Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
1 to 25 of 27  Show
  1. 1
    "Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene."
    Dhakshinamoorthy S., Jaiswal A.K.
    Oncogene 20:3906-3917(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Category: Sequences.
    Strain: Sprague-Dawley.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    "Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression."
    McMahon M., Itoh K., Yamamoto M., Hayes J.D.
    J. Biol. Chem. 278:21592-21600(2003) [PubMed] [Europe PMC] [Abstract]
    Annotation: Keap1 negatively regulates Nrf2 by both enhancing its rate of proteasomal degradation and altering its subcellular distributionImported.
    Source: GeneRIF:117519.

    This publication is mapped to 5 other entries.

  3. 3
    "Keap1 in adhesion complexes."
    Velichkova M., Hasson T.
    Cell Motil. Cytoskeleton 56:109-119(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Source: RGD:621619.

    This publication is mapped to 1 other entry.

  4. 4
    "Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1."
    Nguyen T., Sherratt P.J., Nioi P., Yang C.S., Pickett C.B.
    J. Biol. Chem. 280:32485-32492(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: stabilization of Nrf2 in cells under stress represents the central regulatory response mediated by mechanisms that interfere with its interaction with Keap1 leading to the induction of antioxidant enzymes important to maintain cellular redox homeostasisImported.
    Source: RGD:621619, GeneRIF:117519.

    This publication is mapped to 9 other entries.

  5. 5
    "Ebselen, a seleno-organic antioxidant, as an electrophile."
    Sakurai T., Kanayama M., Shibata T., Itoh K., Kobayashi A., Yamamoto M., Uchida K.
    Chem. Res. Toxicol. 19:1196-1204(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Source: RGD:621619.

    This publication is mapped to 1 other entry.

  6. 6
    "Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle."
    Kim J.W., Kwon O.Y., Kim M.H.
    Differentiation 75:147-157(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Source: RGD:621619.

    This publication is mapped to 2 other entries.

  7. 7
    "Nitro-linoleic acid inhibits vascular smooth muscle cell proliferation via the Keap1/Nrf2 signaling pathway."
    Villacorta L., Zhang J., Garcia-Barrio M.T., Chen X.L., Freeman B.A., Chen Y.E., Cui T.
    Am. J. Physiol. Heart Circ. Physiol. 293:H770-6(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: These studies provide the first evidence that nitroalkene LNO(2) inhibits VSMC proliferation through activation of the Keap1/Nrf2 signaling pathway.Imported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  8. 8
    "Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway."
    Wruck C.J., Claussen M., Fuhrmann G., Romer L., Schulz A., Pufe T., Waetzig V., Peipp M., Herdegen T., Gotz M.E.
    J. Neural Transm. Suppl. 2007:57-67(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: The neuroprotective effect of luteolin is abolished by the inhibition of the luteolin-induced ERK1/2-activation. Our results highlight the relevance of Nrf2 for neural cell survival conferred by flavonesImported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  9. 9
    "Oxidative injury induces selective rather than global inhibition of proteasomal activity."
    Gurusamy N., Goswami S., Malik G., Das D.K.
    J. Mol. Cell. Cardiol. 44:419-428(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Source: RGD:621619.

    This publication is mapped to 1 other entry.

  10. 10
    "Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure."
    Kim H.J., Vaziri N.D.
    Am. J. Physiol. Renal Physiol. 298:F662-71(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Keap1 up-regulation may contribute to the severity of oxidative stress and inflammation in chronic kidney disease.Imported.
    Source: RGD:621619, GeneRIF:117519.

    This publication is mapped to 2 other entries.

  11. 11
    "Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound."
    Ohnuma T., Nakayama S., Anan E., Nishiyama T., Ogura K., Hiratsuka A.
    Toxicol. Appl. Pharmacol. 244:27-36(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Falcarindiol covalently modifies the Cys151 residue in Keap1 and that the inactivation of Keap1 by falcarindiol leads to activation of the Nrf2/ARE pathway.Imported.
    Source: RGD:621619, GeneRIF:117519.

    This publication is mapped to 1 other entry.

  12. 12
    "The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO)."
    Rinaldi Tosi M.E., Bocanegra V., Manucha W., Gil Lorenzo A., Valles P.G.
    Cell Stress Chaperones 16:57-68(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Source: RGD:621619.

    This publication is mapped to 2 other entries.

  13. 13
    "Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling."
    Palsamy P., Subramanian S.
    Biochim. Biophys. Acta 1812:719-731(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Source: RGD:621619.

    This publication is mapped to 2 other entries.

  14. 14
    "Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells."
    Um H.C., Jang J.H., Kim D.H., Lee C., Surh Y.J.
    Nitric Oxide 25:161-168(2011) [PubMed] [Europe PMC] [Abstract]
    Annotation: Nitric oxide donor S-nitroso-N-acetylpenicillamine induces S-nitrosylation of Keap1 in PC12 cells.Imported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  15. 15
    "Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning."
    Videla L.A., Cornejo P., Romanque P., Santibanez C., Castillo I., Vargas R.
    ScientificWorldJournal 2012:301494-301494(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Source: RGD:621619.

