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Entry version 170 (02 Jun 2021)
Sequence version 1 (27 Apr 2001)
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Protein

Potassium channel subfamily K member 10

Gene

KCNK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P57789

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1299503, TWIK related potassium channel (TREK)
R-HSA-5576886, Phase 4 - resting membrane potential

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium channel subfamily K member 10
Alternative name(s):
Outward rectifying potassium channel protein TREK-2
TREK-2 K(+) channel subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNK10
Synonyms:TREK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6273, KCNK10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605873, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57789

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000100433.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei154 – 180Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST27
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 233CytoplasmicSequence analysisAdd BLAST31
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Intramembranei263 – 294Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST32
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 538CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54207

Open Targets

More...
OpenTargetsi
ENSG00000100433

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30053

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P57789, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2331041

DrugCentral

More...
DrugCentrali
P57789

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
521

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNK10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13431412

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001017581 – 538Potassium channel subfamily K member 10Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P57789

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P57789

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P57789

PeptideAtlas

More...
PeptideAtlasi
P57789

PRoteomics IDEntifications database

More...
PRIDEi
P57789

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57038 [P57789-1]
57039 [P57789-3]
57040 [P57789-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P57789, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P57789

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P57789

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100433, Expressed in cerebellum and 143 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P57789, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P57789, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100433, Tissue enhanced (blood, brain, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119924, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-44050N

Protein interaction database and analysis system

More...
IntActi
P57789, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312811

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P57789

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P57789, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P57789

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni412 – 443DisorderedSequence analysisAdd BLAST32
Regioni510 – 538DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi518 – 538Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1418, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156147

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022504_10_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P57789

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERHPCVT

Database of Orthologous Groups

More...
OrthoDBi
616474at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P57789

TreeFam database of animal gene trees

More...
TreeFami
TF313947

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003280, 2pore_dom_K_chnl
IPR003976, 2pore_dom_K_chnl_TREK
IPR013099, K_chnl_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07885, Ion_trans_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01333, 2POREKCHANEL
PR01499, TREKCHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: P57789-1) [UniParc]FASTAAdd to basket
Also known as: TREK-2a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT
60 70 80 90 100
VVARMEGTSQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS
110 120 130 140 150
QKNTIALEKA EFLRDHVCVS PQELETLIQH ALDADNAGVS PIGNSSNNSS
160 170 180 190 200
HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA
210 220 230 240 250
GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI
260 270 280 290 300
PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV
310 320 330 340 350
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE
360 370 380 390 400
FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF
410 420 430 440 450
AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST
460 470 480 490 500
SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEET EKMCNSDNSS
510 520 530
TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN
Length:538
Mass (Da):59,765
Last modified:April 27, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EA615B08D147FBC
GO
Isoform B (identifier: P57789-4) [UniParc]FASTAAdd to basket
Also known as: TREK-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MEDGFKGDRTEGCRSDS

Show »
Length:543
Mass (Da):60,111
Checksum:i17DB1AFAFAB07C46
GO
Isoform C (identifier: P57789-3) [UniParc]FASTAAdd to basket
Also known as: TREK-2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MKFPIETPRKQVNWDPK

Show »
Length:543
Mass (Da):60,335
Checksum:iB158DF9AF076444D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5Y5G3V5Y5_HUMAN
Potassium channel subfamily K membe...
KCNK10
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti529E → G in AAL95705 (PubMed:11897838).Curated1
Sequence conflicti529E → G in AAL95706 (PubMed:11897838).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06021670K → Q. Corresponds to variant dbSNP:rs398263Ensembl.1
Natural variantiVAR_052428512A → T1 PublicationCorresponds to variant dbSNP:rs17762463Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0066971 – 12MFFLY…FFLSL → MEDGFKGDRTEGCRSDS in isoform B. 3 PublicationsAdd BLAST12
Alternative sequenceiVSP_0066981 – 12MFFLY…FFLSL → MKFPIETPRKQVNWDPK in isoform C. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF279890 mRNA Translation: AAG15191.1
AF385399 mRNA Translation: AAL95705.1
AF385400 mRNA Translation: AAL95706.1
EU978938 mRNA Translation: ACH86097.1
EU978939 mRNA Translation: ACH86098.1
EU978940 mRNA Translation: ACH86099.1
EU978941 mRNA Translation: ACH86100.1
AK313499 mRNA Translation: BAG36281.1
AK315263 mRNA Translation: BAG37680.1
AL049834 Genomic DNA No translation available.
AL133279 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81373.1
CH471061 Genomic DNA Translation: EAW81374.1
CH471061 Genomic DNA Translation: EAW81375.1
BC075021 mRNA Translation: AAH75021.1
BC075022 mRNA Translation: AAH75022.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9880.1 [P57789-1]
CCDS9881.1 [P57789-3]
CCDS9882.1 [P57789-4]

