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Entry version 168 (17 Jun 2020)
Sequence version 2 (22 Sep 2009)
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Protein

Coronin-7

Gene

CORO7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.2 Publications

Caution

Reported to form a E3 ubiquitin-ligase complex and promote degradation of TOB1 (PubMed:21130766). Additional evidence is however required to confirm these data.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processProtein transport, Transport

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P57737

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coronin-7
Short name:
Crn7
Alternative name(s):
70 kDa WD repeat tumor rejection antigen homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CORO7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000262246.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26161 CORO7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611668 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57737

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi472K → R: Impaired ability to regulate the anterograde Golgi to endosome transport. 1 Publication1
Mutagenesisi680K → R: Does not affect ability to regulate the anterograde Golgi to endosome transport. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79585

Open Targets

More...
OpenTargetsi
ENSG00000262246

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134910806

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P57737 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CORO7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016200

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000509341 – 925Coronin-7Add BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei462PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki680Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei915PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The membrane-associated form is phosphorylated on tyrosine residues.By similarity
Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P57737

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P57737

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P57737

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P57737

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P57737

PeptideAtlas

More...
PeptideAtlasi
P57737

PRoteomics IDEntifications database

More...
PRIDEi
P57737

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
47379
57024 [P57737-1]
57025 [P57737-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P57737

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P57737

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P57737

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000262246 Expressed in blood and 164 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P57737 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P57737 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000262246 Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes.

Interacts (when ubiquitinated at Lys-472) with EPS15.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122728, 35 interactors

Protein interaction database and analysis system

More...
IntActi
P57737, 18 interactors

Molecular INTeraction database

More...
MINTi
P57737

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000460885

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P57737 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P57737

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati75 – 115WD 1Add BLAST41
Repeati124 – 163WD 2Add BLAST40
Repeati166 – 205WD 3Add BLAST40
Repeati209 – 253WD 4Add BLAST45
Repeati542 – 582WD 5Add BLAST41
Repeati592 – 632WD 6Add BLAST41
Repeati635 – 674WD 7Add BLAST40
Repeati728 – 768WD 8Add BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1445 Eukaryota
KOG3442 Eukaryota
ENOG410XPE7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156606

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006604_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P57737

KEGG Orthology (KO)

More...
KOi
K18619

Identification of Orthologs from Complete Genome Data

More...
OMAi
VMQGEVN

Database of Orthologous Groups

More...
OrthoDBi
552726at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P57737

TreeFam database of animal gene trees

More...
TreeFami
TF314280

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027331 CORO7
IPR015505 Coronin
IPR015048 DUF1899
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10856 PTHR10856, 1 hit
PTHR10856:SF20 PTHR10856:SF20, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08953 DUF1899, 2 hits
PF00400 WD40, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01166 DUF1899, 2 hits
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P57737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRFRVSKFR HTEARPPRRE SWISDIRAGT APSCRNHIKS SCSLIAFNSD
60 70 80 90 100
RPGVLGIVPL QGQGEDKRRV AHLGCHSDLV TDLDFSPFDD FLLATGSADR
110 120 130 140 150
TVKLWRLPGP GQALPSAPGV VLGPEDLPVE VLQFHPTSDG ILVSAAGTTV
160 170 180 190 200
KVWDAAKQQP LTELAAHGDL VQSAVWSRDG ALVGTACKDK QLRIFDPRTK
210 220 230 240 250
PRASQSTQAH ENSRDSRLAW MGTWEHLVST GFNQMREREV KLWDTRFFSS
260 270 280 290 300
ALASLTLDTS LGCLVPLLDP DSGLLVLAGK GERQLYCYEV VPQQPALSPV
310 320 330 340 350
TQCVLESVLR GAALVPRQAL AVMSCEVLRV LQLSDTAIVP IGYHVPRKAV
360 370 380 390 400
EFHEDLFPDT AGCVPATDPH SWWAGDNQQV QKVSLNPACR PHPSFTSCLV
410 420 430 440 450
PPAEPLPDTA QPAVMETPVG DADASEGFSS PPSSLTSPST PSSLGPSLSS
460 470 480 490 500
TSGIGTSPSL RSLQSLLGPS SKFRHAQGTV LHRDSHITNL KGLNLTTPGE
510 520 530 540 550
SDGFCANKLR VAVPLLSSGG QVAVLELRKP GRLPDTALPT LQNGAAVTDL
560 570 580 590 600
AWDPFDPHRL AVAGEDARIR LWRVPAEGLE EVLTTPETVL TGHTEKICSL
610 620 630 640 650
RFHPLAANVL ASSSYDLTVR IWDLQAGADR LKLQGHQDQI FSLAWSPDGQ
660 670 680 690 700
QLATVCKDGR VRVYRPRSGP EPLQEGPGPK GGRGARIVWV CDGRCLLVSG
710 720 730 740 750
FDSQSERQLL LYEAEALAGG PLAVLGLDVA PSTLLPSYDP DTGLVLLTGK
760 770 780 790 800
GDTRVFLYEL LPESPFFLEC NSFTSPDPHK GLVLLPKTEC DVREVELMRC
810 820 830 840 850
LRLRQSSLEP VAFRLPRVRK EFFQDDVFPD TAVIWEPVLS AEAWLQGANG
860 870 880 890 900
QPWLLSLQPP DMSPVSQAPR EAPARRAPSS AQYLEEKSDQ QKKEELLNAM
910 920
VAKLGNREDP LPQDSFEGVD EDEWD
Length:925
Mass (Da):100,605
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC8680F8CCB409C0
GO
Isoform 2 (identifier: P57737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-162: Missing.

