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Entry version 156 (02 Jun 2021)
Sequence version 1 (21 Feb 2001)
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Protein

Gasdermin-D

Gene

GSDMD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216).

This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216).

3 Publications

Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:28392147, PubMed:32820063).

Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1, CASP4 or CASP5 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190).

After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216, PubMed:29898893).

Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216, PubMed:29898893).

Exhibits bactericidal activity (PubMed:27281216).

Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216).

Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity).

Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (By similarity).

Strongly binds to bacterial and mitochondrial lipids, including cardiolipin (PubMed:27281216).

Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).

By similarity7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The full-length protein before cleavage is inactive: intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of activation signal (PubMed:26375003, PubMed:28928145, PubMed:29576317, PubMed:32109412). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-D, N-terminal) following cleavage by caspases CASP1, CASP4, CASP5 or CASP8 (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:29898893, PubMed:32109412). Cleavage at Asp-87 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis (PubMed:28392147).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity, Necrosis
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P57764

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6798695, Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P57764

Protein family/group databases

Transport Classification Database

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TCDBi
1.C.123.1.1, the pore-forming gasdermin (gasdermin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gasdermin-D1 Publication
Alternative name(s):
Gasdermin domain-containing protein 11 Publication
Cleaved into the following 2 chains:
Gasdermin-D, N-terminalCurated
Short name:
GSDMD-NTBy similarity
Short name:
hGSDMD-NTD1 Publication
Gasdermin-D, C-terminalCurated
Short name:
GSDMD-CTBy similarity
Short name:
hGSDMD-CTD1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSDMD1 PublicationImported
Synonyms:DFNA5L1 Publication, GSDMDC11 Publication
ORF Names:FKSG101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25697, GSDMD

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617042, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57764

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000104518.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Inflammasome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7 – 11RVVRR → AVVAA: Impaired pore-formation. 1 Publication5
Mutagenesisi15E → K: No spontaneous pyroptosis-inducing activity; when associated with D-192. 2 Publications1
Mutagenesisi104I → N: Decreased effectiveness in pore formation and pyroptosis induction. No effect on cleavage by CASP1. 1 Publication1
Mutagenesisi192L → D: Decreased induction of pyroptosis and defects in liposome-binding. No spontaneous pyroptosis-inducing activity; when associated with K-15. 2 Publications1
Mutagenesisi272 – 274FLT → AAA: Does not affect interaction with CASP4. 1 Publication3
Mutagenesisi275D → A: Loss of cleavage by CASP1 and CASP4 and of LPS-induced pyroptosis. Does not affect interaction with CASP1 and CASP4. 2 Publications1
Mutagenesisi277 – 296VPAEG…AEVET → SGGGS: Constitutively active mutant; promotes activation of pyroptosis. 1 PublicationAdd BLAST20
Mutagenesisi283F → A or R: Constitutively active mutant; promotes activation of pyroptosis. 1 Publication1
Mutagenesisi283F → Y: No effect. 1 Publication1
Mutagenesisi290L → D: Spontaneous pyroptosis-inducing activity. 1 Publication1
Mutagenesisi304 – 308LDREL → ADREA: Impairs interaction with CASP1 and CASP4 and subsequent cleavage. 1 Publication5
Mutagenesisi364 – 367VPEL → APEA: Impairs interaction with CASP1 and CASP4 and subsequent cleavage. 1 Publication4
Mutagenesisi373Y → D: Spontaneous pyroptosis-inducing activity. 1 Publication1
Mutagenesisi377A → D: Spontaneous pyroptosis-inducing activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79792

Open Targets

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OpenTargetsi
ENSG00000104518

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162390357

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P57764, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4523247

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSDMD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13124058

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001481751 – 484Gasdermin-DAdd BLAST484
ChainiPRO_00004375261 – 275Gasdermin-D, N-terminal1 PublicationAdd BLAST275
ChainiPRO_0000437527276 – 484Gasdermin-D, C-terminal1 PublicationAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphotyrosineCombined sources1
Modified residuei56S-(2-succinyl)cysteine1 Publication1
Modified residuei158PhosphotyrosineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei191S-(2-succinyl)cysteine1 Publication1
Modified residuei268S-(2-succinyl)cysteine1 Publication1
Modified residuei309S-(2-succinyl)cysteine1 Publication1
Modified residuei467S-(2-succinyl)cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleavage at Asp-275 by CASP1 (mature and uncleaved precursor forms), CASP4, CASP5 or CASP8 relieves autoinhibition and is sufficient to initiate pyroptosis (PubMed:26375003, PubMed:29898893, PubMed:32109412). Cleavage by CASP1 and CASP4 is not strictly dependent on the consensus cleavage site on GSDMD but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Cleavage by CASP8 takes place following inactivation of MAP3K7/TAK1 by Yersinia toxin YopJ (By similarity). Cleavage at Asp-87 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis (PubMed:28392147, PubMed:28045099).By similarity5 Publications
Succination of Cys-191 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits processing by caspases, and ability to initiate pyroptosis (PubMed:32820063). Succination modification is catalyzed by a non-enzymatic reaction caused by an accumulation of fumarate (PubMed:32820063).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei87 – 88Cleavage; by CASP3 or CASP72 Publications2
Sitei275 – 276Cleavage; by caspases CASP1, CASP4, CASP5 and CASP81 Publication2 Publications2

