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UniProtKB - P57759 (ERP29_MOUSE)

Entry version 145 (08 May 2019)
Sequence version 2 (01 Jun 2001)
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Protein

Endoplasmic reticulum resident protein 29

Gene

Erp29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 29
Short name:
ERp29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Erp29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1914647 Erp29

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34By similarityAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002119835 – 262Endoplasmic reticulum resident protein 29Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66Phosphotyrosine; by PKDCCBy similarity1
Modified residuei68Phosphotyrosine; by PKDCCBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P57759

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P57759

MaxQB - The MaxQuant DataBase

More...MaxQBi		P57759

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P57759

PeptideAtlas

More...PeptideAtlasi		P57759

PRoteomics IDEntifications database

More...PRIDEi		P57759

2D gel databases

2-DE database at Universidad Complutense de Madrid

More...COMPLUYEAST-2DPAGEi		P57759

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		P57759

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P57759

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P57759

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P57759

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000029616 Expressed in 288 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P57759 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P57759 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		212160, 1 interactor

Protein interaction database and analysis system

More...IntActi		P57759, 2 interactors

Molecular INTeraction database

More...MINTi		P57759

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000117347

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P57759

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi259 – 262Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IX2F Eukaryota
ENOG4111I8S LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018566

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P57759

KEGG Orthology (KO)

More...KOi		K09586

Identification of Orthologs from Complete Genome Data

More...OMAi		DGCIKEF

Database of Orthologous Groups

More...OrthoDBi		1535651at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P57759

TreeFam database of animal gene trees

More...TreeFami		TF324701

Family and domain databases

Conserved Domains Database

More...CDDi		cd00238 ERp29c, 1 hit
cd03007 PDI_a_ERp29_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1150.12, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016855 ERp29
IPR011679 ERp29_C
IPR036356 ERp29_C_sf
IPR012883 ERp29_N
IPR036249 Thioredoxin-like_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07749 ERp29, 1 hit
PF07912 ERp29_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF027352 ER_p29, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47933 SSF47933, 1 hit
SSF52833 SSF52833, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00014 ER_TARGET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P57759-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAGVSGA ASLSPLLSVL LGLLLLFAPH GGSGLHTKGA LPLDTVTFYK 
        60         70         80         90        100
VIPKSKFVLV KFDTQYPYGE KQDEFKRLAE NSASSEELLV AEVGISDYGD 
       110        120        130        140        150
KLNMELSEKY KLDKESYPVF YLFRDGDLEN PVLYNGAVKV GAIQRWLKGQ 
       160        170        180        190        200
GVYLGMPGCL PAYDALAGEF IKASSIEARQ AILKQGQDGL LSVKETEKKW 
       210        220        230        240        250
ASQYLKIMGK ILDQGEDFPA SEMARIGKLI ENKMSDSKKE ELQKSLNILT 
       260 
AFRKKEAEKE EL
Length:262
Mass (Da):28,823
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA4C83757CA8732B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RG87D6RG87_MOUSE
Endoplasmic reticulum resident prot...
Erp29
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WIM7F8WIM7_MOUSE
Endoplasmic reticulum resident prot...
Erp29
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WJI4F8WJI4_MOUSE
Endoplasmic reticulum resident prot...
Erp29
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK004795 mRNA Translation: BAB23570.1
AK009881 mRNA Translation: BAB26559.1
AK154539 mRNA Translation: BAE32664.1
AK168112 mRNA Translation: BAE40083.1
BC017125 mRNA Translation: AAH17125.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS19634.1

NCBI Reference Sequences

More...RefSeqi		NP_080405.1, NM_026129.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000130451; ENSMUSP00000117347; ENSMUSG00000029616

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67397

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:67397

UCSC genome browser

More...UCSCi		uc008zjf.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004795 mRNA Translation: BAB23570.1
AK009881 mRNA Translation: BAB26559.1
AK154539 mRNA Translation: BAE32664.1
AK168112 mRNA Translation: BAE40083.1
BC017125 mRNA Translation: AAH17125.1
CCDSiCCDS19634.1
RefSeqiNP_080405.1, NM_026129.2

3D structure databases

SMRiP57759
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212160, 1 interactor
IntActiP57759, 2 interactors
MINTiP57759
STRINGi10090.ENSMUSP00000117347

PTM databases

iPTMnetiP57759
PhosphoSitePlusiP57759
SwissPalmiP57759

2D gel databases

COMPLUYEAST-2DPAGEiP57759
REPRODUCTION-2DPAGEiP57759

Proteomic databases

EPDiP57759
jPOSTiP57759
MaxQBiP57759
PaxDbiP57759
PeptideAtlasiP57759
PRIDEiP57759

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000130451; ENSMUSP00000117347; ENSMUSG00000029616
GeneIDi67397
KEGGimmu:67397
UCSCiuc008zjf.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10961
MGIiMGI:1914647 Erp29

Phylogenomic databases

eggNOGiENOG410IX2F Eukaryota
ENOG4111I8S LUCA
GeneTreeiENSGT00390000018566
InParanoidiP57759
KOiK09586
OMAiDGCIKEF
OrthoDBi1535651at2759
PhylomeDBiP57759
TreeFamiTF324701

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Erp29 mouse

Protein Ontology

More...PROi		PR:P57759

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000029616 Expressed in 288 organ(s), highest expression level in spleen
ExpressionAtlasiP57759 baseline and differential
GenevisibleiP57759 MM

Family and domain databases

CDDicd00238 ERp29c, 1 hit
cd03007 PDI_a_ERp29_N, 1 hit
Gene3Di1.20.1150.12, 1 hit
InterProiView protein in InterPro
IPR016855 ERp29
IPR011679 ERp29_C
IPR036356 ERp29_C_sf
IPR012883 ERp29_N
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF07749 ERp29, 1 hit
PF07912 ERp29_N, 1 hit
PIRSFiPIRSF027352 ER_p29, 1 hit
SUPFAMiSSF47933 SSF47933, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERP29_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57759
Secondary accession number(s): Q3THW3, Q9CQ42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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