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Protein

Elongation factor 1-delta

Gene

Eef1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.By similarity
Isoform 3: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Elongation factor
Biological processProtein biosynthesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-delta
Short name:
EF-1-delta
Gene namesi
Name:Eef1d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913906 Eef1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001550472 – 281Elongation factor 1-deltaAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Modified residuei106PhosphoserineBy similarity1
Modified residuei107N6-acetyllysineBy similarity1
Modified residuei117N6-acetyllysine; alternateBy similarity1
Modified residuei117N6-succinyllysine; alternateCombined sources1
Modified residuei119PhosphoserineBy similarity1
Modified residuei129PhosphothreonineBy similarity1
Modified residuei133PhosphoserineCombined sources1
Modified residuei147PhosphothreonineCombined sources1
Modified residuei162Phosphoserine; by CK2Combined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP57776
MaxQBiP57776
PaxDbiP57776
PeptideAtlasiP57776
PRIDEiP57776

2D gel databases

REPRODUCTION-2DPAGEiP57776

PTM databases

iPTMnetiP57776
PhosphoSitePlusiP57776
SwissPalmiP57776

Interactioni

Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 3 interacts with HSF1 and NFE2L2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211625, 3 interactors
IntActiP57776, 7 interactors
MINTiP57776
STRINGi10090.ENSMUSP00000087110

Structurei

3D structure databases

ProteinModelPortaliP57776
SMRiP57776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 115Leucine-zipperBy similarityAdd BLAST36
Regioni173 – 281Catalytic (GEF)By similarityAdd BLAST109

Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

eggNOGiKOG1668 Eukaryota
COG2092 LUCA
HOGENOMiHOG000207272
HOVERGENiHBG000787
InParanoidiP57776
KOiK15410
TreeFamiTF313134

Family and domain databases

CDDicd00292 EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219 eEF-1beta-like_sf
IPR018940 EF-1_beta_acid_region_euk
IPR014038 EF1B_bsu/dsu_GNE
IPR014717 Transl_elong_EF1B/ribosomal_S6
IPR001326 Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587 EF-1_beta_acid, 1 hit
PF00736 EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182 EF-1_beta_acid, 1 hit
SM00888 EF1_GNE, 1 hit
SUPFAMiSSF54984 SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824 EF1BD_1, 1 hit
PS00825 EF1BD_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P57776-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATNFLAHEK IWFDKFKYDD AERRFYEQMN GPVTSGSRQE NGASVILRDI
60 70 80 90 100
ARARENIQKS LAGSSGPGAS SGPGGDHSEL IVRITSLEVE NQNLRGVVQD
110 120 130 140 150
LQQAISKLEA RLSSLEKSSP TPRATAPQTQ HVSPMRQVEP PTKKGATPAE
160 170 180 190 200
DDEDKDIDLF GSDEEEEDKE AARLREERLR QYAEKKAKKP TLVAKSSILL
210 220 230 240 250
DVKPWDDETD MAQLETCVRS IQLDGLVWGA SKLVPVGYGI RKLQIQCVVE
260 270 280
DDKVGTDLLE EEITKFEEHV QSVDIAAFDK I
Length:281
Mass (Da):31,293
Last modified:January 23, 2007 - v3
Checksum:iFD55F872FDA06819
GO
Isoform 2 (identifier: P57776-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-63: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):28,729
Checksum:iE0072696BD8CAACF
GO
Isoform 3 (identifier: P57776-3) [UniParc]FASTAAdd to basket
Also known as: eEF1BdeltaLBy similarity