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P57764

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P57764

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P57764

MaxQB - The MaxQuant DataBase

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MaxQBi
P57764

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P57764

PeptideAtlas

More...
PeptideAtlasi
P57764

PRoteomics IDEntifications database

More...
PRIDEi
P57764

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57029

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P57764

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P57764

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the suprabasal cells of esophagus, as well as in the isthmus/neck, pit, and gland of the stomach, suggesting preferential expression in differentiating cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104518, Expressed in spleen and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P57764, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P57764, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000104518, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane (By similarity). In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor (By similarity). Although this recruitment is also observed in the absence of PYCARD, it is more efficient in its presence (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122891, 8 interactors

Database of interacting proteins

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DIPi
DIP-61775N

Protein interaction database and analysis system

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IntActi
P57764, 13 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000433209

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P57764, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1484
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P57764

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni277 – 296Linker helix loop1 PublicationAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of cleavage by inflammatory caspases CASP1, CASP4 or CASP5 (PubMed:26375003, PubMed:29898893, PubMed:28928145, PubMed:29576317). The linker helix loop inserts into the N-terminal domain (PubMed:28928145). The intrinsic pyroptosis-inducing activity is carried by Gasdermin-D, N-terminal, that is released upon cleavage by inflammatory caspases (PubMed:26375003).4 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gasdermin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S0IQ, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183140

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_040752_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P57764

Database of Orthologous Groups

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OrthoDBi
747086at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P57764

TreeFam database of animal gene trees

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TreeFami
TF331886

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007677, Gasdermin
IPR040460, Gasdermin_pore
IPR041263, Gasdermin_PUB

The PANTHER Classification System

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PANTHERi
PTHR16399, PTHR16399, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04598, Gasdermin, 1 hit
PF17708, Gasdermin_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P57764-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSAFERVVR RVVQELDHGG EFIPVTSLQS STGFQPYCLV VRKPSSSWFW
60 70 80 90 100
KPRYKCVNLS IKDILEPDAA EPDVQRGRSF HFYDAMDGQI QGSVELAAPG
110 120 130 140 150
QAKIAGGAAV SDSSSTSMNV YSLSVDPNTW QTLLHERHLR QPEHKVLQQL
160 170 180 190 200
RSRGDNVYVV TEVLQTQKEV EVTRTHKREG SGRFSLPGAT CLQGEGQGHL
210 220 230 240 250
SQKKTVTIPS GSTLAFRVAQ LVIDSDLDVL LFPDKKQRTF QPPATGHKRS
260 270 280 290 300
TSEGAWPQLP SGLSMMRCLH NFLTDGVPAE GAFTEDFQGL RAEVETISKE
310 320 330 340 350
LELLDRELCQ LLLEGLEGVL RDQLALRALE EALEQGQSLG PVEPLDGPAG
360 370 380 390 400
AVLECLVLSS GMLVPELAIP VVYLLGALTM LSETQHKLLA EALESQTLLG
410 420 430 440 450
PLELVGSLLE QSAPWQERST MSLPPGLLGN SWGEGAPAWV LLDECGLELG
460 470 480
EDTPHVCWEP QAQGRMCALY ASLALLSGLS QEPH
Length:484
Mass (Da):52,801
Last modified:February 21, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7CE8073E0C0194D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1A6G3V1A6_HUMAN
Gasdermin domain containing 1, isof...
GSDMD GSDMDC1, hCG_32063
532Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIB2E9PIB2_HUMAN
Gasdermin-D
GSDMD
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRF1E9PRF1_HUMAN
Gasdermin-D
GSDMD
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQR9E9PQR9_HUMAN
Gasdermin-D
GSDMD
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ48E9PQ48_HUMAN
Gasdermin-D
GSDMD
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNZ0E9PNZ0_HUMAN
Gasdermin-D
GSDMD
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDB0H0YDB0_HUMAN
Gasdermin-D
GSDMD
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti360 – 483SGMLV…LSQEP → PECWCRNSLSLLSTCWG in AAG22861 (Ref. 1) CuratedAdd BLAST124
Sequence conflicti386H → R in BAF84506 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY008304 mRNA Translation: AAG22861.1
AK022212 mRNA Translation: BAB13986.1
AK291817 mRNA Translation: BAF84506.1
AC067930 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82243.1
CH471162 Genomic DNA Translation: EAW82245.1
BC008904 mRNA Translation: AAH08904.1
BC069000 mRNA Translation: AAH69000.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34956.1

