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UniProtKB - P58021 (TM9S2_MOUSE)

Entry version 114 (08 May 2019)
Sequence version 1 (27 Apr 2001)
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Protein

Transmembrane 9 superfamily member 2

Gene

Tm9sf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the intracellular compartments, may function as a channel or small molecule transporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • protein localization to membrane Source: GO_Central
Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane 9 superfamily member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tm9sf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1915309 Tm9sf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 299LumenalSequence analysisAdd BLAST271
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 373CytoplasmicSequence analysisAdd BLAST53
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 397LumenalSequence analysis3
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 436CytoplasmicSequence analysisAdd BLAST18
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 465LumenalSequence analysis8
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 521CytoplasmicSequence analysisAdd BLAST35
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21
Topological domaini543 – 553LumenalSequence analysisAdd BLAST11
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 590CytoplasmicSequence analysisAdd BLAST16
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Topological domaini612 – 630LumenalSequence analysisAdd BLAST19
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 662CytoplasmicSequence analysisAdd BLAST11

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003436629 – 662Transmembrane 9 superfamily member 2Add BLAST634

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P58021

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P58021

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P58021

PeptideAtlas

More...PeptideAtlasi		P58021

PRoteomics IDEntifications database

More...PRIDEi		P58021

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P58021

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P58021

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P58021

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000025544 Expressed in 304 organ(s), highest expression level in primary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P58021 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P58021 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000026624

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. [View classification]Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1278 Eukaryota
ENOG410XPIW LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157563

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000216679

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P58021

KEGG Orthology (KO)

More...KOi		K17086

Identification of Orthologs from Complete Genome Data

More...OMAi		GFLFLCY

Database of Orthologous Groups

More...OrthoDBi		641127at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P58021

TreeFam database of animal gene trees

More...TreeFami		TF300394

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004240 EMP70

The PANTHER Classification System

More...PANTHERi		PTHR10766 PTHR10766, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02990 EMP70, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P58021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRPPASPP AQGSRLLLLS LLLLGTVPGP RPGSAFYLPG LAPVNFCAEE 
        60         70         80         90        100
KSNECKADIE LFVNRLDSVE SVLPYEYTAF DFCQASEGKR PSENLGQVLF 
       110        120        130        140        150
GERIEPSPYK FTFNKKETCK LVCTKTYNTE KAEDKQKLDF LKKSMLLNYQ 
       160        170        180        190        200
HHWIVDNMPV TWCYEVEDSQ KFCNPGFPIG CYITDKGHAK DACVISSEFH 
       210        220        230        240        250
ERDTFYIFNH VDIKIYYHVV ETGSMGARLV AAKLEPKSFK HTHIDKPDCS 
       260        270        280        290        300
GPAMDISNKA SGEIKIAYTY SISFEEEKNI RWASRWDYIL ESMPHTHIQW 
       310        320        330        340        350
FSIMNSLVIV LFLSGMVAMI MLRTLHKDIA RYNQMDSTED AQEEFGWKLV 
       360        370        380        390        400
HGDIFRPPRK GMLLSVFLGS GTQILIMTFV TLFFACLGFL SPANRGALMT 
       410        420        430        440        450
CAVVLWVLLG TPAGYVAARF YKSFGGEKWK TNVLLTSFLC PGIVFADFFI 
       460        470        480        490        500
MNLILWGEGS SAAIPFGTLV AILALWFCIS VPLTFIGAYF GFKKNAIEHP 
       510        520        530        540        550
VRTNQIPRQI PEQSFYTKPL PGIIMGGILP FGCIFIQLFF ILNSIWSHQM 
       560        570        580        590        600
YYMFGFLFLV FIILVITCSE ATILLCYFHL CAEDYHWQWR SFLTSGFTAV 
       610        620        630        640        650
YFLIYAIHYF FSKLQITGTA STILYFGYTM IMVLIFFLFT GTIGFFACFW 
       660 
FVTKIYSVVK VD
Length:662
Mass (Da):75,330
Last modified:April 27, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85F113A5D21733E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ69E9PZ69_MOUSE
Transmembrane 9 superfamily member
Tm9sf2
497Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q850E9Q850_MOUSE
Transmembrane 9 superfamily member ...
Tm9sf2
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC003862 mRNA Translation: AAH03862.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27345.1

NCBI Reference Sequences

More...RefSeqi		NP_542123.3, NM_080556.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000026624; ENSMUSP00000026624; ENSMUSG00000025544

Database of genes from NCBI RefSeq genomes

More...GeneIDi		68059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:68059

UCSC genome browser

More...UCSCi		uc007vaw.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003862 mRNA Translation: AAH03862.1
CCDSiCCDS27345.1
RefSeqiNP_542123.3, NM_080556.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026624

PTM databases

iPTMnetiP58021
PhosphoSitePlusiP58021
SwissPalmiP58021

Proteomic databases

EPDiP58021
jPOSTiP58021
PaxDbiP58021
PeptideAtlasiP58021
PRIDEiP58021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026624; ENSMUSP00000026624; ENSMUSG00000025544
GeneIDi68059
KEGGimmu:68059
UCSCiuc007vaw.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9375
MGIiMGI:1915309 Tm9sf2

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
GeneTreeiENSGT00940000157563
HOGENOMiHOG000216679
InParanoidiP58021
KOiK17086
OMAiGFLFLCY
OrthoDBi641127at2759
PhylomeDBiP58021
TreeFamiTF300394

Miscellaneous databases

Protein Ontology

More...PROi		PR:P58021

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000025544 Expressed in 304 organ(s), highest expression level in primary oocyte
ExpressionAtlasiP58021 baseline and differential
GenevisibleiP58021 MM

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM9S2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58021
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 8, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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