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UniProtKB - P57739 (CLD2_HUMAN)
Protein
Claudin-2
Gene
CLDN2
Organism
Homo sapiens (Human)
Status
Functioni
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
By similarityGO - Molecular functioni
- identical protein binding Source: UniProtKB
- structural molecule activity Source: InterPro
GO - Biological processi
- bicellular tight junction assembly Source: GO_Central
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
- cell adhesion Source: GO_Central
- cell-cell adhesion Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P57739 |
Reactomei | R-HSA-420029, Tight junction interactions |
SignaLinki | P57739 |
SIGNORi | P57739 |
Names & Taxonomyi
Protein namesi | Recommended name: Claudin-2Alternative name(s): SP82 |
Gene namesi | Name:CLDN2 ORF Names:PSEC0059, SP82, UNQ705/PRO1356 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2041, CLDN2 |
MIMi | 300520, gene |
neXtProti | NX_P57739 |
VEuPathDBi | HostDB:ENSG00000165376 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- tight junction By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- bicellular tight junction Source: UniProtKB
- cell-cell junction Source: ARUK-UCL
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 29 – 81 | ExtracellularSequence analysisAdd BLAST | 53 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 116 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 162 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 163 – 183 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 230 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPathology & Biotechi
Involvement in diseasei
Azoospermia, obstructive, with nephrolithiasis (OAZON)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionAn X-linked recessive, male infertility disorder characterized by epidydimal obstruction, hypercalciuria and kidney stones.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_085653 | 161 | G → R in OAZON; unknown pathological significance. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 9075 |
GeneReviewsi | CLDN2 |
MalaCardsi | CLDN2 |
MIMi | 301060, phenotype |
OpenTargetsi | ENSG00000165376 |
PharmGKBi | PA26567 |
Miscellaneous databases
Pharosi | P57739, Tbio |
Genetic variation databases
BioMutai | CLDN2 |
DMDMi | 12229749 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144734 | 1 – 230 | Claudin-2Add BLAST | 230 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 64 | 1 Publication | ||
Cross-linki | 218 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Modified residuei | 219 | PhosphoserineBy similarity | 1 | |
Modified residuei | 223 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.
Keywords - PTMi
Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P57739 |
MassIVEi | P57739 |
MaxQBi | P57739 |
PaxDbi | P57739 |
PeptideAtlasi | P57739 |
PRIDEi | P57739 |
ProteomicsDBi | 57027 |
PTM databases
iPTMneti | P57739 |
PhosphoSitePlusi | P57739 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165376, Expressed in kidney epithelium and 93 other tissues |
Genevisiblei | P57739, HS |
Organism-specific databases
HPAi | ENSG00000165376, Tissue enhanced (choroid plexus, gallbladder, kidney, seminal vesicle) |
Interactioni
Subunit structurei
Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
By similarityBinary interactionsi
P57739
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114532, 28 interactors |
IntActi | P57739, 22 interactors |
STRINGi | 9606.ENSP00000441283 |
Miscellaneous databases
RNActi | P57739, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P57739 |
SMRi | P57739 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 205 – 230 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 229 – 230 | Interactions with TJP1, TJP2 and TJP3By similarity | 2 |
Sequence similaritiesi
Belongs to the claudin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R10A, Eukaryota |
GeneTreei | ENSGT00940000160785 |
HOGENOMi | CLU_076370_1_2_1 |
InParanoidi | P57739 |
OMAi | VWNIHVV |
OrthoDBi | 1209440at2759 |
PhylomeDBi | P57739 |
TreeFami | TF331936 |
Family and domain databases
InterProi | View protein in InterPro IPR006187, Claudin IPR005411, Claudin2 IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR12002, PTHR12002, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01589, CLAUDIN2 |
PROSITEi | View protein in PROSITE PS01346, CLAUDIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P57739-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLGLQLVG YILGLLGLLG TLVAMLLPSW KTSSYVGASI VTAVGFSKGL
60 70 80 90 100
WMECATHSTG ITQCDIYSTL LGLPADIQAA QAMMVTSSAI SSLACIISVV
110 120 130 140 150
