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Protein

Serine protease inhibitor Kazal-type 7

Gene

SPINK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable serine protease inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei47 – 48Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.057

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 7
Alternative name(s):
Esophagus cancer-related gene 2 protein
Short name:
ECRG-2
Gene namesi
Name:SPINK7
Synonyms:ECG2
ORF Names:UNQ745/PRO1474
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145879.10
HGNCiHGNC:24643 SPINK7
neXtProtiNX_P58062

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi84651
OpenTargetsiENSG00000145879
PharmGKBiPA143485620

Polymorphism and mutation databases

BioMutaiSPINK7
DMDMi13959341

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001656520 – 85Serine protease inhibitor Kazal-type 7Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 67PROSITE-ProRule annotation1 Publication
Disulfide bondi45 ↔ 64PROSITE-ProRule annotation1 Publication
Disulfide bondi53 ↔ 85PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP58062
PeptideAtlasiP58062
PRIDEiP58062
ProteomicsDBi57048

Expressioni

Gene expression databases

BgeeiENSG00000145879
CleanExiHS_SPINK7
ExpressionAtlasiP58062 baseline and differential
GenevisibleiP58062 HS

Organism-specific databases

HPAiHPA036294

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124174, 20 interactors
IntActiP58062, 7 interactors
STRINGi9606.ENSP00000274565

Structurei

Secondary structure

185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 36Combined sources4
Beta strandi52 – 54Combined sources3
Beta strandi59 – 62Combined sources4
Helixi63 – 72Combined sources10
Beta strandi75 – 77Combined sources3
Beta strandi79 – 83Combined sources5

3D structure databases

ProteinModelPortaliP58062
SMRiP58062
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 85Kazal-likePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3649 Eukaryota
ENOG410YC3T LUCA
GeneTreeiENSGT00860000133862
HOGENOMiHOG000090244
HOVERGENiHBG006182
InParanoidiP58062
OMAiTVDCSIY
OrthoDBiEOG091G1BGL
PhylomeDBiP58062

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITGGLLLL CTVVYFCSSS EAASLSPKKV DCSIYKKYPV VAIPCPITYL
60 70 80
PVCGSDYITY GNECHLCTES LKSNGRVQFL HDGSC
Length:85
Mass (Da):9,232
Last modified:May 4, 2001 - v1
Checksum:iAE861AC8E1EA07D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268198 mRNA Translation: AAK27795.1
AY359072 mRNA Translation: AAQ89431.1
BC109385 mRNA Translation: AAI09386.1
BC110067 mRNA Translation: AAI10068.1
CCDSiCCDS4289.1
RefSeqiNP_115955.1, NM_032566.2
UniGeneiHs.244569

Genome annotation databases

EnsembliENST00000274565; ENSP00000274565; ENSG00000145879
GeneIDi84651
KEGGihsa:84651
UCSCiuc003lpd.4 human

Similar proteinsi

Entry informationi

Entry nameiISK7_HUMAN
AccessioniPrimary (citable) accession number: P58062
Secondary accession number(s): Q32LY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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