    This publication is mapped to 1 other entry.

  16. 16
    "Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy."
    Zhong Q., Mishra M., Kowluru R.A.
    Invest. Ophthalmol. Vis. Sci. 54:3941-3948(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Source: RGD:621619.

    This publication is mapped to 2 other entries.

  17. 17
    "Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts."
    Nordgren K.K., Wallace K.B.
    Toxicol. Appl. Pharmacol. 274:107-116(2014) [PubMed] [Europe PMC] [Abstract]
    Annotation: In doxorubicin-induced oxidative injury Keap1 protein contributes to the oxidative stress response.Imported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  18. 18
    "[Mechanism of cardiac function changes in rat models of Sjogren's syndrome based on Keap1-Nrf2/ARE signaling pathways]."
    Wang F., Liu J., Ye Y., Zhang X., Wan L.
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:497-501(2014) [PubMed] [Europe PMC] [Abstract]
    Annotation: Data suggest that the immune imbalance in Sjogren's syndrome (SS) may be related with the up-regulated levels of Keap1 Nfr2 mRNAs.Imported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  19. 19
    "Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat."
    Padiya R., Chowdhury D., Borkar R., Srinivas R., Pal Bhadra M., Banerjee S.K.
    PLoS ONE 9:e94228-e94228(2014) [PubMed] [Europe PMC] [Abstract]
    Annotation: study demonstrates that raw garlic homogenate is effective in reducing cardiac hypertrophy and fructose-induced myocardial oxidative stress through PI3K/AKT/Nrf2-Keap1 dependent pathway.Imported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  20. 20
    "MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis."
    Yang J.J., Tao H., Hu W., Liu L.P., Shi K.H., Deng Z.Y., Li J.
    Cell. Signal. 26:2381-2389(2014) [PubMed] [Europe PMC] [Abstract]
    Annotation: study demonstrates that miRNA-200a regulates the Keap1/Nrf2 pathway in hepatic stellate cell and fibrosisImported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  21. 21
    "Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic retinopathy."
    Mishra M., Zhong Q., Kowluru R.A.
    Invest. Ophthalmol. Vis. Sci. 55:7256-7265(2014) [PubMed] [Europe PMC] [Abstract]
    Annotation: Epigenetic modifications at Keap1 promoter by SetD7 facilitate its binding with Sp1 increasing its expression. Keap1 restrains Nrf2 in the cytosol impairing its transcriptional activity.Imported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  22. 22
    "Alterations in the Nrf2-Keap1 signaling pathway and its downstream target genes in rat brain under stress."
    Djordjevic J., Djordjevic A., Adzic M., Mitic M., Lukic I., Radojcic M.B.
    Brain Res. 1602:20-31(2015) [PubMed] [Europe PMC] [Abstract]
    Annotation: Results reveal maladaptive character of chronic isolation at the level of the Nrf2/Keap1 system and Nrf2 regulated genes involved in the production and utilization of glutathione followed by proinflammatory conditions (judged by NFkappaB)Imported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  23. 23
    "Nrf2 transcriptional derepression from Keap1 by dietary polyphenols."
    Bayele H.K., Debnam E.S., Srai K.S.
    Biochem. Biophys. Res. Commun. 469:521-528(2016) [PubMed] [Europe PMC] [Abstract]
    Annotation: Our data suggest that polyphenols may induce cellular defense genes by derepressing Nrf2 inhibition by Keap1.Imported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  24. 24
    "Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation."
    Wu K.L.H., Wu C.W., Chao Y.M., Hung C.Y., Chan J.Y.H.
    Free Radic. Biol. Med. 97:58-74(2016) [PubMed] [Europe PMC] [Abstract]
    Annotation: these results indicate that defect mitochondrial biogenesis in RVLM neurons entailing redox-sensitive and IL-1beta-dependent suppression of TFAM because of the increase in the formation of Keap1/Nrf2 complex reductions in nuclear translocation of the activated Nrf2 and its binding to the Tfam gene promoter may underlie hypertension developed under the LPS-induced systemic inflammationImported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

  25. 25
    "Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: An in-vivo and in-silico study."
    Shanmugam T., Selvaraj M., Poomalai S.
    Int. Immunopharmacol. 39:128-139(2016) [PubMed] [Europe PMC] [Abstract]
    Annotation: this paper shows that that epigallocatechin gallate potentially abrogates fluoride-induced oxidative lung injury by activation of the Nrf2/Keap1 pathwayImported.
    Source: GeneRIF:117519.

    This publication is mapped to 1 other entry.

1 to 25 of 27  Show

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health