NCBI Reference Sequences

More...
RefSeqi
NP_066984.1, NM_021161.4 [P57789-1]
NP_612190.1, NM_138317.2 [P57789-3]
NP_612191.1, NM_138318.2 [P57789-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312350; ENSP00000310568; ENSG00000100433 [P57789-4]
ENST00000319231; ENSP00000312811; ENSG00000100433 [P57789-3]
ENST00000340700; ENSP00000343104; ENSG00000100433 [P57789-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54207

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54207

UCSC genome browser

More...
UCSCi
uc001xwm.4, human [P57789-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279890 mRNA Translation: AAG15191.1
AF385399 mRNA Translation: AAL95705.1
AF385400 mRNA Translation: AAL95706.1
EU978938 mRNA Translation: ACH86097.1
EU978939 mRNA Translation: ACH86098.1
EU978940 mRNA Translation: ACH86099.1
EU978941 mRNA Translation: ACH86100.1
AK313499 mRNA Translation: BAG36281.1
AK315263 mRNA Translation: BAG37680.1
AL049834 Genomic DNA No translation available.
AL133279 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81373.1
CH471061 Genomic DNA Translation: EAW81374.1
CH471061 Genomic DNA Translation: EAW81375.1
BC075021 mRNA Translation: AAH75021.1
BC075022 mRNA Translation: AAH75022.1
CCDSiCCDS9880.1 [P57789-1]
CCDS9881.1 [P57789-3]
CCDS9882.1 [P57789-4]
RefSeqiNP_066984.1, NM_021161.4 [P57789-1]
NP_612190.1, NM_138317.2 [P57789-3]
NP_612191.1, NM_138318.2 [P57789-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BW5X-ray3.20A/B/C/D62-335[»]
4XDJX-ray3.80A/B/C/D62-335[»]
4XDKX-ray3.60A/B/C/D62-335[»]
4XDLX-ray3.50A/B/C/D62-335[»]
SMRiP57789
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119924, 1 interactor
DIPiDIP-44050N
IntActiP57789, 1 interactor
STRINGi9606.ENSP00000312811

Chemistry databases

BindingDBiP57789
ChEMBLiCHEMBL2331041
DrugCentraliP57789
GuidetoPHARMACOLOGYi521

PTM databases

GlyGeniP57789, 3 sites
iPTMnetiP57789
PhosphoSitePlusiP57789

Genetic variation databases

BioMutaiKCNK10
DMDMi13431412

Proteomic databases

jPOSTiP57789
MassIVEiP57789
PaxDbiP57789
PeptideAtlasiP57789
PRIDEiP57789
ProteomicsDBi57038 [P57789-1]
57039 [P57789-3]
57040 [P57789-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
13325, 210 antibodies

The DNASU plasmid repository

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DNASUi
54207

Genome annotation databases

EnsembliENST00000312350; ENSP00000310568; ENSG00000100433 [P57789-4]
ENST00000319231; ENSP00000312811; ENSG00000100433 [P57789-3]
ENST00000340700; ENSP00000343104; ENSG00000100433 [P57789-1]
GeneIDi54207
KEGGihsa:54207
UCSCiuc001xwm.4, human [P57789-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54207
DisGeNETi54207

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNK10
HGNCiHGNC:6273, KCNK10
HPAiENSG00000100433, Tissue enhanced (blood, brain, intestine)
MIMi605873, gene
neXtProtiNX_P57789
OpenTargetsiENSG00000100433
PharmGKBiPA30053
VEuPathDBiHostDB:ENSG00000100433.15

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1418, Eukaryota
GeneTreeiENSGT00940000156147
HOGENOMiCLU_022504_10_0_1
InParanoidiP57789
OMAiERHPCVT
OrthoDBi616474at2759
PhylomeDBiP57789
TreeFamiTF313947

Enzyme and pathway databases

PathwayCommonsiP57789
ReactomeiR-HSA-1299503, TWIK related potassium channel (TREK)
R-HSA-5576886, Phase 4 - resting membrane potential

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54207, 5 hits in 976 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KCNK10, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNK10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54207
PharosiP57789, Tclin

Protein Ontology

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PROi
PR:P57789
RNActiP57789, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100433, Expressed in cerebellum and 143 other tissues
ExpressionAtlasiP57789, baseline and differential
GenevisibleiP57789, HS

Family and domain databases

InterProiView protein in InterPro
IPR003280, 2pore_dom_K_chnl
IPR003976, 2pore_dom_K_chnl_TREK
IPR013099, K_chnl_dom
PfamiView protein in Pfam
PF07885, Ion_trans_2, 2 hits
PRINTSiPR01333, 2POREKCHANEL
PR01499, TREKCHANNEL

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNKA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57789
Secondary accession number(s): B2R8T4
, B2RCT3, B5TJL4, Q6B014, Q8TDK7, Q8TDK8, Q9HB59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: June 2, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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