Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-cell leukemia translocation-altered gene protein

Gene

TCTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for cellular fusion during osteoclastogenesis.1 Publication

GO - Biological processi

  • negative regulation of osteoclast differentiation Source: UniProtKB
  • osteoclast fusion Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia translocation-altered gene protein
Alternative name(s):
T-cell leukemia translocation-associated gene protein
Gene namesi
Name:TCTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000145022.4
HGNCiHGNC:11692 TCTA
MIMi600690 gene
neXtProtiNX_P57738

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 8ExtracellularSequence analysis7
Transmembranei9 – 26HelicalSequence analysisAdd BLAST18
Topological domaini27 – 40CytoplasmicSequence analysisAdd BLAST14
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 103ExtracellularSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(1;3)(p34;p21).

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi6988
OpenTargetsiENSG00000145022
PharmGKBiPA36412

Polymorphism and mutation databases

BioMutaiTCTA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000724702 – 103T-cell leukemia translocation-altered gene proteinAdd BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiP57738
PaxDbiP57738
PeptideAtlasiP57738
PRIDEiP57738
ProteomicsDBi57026
TopDownProteomicsiP57738

PTM databases

iPTMnetiP57738
PhosphoSitePlusiP57738

Expressioni

Tissue specificityi

Ubiquitous. Highest level of expression in kidney. Present in monocytes, osteoclasts, macrophages, synoviocytes and synovial lining cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000145022 Expressed in 217 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TCTA
GenevisibleiP57738 HS

Organism-specific databases

HPAiHPA007342

Interactioni

Protein-protein interaction databases

BioGridi112848, 2 interactors
IntActiP57738, 5 interactors
MINTiP57738
STRINGi9606.ENSP00000273590

Structurei

3D structure databases

ProteinModelPortaliP57738
SMRiP57738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCTA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3NY Eukaryota
ENOG41127ZJ LUCA
GeneTreeiENSGT00390000004490
HOGENOMiHOG000154534
HOVERGENiHBG017901
InParanoidiP57738
OMAiAWGFYGS
OrthoDBiEOG091G0X5J
PhylomeDBiP57738
TreeFamiTF330748

Family and domain databases

InterProiView protein in InterPro
IPR016560 TCTA
PANTHERiPTHR32267 PTHR32267, 1 hit
PfamiView protein in Pfam
PF15128 T_cell_tran_alt, 1 hit
PIRSFiPIRSF009935 TCTA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57738-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESWSGQAL QALPATVLGA LGSEFLREWE AQDMRVTLFK LLLLWLVLSL
60 70 80 90 100
LGIQLAWGFY GNTVTGLYHR PGLGGQNGST PDGSTHFPSW EMAANEPLKT

HRE
Length:103
Mass (Da):11,341
Last modified:January 11, 2001 - v1
Checksum:i62FA7ECC2241D85E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103E → D in CAG33692 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41143 mRNA Translation: AAA97514.1
AK311839 mRNA Translation: BAG34781.1
CR457411 mRNA Translation: CAG33692.1
AC104452 Genomic DNA No translation available.
BC005157 mRNA Translation: AAH05157.2
CCDSiCCDS2796.1
PIRiI52722
RefSeqiNP_071503.1, NM_022171.2
UniGeneiHs.517962

Genome annotation databases

EnsembliENST00000273590; ENSP00000273590; ENSG00000145022
GeneIDi6988
KEGGihsa:6988
UCSCiuc003cwv.5 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41143 mRNA Translation: AAA97514.1
AK311839 mRNA Translation: BAG34781.1
CR457411 mRNA Translation: CAG33692.1
AC104452 Genomic DNA No translation available.
BC005157 mRNA Translation: AAH05157.2
CCDSiCCDS2796.1
PIRiI52722
RefSeqiNP_071503.1, NM_022171.2
UniGeneiHs.517962

3D structure databases

ProteinModelPortaliP57738
SMRiP57738
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112848, 2 interactors
IntActiP57738, 5 interactors
MINTiP57738
STRINGi9606.ENSP00000273590

PTM databases

iPTMnetiP57738
PhosphoSitePlusiP57738

Polymorphism and mutation databases

BioMutaiTCTA

Proteomic databases

MaxQBiP57738
PaxDbiP57738
PeptideAtlasiP57738
PRIDEiP57738
ProteomicsDBi57026
TopDownProteomicsiP57738

Protocols and materials databases

DNASUi6988
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273590; ENSP00000273590; ENSG00000145022
GeneIDi6988
KEGGihsa:6988
UCSCiuc003cwv.5 human

Organism-specific databases

CTDi6988
DisGeNETi6988
EuPathDBiHostDB:ENSG00000145022.4
GeneCardsiTCTA
HGNCiHGNC:11692 TCTA
HPAiHPA007342
MIMi600690 gene
neXtProtiNX_P57738
OpenTargetsiENSG00000145022
PharmGKBiPA36412
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3NY Eukaryota
ENOG41127ZJ LUCA
GeneTreeiENSGT00390000004490
HOGENOMiHOG000154534
HOVERGENiHBG017901
InParanoidiP57738
OMAiAWGFYGS
OrthoDBiEOG091G0X5J
PhylomeDBiP57738
TreeFamiTF330748

Miscellaneous databases

ChiTaRSiTCTA human
GenomeRNAii6988
PROiPR:P57738
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145022 Expressed in 217 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TCTA
GenevisibleiP57738 HS

Family and domain databases

InterProiView protein in InterPro
IPR016560 TCTA
PANTHERiPTHR32267 PTHR32267, 1 hit
PfamiView protein in Pfam
PF15128 T_cell_tran_alt, 1 hit
PIRSFiPIRSF009935 TCTA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCTA_HUMAN
AccessioniPrimary (citable) accession number: P57738
Secondary accession number(s): B2R4I4, Q6I9U4, Q9BSB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again