UniProtKB - P58005 (SESN3_HUMAN)

BLAST

>sp|P58005|SESN3_HUMAN Sestrin-3 OS=Homo sapiens OX=9606 GN=SESN3 PE=1 SV=2
MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTN
FLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQ
CSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKT
GENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLAND
NNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFV
VSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHG
FSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDY
DYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAEL
LYALRAITRHLT

Align

Format
Add to basket Added to basket
History
Entry version 132 (07 Nov 2018)
Sequence version 2 (23 Jan 2002)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Sestrin-3

Gene

SESN3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	398	Leucine; via carbonyl oxygenBy similarity		1
Binding siteⁱ	463	LeucineBy similarity		1

GO - Molecular functionⁱ

leucine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxidoreductase activity, acting on peroxide as acceptor
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to amino acid starvation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25263562
cellular response to amino acid stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to glucose starvation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25263562
cellular response to leucine
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to leucine starvation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glucose homeostasis Source: Ensembl
negative regulation of TORC1 signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25263562
positive regulation of macroautophagy
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of insulin receptor signaling pathway Source: Ensembl
regulation of protein kinase B signaling Source: Ensembl
regulation of response to reactive oxygen species Source: InterPro
response to insulin Source: Ensembl
TORC2 signaling Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase

Molecular function

Oxidoreductase

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5628897 TP53 Regulates Metabolic Genes
SIGNORⁱ	P58005

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sestrin-3Curated
Gene namesⁱ	Name:SESN3Imported Synonyms:SEST31 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149212.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23060 SESN3
MIMⁱ	607768 gene
neXtProtⁱ	NX_P58005

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	143686
Open Targets More...OpenTargetsⁱ	ENSG00000149212
PharmGKBⁱ	PA134914983

Polymorphism and mutation databases

DMDMⁱ	20141774

DMDMⁱ

20141774

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000221183	1 – 492	Sestrin-3Add BLAST		492

Proteomic databases

EPDⁱ	P58005
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P58005
PaxDbⁱ	P58005
PeptideAtlas More...PeptideAtlasⁱ	P58005
PRIDEⁱ	P58005
ProteomicsDBⁱ	57044 57046 [P58005-3]

PTM databases

iPTMnetⁱ	P58005
PhosphoSitePlusⁱ	P58005

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000149212 Expressed in 210 organ(s), highest expression level in sperm
CleanExⁱ	HS_SESN3
ExpressionAtlasⁱ	P58005 baseline and differential
Genevisibleⁱ	P58005 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037935

HPAⁱ

HPA037935

Interactionⁱ

Subunit structureⁱ

Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by leucine (PubMed:25263562, PubMed:26449471). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). Interacts with the TORC2 complex; through RICTOR (By similarity).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
WDR24	Q96S15	3	EBI-16179942,EBI-746424

With

Entry

#Exp.

IntAct

Notes

WDR24

Q96S15

EBI-16179942,EBI-746424

Protein-protein interaction databases

BioGridⁱ	126817, 4 interactors
Database of interacting proteins More...DIPⁱ	DIP-62045N
IntActⁱ	P58005, 3 interactors
STRINGⁱ	9606.ENSP00000441927

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P58005
SMRⁱ	P58005
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	310 – 492	C-terminal domain; mediates TORC1 regulationBy similarityAdd BLAST		183
Regionⁱ	386 – 389	Leucine-bindingBy similarity		4

Domainⁱ

The C-terminal domain may mediate interaction with GATOR2 and regulation of TORC1 signaling.By similarity

Sequence similaritiesⁱ

Belongs to the sestrin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3746 Eukaryota ENOG410XP7Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000040103
HOGENOMⁱ	HOG000232949
HOVERGENⁱ	HBG054648
InParanoidⁱ	P58005
KEGG Orthology (KO) More...KOⁱ	K10141
OMAⁱ	DPGFGYK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IVA
PhylomeDBⁱ	P58005
TreeFamⁱ	TF314230

Family and domain databases

Gene3Dⁱ	1.20.1290.10, 1 hit
InterProⁱ	View protein in InterPro IPR029032 AhpD-like IPR006730 Sestrin
PANTHERⁱ	PTHR12474 PTHR12474, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04636 PA26, 1 hit
SUPFAMⁱ	SSF69118 SSF69118, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P58005-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV 
        60         70         80         90        100
QANTVDERTN FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD 
       110        120        130        140        150
GPLPLPYRHY IAIMAAARHQ CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ 
       160        170        180        190        200
RLKNLNEINK LLAHRPWLIT KEHIQKLVKT GENNWSLPEL VHAVVLLAHY 
       210        220        230        240        250
HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND NNIENASLSG 
       260        270        280        290        300
SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV 
       310        320        330        340        350
VSGDTFHSFP HSDFEDDMII TSDVSRYIED PGFGYEDFAR RGEEHLPTFR 
       360        370        380        390        400
AQDYTWENHG FSLVNRLYSD IGHLLDEKFR MVYNLTYNTM ATHEDVDTTM 
       410        420        430        440        450
LRRALFNYVH CMFGIRYDDY DYGEVNQLLE RSLKVYIKTV TCYPERTTKR 
       460        470        480        490 
MYDSYWRQFK HSEKVHVNLL LMEARMQAEL LYALRAITRH LT

Length:492

Mass (Da):57,291

Last modified:January 23, 2002 - v2

Checksum:ⁱ0B165C6BAE5A49CF

Isoform 3 (identifier: P58005-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
313-321: DFEDDMIIT → GAFLHFFAF
322-492: Missing.

