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Protein

Regulator of G-protein signaling 8

Gene

RGS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).By similarity1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 8
Short name:
RGS8
Gene namesi
Name:RGS8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000135824.12
HGNCiHGNC:16810 RGS8
MIMi607189 gene
neXtProtiNX_P57771

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi85397
OpenTargetsiENSG00000135824
PharmGKBiPA34379

Chemistry databases

ChEMBLiCHEMBL2034803
GuidetoPHARMACOLOGYi2813

Polymorphism and mutation databases

BioMutaiRGS8
DMDMi13124465

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041991 – 180Regulator of G-protein signaling 8Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP57771
PeptideAtlasiP57771
PRIDEiP57771
ProteomicsDBi57032
57033 [P57771-2]

PTM databases

iPTMnetiP57771
PhosphoSitePlusiP57771

Expressioni

Gene expression databases

BgeeiENSG00000135824 Expressed in 79 organ(s), highest expression level in caudate nucleus
CleanExiHS_RGS8
ExpressionAtlasiP57771 baseline and differential
GenevisibleiP57771 HS

Organism-specific databases

HPAiHPA076764

Interactioni

Subunit structurei

Interacts with GNAO1 (By similarity). Interacts with GNAI3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-10216117,EBI-618309

Protein-protein interaction databases

BioGridi124512, 4 interactors
DIPiDIP-59093N
IntActiP57771, 6 interactors
STRINGi9606.ENSP00000258302

Chemistry databases

BindingDBiP57771

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP57771
SMRiP57771
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57771

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 171RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiP57771
KOiK16449
OMAiSHKSDSY
OrthoDBiEOG091G0BDG
PhylomeDBiP57771
TreeFamiTF315837

Family and domain databases

CDDicd08711 RGS_RGS8, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034948 RGS8
IPR034949 RGS_RGS8
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF147 PTHR10845:SF147, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P57771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA
60 70 80 90 100
TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK
110 120 130 140 150
LVSKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNLQEPSL TCFDQAQGKV
160 170 180
HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
Length:180
Mass (Da):20,917
Last modified:February 21, 2001 - v1
Checksum:i198965B4C27F64C9
GO
Isoform 2 (identifier: P57771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAALLMPRR → MWNTLTRSLSDHPVGKDPQAMRTGQRQ

Show »
Length:198
Mass (Da):22,970
Checksum:i2A167BCE750725E5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD36D6RD36_HUMAN
Regulator of G-protein-signaling 8
RGS8
57Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364211 – 9MAALLMPRR → MWNTLTRSLSDHPVGKDPQA MRTGQRQ in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297015 mRNA Translation: AAG45337.1
AF300649 mRNA Translation: AAG18443.1
AK296514 mRNA Translation: BAG59146.1
AK294660 mRNA Translation: BAG57830.1
AL353778 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91130.1
BC069677 mRNA Translation: AAH69677.1
BC069718 mRNA Translation: AAH69718.1
BC103865 mRNA Translation: AAI03866.1
BC103866 mRNA Translation: AAI03867.1
BC103867 mRNA Translation: AAI03868.1
CCDSiCCDS1349.1 [P57771-2]
CCDS41443.1 [P57771-1]
RefSeqiNP_001095920.1, NM_001102450.2 [P57771-1]
NP_203131.1, NM_033345.3 [P57771-2]
XP_005245612.1, XM_005245555.3 [P57771-1]
XP_011508391.1, XM_011510089.2 [P57771-2]
XP_011508392.1, XM_011510090.2 [P57771-1]
XP_016858120.1, XM_017002631.1 [P57771-2]
XP_016858121.1, XM_017002632.1 [P57771-2]
XP_016858122.1, XM_017002633.1 [P57771-2]
XP_016858123.1, XM_017002634.1 [P57771-2]
XP_016858124.1, XM_017002635.1 [P57771-1]
XP_016858125.1, XM_017002636.1 [P57771-1]
XP_016858126.1, XM_017002637.1 [P57771-1]
UniGeneiHs.20982
Hs.458417

