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Protein

Sorting nexin-16

Gene

SNX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144Phosphatidylinositol 3-phosphateCurated1
Binding sitei146Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei184Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • early endosome to late endosome transport Source: UniProtKB
  • endosome to lysosome transport Source: UniProtKB
  • negative regulation of ATPase activity Source: GO_Central
  • negative regulation of ion transport Source: GO_Central
  • protein targeting to lysosome Source: UniProtKB
  • regulation of membrane potential Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-16
Gene namesi
Name:SNX16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104497.13
HGNCiHGNC:14980 SNX16
MIMi614903 gene
neXtProtiNX_P57768

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi144R → A: Abolishes binding to membranes enriched in phosphatidylinositol 3-phosphate. 1 Publication1
Mutagenesisi145Y → A: Abolishes binding to phosphatidylinositol 3-phosphate. 1 Publication1

Organism-specific databases

DisGeNETi64089
OpenTargetsiENSG00000104497
PharmGKBiPA134972049

Polymorphism and mutation databases

BioMutaiSNX16
DMDMi116242795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138631 – 344Sorting nexin-16Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP57768
MaxQBiP57768
PaxDbiP57768
PeptideAtlasiP57768
PRIDEiP57768
ProteomicsDBi57030
57031 [P57768-2]

PTM databases

iPTMnetiP57768
PhosphoSitePlusiP57768

Expressioni

Tissue specificityi

Detected in placenta, lung, liver,heart and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000104497 Expressed in 204 organ(s), highest expression level in sperm
CleanExiHS_SNX16
ExpressionAtlasiP57768 baseline and differential
GenevisibleiP57768 HS

Organism-specific databases

HPAiHPA024730
HPA024731
HPA024817

Interactioni

Subunit structurei

Homooligomer. Interacts with EGFR (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122051, 12 interactors
IntActiP57768, 4 interactors
STRINGi9606.ENSP00000322652

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP57768
SMRiP57768
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 218PXPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili223 – 278Sequence analysisAdd BLAST56

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IMHW Eukaryota
ENOG410Z8KU LUCA
GeneTreeiENSGT00390000005651
HOGENOMiHOG000013075
HOVERGENiHBG057106
InParanoidiP57768
KOiK17928
OMAiETNYRFQ
OrthoDBiEOG091G0JVO
PhylomeDBiP57768
TreeFamiTF324116

Family and domain databases

CDDicd07276 PX_SNX16, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR037911 SNX16_PX
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P57768-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATPYVPVPM PIGNSASSFT TNRNQRSSSF GSVSTSSNSS KGQLEDSNMG
60 70 80 90 100
NFKQTSVPDQ MDNTSSVCSS PLIRTKFTGT ASSIEYSTRP RDTEEQNPET
110 120 130 140 150
VNWEDRPSTP TILGYEVMEE RAKFTVYKIL VKKTPEESWV VFRRYTDFSR
160 170 180 190 200
LNDKLKEMFP GFRLALPPKR WFKDNYNADF LEDRQLGLQA FLQNLVAHKD
210 220 230 240 250
IANCLAVREF LCLDDPPGPF DSLEESRAFC ETLEETNYRL QKELLEKQKE
260 270 280 290 300
MESLKKLLSE KQLHIDTLEN RIRTLSLEPE ESLDVSETEG EQILKVESSA
310 320 330 340
LEVDQDVLDE ESRADNKPCL SFSEPENAVS EIEVAEVAYD AEED
Length:344
Mass (Da):39,167
Last modified:October 17, 2006 - v2
Checksum:i213744E94B5B3BB8
GO
Isoform 2 (identifier: P57768-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-154: Missing.