« Hide

        10         20         30         40         50
MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV 
        60         70         80         90        100
QANTVDERTN FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD 
       110        120        130        140        150
GPLPLPYRHY IAIMAAARHQ CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ 
       160        170        180        190        200
RLKNLNEINK LLAHRPWLIT KEHIQKLVKT GENNWSLPEL VHAVVLLAHY 
       210        220        230        240        250
HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND NNIENASLSG 
       260        270        280        290        300
SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV 
       310        320 
VSGDTFHSFP HSGAFLHFFA F

Note: No experimental confirmation available.

Show »

Length:321

Mass (Da):36,614

Checksum:ⁱ23AECD8BE05E6C0A

Isoform 2 (identifier: P58005-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-78: Missing.
115-175: Missing.

« Hide

        10         20         30         40         50
MSLHTQYLES FLRSQFYMLR MDGPLPLPYR HYIAIMKLVK TGENNWSLPE 
        60         70         80         90        100
LVHAVVLLAH YHALASFVFG SGINPERDPE ISNGFRLISV NNFCVCDLAN 
       110        120        130        140        150
DNNIENASLS GSNFGIVDSL SELEALMERM KRLQEEREDE EASQEEMSTR 
       160        170        180        190        200
FEKEKKESLF VVSGDTFHSF PHSDFEDDMI ITSDVSRYIE DPGFGYEDFA 
       210        220        230        240        250
RRGEEHLPTF RAQDYTWENH GFSLVNRLYS DIGHLLDEKF RMVYNLTYNT 
       260        270        280        290        300
MATHEDVDTT MLRRALFNYV HCMFGIRYDD YDYGEVNQLL ERSLKVYIKT 
       310        320        330        340        350
VTCYPERTTK RMYDSYWRQF KHSEKVHVNL LLMEARMQAE LLYALRAITR 

HLT

Note: No experimental confirmation available.

Show »

Length:353

Mass (Da):41,522

Checksum:ⁱ736233C2D8B9644D

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H1K7	F5H1K7_HUMAN	Sestrin-3 Sestrin-3	SESN3	70	Annotation score:
A0A0U1RR17	A0A0U1RR17_HUMAN	Sestrin-3 Sestrin-3	SESN3	83	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051958	71	R → C. Corresponds to variant dbSNP:rs10160385Ensembl.		1
Natural variantⁱVAR_051959	227	I → T. Corresponds to variant dbSNP:rs11021069Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_054563	1 – 78	Missing in isoform 2. 1 PublicationAdd BLAST	78
Alternative sequenceⁱVSP_054564	115 – 175	Missing in isoform 2. 1 PublicationAdd BLAST	61
Alternative sequenceⁱVSP_006063	313 – 321	DFEDDMIIT → GAFLHFFAF in isoform 3. 1 Publication	9
Alternative sequenceⁱVSP_006064	322 – 492	Missing in isoform 3. 1 PublicationAdd BLAST	171

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096300 mRNA Translation: BAC04754.1 AK302366 mRNA Translation: BAH13685.1 AP000787 Genomic DNA No translation available. BC017296 mRNA Translation: AAH17296.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS60938.1 [P58005-4] CCDS8303.1 [P58005-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001258523.1, NM_001271594.1 [P58005-4] NP_653266.2, NM_144665.3 [P58005-1]
UniGeneⁱ	Hs.120633

Genome annotation databases

Ensemblⁱ	ENST00000278499; ENSP00000278499; ENSG00000149212 [P58005-4] ENST00000416495; ENSP00000407008; ENSG00000149212 [P58005-3] ENST00000536441; ENSP00000441927; ENSG00000149212 [P58005-1]
GeneIDⁱ	143686
KEGGⁱ	hsa:143686
UCSC genome browser More...UCSCⁱ	uc001pfj.5 human [P58005-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P58005-4	SESN3 isoform 2		PONAB		353	UniRef100_A0A2J8XWN9
Uncharacterized protein		NOMLE		353

