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Protein

Poly(rC)-binding protein 4

Gene

Pcbp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Ribonucleoprotein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(rC)-binding protein 4
Alternative name(s):
Alpha-CP4
Gene namesi
Name:Pcbp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1890471 Pcbp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000500951 – 403Poly(rC)-binding protein 4Add BLAST403

Proteomic databases

MaxQBiP57724
PaxDbiP57724
PeptideAtlasiP57724
PRIDEiP57724

PTM databases

iPTMnetiP57724
PhosphoSitePlusiP57724

Expressioni

Tissue specificityi

Widely expressed, with highest levels in testis and lowest in heart.1 Publication

Gene expression databases

CleanExiMM_PCBP4

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024260

Structurei

3D structure databases

ProteinModelPortaliP57724
SMRiP57724
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 67KH 1PROSITE-ProRule annotationAdd BLAST51
Domaini101 – 154KH 2PROSITE-ProRule annotationAdd BLAST54
Domaini241 – 293KH 3PROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2190 Eukaryota
ENOG410XNN8 LUCA
HOGENOMiHOG000182823
HOVERGENiHBG053520
InParanoidiP57724
KOiK21444
PhylomeDBiP57724
TreeFamiTF318292

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR033088 PCBP4
PANTHERiPTHR10288:SF166 PTHR10288:SF166, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

P57724-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSDAGLEE GPELSITLTL RMLMHGKEVG SIIGKKGETV KRIREQSSAR
60 70 80 90 100
ITISEGSCPE RITTITGSTA AVFHAVSMIA FKLDEDLCAA PANGGSVSRP
110 120 130 140 150
PVTLRLVIPA SQCGSLIGKA GTKIKEIRET TGAQVQVAGD LLPNSTERAV
160 170 180 190 200
TVSGVPDAII LCVRQICAVI LESPPKGATI PYHPSLSLGT VLLSANQGFS
210 220 230 240 250
VQGQYGAVTP AEVTKLQQLS GHAVPFASPS VVPGMDPSTQ TSSQEFLVPN
260 270 280 290 300
DLIGCVIGRQ GSKISEIRQM SGAHIKIGNQ AEGAGERHVT ITGSPVSIAL
310 320 330 340 350
AQYLITACLE TAKSTSGGTP GSAPADLPTP FSPPLTALPT APPGLLGTPY
360 370 380 390 400
AISLSNFIGL KPVPFLALPP ASPGPPPGLA AYTAKMAAAN GSKKAERQKF

SPY
Length:403
Mass (Da):41,399
Last modified:January 11, 2001 - v1
Checksum:iD4DBFF490CEFE90A
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J044A0A0R4J044_MOUSE
Poly(rC)-binding protein 4
Pcbp4
403Annotation score:
A0A087WSI1A0A087WSI1_MOUSE
Poly(rC)-binding protein 4
Pcbp4
119Annotation score:
A0A087WRH3A0A087WRH3_MOUSE
Poly(rC)-binding protein 4
Pcbp4
197Annotation score:
A0A087WR61A0A087WR61_MOUSE
Poly(rC)-binding protein 4
Pcbp4
113Annotation score:
A0A087WP16A0A087WP16_MOUSE
Poly(rC)-binding protein 4
Pcbp4
168Annotation score:
A0A087WPG7A0A087WPG7_MOUSE
Poly(rC)-binding protein 4
Pcbp4
215Annotation score:
A0A087WRJ6A0A087WRJ6_MOUSE
Poly(rC)-binding protein 4
Pcbp4
150Annotation score:
A0A1L1SUS5A0A1L1SUS5_MOUSE
Poly(rC)-binding protein 4
Pcbp4
149Annotation score:
A0A087WQ06A0A087WQ06_MOUSE
Poly(rC)-binding protein 4
Pcbp4
77Annotation score:
A0A1L1SQL8A0A1L1SQL8_MOUSE
Poly(rC)-binding protein 4
Pcbp4
222Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235M → L in AAH10694 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176328 mRNA Translation: AAG09239.1
BC010694 mRNA Translation: AAH10694.1
CCDSiCCDS23479.1
RefSeqiNP_067542.3, NM_021567.5
XP_006511842.1, XM_006511779.3
XP_006511843.1, XM_006511780.1
UniGeneiMm.286394

Genome annotation databases

GeneIDi59092
KEGGimmu:59092
UCSCiuc009rjt.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176328 mRNA Translation: AAG09239.1
BC010694 mRNA Translation: AAH10694.1
CCDSiCCDS23479.1
RefSeqiNP_067542.3, NM_021567.5
XP_006511842.1, XM_006511779.3
XP_006511843.1, XM_006511780.1
UniGeneiMm.286394

3D structure databases

ProteinModelPortaliP57724
SMRiP57724
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024260

PTM databases

iPTMnetiP57724
PhosphoSitePlusiP57724

Proteomic databases

MaxQBiP57724
PaxDbiP57724
PeptideAtlasiP57724
PRIDEiP57724

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi59092
KEGGimmu:59092
UCSCiuc009rjt.3 mouse

Organism-specific databases

CTDi57060
MGIiMGI:1890471 Pcbp4

Phylogenomic databases

eggNOGiKOG2190 Eukaryota
ENOG410XNN8 LUCA
HOGENOMiHOG000182823
HOVERGENiHBG053520
InParanoidiP57724
KOiK21444
PhylomeDBiP57724
TreeFamiTF318292

Miscellaneous databases

PROiPR:P57724
SOURCEiSearch...

Gene expression databases

CleanExiMM_PCBP4

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR033088 PCBP4
PANTHERiPTHR10288:SF166 PTHR10288:SF166, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCBP4_MOUSE
AccessioniPrimary (citable) accession number: P57724
Secondary accession number(s): Q91VR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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