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UniProtKB - P57739 (CLD2_HUMAN)

Entry version 171 (25 May 2022)
Sequence version 1 (11 Jan 2001)
Previous versions | rss
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Protein

Claudin-2

Gene

CLDN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P57739

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-420029, Tight junction interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P57739

SIGNOR Signaling Network Open Resource

More...SIGNORi		P57739

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Claudin-2
Alternative name(s):
SP82
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLDN2
ORF Names:PSEC0059, SP82, UNQ705/PRO1356
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2041, CLDN2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300520, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P57739

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165376

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 162ExtracellularSequence analysisAdd BLAST25
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 230CytoplasmicSequence analysisAdd BLAST47

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Azoospermia, obstructive, with nephrolithiasis (OAZON)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionAn X-linked recessive, male infertility disorder characterized by epidydimal obstruction, hypercalciuria and kidney stones.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_085653161G → R in OAZON; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		9075

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CLDN2

MalaCards human disease database

More...MalaCardsi		CLDN2
MIMi301060, phenotype

Open Targets

More...OpenTargetsi		ENSG00000165376

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26567

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P57739, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLDN2

Domain mapping of disease mutations (DMDM)

More...DMDMi		12229749

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447341 – 230Claudin-2Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 641 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei219PhosphoserineBy similarity1
Modified residuei223PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P57739

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P57739

MaxQB - The MaxQuant DataBase

More...MaxQBi		P57739

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P57739

PeptideAtlas

More...PeptideAtlasi		P57739

PRoteomics IDEntifications database

More...PRIDEi		P57739

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57027

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P57739

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P57739

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165376, Expressed in kidney epithelium and 93 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P57739, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165376, Tissue enhanced (choroid plexus, gallbladder, kidney, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114532, 28 interactors

Protein interaction database and analysis system

More...IntActi		P57739, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000441283

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P57739, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P57739

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P57739

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni205 – 230DisorderedSequence analysisAdd BLAST26
Regioni229 – 230Interactions with TJP1, TJP2 and TJP3By similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R10A, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_076370_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P57739

Identification of Orthologs from Complete Genome Data

More...OMAi		VWNIHVV

Database of Orthologous Groups

More...OrthoDBi		1209440at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P57739

TreeFam database of animal gene trees

More...TreeFami		TF331936

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006187, Claudin
IPR005411, Claudin2
IPR017974, Claudin_CS
IPR004031, PMP22/EMP/MP20/Claudin

The PANTHER Classification System

More...PANTHERi		PTHR12002, PTHR12002, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00822, PMP22_Claudin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01589, CLAUDIN2

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01346, CLAUDIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P57739-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLGLQLVG YILGLLGLLG TLVAMLLPSW KTSSYVGASI VTAVGFSKGL 
        60         70         80         90        100
WMECATHSTG ITQCDIYSTL LGLPADIQAA QAMMVTSSAI SSLACIISVV 
       110        120        130        140        150
GMRCTVFCQE SRAKDRVAVA GGVFFILGGL LGFIPVAWNL HGILRDFYSP 
       160        170        180        190        200
LVPDSMKFEI GEALYLGIIS SLFSLIAGII LCFSCSSQRN RSNYYDAYQA 
       210        220        230
QPLATRSSPR PGQPPKVKSE FNSYSLTGYV
Length:230
Mass (Da):24,549
Last modified:January 11, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52CA642D4A62B70D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_085653161G → R in OAZON; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF250558 mRNA Translation: AAF98151.1
AY358474 mRNA Translation: AAQ88838.1
AK312515 mRNA Translation: BAG35416.1
AF177340 mRNA Translation: AAG17984.1
AK075371 mRNA Translation: BAC11575.1
AK075405 mRNA Translation: BAG52130.1
AL158821 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02730.1
CH471120 Genomic DNA Translation: EAX02731.1
BC014424 mRNA Translation: AAH14424.1
BC071747 mRNA Translation: AAH71747.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14524.1

