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Protein

Left-right determination factor 2

Gene

Lefty2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for left-right asymmetry determination of organ systems in mammals.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Left-right determination factor 2
Alternative name(s):
Left-right determination factor B
Protein lefty-2
Protein lefty-B
Gene namesi
Name:Lefty2
Synonyms:Leftb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2443573 Lefty2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PropeptideiPRO_000003381222 – 77Or 135Sequence analysisAdd BLAST56
ChainiPRO_000003381378 – 368Left-right determination factor 2Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi253 ↔ 266By similarity
Disulfide bondi265 ↔ 318By similarity
Disulfide bondi295 ↔ 353By similarity
Disulfide bondi299 ↔ 355By similarity

Post-translational modificationi

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP57785
PeptideAtlasiP57785
PRIDEiP57785

PTM databases

iPTMnetiP57785
PhosphoSitePlusiP57785

Expressioni

Developmental stagei

At the primitive streak stage (E7.0), expressed in the emerging mesoderm. By E8.0, expressed exclusively on the left side of developing embryos with expression predominantly in the lateral-plate mesoderm (LPM). Weak expression in the prospective floor plate (PFP).

Gene expression databases

BgeeiENSMUSG00000066652 Expressed in 51 organ(s), highest expression level in embryo
CleanExiMM_LEFTY2
GenevisibleiP57785 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082952

Structurei

3D structure databases

ProteinModelPortaliP57785
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00390000010056
HOGENOMiHOG000113317
HOVERGENiHBG074429
InParanoidiP57785
KOiK04668
OMAiMAIPTHV
OrthoDBiEOG091G09EN
PhylomeDBiP57785
TreeFamiTF106462

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR003942 LRDF
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF037402 TGFb4, 1 hit
PRINTSiPR01427 TGFBETA4
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57785-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLWLCWAL WVLPLAGPGA AMTEEQVLSS LLQQLQLSQA PTLDSADVEE
60 70 80 90 100
MAIPTHVRSQ YVALLQGSHA DRSRGKRFSQ NFREVAGRFL MSETSTHLLV
110 120 130 140 150
FGMEQRLPPN SELVQAVLRL FQEPVPRTAL RRFERLSPHS ARARVTIEWL
160 170 180 190 200
RVREDGSNRT ALIDSRLVSI HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ
210 220 230 240 250
VSVQREHLGP GTWSAHKLVR FAAQGTPDGK GQGEPQLELH TLDLKDYGAQ
260 270 280 290 300
GNCDPEVPVT EGTRCCRQEM YLDLQGMKWA ENWILEPPGF LTYECVGSCL
310 320 330 340 350
QLPESLTIGW PFLGPRQCVA SEMTSLPMIV SVKEGGRTRP QVVSLPNMRV
360
QTCSCASDGA LIPRGIDL
Length:368
Mass (Da):41,175
Last modified:February 6, 2007 - v2
Checksum:i5BEE8B2F1305A44B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82F → L (PubMed:9348041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031621 mRNA Translation: BAC27483.1
BC066224 mRNA Translation: AAH66224.1
CCDSiCCDS15575.1
RefSeqiNP_796073.1, NM_177099.4
UniGeneiMm.87078

Genome annotation databases

EnsembliENSMUST00000085797; ENSMUSP00000082952; ENSMUSG00000066652
GeneIDi320202
KEGGimmu:320202
UCSCiuc007dwu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031621 mRNA Translation: BAC27483.1
BC066224 mRNA Translation: AAH66224.1
CCDSiCCDS15575.1
RefSeqiNP_796073.1, NM_177099.4
UniGeneiMm.87078

3D structure databases

ProteinModelPortaliP57785
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082952

PTM databases

iPTMnetiP57785
PhosphoSitePlusiP57785

Proteomic databases

PaxDbiP57785
PeptideAtlasiP57785
PRIDEiP57785

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085797; ENSMUSP00000082952; ENSMUSG00000066652
GeneIDi320202
KEGGimmu:320202
UCSCiuc007dwu.1 mouse

Organism-specific databases

CTDi7044
MGIiMGI:2443573 Lefty2

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00390000010056
HOGENOMiHOG000113317
HOVERGENiHBG074429
InParanoidiP57785
KOiK04668
OMAiMAIPTHV
OrthoDBiEOG091G09EN
PhylomeDBiP57785
TreeFamiTF106462

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Miscellaneous databases

PROiPR:P57785
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066652 Expressed in 51 organ(s), highest expression level in embryo
CleanExiMM_LEFTY2
GenevisibleiP57785 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR003942 LRDF
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF037402 TGFb4, 1 hit
PRINTSiPR01427 TGFBETA4
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLFTY2_MOUSE
AccessioniPrimary (citable) accession number: P57785
Secondary accession number(s): Q8BMF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 6, 2007
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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