oocyte and 279 other tissues
ExpressionAtlasiP58069, baseline and differential
GenevisibleiP58069, MM

Family and domain databases

CDDicd13370, PH_GAP1m_mammal-like, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR037773, RASA2_PH
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001562, Znf_Btk_motif
PANTHERiPTHR10194, PTHR10194, 1 hit
PfamiView protein in Pfam
PF00779, BTK, 1 hit
PF00168, C2, 2 hits
PF00169, PH, 1 hit
PF00616, RasGAP, 2 hits
PRINTSiPR00402, TECBTKDOMAIN
SMARTiView protein in SMART
SM00107, BTK, 1 hit
SM00239, C2, 2 hits
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS51113, ZF_BTK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASA2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58069
Secondary accession number(s): G3X918
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: September 18, 2013
Last modified: August 12, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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