NCBI Reference Sequences

More...RefSeqi		NP_001164563.1, NM_001171092.1
NP_001164566.1, NM_001171095.1
NP_065117.1, NM_020384.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336803.2; ENSP00000336571.1; ENSG00000165376.12
ENST00000540876.1; ENSP00000443230.1; ENSG00000165376.12
ENST00000541806.6; ENSP00000441283.1; ENSG00000165376.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9075

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000336803.2; ENSP00000336571.1; NM_020384.4; NP_065117.1

UCSC genome browser

More...UCSCi		uc004emq.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250558 mRNA Translation: AAF98151.1
AY358474 mRNA Translation: AAQ88838.1
AK312515 mRNA Translation: BAG35416.1
AF177340 mRNA Translation: AAG17984.1
AK075371 mRNA Translation: BAC11575.1
AK075405 mRNA Translation: BAG52130.1
AL158821 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02730.1
CH471120 Genomic DNA Translation: EAX02731.1
BC014424 mRNA Translation: AAH14424.1
BC071747 mRNA Translation: AAH71747.1
CCDSiCCDS14524.1
RefSeqiNP_001164563.1, NM_001171092.1
NP_001164566.1, NM_001171095.1
NP_065117.1, NM_020384.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YYXX-ray1.79A/B224-230[»]
AlphaFoldDBiP57739
SMRiP57739
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114532, 28 interactors
IntActiP57739, 22 interactors
STRINGi9606.ENSP00000441283

PTM databases

iPTMnetiP57739
PhosphoSitePlusiP57739

Genetic variation databases

BioMutaiCLDN2
DMDMi12229749

Proteomic databases

jPOSTiP57739
MassIVEiP57739
MaxQBiP57739
PaxDbiP57739
PeptideAtlasiP57739
PRIDEiP57739
ProteomicsDBi57027

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3617, 585 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		9075

Genome annotation databases

EnsembliENST00000336803.2; ENSP00000336571.1; ENSG00000165376.12
ENST00000540876.1; ENSP00000443230.1; ENSG00000165376.12
ENST00000541806.6; ENSP00000441283.1; ENSG00000165376.12
GeneIDi9075
KEGGihsa:9075
MANE-SelectiENST00000336803.2; ENSP00000336571.1; NM_020384.4; NP_065117.1
UCSCiuc004emq.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9075
DisGeNETi9075

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLDN2
GeneReviewsiCLDN2
HGNCiHGNC:2041, CLDN2
HPAiENSG00000165376, Tissue enhanced (choroid plexus, gallbladder, kidney, seminal vesicle)
MalaCardsiCLDN2
MIMi300520, gene
301060, phenotype
neXtProtiNX_P57739
OpenTargetsiENSG00000165376
PharmGKBiPA26567
VEuPathDBiHostDB:ENSG00000165376

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502R10A, Eukaryota
GeneTreeiENSGT00940000160785
HOGENOMiCLU_076370_1_2_1
InParanoidiP57739
OMAiVWNIHVV
OrthoDBi1209440at2759
PhylomeDBiP57739
TreeFamiTF331936

Enzyme and pathway databases

PathwayCommonsiP57739
ReactomeiR-HSA-420029, Tight junction interactions
SignaLinkiP57739
SIGNORiP57739

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9075, 13 hits in 686 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CLDN2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CLDN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9075
PharosiP57739, Tbio

Protein Ontology

More...PROi		PR:P57739
RNActiP57739, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165376, Expressed in kidney epithelium and 93 other tissues
GenevisibleiP57739, HS

Family and domain databases

InterProiView protein in InterPro
IPR006187, Claudin
IPR005411, Claudin2
IPR017974, Claudin_CS
IPR004031, PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002, PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822, PMP22_Claudin, 1 hit
PRINTSiPR01589, CLAUDIN2
PROSITEiView protein in PROSITE
PS01346, CLAUDIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57739
Secondary accession number(s): B2R6B9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: May 25, 2022
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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