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRSGKASCAL...MSSLRPNRKM

Show »
Length:660
Mass (Da):72,931
Checksum:i0B4B8EBE385ADDA4
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1E2A0A0R4J1E2_MOUSE
Elongation factor 1-delta
Eef1d
660Annotation score:
Q80T06Q80T06_MOUSE
Elongation factor 1-delta
Eef1d
281Annotation score:
Q91VK2Q91VK2_MOUSE
Eef1d protein
Eef1d mCG_22130
276Annotation score:
F6ZFU0F6ZFU0_MOUSE
Elongation factor 1-delta
Eef1d
552Annotation score:
A0A0R4J1L2A0A0R4J1L2_MOUSE
Elongation factor 1-delta
Eef1d mCG_22130
257Annotation score:
E9QN08E9QN08_MOUSE
Elongation factor 1-delta
Eef1d
245Annotation score:
D3YY68D3YY68_MOUSE
Elongation factor 1-delta
Eef1d mCG_22130
190Annotation score:
D3YUQ9D3YUQ9_MOUSE
Elongation factor 1-delta
Eef1d
193Annotation score:
D3YZT9D3YZT9_MOUSE
Elongation factor 1-delta
Eef1d
210Annotation score:
D3Z7N2D3Z7N2_MOUSE
Elongation factor 1-delta
Eef1d
129Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279D → N in BAB26870 (PubMed:16141072).Curated1
Sequence conflicti279D → N in BAB30841 (PubMed:16141072).Curated1
Sequence conflicti279D → N in AAH79855 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0378851M → MRSGKASCALETVWEDRHKY EGAERRFHEQEATQVVAAAA TAAATASASVQQLLDEVPAV NGPSQEDTEDTEEAEAPNTS SRSDPGKSHECKKPIQKKRK RSPKSWLGQADLALVGLSAD HVWLDKPLFDQAESSYRQRL ADVAAQAAQPPALAPRGPCT HGSHVACHHVTWGIWVNKSC FDQAERAFVEWSQSLLLAAE GSHRQGTPDTGQQAVTPDLA LACQPCPPANGQPPLGSLQA LVREVWLEKPRYDAAERGFY EALFDGHPPGKVRLQERASQ AEGTRRGRRDHRSCNNVGNK RAGSKRANGEAPPAFPYWYF LHKDAEAPWLSKPTYDSAEC RHHAVEALRIAWRLEAASLA HRPTPRSGPSMSSLRPNRKM in isoform 3. 1 Publication1
Alternative sequenceiVSP_00135940 – 63Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304351 mRNA Translation: AAG17466.1
AK010308 mRNA No translation available.
AK010347 mRNA Translation: BAB26870.1
AK017616 mRNA Translation: BAB30841.1
AK017796 mRNA No translation available.
BC079855 mRNA Translation: AAH79855.1
CCDSiCCDS27553.1 [P57776-3]
CCDS27554.1 [P57776-1]
CCDS70638.1 [P57776-2]
RefSeqiNP_001272358.1, NM_001285429.1
NP_001272359.1, NM_001285430.1
NP_001272360.1, NM_001285431.1
NP_001272361.1, NM_001285432.1
NP_001272362.1, NM_001285433.1
NP_001272363.1, NM_001285434.1
NP_075729.2, NM_023240.3
NP_083939.1, NM_029663.2
UniGeneiMm.258927

Genome annotation databases

GeneIDi66656
KEGGimmu:66656
UCSCiuc007whj.2 mouse [P57776-3]
uc007whm.2 mouse [P57776-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304351 mRNA Translation: AAG17466.1
AK010308 mRNA No translation available.
AK010347 mRNA Translation: BAB26870.1
AK017616 mRNA Translation: BAB30841.1
AK017796 mRNA No translation available.
BC079855 mRNA Translation: AAH79855.1
CCDSiCCDS27553.1 [P57776-3]
CCDS27554.1 [P57776-1]
CCDS70638.1 [P57776-2]
RefSeqiNP_001272358.1, NM_001285429.1
NP_001272359.1, NM_001285430.1
NP_001272360.1, NM_001285431.1
NP_001272361.1, NM_001285432.1
NP_001272362.1, NM_001285433.1
NP_001272363.1, NM_001285434.1
NP_075729.2, NM_023240.3
NP_083939.1, NM_029663.2
UniGeneiMm.258927

3D structure databases

ProteinModelPortaliP57776
SMRiP57776
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211625, 3 interactors
IntActiP57776, 7 interactors
MINTiP57776
STRINGi10090.ENSMUSP00000087110

PTM databases

iPTMnetiP57776
PhosphoSitePlusiP57776
SwissPalmiP57776

2D gel databases

REPRODUCTION-2DPAGEiP57776

Proteomic databases

EPDiP57776
MaxQBiP57776
PaxDbiP57776
PeptideAtlasiP57776
PRIDEiP57776

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi66656
KEGGimmu:66656
UCSCiuc007whj.2 mouse [P57776-3]
uc007whm.2 mouse [P57776-2]

Organism-specific databases

CTDi1936
MGIiMGI:1913906 Eef1d

Phylogenomic databases

eggNOGiKOG1668 Eukaryota
COG2092 LUCA
HOGENOMiHOG000207272
HOVERGENiHBG000787
InParanoidiP57776
KOiK15410
TreeFamiTF313134

Miscellaneous databases

ChiTaRSiEef1d mouse
PROiPR:P57776
SOURCEiSearch...

Family and domain databases

CDDicd00292 EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219 eEF-1beta-like_sf
IPR018940 EF-1_beta_acid_region_euk
IPR014038 EF1B_bsu/dsu_GNE
IPR014717 Transl_elong_EF1B/ribosomal_S6
IPR001326 Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587 EF-1_beta_acid, 1 hit
PF00736 EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182 EF-1_beta_acid, 1 hit
SM00888 EF1_GNE, 1 hit
SUPFAMiSSF54984 SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824 EF1BD_1, 1 hit
PS00825 EF1BD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEF1D_MOUSE
AccessioniPrimary (citable) accession number: P57776
Secondary accession number(s): Q68FG5
, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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