Protein	Similar proteins		Species	Score	Length	Source
P58005	Testis cDNA, clone: QtsA-16302, similar to human sestrin 3 (SESN3)		MACFA		533	UniRef90_P58005
Uncharacterized protein		MACMU		530
Uncharacterized protein		CERAT		530
Uncharacterized protein		RHIRO		530
Uncharacterized protein		PAPAN		530
+189
P58005-3	SESN3 isoform 3		PONAB		324	UniRef90_P58005-3
SESN3 isoform 6		PANTR		324
Uncharacterized protein		FELCA		315
P58005-4	Sestrin-3		MOUSE		353	UniRef90_A0A140LIE1
sestrin-3 isoform X3		ODORO		427
sestrin-3 isoform X2		LEPWE		427
Uncharacterized protein		Cebus capucinus imitator		353
Uncharacterized protein		PROCO		353
+32

Protein	Similar proteins		Species	Score	Length	Source
P58005	Sestrin-1		HUMAN		492	UniRef50_Q9Y6P5
Sestrin-1		MACFA		492
Sestrin-1		MOUSE		492
Sestrin 1		PANTR		492
Uncharacterized protein		PANPA		465
+949
P58005-3	SESN3 isoform 3		PONAB		324	UniRef50_P58005-3
SESN3 isoform 6		PANTR		324
Uncharacterized protein		FELCA		315
Uncharacterized protein (Fragment)		LITCT		277
Uncharacterized protein (Fragment)		MICCO		337
+3
P58005-4	Sestrin-3		MOUSE		353	UniRef50_A0A140LIE1
sestrin-3 isoform X3		ODORO		427
sestrin-3 isoform X2		LEPWE		427
SESN3 isoform 1		PANTR		353
Uncharacterized protein		PANPA		353
+42

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096300 mRNA Translation: BAC04754.1 AK302366 mRNA Translation: BAH13685.1 AP000787 Genomic DNA No translation available. BC017296 mRNA Translation: AAH17296.1
CCDSⁱ	CCDS60938.1 [P58005-4] CCDS8303.1 [P58005-1]
RefSeqⁱ	NP_001258523.1, NM_001271594.1 [P58005-4] NP_653266.2, NM_144665.3 [P58005-1]
UniGeneⁱ	Hs.120633

3D structure databases

ProteinModelPortalⁱ	P58005
SMRⁱ	P58005
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126817, 4 interactors
DIPⁱ	DIP-62045N
IntActⁱ	P58005, 3 interactors
STRINGⁱ	9606.ENSP00000441927

PTM databases

iPTMnetⁱ	P58005
PhosphoSitePlusⁱ	P58005

Polymorphism and mutation databases

DMDMⁱ	20141774

DMDMⁱ

20141774

Proteomic databases

EPDⁱ	P58005
MaxQBⁱ	P58005
PaxDbⁱ	P58005
PeptideAtlasⁱ	P58005
PRIDEⁱ	P58005
ProteomicsDBⁱ	57044 57046 [P58005-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	143686
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000278499; ENSP00000278499; ENSG00000149212 [P58005-4] ENST00000416495; ENSP00000407008; ENSG00000149212 [P58005-3] ENST00000536441; ENSP00000441927; ENSG00000149212 [P58005-1]
GeneIDⁱ	143686
KEGGⁱ	hsa:143686
UCSCⁱ	uc001pfj.5 human [P58005-1]

Organism-specific databases

CTDⁱ	143686
DisGeNETⁱ	143686
EuPathDBⁱ	HostDB:ENSG00000149212.11
GeneCardsⁱ	SESN3
HGNCⁱ	HGNC:23060 SESN3
HPAⁱ	HPA037935
MIMⁱ	607768 gene
neXtProtⁱ	NX_P58005
OpenTargetsⁱ	ENSG00000149212
PharmGKBⁱ	PA134914983
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3746 Eukaryota ENOG410XP7Z LUCA
GeneTreeⁱ	ENSGT00440000040103
HOGENOMⁱ	HOG000232949
HOVERGENⁱ	HBG054648
InParanoidⁱ	P58005
KOⁱ	K10141
OMAⁱ	DPGFGYK
OrthoDBⁱ	EOG091G0IVA
PhylomeDBⁱ	P58005
TreeFamⁱ	TF314230

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5628897 TP53 Regulates Metabolic Genes
SIGNORⁱ	P58005

Miscellaneous databases

ChiTaRSⁱ	SESN3 human
GenomeRNAiⁱ	143686
Protein Ontology More...PROⁱ	PR:P58005
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149212 Expressed in 210 organ(s), highest expression level in sperm
CleanExⁱ	HS_SESN3
ExpressionAtlasⁱ	P58005 baseline and differential
Genevisibleⁱ	P58005 HS

Family and domain databases

Gene3Dⁱ	1.20.1290.10, 1 hit
InterProⁱ	View protein in InterPro IPR029032 AhpD-like IPR006730 Sestrin
PANTHERⁱ	PTHR12474 PTHR12474, 1 hit
Pfamⁱ	View protein in Pfam PF04636 PA26, 1 hit
SUPFAMⁱ	SSF69118 SSF69118, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SESN3_HUMAN
Accessionⁱ	P58005Primary (citable) accession number: P58005 Secondary accession number(s): B7Z7P9, Q96AD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	January 23, 2002
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P58005 (SESN3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Sestrin-3

SESN3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