UniProtKB - P58005 (SESN3_HUMAN)
Sestrin-3
SESN3
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 398 | Leucine; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 463 | LeucineBy similarity | 1 |
GO - Molecular functioni
- leucine binding Source: GO_Central
- oxidoreductase activity, acting on peroxide as acceptor Source: GO_Central
GO - Biological processi
- cellular response to amino acid starvation Source: UniProtKB
- cellular response to amino acid stimulus Source: GO_Central
- cellular response to glucose starvation Source: UniProtKB
- cellular response to leucine Source: GO_Central
- cellular response to leucine starvation Source: GO_Central
- glucose homeostasis Source: Ensembl
- negative regulation of TORC1 signaling Source: UniProtKB
- positive regulation of macroautophagy Source: GO_Central
- regulation of insulin receptor signaling pathway Source: Ensembl
- regulation of protein kinase B signaling Source: Ensembl
- regulation of response to reactive oxygen species Source: InterPro
- response to insulin Source: Ensembl
- TORC2 signaling Source: Ensembl
Keywordsi
Molecular function | Oxidoreductase |
Enzyme and pathway databases
PathwayCommonsi | P58005 |
Reactomei | R-HSA-5628897, TP53 Regulates Metabolic Genes |
SIGNORi | P58005 |
Names & Taxonomyi
Protein namesi | Recommended name: Sestrin-3Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149212.11 |
HGNCi | HGNC:23060, SESN3 |
MIMi | 607768, gene |
neXtProti | NX_P58005 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Nucleus
- nucleus Source: InterPro
Other locations
- cytoplasm Source: UniProtKB
- TORC2 complex Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 143686 |
OpenTargetsi | ENSG00000149212 |
PharmGKBi | PA134914983 |
Miscellaneous databases
Pharosi | P58005, Tbio |
Polymorphism and mutation databases
BioMutai | SESN3 |
DMDMi | 20141774 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221183 | 1 – 492 | Sestrin-3Add BLAST | 492 |
Proteomic databases
EPDi | P58005 |
jPOSTi | P58005 |
MassIVEi | P58005 |
MaxQBi | P58005 |
PaxDbi | P58005 |
PeptideAtlasi | P58005 |
PRIDEi | P58005 |
ProteomicsDBi | 57044 [P58005-1] 57046 [P58005-3] |
PTM databases
iPTMneti | P58005 |
PhosphoSitePlusi | P58005 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000149212, Expressed in sperm and 223 other tissues |
ExpressionAtlasi | P58005, baseline and differential |
Genevisiblei | P58005, HS |
Organism-specific databases
HPAi | ENSG00000149212, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by leucine (PubMed:25263562, PubMed:26449471).
Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925).
Interacts with the TORC2 complex; through RICTOR (By similarity).
By similarity3 PublicationsBinary interactionsi
P58005
With | #Exp. | IntAct |
---|---|---|
WDR24 [Q96S15] | 3 | EBI-16179942,EBI-746424 |
Protein-protein interaction databases
BioGRIDi | 126817, 8 interactors |
DIPi | DIP-62045N |
IntActi | P58005, 5 interactors |
STRINGi | 9606.ENSP00000441927 |
Miscellaneous databases
RNActi | P58005, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 310 – 492 | C-terminal domain; mediates TORC1 regulationBy similarityAdd BLAST | 183 | |
Regioni | 386 – 389 | Leucine-bindingBy similarity | 4 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3746, Eukaryota |
GeneTreei | ENSGT00950000183168 |
HOGENOMi | CLU_020429_2_0_1 |
InParanoidi | P58005 |
OMAi | MSLHAQY |
OrthoDBi | 588598at2759 |
PhylomeDBi | P58005 |
TreeFami | TF314230 |
Family and domain databases
Gene3Di | 1.20.1290.10, 1 hit |
InterProi | View protein in InterPro IPR029032, AhpD-like IPR006730, Sestrin |
PANTHERi | PTHR12474, PTHR12474, 1 hit |
Pfami | View protein in Pfam PF04636, PA26, 1 hit |
SUPFAMi | SSF69118, SSF69118, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV
60 70 80 90 100
QANTVDERTN FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD
110 120 130 140 150
GPLPLPYRHY IAIMAAARHQ CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ
160 170 180 190 200
RLKNLNEINK LLAHRPWLIT KEHIQKLVKT GENNWSLPEL VHAVVLLAHY
210 220 230 240 250
HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND NNIENASLSG
260 270 280 290 300
SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV
310 320 330 340 350
VSGDTFHSFP HSDFEDDMII TSDVSRYIED PGFGYEDFAR RGEEHLPTFR
360 370 380 390 400
AQDYTWENHG FSLVNRLYSD IGHLLDEKFR MVYNLTYNTM ATHEDVDTTM
410 420 430 440 450
LRRALFNYVH CMFGIRYDDY DYGEVNQLLE RSLKVYIKTV TCYPERTTKR
460 470 480 490