Note: No experimental confirmation available.
Show »
Length:315
Mass (Da):35,566
Checksum:iC4930631DA99C4D3
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGW2A0A0C4DGW2_HUMAN
Sorting nexin-16
SNX16
343Annotation score:
E5RGS8E5RGS8_HUMAN
Sorting nexin-16
SNX16
162Annotation score:
E5RGQ6E5RGQ6_HUMAN
Sorting nexin-16
SNX16
203Annotation score:
E5RH07E5RH07_HUMAN
Sorting nexin-16
SNX16
174Annotation score:
E5RHF1E5RHF1_HUMAN
Sorting nexin-16
SNX16
92Annotation score:
E5RJ65E5RJ65_HUMAN
Sorting nexin-16
SNX16
84Annotation score:
E5RG30E5RG30_HUMAN
Sorting nexin-16
SNX16
73Annotation score:
E5RJ81E5RJ81_HUMAN
Sorting nexin-16
SNX16
36Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308 – 311LDEE → WMR in AAG25676 (Ref. 1) Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05247998P → L. Corresponds to variant dbSNP:rs16919654Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042944126 – 154Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305779 mRNA Translation: AAG25676.1
AK290903 mRNA Translation: BAF83592.1
AL833763 mRNA Translation: CAH56235.1
AC087349 Genomic DNA No translation available.
AC132219 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87108.1
CH471068 Genomic DNA Translation: EAW87109.1
BC033630 mRNA Translation: AAH33630.1
CCDSiCCDS6234.1 [P57768-1]
CCDS6235.1 [P57768-2]
RefSeqiNP_071416.2, NM_022133.3 [P57768-1]
NP_690049.1, NM_152836.2 [P57768-1]
NP_690050.1, NM_152837.2 [P57768-2]
UniGeneiHs.492121

Genome annotation databases

EnsembliENST00000345957; ENSP00000322652; ENSG00000104497 [P57768-1]
ENST00000353788; ENSP00000322631; ENSG00000104497 [P57768-2]
ENST00000396330; ENSP00000379621; ENSG00000104497 [P57768-1]
GeneIDi64089
KEGGihsa:64089
UCSCiuc003ycn.4 human [P57768-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305779 mRNA Translation: AAG25676.1
AK290903 mRNA Translation: BAF83592.1
AL833763 mRNA Translation: CAH56235.1
AC087349 Genomic DNA No translation available.
AC132219 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87108.1
CH471068 Genomic DNA Translation: EAW87109.1
BC033630 mRNA Translation: AAH33630.1
CCDSiCCDS6234.1 [P57768-1]
CCDS6235.1 [P57768-2]
RefSeqiNP_071416.2, NM_022133.3 [P57768-1]
NP_690049.1, NM_152836.2 [P57768-1]
NP_690050.1, NM_152837.2 [P57768-2]
UniGeneiHs.492121

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GW0X-ray3.30A/B/C/D/E/F100-278[»]
5GW1X-ray3.35A/B/C/D/E/F/G/H100-278[»]
ProteinModelPortaliP57768
SMRiP57768
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122051, 12 interactors
IntActiP57768, 4 interactors
STRINGi9606.ENSP00000322652

PTM databases

iPTMnetiP57768
PhosphoSitePlusiP57768

Polymorphism and mutation databases

BioMutaiSNX16
DMDMi116242795

Proteomic databases

EPDiP57768
MaxQBiP57768
PaxDbiP57768
PeptideAtlasiP57768
PRIDEiP57768
ProteomicsDBi57030
57031 [P57768-2]

Protocols and materials databases

DNASUi64089
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345957; ENSP00000322652; ENSG00000104497 [P57768-1]
ENST00000353788; ENSP00000322631; ENSG00000104497 [P57768-2]
ENST00000396330; ENSP00000379621; ENSG00000104497 [P57768-1]
GeneIDi64089
KEGGihsa:64089
UCSCiuc003ycn.4 human [P57768-1]

Organism-specific databases

CTDi64089
DisGeNETi64089
EuPathDBiHostDB:ENSG00000104497.13
GeneCardsiSNX16
HGNCiHGNC:14980 SNX16
HPAiHPA024730
HPA024731
HPA024817
MIMi614903 gene
neXtProtiNX_P57768
OpenTargetsiENSG00000104497
PharmGKBiPA134972049
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMHW Eukaryota
ENOG410Z8KU LUCA
GeneTreeiENSGT00390000005651
HOGENOMiHOG000013075
HOVERGENiHBG057106
InParanoidiP57768
KOiK17928
OMAiETNYRFQ
OrthoDBiEOG091G0JVO
PhylomeDBiP57768
TreeFamiTF324116

Miscellaneous databases

GenomeRNAii64089
PROiPR:P57768
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104497 Expressed in 204 organ(s), highest expression level in sperm
CleanExiHS_SNX16
ExpressionAtlasiP57768 baseline and differential
GenevisibleiP57768 HS

Family and domain databases

CDDicd07276 PX_SNX16, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR037911 SNX16_PX
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX16_HUMAN
AccessioniPrimary (citable) accession number: P57768
Secondary accession number(s): A8K4D8, Q658L0, Q8N4U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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