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Protein

Caspase recruitment domain-containing protein 18

Gene

CARD18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.1 Publication

GO - Molecular functioni

  • CARD domain binding Source: UniProtKB
  • caspase binding Source: UniProtKB
  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 18
Alternative name(s):
Caspase-1 inhibitor Iceberg
Gene namesi
Name:CARD18
Synonyms:ICEBERG
ORF Names:UNQ5804/PRO19611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000255501.1
HGNCiHGNC:28861 CARD18
MIMi605354 gene
neXtProtiNX_P57730

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi59082
OpenTargetsiENSG00000255501
PharmGKBiPA164717642

Polymorphism and mutation databases

BioMutaiCARD18
DMDMi12230142

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841451 – 90Caspase recruitment domain-containing protein 18Add BLAST90

Proteomic databases

PaxDbiP57730
PeptideAtlasiP57730
PRIDEiP57730
ProteomicsDBi57022

PTM databases

iPTMnetiP57730
PhosphoSitePlusiP57730

Expressioni

Tissue specificityi

Primarily expressed in the heart and placenta.1 Publication

Inductioni

Up-regulated in response to TNF and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000255501 Expressed in 57 organ(s), highest expression level in zone of skin
CleanExiHS_CARD18
ExpressionAtlasiP57730 baseline and differential
GenevisibleiP57730 HS

Organism-specific databases

HPAiHPA038582

Interactioni

Subunit structurei

Interacts with pro-CASP1. Interacts with CARD8.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CASP1P294663EBI-16203975,EBI-516667

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-41317N
IntActiP57730, 1 interactor
STRINGi9606.ENSP00000436691

Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP57730
SMRiP57730
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57730

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90CARDPROSITE-ProRule annotationAdd BLAST90

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00510000049857
HOVERGENiHBG006113
InParanoidiP57730
KOiK12806
OMAiEDMNKVR
OrthoDBiEOG091G10JS
PhylomeDBiP57730

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
PANTHERiPTHR10454 PTHR10454, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P57730-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV
60 70 80 90
MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH
Length:90
Mass (Da):10,138
Last modified:January 11, 2001 - v1
Checksum:i7E74C74263367101
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EA35G5EA35_HUMAN
Caspase recruitment domain-containi...
CARD18 ICEBERG, hCG_1645817
51Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208005 mRNA Translation: AAG23528.1
AY358231 mRNA Translation: AAQ88598.1
BC131610 mRNA Translation: AAI31611.1
CCDSiCCDS53705.1
RefSeqiNP_067546.1, NM_021571.3
UniGeneiHs.56279

Genome annotation databases

EnsembliENST00000530950; ENSP00000436691; ENSG00000255501
GeneIDi59082
KEGGihsa:59082
UCSCiuc021qpy.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208005 mRNA Translation: AAG23528.1
AY358231 mRNA Translation: AAQ88598.1
BC131610 mRNA Translation: AAI31611.1
CCDSiCCDS53705.1
RefSeqiNP_067546.1, NM_021571.3
UniGeneiHs.56279

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DGNNMR-A2-90[»]
ProteinModelPortaliP57730
SMRiP57730
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-41317N
IntActiP57730, 1 interactor
STRINGi9606.ENSP00000436691

PTM databases

iPTMnetiP57730
PhosphoSitePlusiP57730

Polymorphism and mutation databases

BioMutaiCARD18
DMDMi12230142

Proteomic databases

PaxDbiP57730
PeptideAtlasiP57730
PRIDEiP57730
ProteomicsDBi57022

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000530950; ENSP00000436691; ENSG00000255501
GeneIDi59082
KEGGihsa:59082
UCSCiuc021qpy.2 human

Organism-specific databases

CTDi59082
DisGeNETi59082
EuPathDBiHostDB:ENSG00000255501.1
GeneCardsiCARD18
HGNCiHGNC:28861 CARD18
HPAiHPA038582
MIMi605354 gene
neXtProtiNX_P57730
OpenTargetsiENSG00000255501
PharmGKBiPA164717642
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00510000049857
HOVERGENiHBG006113
InParanoidiP57730
KOiK12806
OMAiEDMNKVR
OrthoDBiEOG091G10JS
PhylomeDBiP57730

Miscellaneous databases

EvolutionaryTraceiP57730
GenomeRNAii59082
PROiPR:P57730
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000255501 Expressed in 57 organ(s), highest expression level in zone of skin
CleanExiHS_CARD18
ExpressionAtlasiP57730 baseline and differential
GenevisibleiP57730 HS

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
PANTHERiPTHR10454 PTHR10454, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAR18_HUMAN
AccessioniPrimary (citable) accession number: P57730
Secondary accession number(s): A2RRF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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