MYDSYWRQFK HSEKVHVNLL LMEARMQAEL LYALRAITRH LT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RR17 | A0A0U1RR17_HUMAN | Sestrin-3 | SESN3 | 83 | Annotation score: | ||
F5H1K7 | F5H1K7_HUMAN | Sestrin-3 | SESN3 | 70 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051958 | 71 | R → C. Corresponds to variant dbSNP:rs10160385Ensembl. | 1 | |
Natural variantiVAR_051959 | 227 | I → T. Corresponds to variant dbSNP:rs11021069Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054563 | 1 – 78 | Missing in isoform 2. 1 PublicationAdd BLAST | 78 | |
Alternative sequenceiVSP_054564 | 115 – 175 | Missing in isoform 2. 1 PublicationAdd BLAST | 61 | |
Alternative sequenceiVSP_006063 | 313 – 321 | DFEDDMIIT → GAFLHFFAF in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_006064 | 322 – 492 | Missing in isoform 3. 1 PublicationAdd BLAST | 171 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096300 mRNA Translation: BAC04754.1 AK302366 mRNA Translation: BAH13685.1 AP000787 Genomic DNA No translation available. BC017296 mRNA Translation: AAH17296.1 |
CCDSi | CCDS60938.1 [P58005-4] CCDS8303.1 [P58005-1] |
RefSeqi | NP_001258523.1, NM_001271594.1 [P58005-4] NP_653266.2, NM_144665.3 [P58005-1] |
Genome annotation databases
Ensembli | ENST00000278499; ENSP00000278499; ENSG00000149212 [P58005-4] ENST00000416495; ENSP00000407008; ENSG00000149212 [P58005-3] ENST00000536441; ENSP00000441927; ENSG00000149212 [P58005-1] |
GeneIDi | 143686 |
KEGGi | hsa:143686 |
UCSCi | uc001pfj.5, human [P58005-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096300 mRNA Translation: BAC04754.1 AK302366 mRNA Translation: BAH13685.1 AP000787 Genomic DNA No translation available. BC017296 mRNA Translation: AAH17296.1 |
CCDSi | CCDS60938.1 [P58005-4] CCDS8303.1 [P58005-1] |
RefSeqi | NP_001258523.1, NM_001271594.1 [P58005-4] NP_653266.2, NM_144665.3 [P58005-1] |
3D structure databases
SMRi | P58005 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126817, 8 interactors |
DIPi | DIP-62045N |
IntActi | P58005, 5 interactors |
STRINGi | 9606.ENSP00000441927 |
PTM databases
iPTMneti | P58005 |
PhosphoSitePlusi | P58005 |
Polymorphism and mutation databases
BioMutai | SESN3 |
DMDMi | 20141774 |
Proteomic databases
EPDi | P58005 |
jPOSTi | P58005 |
MassIVEi | P58005 |
MaxQBi | P58005 |
PaxDbi | P58005 |
PeptideAtlasi | P58005 |
PRIDEi | P58005 |
ProteomicsDBi | 57044 [P58005-1] 57046 [P58005-3] |
Protocols and materials databases
Antibodypediai | 31660, 202 antibodies |
DNASUi | 143686 |
Genome annotation databases
Ensembli | ENST00000278499; ENSP00000278499; ENSG00000149212 [P58005-4] ENST00000416495; ENSP00000407008; ENSG00000149212 [P58005-3] ENST00000536441; ENSP00000441927; ENSG00000149212 [P58005-1] |
GeneIDi | 143686 |
KEGGi | hsa:143686 |
UCSCi | uc001pfj.5, human [P58005-1] |
Organism-specific databases
CTDi | 143686 |
DisGeNETi | 143686 |
EuPathDBi | HostDB:ENSG00000149212.11 |
GeneCardsi | SESN3 |
HGNCi | HGNC:23060, SESN3 |
HPAi | ENSG00000149212, Low tissue specificity |
MIMi | 607768, gene |
neXtProti | NX_P58005 |
OpenTargetsi | ENSG00000149212 |
PharmGKBi | PA134914983 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3746, Eukaryota |
GeneTreei | ENSGT00950000183168 |
HOGENOMi | CLU_020429_2_0_1 |
InParanoidi | P58005 |
OMAi | MSLHAQY |
OrthoDBi | 588598at2759 |
PhylomeDBi | P58005 |
TreeFami | TF314230 |
Enzyme and pathway databases
PathwayCommonsi | P58005 |
Reactomei | R-HSA-5628897, TP53 Regulates Metabolic Genes |
SIGNORi | P58005 |
Miscellaneous databases
BioGRID-ORCSi | 143686, 3 hits in 848 CRISPR screens |
ChiTaRSi | SESN3, human |
GenomeRNAii | 143686 |
Pharosi | P58005, Tbio |
PROi | PR:P58005 |
RNActi | P58005, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149212, Expressed in sperm and 223 other tissues |
ExpressionAtlasi | P58005, baseline and differential |
Genevisiblei | P58005, HS |
Family and domain databases
Gene3Di | 1.20.1290.10, 1 hit |
InterProi | View protein in InterPro IPR029032, AhpD-like IPR006730, Sestrin |
PANTHERi | PTHR12474, PTHR12474, 1 hit |
Pfami | View protein in Pfam PF04636, PA26, 1 hit |
SUPFAMi | SSF69118, SSF69118, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SESN3_HUMAN | |
Accessioni | P58005Primary (citable) accession number: P58005 Secondary accession number(s): B7Z7P9, Q96AD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | January 23, 2002 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations