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UniProtKB - P57771 (RGS8_HUMAN)

Entry version 156 (17 Jun 2020)
Sequence version 1 (21 Feb 2001)
Previous versions | rss
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Protein

Regulator of G-protein signaling 8

Gene

RGS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418594 G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 8
Short name:
RGS8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000135824.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:16810 RGS8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607189 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P57771

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		85397

Open Targets

More...OpenTargetsi		ENSG00000135824

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34379

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P57771 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2034803

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2813

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RGS8

Domain mapping of disease mutations (DMDM)

More...DMDMi		13124465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041991 – 180Regulator of G-protein signaling 8Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P57771

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P57771

PeptideAtlas

More...PeptideAtlasi		P57771

PRoteomics IDEntifications database

More...PRIDEi		P57771

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57032 [P57771-1]
57033 [P57771-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P57771

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P57771

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135824 Expressed in caudate nucleus and 78 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P57771 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P57771 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135824 Tissue enhanced (brain, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNAO1 (By similarity).

Interacts with GNAI3.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124512, 6 interactors

Database of interacting proteins

More...DIPi		DIP-59093N

Protein interaction database and analysis system

More...IntActi		P57771, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000258302

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P57771

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P57771 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P57771

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P57771

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 171RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154304

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059863_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P57771

KEGG Orthology (KO)

More...KOi		K16449

Identification of Orthologs from Complete Genome Data

More...OMAi		DIVNRAH

Database of Orthologous Groups

More...OrthoDBi		1588190at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P57771

TreeFam database of animal gene trees

More...TreeFami		TF315837

Family and domain databases

Conserved Domains Database

More...CDDi		cd08711 RGS_RGS8, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.196.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016137 RGS
IPR034948 RGS8
IPR034949 RGS_RGS8
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3

The PANTHER Classification System

More...PANTHERi		PTHR10845:SF147 PTHR10845:SF147, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097 SSF48097, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P57771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA 
        60         70         80         90        100
TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK 
       110        120        130        140        150
LVSKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNLQEPSL TCFDQAQGKV 
       160        170        180
HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
Length:180
Mass (Da):20,917
Last modified:February 21, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i198965B4C27F64C9
GO
Isoform 2 (identifier: P57771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAALLMPRR → MWNTLTRSLSDHPVGKDPQAMRTGQRQ

Show »
Length:198
Mass (Da):22,970
Checksum:i2A167BCE750725E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD36D6RD36_HUMAN
Regulator of G-protein-signaling 8
RGS8
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0364211 – 9MAALLMPRR → MWNTLTRSLSDHPVGKDPQA MRTGQRQ in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF297015 mRNA Translation: AAG45337.1
AF300649 mRNA Translation: AAG18443.1
AK296514 mRNA Translation: BAG59146.1
AK294660 mRNA Translation: BAG57830.1
AL353778 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91130.1
BC069677 mRNA Translation: AAH69677.1
BC069718 mRNA Translation: AAH69718.1
BC103865 mRNA Translation: AAI03866.1
BC103866 mRNA Translation: AAI03867.1
BC103867 mRNA Translation: AAI03868.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1349.1 [P57771-2]
CCDS41443.1 [P57771-1]

NCBI Reference Sequences

More...RefSeqi		NP_001095920.1, NM_001102450.2 [P57771-1]
NP_203131.1, NM_033345.3 [P57771-2]
XP_005245612.1, XM_005245555.3 [P57771-1]
XP_011508391.1, XM_011510089.2 [P57771-2]
XP_011508392.1, XM_011510090.2 [P57771-1]
XP_016858120.1, XM_017002631.1 [P57771-2]
XP_016858121.1, XM_017002632.1 [P57771-2]
XP_016858122.1, XM_017002633.1 [P57771-2]
XP_016858123.1, XM_017002634.1 [P57771-2]
XP_016858124.1, XM_017002635.1 [P57771-1]
XP_016858125.1, XM_017002636.1
XP_016858126.1, XM_017002637.1 [P57771-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258302; ENSP00000258302; ENSG00000135824 [P57771-2]
ENST00000367556; ENSP00000356527; ENSG00000135824 [P57771-1]
ENST00000367557; ENSP00000356528; ENSG00000135824 [P57771-1]
ENST00000483095; ENSP00000426289; ENSG00000135824 [P57771-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		85397

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:85397

UCSC genome browser

More...UCSCi		uc001gpm.2 human [P57771-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297015 mRNA Translation: AAG45337.1
AF300649 mRNA Translation: AAG18443.1
AK296514 mRNA Translation: BAG59146.1
AK294660 mRNA Translation: BAG57830.1
AL353778 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91130.1
BC069677 mRNA Translation: AAH69677.1
BC069718 mRNA Translation: AAH69718.1
BC103865 mRNA Translation: AAI03866.1
BC103866 mRNA Translation: AAI03867.1
BC103867 mRNA Translation: AAI03868.1
CCDSiCCDS1349.1 [P57771-2]
CCDS41443.1 [P57771-1]
RefSeqiNP_001095920.1, NM_001102450.2 [P57771-1]
NP_203131.1, NM_033345.3 [P57771-2]
XP_005245612.1, XM_005245555.3 [P57771-1]
XP_011508391.1, XM_011510089.2 [P57771-2]
XP_011508392.1, XM_011510090.2 [P57771-1]
XP_016858120.1, XM_017002631.1 [P57771-2]
XP_016858121.1, XM_017002632.1 [P57771-2]
XP_016858122.1, XM_017002633.1 [P57771-2]
XP_016858123.1, XM_017002634.1 [P57771-2]
XP_016858124.1, XM_017002635.1 [P57771-1]
XP_016858125.1, XM_017002636.1
XP_016858126.1, XM_017002637.1 [P57771-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IHDX-ray1.70A42-173[»]
2ODEX-ray1.90B/D42-180[»]
5DO9X-ray2.60B/D/F42-173[»]
SMRiP57771
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124512, 6 interactors
DIPiDIP-59093N
IntActiP57771, 10 interactors
STRINGi9606.ENSP00000258302

Chemistry databases

BindingDBiP57771
ChEMBLiCHEMBL2034803
GuidetoPHARMACOLOGYi2813

PTM databases

iPTMnetiP57771
PhosphoSitePlusiP57771

Polymorphism and mutation databases

BioMutaiRGS8
DMDMi13124465

Proteomic databases

MassIVEiP57771
PaxDbiP57771
PeptideAtlasiP57771
PRIDEiP57771
ProteomicsDBi57032 [P57771-1]
57033 [P57771-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34440 130 antibodies

The DNASU plasmid repository

More...DNASUi		85397

Genome annotation databases

EnsembliENST00000258302; ENSP00000258302; ENSG00000135824 [P57771-2]
ENST00000367556; ENSP00000356527; ENSG00000135824 [P57771-1]
ENST00000367557; ENSP00000356528; ENSG00000135824 [P57771-1]
ENST00000483095; ENSP00000426289; ENSG00000135824 [P57771-1]
GeneIDi85397
KEGGihsa:85397
UCSCiuc001gpm.2 human [P57771-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		85397
DisGeNETi85397
EuPathDBiHostDB:ENSG00000135824.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		RGS8
HGNCiHGNC:16810 RGS8
HPAiENSG00000135824 Tissue enhanced (brain, thyroid gland)
MIMi607189 gene
neXtProtiNX_P57771
OpenTargetsiENSG00000135824
PharmGKBiPA34379

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000154304
HOGENOMiCLU_059863_3_1_1
InParanoidiP57771
KOiK16449
OMAiDIVNRAH
OrthoDBi1588190at2759
PhylomeDBiP57771
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		85397 1 hit in 780 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RGS8 human
EvolutionaryTraceiP57771

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RGS8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		85397
PharosiP57771 Tchem

Protein Ontology

More...PROi		PR:P57771
RNActiP57771 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135824 Expressed in caudate nucleus and 78 other tissues
ExpressionAtlasiP57771 baseline and differential
GenevisibleiP57771 HS

Family and domain databases

CDDicd08711 RGS_RGS8, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034948 RGS8
IPR034949 RGS_RGS8
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF147 PTHR10845:SF147, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57771
Secondary accession number(s): B4DGL9, Q3SYD2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: June 17, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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