UniProtKB - P57759 (ERP29_MOUSE)
Protein
Endoplasmic reticulum resident protein 29
Gene
Erp29
Organism
Mus musculus (Mouse)
Status
Functioni
Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
GO - Molecular functioni
- chaperone binding Source: MGI
- protein homodimerization activity Source: MGI
GO - Biological processi
- activation of MAPK activity Source: MGI
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: ParkinsonsUK-UCL
- negative regulation of gene expression Source: MGI
- negative regulation of protein secretion Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- protein secretion Source: InterPro
- regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Names & Taxonomyi
Protein namesi | Recommended name: Endoplasmic reticulum resident protein 29Short name: ERp29 |
Gene namesi | Name:Erp29 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914647, Erp29 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen PROSITE-ProRule annotation
Other locations
- Melanosome By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
- smooth endoplasmic reticulum Source: MGI
Other locations
- cell surface Source: MGI
- melanosome Source: UniProtKB-SubCell
- transport vesicle Source: MGI
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | By similarityAdd BLAST | 34 | |
ChainiPRO_0000021198 | 35 – 262 | Endoplasmic reticulum resident protein 29Add BLAST | 228 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | Phosphotyrosine; by PKDCCBy similarity | 1 | |
Modified residuei | 68 | Phosphotyrosine; by PKDCCBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P57759 |
jPOSTi | P57759 |
MaxQBi | P57759 |
PaxDbi | P57759 |
PeptideAtlasi | P57759 |
PRIDEi | P57759 |
2D gel databases
COMPLUYEAST-2DPAGEi | P57759 |
REPRODUCTION-2DPAGEi | P57759 |
PTM databases
iPTMneti | P57759 |
PhosphoSitePlusi | P57759 |
SwissPalmi | P57759 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029616, Expressed in spleen and 303 other tissues |
Genevisiblei | P57759, MM |
Interactioni
Subunit structurei
Homodimer.
Part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity).
By similarityGO - Molecular functioni
- chaperone binding Source: MGI
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 212160, 1 interactor |
IntActi | P57759, 2 interactors |
MINTi | P57759 |
STRINGi | 10090.ENSMUSP00000117347 |
Miscellaneous databases
RNActi | P57759, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 259 – 262 | Prevents secretion from ERPROSITE-ProRule annotation | 4 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QSHC, Eukaryota |
GeneTreei | ENSGT00390000018566 |
HOGENOMi | CLU_061309_1_0_1 |
InParanoidi | P57759 |
OMAi | DGCIKEF |
OrthoDBi | 1535651at2759 |
PhylomeDBi | P57759 |
TreeFami | TF324701 |
Family and domain databases
CDDi | cd00238, ERp29c, 1 hit cd03007, PDI_a_ERp29_N, 1 hit |
Gene3Di | 1.20.1150.12, 1 hit 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR016855, ERp29 IPR011679, ERp29_C IPR036356, ERp29_C_sf IPR012883, ERp29_N IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12211, PTHR12211, 1 hit |
Pfami | View protein in Pfam PF07749, ERp29, 1 hit PF07912, ERp29_N, 1 hit |
PIRSFi | PIRSF027352, ER_p29, 1 hit |
SUPFAMi | SSF47933, SSF47933, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P57759-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAGVSGA ASLSPLLSVL LGLLLLFAPH GGSGLHTKGA LPLDTVTFYK
60 70 80 90 100