Show »
Length:840
Mass (Da):91,655
Checksum:i0C11C60E67B6724C
GO
Isoform 3 (identifier: P57737-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     925-925: D → AKYLAQIIVM...DREKGQMPHT

Show »
Length:1,048
Mass (Da):114,166
Checksum:iD5E7A7A7418F3DDC
GO
Isoform 4 (identifier: P57737-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-95: Missing.

Show »
Length:907
Mass (Da):98,579
Checksum:i7C3C5C07E5FA2C8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L426I3L426_HUMAN
Coronin
CORO7
206Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2Y6I3L2Y6_HUMAN
Coronin
CORO7
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1M1I3L1M1_HUMAN
Coronin
CORO7
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI06I3NI06_HUMAN
Coronin
CORO7
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1G9I3L1G9_HUMAN
Coronin
CORO7
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EP81E7EP81_HUMAN
Coronin-7
CORO7
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L212I3L212_HUMAN
Coronin-7
CORO7
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0X8I3L0X8_HUMAN
Coronin-7
CORO7
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0Z7I3L0Z7_HUMAN
Coronin-7
CORO7
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L442I3L442_HUMAN
Coronin-7
CORO7
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324S → G in BAB15211 (PubMed:14702039).Curated1
Sequence conflicti371S → G in BAB15211 (PubMed:14702039).Curated1
Sequence conflicti848A → T in BAB15211 (PubMed:14702039).Curated1
Isoform 3 (identifier: P57737-3)
Sequence conflicti1037Q → K in BC032732 (PubMed:15616553).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057585174A → V. Corresponds to variant dbSNP:rs17137007Ensembl.1
Natural variantiVAR_057586193R → Q1 PublicationCorresponds to variant dbSNP:rs3747579Ensembl.1
Natural variantiVAR_057587257L → S. Corresponds to variant dbSNP:rs35357594Ensembl.1
Natural variantiVAR_057588403A → T. Corresponds to variant dbSNP:rs9928967Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03815278 – 162Missing in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_04675278 – 95Missing in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_046022925D → AKYLAQIIVMGVQVVGRAFA RALRQEFAASRAAADARGRA GHRSAAASNLSGLSLQEAQQ ILNVSKLSPEEVQKNYEHLF KVNDKSVGGSFYLQSKVVRA KERLDEELKIQAQEDREKGQ MPHT in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK025674 mRNA Translation: BAB15211.1
AK294045 mRNA Translation: BAG57397.1
AK296807 mRNA Translation: BAG59380.1
AC012676 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85307.1
BC032732 mRNA No translation available.
BC117289 mRNA Translation: AAI17290.1
BC117291 mRNA Translation: AAI17292.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10513.1 [P57737-1]
CCDS55982.1 [P57737-2]
CCDS58417.1 [P57737-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001188401.1, NM_001201472.1 [P57737-4]
NP_001188402.1, NM_001201473.1 [P57737-2]
NP_078811.3, NM_024535.4 [P57737-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251166; ENSP00000251166; ENSG00000262246 [P57737-1]
ENST00000537233; ENSP00000440460; ENSG00000262246 [P57737-4]
ENST00000574025; ENSP00000461702; ENSG00000262246 [P57737-2]
ENST00000614702; ENSP00000482646; ENSG00000282725 [P57737-1]
ENST00000617235; ENSP00000483187; ENSG00000282725 [P57737-4]
ENST00000631534; ENSP00000488867; ENSG00000282725 [P57737-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79585

