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Entry version 155 (10 Apr 2019)
Sequence version 1 (11 Jan 2001)
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Protein

Claudin-2

Gene

CLDN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-420029 Tight junction interactions

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P57739

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Claudin-2
Alternative name(s):
SP82
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLDN2
ORF Names:PSEC0059, SP82, UNQ705/PRO1356
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165376.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2041 CLDN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300520 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57739

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 162ExtracellularSequence analysisAdd BLAST25
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 230CytoplasmicSequence analysisAdd BLAST47

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9075

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CLDN2

Open Targets

More...
OpenTargetsi
ENSG00000165376

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26567

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLDN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12229749

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447341 – 230Claudin-2Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 641 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei219PhosphoserineBy similarity1
Modified residuei223PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P57739

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P57739

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P57739

PeptideAtlas

More...
PeptideAtlasi
P57739

PRoteomics IDEntifications database

More...
PRIDEi
P57739

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57027

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P57739

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P57739

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165376 Expressed in 74 organ(s), highest expression level in kidney epithelium

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P57739 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002609
HPA051548

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114532, 9 interactors

Protein interaction database and analysis system

More...
IntActi
P57739, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000441283

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YYXX-ray1.79A/B224-230[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P57739

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P57739

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni229 – 230Interactions with TJP1, TJP2 and TJP3By similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG06 Eukaryota
ENOG410YBJ7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220937

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000643

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P57739

KEGG Orthology (KO)

More...
KOi
K06087

Identification of Orthologs from Complete Genome Data

More...
OMAi
ILCFSCP

Database of Orthologous Groups

More...
OrthoDBi
1209440at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P57739

TreeFam database of animal gene trees

More...
TreeFami
TF331936

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006187 Claudin
IPR005411 Claudin2
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin

The PANTHER Classification System

More...
PANTHERi
PTHR12002 PTHR12002, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00822 PMP22_Claudin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01589 CLAUDIN2

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01346 CLAUDIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P57739-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLGLQLVG YILGLLGLLG TLVAMLLPSW KTSSYVGASI VTAVGFSKGL
60 70 80 90 100
WMECATHSTG ITQCDIYSTL LGLPADIQAA QAMMVTSSAI SSLACIISVV
110 120 130 140 150
GMRCTVFCQE SRAKDRVAVA GGVFFILGGL LGFIPVAWNL HGILRDFYSP
160 170 180 190 200
LVPDSMKFEI GEALYLGIIS SLFSLIAGII LCFSCSSQRN RSNYYDAYQA
210 220 230
QPLATRSSPR PGQPPKVKSE FNSYSLTGYV
Length:230
Mass (Da):24,549
Last modified:January 11, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52CA642D4A62B70D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF250558 mRNA Translation: AAF98151.1
AY358474 mRNA Translation: AAQ88838.1
AK312515 mRNA Translation: BAG35416.1
AF177340 mRNA Translation: AAG17984.1
AK075371 mRNA Translation: BAC11575.1
AK075405 mRNA Translation: BAG52130.1
AL158821 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02730.1
CH471120 Genomic DNA Translation: EAX02731.1
BC014424 mRNA Translation: AAH14424.1
BC071747 mRNA Translation: AAH71747.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14524.1

NCBI Reference Sequences

More...
RefSeqi
NP_001164563.1, NM_001171092.1
NP_001164566.1, NM_001171095.1
NP_065117.1, NM_020384.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.522746

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336803; ENSP00000336571; ENSG00000165376
ENST00000540876; ENSP00000443230; ENSG00000165376
ENST00000541806; ENSP00000441283; ENSG00000165376

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9075

UCSC genome browser

More...
UCSCi
uc004emq.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250558 mRNA Translation: AAF98151.1
AY358474 mRNA Translation: AAQ88838.1
AK312515 mRNA Translation: BAG35416.1
AF177340 mRNA Translation: AAG17984.1
AK075371 mRNA Translation: BAC11575.1
AK075405 mRNA Translation: BAG52130.1
AL158821 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02730.1
CH471120 Genomic DNA Translation: EAX02731.1
BC014424 mRNA Translation: AAH14424.1
BC071747 mRNA Translation: AAH71747.1
CCDSiCCDS14524.1
RefSeqiNP_001164563.1, NM_001171092.1
NP_001164566.1, NM_001171095.1
NP_065117.1, NM_020384.3
UniGeneiHs.522746

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YYXX-ray1.79A/B224-230[»]
ProteinModelPortaliP57739
SMRiP57739
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114532, 9 interactors
IntActiP57739, 21 interactors
STRINGi9606.ENSP00000441283

PTM databases

iPTMnetiP57739
PhosphoSitePlusiP57739

Polymorphism and mutation databases

BioMutaiCLDN2
DMDMi12229749

Proteomic databases

jPOSTiP57739
MaxQBiP57739
PaxDbiP57739
PeptideAtlasiP57739
PRIDEiP57739
ProteomicsDBi57027

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9075
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336803; ENSP00000336571; ENSG00000165376
ENST00000540876; ENSP00000443230; ENSG00000165376
ENST00000541806; ENSP00000441283; ENSG00000165376
GeneIDi9075
KEGGihsa:9075
UCSCiuc004emq.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9075
DisGeNETi9075
EuPathDBiHostDB:ENSG00000165376.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLDN2
GeneReviewsiCLDN2
HGNCiHGNC:2041 CLDN2
HPAiCAB002609
HPA051548
MIMi300520 gene
neXtProtiNX_P57739
OpenTargetsiENSG00000165376
PharmGKBiPA26567

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG06 Eukaryota
ENOG410YBJ7 LUCA
GeneTreeiENSGT00940000160785
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiP57739
KOiK06087
OMAiILCFSCP
OrthoDBi1209440at2759
PhylomeDBiP57739
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions
SIGNORiP57739

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLDN2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CLDN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9075

Protein Ontology

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PROi
PR:P57739

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165376 Expressed in 74 organ(s), highest expression level in kidney epithelium
GenevisibleiP57739 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR005411 Claudin2
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01589 CLAUDIN2
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57739
Secondary accession number(s): B2R6B9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: April 10, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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