Genome annotation databases

EnsembliENST00000258302; ENSP00000258302; ENSG00000135824 [P57771-2]
ENST00000367556; ENSP00000356527; ENSG00000135824 [P57771-1]
ENST00000367557; ENSP00000356528; ENSG00000135824 [P57771-1]
ENST00000483095; ENSP00000426289; ENSG00000135824 [P57771-1]
GeneIDi85397
KEGGihsa:85397
UCSCiuc001gpm.2 human [P57771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297015 mRNA Translation: AAG45337.1
AF300649 mRNA Translation: AAG18443.1
AK296514 mRNA Translation: BAG59146.1
AK294660 mRNA Translation: BAG57830.1
AL353778 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91130.1
BC069677 mRNA Translation: AAH69677.1
BC069718 mRNA Translation: AAH69718.1
BC103865 mRNA Translation: AAI03866.1
BC103866 mRNA Translation: AAI03867.1
BC103867 mRNA Translation: AAI03868.1
CCDSiCCDS1349.1 [P57771-2]
CCDS41443.1 [P57771-1]
RefSeqiNP_001095920.1, NM_001102450.2 [P57771-1]
NP_203131.1, NM_033345.3 [P57771-2]
XP_005245612.1, XM_005245555.3 [P57771-1]
XP_011508391.1, XM_011510089.2 [P57771-2]
XP_011508392.1, XM_011510090.2 [P57771-1]
XP_016858120.1, XM_017002631.1 [P57771-2]
XP_016858121.1, XM_017002632.1 [P57771-2]
XP_016858122.1, XM_017002633.1 [P57771-2]
XP_016858123.1, XM_017002634.1 [P57771-2]
XP_016858124.1, XM_017002635.1 [P57771-1]
XP_016858125.1, XM_017002636.1 [P57771-1]
XP_016858126.1, XM_017002637.1 [P57771-1]
UniGeneiHs.20982
Hs.458417

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IHDX-ray1.70A42-173[»]
2ODEX-ray1.90B/D42-180[»]
5DO9X-ray2.60B/D/F42-173[»]
ProteinModelPortaliP57771
SMRiP57771
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124512, 4 interactors
DIPiDIP-59093N
IntActiP57771, 6 interactors
STRINGi9606.ENSP00000258302

Chemistry databases

BindingDBiP57771
ChEMBLiCHEMBL2034803
GuidetoPHARMACOLOGYi2813

PTM databases

iPTMnetiP57771
PhosphoSitePlusiP57771

Polymorphism and mutation databases

BioMutaiRGS8
DMDMi13124465

Proteomic databases

PaxDbiP57771
PeptideAtlasiP57771
PRIDEiP57771
ProteomicsDBi57032
57033 [P57771-2]

Protocols and materials databases

DNASUi85397
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258302; ENSP00000258302; ENSG00000135824 [P57771-2]
ENST00000367556; ENSP00000356527; ENSG00000135824 [P57771-1]
ENST00000367557; ENSP00000356528; ENSG00000135824 [P57771-1]
ENST00000483095; ENSP00000426289; ENSG00000135824 [P57771-1]
GeneIDi85397
KEGGihsa:85397
UCSCiuc001gpm.2 human [P57771-1]

Organism-specific databases

CTDi85397
DisGeNETi85397
EuPathDBiHostDB:ENSG00000135824.12
GeneCardsiRGS8
HGNCiHGNC:16810 RGS8
HPAiHPA076764
MIMi607189 gene
neXtProtiNX_P57771
OpenTargetsiENSG00000135824
PharmGKBiPA34379
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiP57771
KOiK16449
OMAiSHKSDSY
OrthoDBiEOG091G0BDG
PhylomeDBiP57771
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiRGS8 human
EvolutionaryTraceiP57771
GeneWikiiRGS8
GenomeRNAii85397
PROiPR:P57771
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135824 Expressed in 79 organ(s), highest expression level in caudate nucleus
CleanExiHS_RGS8
ExpressionAtlasiP57771 baseline and differential
GenevisibleiP57771 HS

Family and domain databases

CDDicd08711 RGS_RGS8, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034948 RGS8
IPR034949 RGS_RGS8
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF147 PTHR10845:SF147, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS8_HUMAN
AccessioniPrimary (citable) accession number: P57771
Secondary accession number(s): B4DGL9, Q3SYD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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