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79585

UCSC genome browser

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UCSCi
uc002cwh.5 human [P57737-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025674 mRNA Translation: BAB15211.1
AK294045 mRNA Translation: BAG57397.1
AK296807 mRNA Translation: BAG59380.1
AC012676 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85307.1
BC032732 mRNA No translation available.
BC117289 mRNA Translation: AAI17290.1
BC117291 mRNA Translation: AAI17292.1
CCDSiCCDS10513.1 [P57737-1]
CCDS55982.1 [P57737-2]
CCDS58417.1 [P57737-4]
RefSeqiNP_001188401.1, NM_001201472.1 [P57737-4]
NP_001188402.1, NM_001201473.1 [P57737-2]
NP_078811.3, NM_024535.4 [P57737-1]

3D structure databases

SMRiP57737
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122728, 35 interactors
IntActiP57737, 18 interactors
MINTiP57737
STRINGi9606.ENSP00000460885

PTM databases

iPTMnetiP57737
MetOSiteiP57737
PhosphoSitePlusiP57737

Polymorphism and mutation databases

BioMutaiCORO7
DMDMi259016200

Proteomic databases

EPDiP57737
jPOSTiP57737
MassIVEiP57737
MaxQBiP57737
PaxDbiP57737
PeptideAtlasiP57737
PRIDEiP57737
ProteomicsDBi47379
57024 [P57737-1]
57025 [P57737-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
61575 130 antibodies

The DNASU plasmid repository

More...
DNASUi
79585

Genome annotation databases

EnsembliENST00000251166; ENSP00000251166; ENSG00000262246 [P57737-1]
ENST00000537233; ENSP00000440460; ENSG00000262246 [P57737-4]
ENST00000574025; ENSP00000461702; ENSG00000262246 [P57737-2]
ENST00000614702; ENSP00000482646; ENSG00000282725 [P57737-1]
ENST00000617235; ENSP00000483187; ENSG00000282725 [P57737-4]
ENST00000631534; ENSP00000488867; ENSG00000282725 [P57737-2]
GeneIDi79585
KEGGihsa:79585
UCSCiuc002cwh.5 human [P57737-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79585
DisGeNETi79585
EuPathDBiHostDB:ENSG00000262246.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CORO7
HGNCiHGNC:26161 CORO7
HPAiENSG00000262246 Tissue enhanced (bone)
MIMi611668 gene
neXtProtiNX_P57737
OpenTargetsiENSG00000262246
PharmGKBiPA134910806

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1445 Eukaryota
KOG3442 Eukaryota
ENOG410XPE7 LUCA
GeneTreeiENSGT00940000156606
HOGENOMiCLU_006604_0_0_1
InParanoidiP57737
KOiK18619
OMAiVMQGEVN
OrthoDBi552726at2759
PhylomeDBiP57737
TreeFamiTF314280

Enzyme and pathway databases

SignaLinkiP57737

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79585 2 hits in 785 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79585
PharosiP57737 Tbio

Protein Ontology

More...
PROi
PR:P57737
RNActiP57737 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000262246 Expressed in blood and 164 other tissues
ExpressionAtlasiP57737 baseline and differential
GenevisibleiP57737 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR027331 CORO7
IPR015505 Coronin
IPR015048 DUF1899
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF20 PTHR10856:SF20, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 2 hits
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM01166 DUF1899, 2 hits
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCORO7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57737
Secondary accession number(s): B4DFD6
, B4DL18, I3L416, Q17RK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: September 22, 2009
Last modified: June 17, 2020
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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