NCBI Reference Sequences

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RefSeqi
NP_001159709.1, NM_001166237.1
NP_079012.3, NM_024736.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262580; ENSP00000262580; ENSG00000104518
ENST00000526406; ENSP00000433209; ENSG00000104518
ENST00000615119; ENSP00000482096; ENSG00000278718
ENST00000631751; ENSP00000488012; ENSG00000278718

Database of genes from NCBI RefSeq genomes

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GeneIDi
79792

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79792

UCSC genome browser

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UCSCi
uc003yyg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008304 mRNA Translation: AAG22861.1
AK022212 mRNA Translation: BAB13986.1
AK291817 mRNA Translation: BAF84506.1
AC067930 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82243.1
CH471162 Genomic DNA Translation: EAW82245.1
BC008904 mRNA Translation: AAH08904.1
BC069000 mRNA Translation: AAH69000.1
CCDSiCCDS34956.1
RefSeqiNP_001159709.1, NM_001166237.1
NP_079012.3, NM_024736.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NH1X-ray2.04A278-484[»]
5WQTX-ray2.64A/B276-484[»]
6AO4X-ray2.90A277-484[»]
6KN0X-ray2.79E/F283-480[»]
6N9OX-ray3.50A/B/C/D1-484[»]
SMRiP57764
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122891, 8 interactors
DIPiDIP-61775N
IntActiP57764, 13 interactors
STRINGi9606.ENSP00000433209

Chemistry databases

ChEMBLiCHEMBL4523247

Protein family/group databases

TCDBi1.C.123.1.1, the pore-forming gasdermin (gasdermin) family

PTM databases

iPTMnetiP57764
PhosphoSitePlusiP57764

Genetic variation databases

BioMutaiGSDMD
DMDMi13124058

Proteomic databases

EPDiP57764
jPOSTiP57764
MassIVEiP57764
MaxQBiP57764
PaxDbiP57764
PeptideAtlasiP57764
PRIDEiP57764
ProteomicsDBi57029

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27909, 149 antibodies

The DNASU plasmid repository

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DNASUi
79792

Genome annotation databases

EnsembliENST00000262580; ENSP00000262580; ENSG00000104518
ENST00000526406; ENSP00000433209; ENSG00000104518
ENST00000615119; ENSP00000482096; ENSG00000278718
ENST00000631751; ENSP00000488012; ENSG00000278718
GeneIDi79792
KEGGihsa:79792
UCSCiuc003yyg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79792
DisGeNETi79792

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GSDMD
HGNCiHGNC:25697, GSDMD
HPAiENSG00000104518, Low tissue specificity
MIMi617042, gene
neXtProtiNX_P57764
OpenTargetsiENSG00000104518
PharmGKBiPA162390357
VEuPathDBiHostDB:ENSG00000104518.10

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S0IQ, Eukaryota
GeneTreeiENSGT00950000183140
HOGENOMiCLU_040752_1_0_1
InParanoidiP57764
OrthoDBi747086at2759
PhylomeDBiP57764
TreeFamiTF331886

Enzyme and pathway databases

PathwayCommonsiP57764
ReactomeiR-HSA-6798695, Neutrophil degranulation
SIGNORiP57764

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79792, 20 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GSDMD, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79792
PharosiP57764, Tbio

Protein Ontology

More...
PROi
PR:P57764
RNActiP57764, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104518, Expressed in spleen and 188 other tissues
ExpressionAtlasiP57764, baseline and differential
GenevisibleiP57764, HS

Family and domain databases

InterProiView protein in InterPro
IPR007677, Gasdermin
IPR040460, Gasdermin_pore
IPR041263, Gasdermin_PUB
PANTHERiPTHR16399, PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598, Gasdermin, 1 hit
PF17708, Gasdermin_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSDMD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57764
Secondary accession number(s): A8K702, D3DWJ9, Q96Q98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: June 2, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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