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Protein

U2 small nuclear ribonucleoprotein A'

Gene

Snrpa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA.By similarity

GO - Molecular functioni

  • U2 snRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein A'
Short name:
U2 snRNP A'
Gene namesi
Name:Snrpa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916231 Snrpa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741751 – 255U2 small nuclear ribonucleoprotein A'Add BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172N6-acetyllysine; alternateCombined sources1
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei178PhosphoserineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei236PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP57784
MaxQBiP57784
PaxDbiP57784
PeptideAtlasiP57784
PRIDEiP57784

PTM databases

iPTMnetiP57784
PhosphoSitePlusiP57784

Expressioni

Gene expression databases

BgeeiENSMUSG00000030512 Expressed in 301 organ(s), highest expression level in respiratory primordium
CleanExiMM_SNRPA1
ExpressionAtlasiP57784 baseline and differential
GenevisibleiP57784 MM

Interactioni

Subunit structurei

Identified in the spliceosome B complex. Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B. Contributes to the binding of stem loop IV of U2 snRNA with SNRPB2.By similarity

Protein-protein interaction databases

IntActiP57784, 10 interactors
MINTiP57784
STRINGi10090.ENSMUSP00000117947

Structurei

3D structure databases

ProteinModelPortaliP57784
SMRiP57784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 41LRR 1Add BLAST22
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 86LRR 3Add BLAST22
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1644 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00510000047131
HOGENOMiHOG000175472
HOVERGENiHBG007330
InParanoidiP57784
KOiK11092
OMAiTKPNYRE
OrthoDBiEOG091G0M17
PhylomeDBiP57784
TreeFamiTF313776

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P57784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLTAELIE QAAQYTNAVR DRELDLRGYK IPVIENLGAT LDQFDAIDFS
60 70 80 90 100
DNEIRKLDGF PLLRRLKTLL VNNNRICRIG EGLDQALPCL TELILTNNSL
110 120 130 140 150
VELGDLDPLA SLKSLTYLSI LRNPVTNKKH YRLYVIYKVP QVRVLDFQKV
160 170 180 190 200
KLKERQEAEK MFKGKRGAQL AKDIARRSKT FNPGAGLPTD KKKGGPSAGD
210 220 230 240 250
VEAIKNAIAN ASTLAEVERL KGLLQSGQIP GRERRSGPSD EGEEEIEDDT

VTNGS
Length:255
Mass (Da):28,357
Last modified:May 23, 2003 - v2
Checksum:iD5847A07883A734D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E883G5E883_MOUSE
Small nuclear ribonucleoprotein pol...
Snrpa1 mCG_19965
154Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63L → S in AAH13777 (PubMed:15489334).Curated1
Sequence conflicti172 – 173KD → N in AAF35392 (PubMed:12036604).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230356 mRNA Translation: AAF35392.1
BC013777 mRNA Translation: AAH13777.1
BC029642 mRNA Translation: AAH29642.1
AK088438 mRNA Translation: BAC40353.1
AK151800 mRNA Translation: BAE30700.1
AK152546 mRNA Translation: BAE31301.1
AK153502 mRNA Translation: BAE32048.1
CCDSiCCDS21342.1
RefSeqiNP_067311.4, NM_021336.4
UniGeneiMm.22362

Genome annotation databases

EnsembliENSMUST00000153609; ENSMUSP00000117947; ENSMUSG00000030512
GeneIDi68981
KEGGimmu:68981
UCSCiuc009hgy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230356 mRNA Translation: AAF35392.1
BC013777 mRNA Translation: AAH13777.1
BC029642 mRNA Translation: AAH29642.1
AK088438 mRNA Translation: BAC40353.1
AK151800 mRNA Translation: BAE30700.1
AK152546 mRNA Translation: BAE31301.1
AK153502 mRNA Translation: BAE32048.1
CCDSiCCDS21342.1
RefSeqiNP_067311.4, NM_021336.4
UniGeneiMm.22362

3D structure databases

ProteinModelPortaliP57784
SMRiP57784
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP57784, 10 interactors
MINTiP57784
STRINGi10090.ENSMUSP00000117947

PTM databases

iPTMnetiP57784
PhosphoSitePlusiP57784

Proteomic databases

EPDiP57784
MaxQBiP57784
PaxDbiP57784
PeptideAtlasiP57784
PRIDEiP57784

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000153609; ENSMUSP00000117947; ENSMUSG00000030512
GeneIDi68981
KEGGimmu:68981
UCSCiuc009hgy.2 mouse

Organism-specific databases

CTDi6627
MGIiMGI:1916231 Snrpa1

Phylogenomic databases

eggNOGiKOG1644 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00510000047131
HOGENOMiHOG000175472
HOVERGENiHBG007330
InParanoidiP57784
KOiK11092
OMAiTKPNYRE
OrthoDBiEOG091G0M17
PhylomeDBiP57784
TreeFamiTF313776

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:P57784
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030512 Expressed in 301 organ(s), highest expression level in respiratory primordium
CleanExiMM_SNRPA1
ExpressionAtlasiP57784 baseline and differential
GenevisibleiP57784 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRU2A_MOUSE
AccessioniPrimary (citable) accession number: P57784
Secondary accession number(s): Q3U7R8
, Q8K2W4, Q91YW1, Q9JKQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 23, 2003
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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