GMRCTVFCQE SRAKDRVAVA GGVFFILGGL LGFIPVAWNL HGILRDFYSP
160 170 180 190 200
LVPDSMKFEI GEALYLGIIS SLFSLIAGII LCFSCSSQRN RSNYYDAYQA
210 220 230
QPLATRSSPR PGQPPKVKSE FNSYSLTGYV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_085653 | 161 | G → R in OAZON; unknown pathological significance. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250558 mRNA Translation: AAF98151.1 AY358474 mRNA Translation: AAQ88838.1 AK312515 mRNA Translation: BAG35416.1 AF177340 mRNA Translation: AAG17984.1 AK075371 mRNA Translation: BAC11575.1 AK075405 mRNA Translation: BAG52130.1 AL158821 Genomic DNA No translation available. CH471120 Genomic DNA Translation: EAX02730.1 CH471120 Genomic DNA Translation: EAX02731.1 BC014424 mRNA Translation: AAH14424.1 BC071747 mRNA Translation: AAH71747.1 |
CCDSi | CCDS14524.1 |
RefSeqi | NP_001164563.1, NM_001171092.1 NP_001164566.1, NM_001171095.1 NP_065117.1, NM_020384.3 |
Genome annotation databases
Ensembli | ENST00000336803.2; ENSP00000336571.1; ENSG00000165376.12 ENST00000540876.1; ENSP00000443230.1; ENSG00000165376.12 ENST00000541806.6; ENSP00000441283.1; ENSG00000165376.12 |
GeneIDi | 9075 |
KEGGi | hsa:9075 |
MANE-Selecti | ENST00000336803.2; ENSP00000336571.1; NM_020384.4; NP_065117.1 |
UCSCi | uc004emq.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250558 mRNA Translation: AAF98151.1 AY358474 mRNA Translation: AAQ88838.1 AK312515 mRNA Translation: BAG35416.1 AF177340 mRNA Translation: AAG17984.1 AK075371 mRNA Translation: BAC11575.1 AK075405 mRNA Translation: BAG52130.1 AL158821 Genomic DNA No translation available. CH471120 Genomic DNA Translation: EAX02730.1 CH471120 Genomic DNA Translation: EAX02731.1 BC014424 mRNA Translation: AAH14424.1 BC071747 mRNA Translation: AAH71747.1 |
CCDSi | CCDS14524.1 |
RefSeqi | NP_001164563.1, NM_001171092.1 NP_001164566.1, NM_001171095.1 NP_065117.1, NM_020384.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4YYX | X-ray | 1.79 | A/B | 224-230 | [»] | |
AlphaFoldDBi | P57739 | |||||
SMRi | P57739 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114532, 28 interactors |
IntActi | P57739, 22 interactors |
STRINGi | 9606.ENSP00000441283 |
PTM databases
iPTMneti | P57739 |
PhosphoSitePlusi | P57739 |
Genetic variation databases
BioMutai | CLDN2 |
DMDMi | 12229749 |
Proteomic databases
jPOSTi | P57739 |
MassIVEi | P57739 |
MaxQBi | P57739 |
PaxDbi | P57739 |
PeptideAtlasi | P57739 |
PRIDEi | P57739 |
ProteomicsDBi | 57027 |
Protocols and materials databases
Antibodypediai | 3617, 585 antibodies from 33 providers |
DNASUi | 9075 |
Genome annotation databases
Ensembli | ENST00000336803.2; ENSP00000336571.1; ENSG00000165376.12 ENST00000540876.1; ENSP00000443230.1; ENSG00000165376.12 ENST00000541806.6; ENSP00000441283.1; ENSG00000165376.12 |
GeneIDi | 9075 |
KEGGi | hsa:9075 |
MANE-Selecti | ENST00000336803.2; ENSP00000336571.1; NM_020384.4; NP_065117.1 |
UCSCi | uc004emq.2, human |
Organism-specific databases
CTDi | 9075 |
DisGeNETi | 9075 |
GeneCardsi | CLDN2 |
GeneReviewsi | CLDN2 |
HGNCi | HGNC:2041, CLDN2 |
HPAi | ENSG00000165376, Tissue enhanced (choroid plexus, gallbladder, kidney, seminal vesicle) |
MalaCardsi | CLDN2 |
MIMi | 300520, gene 301060, phenotype |
neXtProti | NX_P57739 |
OpenTargetsi | ENSG00000165376 |
PharmGKBi | PA26567 |
VEuPathDBi | HostDB:ENSG00000165376 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R10A, Eukaryota |
GeneTreei | ENSGT00940000160785 |
HOGENOMi | CLU_076370_1_2_1 |
InParanoidi | P57739 |
OMAi | VWNIHVV |
OrthoDBi | 1209440at2759 |
PhylomeDBi | P57739 |
TreeFami | TF331936 |
Enzyme and pathway databases
PathwayCommonsi | P57739 |
Reactomei | R-HSA-420029, Tight junction interactions |
SignaLinki | P57739 |
SIGNORi | P57739 |
Miscellaneous databases
BioGRID-ORCSi | 9075, 13 hits in 686 CRISPR screens |
ChiTaRSi | CLDN2, human |
GeneWikii | CLDN2 |
GenomeRNAii | 9075 |
Pharosi | P57739, Tbio |
PROi | PR:P57739 |
RNActi | P57739, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165376, Expressed in kidney epithelium and 93 other tissues |
Genevisiblei | P57739, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006187, Claudin IPR005411, Claudin2 IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin |
PANTHERi | PTHR12002, PTHR12002, 1 hit |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PRINTSi | PR01589, CLAUDIN2 |
PROSITEi | View protein in PROSITE PS01346, CLAUDIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CLD2_HUMAN | |
Accessioni | P57739Primary (citable) accession number: P57739 Secondary accession number(s): B2R6B9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 11, 2001 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families