UniProtKB - P58021 (TM9S2_MOUSE)
Protein
Transmembrane 9 superfamily member 2
Gene
Tm9sf2
Organism
Mus musculus (Mouse)
Status
Functioni
In the intracellular compartments, may function as a channel or small molecule transporter.By similarity
GO - Biological processi
- protein localization to membrane Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane 9 superfamily member 2 |
Gene namesi | Name:Tm9sf2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915309, Tm9sf2 |
Subcellular locationi
Golgi apparatus
- Postsynaptic Golgi apparatus By similarity
Cytoskeleton
- microtubule organizing center By similarity
Endosome
- Endosome membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Endosome
- endosome membrane Source: UniProtKB-SubCell
Golgi apparatus
- postsynaptic Golgi apparatus Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 299 | LumenalSequence analysisAdd BLAST | 271 | |
Transmembranei | 300 – 320 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 321 – 373 | CytoplasmicSequence analysisAdd BLAST | 53 | |
Transmembranei | 374 – 394 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 395 – 397 | LumenalSequence analysis | 3 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 419 – 436 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 437 – 457 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 458 – 465 | LumenalSequence analysis | 8 | |
Transmembranei | 466 – 486 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 487 – 521 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 522 – 542 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 543 – 553 | LumenalSequence analysisAdd BLAST | 11 | |
Transmembranei | 554 – 574 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 575 – 590 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 591 – 611 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 612 – 630 | LumenalSequence analysisAdd BLAST | 19 | |
Transmembranei | 631 – 651 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 652 – 662 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000034366 | 29 – 662 | Transmembrane 9 superfamily member 2Add BLAST | 634 |
Proteomic databases
EPDi | P58021 |
jPOSTi | P58021 |
PaxDbi | P58021 |
PeptideAtlasi | P58021 |
PRIDEi | P58021 |
PTM databases
iPTMneti | P58021 |
PhosphoSitePlusi | P58021 |
SwissPalmi | P58021 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025544, Expressed in primary oocyte and 318 other tissues |
ExpressionAtlasi | P58021, baseline and differential |
Genevisiblei | P58021, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026624 |
Miscellaneous databases
RNActi | P58021, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1278, Eukaryota |
GeneTreei | ENSGT00940000157563 |
InParanoidi | P58021 |
OMAi | GFLFLCY |
OrthoDBi | 641127at2759 |
PhylomeDBi | P58021 |
TreeFami | TF300394 |
Family and domain databases
InterProi | View protein in InterPro IPR004240, EMP70 |
PANTHERi | PTHR10766, PTHR10766, 1 hit |
Pfami | View protein in Pfam PF02990, EMP70, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P58021-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSRPPASPP AQGSRLLLLS LLLLGTVPGP RPGSAFYLPG LAPVNFCAEE
60 70 80 90 100
KSNECKADIE LFVNRLDSVE SVLPYEYTAF DFCQASEGKR PSENLGQVLF
110 120 130 140 150
GERIEPSPYK FTFNKKETCK LVCTKTYNTE KAEDKQKLDF LKKSMLLNYQ
160 170 180 190 200
HHWIVDNMPV TWCYEVEDSQ KFCNPGFPIG CYITDKGHAK DACVISSEFH
210 220 230 240 250
ERDTFYIFNH VDIKIYYHVV ETGSMGARLV AAKLEPKSFK HTHIDKPDCS
260 270 280 290 300
GPAMDISNKA SGEIKIAYTY SISFEEEKNI RWASRWDYIL ESMPHTHIQW
310 320 330 340 350
FSIMNSLVIV LFLSGMVAMI MLRTLHKDIA RYNQMDSTED AQEEFGWKLV
360 370 380 390 400
HGDIFRPPRK GMLLSVFLGS GTQILIMTFV TLFFACLGFL SPANRGALMT
410 420 430 440 450
CAVVLWVLLG TPAGYVAARF YKSFGGEKWK TNVLLTSFLC PGIVFADFFI
460 470 480 490 500
MNLILWGEGS SAAIPFGTLV AILALWFCIS VPLTFIGAYF GFKKNAIEHP
510 520 530 540 550
VRTNQIPRQI PEQSFYTKPL PGIIMGGILP FGCIFIQLFF ILNSIWSHQM
560 570 580 590 600
YYMFGFLFLV FIILVITCSE ATILLCYFHL CAEDYHWQWR SFLTSGFTAV
610 620 630 640 650
YFLIYAIHYF FSKLQITGTA STILYFGYTM IMVLIFFLFT GTIGFFACFW
660
FVTKIYSVVK VD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PZ69 | E9PZ69_MOUSE | Transmembrane 9 superfamily member | Tm9sf2 | 497 | Annotation score: | ||
E9Q850 | E9Q850_MOUSE | Transmembrane 9 superfamily member ... | Tm9sf2 | 57 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC003862 mRNA Translation: AAH03862.1 |
CCDSi | CCDS27345.1 |
RefSeqi | NP_542123.3, NM_080556.3 |
Genome annotation databases
Ensembli | ENSMUST00000026624; ENSMUSP00000026624; ENSMUSG00000025544 |
GeneIDi | 68059 |
KEGGi | mmu:68059 |
UCSCi | uc007vaw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC003862 mRNA Translation: AAH03862.1 |
CCDSi | CCDS27345.1 |
RefSeqi | NP_542123.3, NM_080556.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026624 |
PTM databases
iPTMneti | P58021 |
PhosphoSitePlusi | P58021 |
SwissPalmi | P58021 |
Proteomic databases
EPDi | P58021 |
jPOSTi | P58021 |
PaxDbi | P58021 |
PeptideAtlasi | P58021 |
PRIDEi | P58021 |
Protocols and materials databases
Antibodypediai | 970, 73 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026624; ENSMUSP00000026624; ENSMUSG00000025544 |
GeneIDi | 68059 |
KEGGi | mmu:68059 |
UCSCi | uc007vaw.1, mouse |
Organism-specific databases
CTDi | 9375 |
MGIi | MGI:1915309, Tm9sf2 |
Phylogenomic databases
eggNOGi | KOG1278, Eukaryota |
GeneTreei | ENSGT00940000157563 |
InParanoidi | P58021 |
OMAi | GFLFLCY |
OrthoDBi | 641127at2759 |
PhylomeDBi | P58021 |
TreeFami | TF300394 |
Miscellaneous databases
BioGRID-ORCSi | 68059, 4 hits in 17 CRISPR screens |
ChiTaRSi | Tm9sf2, mouse |
PROi | PR:P58021 |
RNActi | P58021, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025544, Expressed in primary oocyte and 318 other tissues |
ExpressionAtlasi | P58021, baseline and differential |
Genevisiblei | P58021, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004240, EMP70 |
PANTHERi | PTHR10766, PTHR10766, 1 hit |
Pfami | View protein in Pfam PF02990, EMP70, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM9S2_MOUSE | |
Accessioni | P58021Primary (citable) accession number: P58021 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | April 27, 2001 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families