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Protein

Poly(rC)-binding protein 3

Gene

Pcbp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.By similarity

GO - Molecular functioni

  • C-rich single-stranded DNA binding Source: MGI
  • double-stranded DNA binding Source: MGI
  • RNA binding Source: UniProtKB-KW
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-binding, Ribonucleoprotein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(rC)-binding protein 3
Alternative name(s):
Alpha-CP3
Gene namesi
Name:Pcbp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1890470 Pcbp3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000500931 – 371Poly(rC)-binding protein 3Add BLAST371

Proteomic databases

MaxQBiP57722
PaxDbiP57722
PeptideAtlasiP57722
PRIDEiP57722

PTM databases

iPTMnetiP57722
PhosphoSitePlusiP57722

Expressioni

Tissue specificityi

Widely expressed, with highest levels in testis and fat tissues and lowest in heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000001120
CleanExiMM_PCBP3
ExpressionAtlasiP57722 baseline and differential
GenevisibleiP57722 MM

Interactioni

Protein-protein interaction databases

BioGridi208528, 1 interactor
IntActiP57722, 1 interactor
MINTiP57722
STRINGi10090.ENSMUSP00000001148

Structurei

3D structure databases

ProteinModelPortaliP57722
SMRiP57722
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 95KH 1PROSITE-ProRule annotationAdd BLAST51
Domaini129 – 182KH 2PROSITE-ProRule annotationAdd BLAST54
Domaini293 – 357KH 3PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2190 Eukaryota
ENOG410XNN8 LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000182823
HOVERGENiHBG053520
InParanoidiP57722
KOiK21444
OMAiIQMAVQL
OrthoDBiEOG091G0DHI
PhylomeDBiP57722
TreeFamiTF318292

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57722-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEGDAIWAP PILPHSTLGT LSHHPELHFG GKMESKVSEG GLNVTLTIRL
60 70 80 90 100
LMHGKEVGSI IGKKGETVKK MREESGARIN ISEGNCPERI VTITGPTDAI
110 120 130 140 150
FKAFAMIAYK FEEDIINSMS NSPATSKPPV TLRLVVPASQ CGSLIGKGGS
160 170 180 190 200
KIKEIRESTG AQVQVAGDML PNSTERAVTI SGTPDAIIQC VKQICVVMLE
210 220 230 240 250
SPPKGATIPY RPKPASTPVI FAGGQAYTIQ GQYAIPHPDQ LTKLHQLAMQ
260 270 280 290 300
QTPFPPLGQT NPAFPGEKLP LHSSEEAQNL MGQSSGLDAS PPASTHELTI
310 320 330 340 350
PNDLIGCIIG RQGTKINEIR QMSGAQIKIA NATEGSSERQ ITITGTPANI
360 370
SLAQYLINAR LTSEVTGMGA L
Length:371
Mass (Da):39,294
Last modified:May 18, 2010 - v3
Checksum:iBDBAFEB7EA99DDD7
GO
Isoform 2 (identifier: P57722-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-240: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:370
Mass (Da):39,166
Checksum:i9E0E2900460FE7FA
GO

Sequence cautioni

The sequence AAG09238 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188I → F in AAG09238 (PubMed:10936052).Curated1
Sequence conflicti216S → C in AAG09238 (PubMed:10936052).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010015240Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176327 mRNA Translation: AAG09238.1 Different initiation.
AK034811 mRNA Translation: BAC28838.1
AK079564 mRNA Translation: BAC37686.1
CCDSiCCDS35946.2 [P57722-1]
CCDS83716.1 [P57722-2]
RefSeqiNP_001334145.1, NM_001347216.1 [P57722-2]
NP_067543.2, NM_021568.2 [P57722-1]
XP_017169527.1, XM_017314038.1 [P57722-1]
UniGeneiMm.272803

Genome annotation databases

EnsembliENSMUST00000001148; ENSMUSP00000001148; ENSMUSG00000001120 [P57722-1]
ENSMUST00000105411; ENSMUSP00000101051; ENSMUSG00000001120 [P57722-2]
ENSMUST00000168465; ENSMUSP00000129465; ENSMUSG00000001120 [P57722-1]
GeneIDi59093
KEGGimmu:59093
UCSCiuc007fuz.2 mouse [P57722-1]
uc007fva.2 mouse [P57722-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPCBP3_MOUSE
AccessioniPrimary (citable) accession number: P57722
Secondary accession number(s): Q8BSB0, Q8C544
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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