VIPKSKFVLV KFDTQYPYGE KQDEFKRLAE NSASSEELLV AEVGISDYGD
110 120 130 140 150
KLNMELSEKY KLDKESYPVF YLFRDGDLEN PVLYNGAVKV GAIQRWLKGQ
160 170 180 190 200
GVYLGMPGCL PAYDALAGEF IKASSIEARQ AILKQGQDGL LSVKETEKKW
210 220 230 240 250
ASQYLKIMGK ILDQGEDFPA SEMARIGKLI ENKMSDSKKE ELQKSLNILT
260
AFRKKEAEKE EL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RG87 | D6RG87_MOUSE | Endoplasmic reticulum resident prot... | Erp29 | 95 | Annotation score: | ||
F8WJI4 | F8WJI4_MOUSE | Endoplasmic reticulum resident prot... | Erp29 | 55 | Annotation score: | ||
F8WIM7 | F8WIM7_MOUSE | Endoplasmic reticulum resident prot... | Erp29 | 57 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK004795 mRNA Translation: BAB23570.1 AK009881 mRNA Translation: BAB26559.1 AK154539 mRNA Translation: BAE32664.1 AK168112 mRNA Translation: BAE40083.1 BC017125 mRNA Translation: AAH17125.1 |
CCDSi | CCDS19634.1 |
RefSeqi | NP_080405.1, NM_026129.2 |
Genome annotation databases
Ensembli | ENSMUST00000130451; ENSMUSP00000117347; ENSMUSG00000029616 |
GeneIDi | 67397 |
KEGGi | mmu:67397 |
UCSCi | uc008zjf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK004795 mRNA Translation: BAB23570.1 AK009881 mRNA Translation: BAB26559.1 AK154539 mRNA Translation: BAE32664.1 AK168112 mRNA Translation: BAE40083.1 BC017125 mRNA Translation: AAH17125.1 |
CCDSi | CCDS19634.1 |
RefSeqi | NP_080405.1, NM_026129.2 |
3D structure databases
SMRi | P57759 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212160, 1 interactor |
IntActi | P57759, 2 interactors |
MINTi | P57759 |
STRINGi | 10090.ENSMUSP00000117347 |
PTM databases
iPTMneti | P57759 |
PhosphoSitePlusi | P57759 |
SwissPalmi | P57759 |
2D gel databases
COMPLUYEAST-2DPAGEi | P57759 |
REPRODUCTION-2DPAGEi | P57759 |
Proteomic databases
EPDi | P57759 |
jPOSTi | P57759 |
MaxQBi | P57759 |
PaxDbi | P57759 |
PeptideAtlasi | P57759 |
PRIDEi | P57759 |
Protocols and materials databases
Antibodypediai | 18632, 312 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000130451; ENSMUSP00000117347; ENSMUSG00000029616 |
GeneIDi | 67397 |
KEGGi | mmu:67397 |
UCSCi | uc008zjf.1, mouse |
Organism-specific databases
CTDi | 10961 |
MGIi | MGI:1914647, Erp29 |
Phylogenomic databases
eggNOGi | ENOG502QSHC, Eukaryota |
GeneTreei | ENSGT00390000018566 |
HOGENOMi | CLU_061309_1_0_1 |
InParanoidi | P57759 |
OMAi | DGCIKEF |
OrthoDBi | 1535651at2759 |
PhylomeDBi | P57759 |
TreeFami | TF324701 |
Miscellaneous databases
BioGRID-ORCSi | 67397, 2 hits in 18 CRISPR screens |
ChiTaRSi | Erp29, mouse |
PROi | PR:P57759 |
RNActi | P57759, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029616, Expressed in spleen and 303 other tissues |
Genevisiblei | P57759, MM |
Family and domain databases
CDDi | cd00238, ERp29c, 1 hit cd03007, PDI_a_ERp29_N, 1 hit |
Gene3Di | 1.20.1150.12, 1 hit 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR016855, ERp29 IPR011679, ERp29_C IPR036356, ERp29_C_sf IPR012883, ERp29_N IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12211, PTHR12211, 1 hit |
Pfami | View protein in Pfam PF07749, ERp29, 1 hit PF07912, ERp29_N, 1 hit |
PIRSFi | PIRSF027352, ER_p29, 1 hit |
SUPFAMi | SSF47933, SSF47933, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERP29_MOUSE | |
Accessioni | P57759Primary (citable) accession number: P57759 Secondary accession number(s): Q3THW3, Q9CQ42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot