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Protein

Estrogen receptor

Gene

esr1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi152 – 217Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri152 – 172NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri188 – 212NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • estrogen receptor activity Source: ZFIN
  • RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding Source: ZFIN
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone binding Source: ZFIN
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to estrogen stimulus Source: ZFIN
  • posterior lateral line neuromast primordium migration Source: ZFIN
  • response to estradiol Source: ZFIN
  • response to estrogen Source: ZFIN
  • response to xenobiotic stimulus Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:esr1
Synonyms:esr, nr3a1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-020806-5 esr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536281 – 569Estrogen receptorAdd BLAST569

Proteomic databases

PaxDbiP57717
PRIDEiP57717

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024987

Structurei

3D structure databases

ProteinModelPortaliP57717
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini279 – 515NR LBDPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 151ModulatingBy similarityAdd BLAST151
Regioni218 – 278HingeAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi284 – 288Poly-Leu5
Compositional biasi475 – 479Poly-Leu5

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 172NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri188 – 212NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000233468
HOVERGENiHBG108344
InParanoidiP57717
KOiK08550

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P57717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPKEEHSAG GISSSVNYLD GAYEYPNPTQ TFGTSSPAEP ASVGYYPAPP
60 70 80 90 100
DPHEEHLQTL GGGSSSPLMF APSSPQLSPY LSHHGGHHTT PHQVSYYLDS
110 120 130 140 150
SSSTVYRSSV VSSQQAAVGL CEELCSATDR QELYTGSRAA GGFDSGKETR
160 170 180 190 200
FCAVCSDYAS GYHYGVWSCE GCKAFFKRSI QGHNDYVCPA TNQCTIDRNR
210 220 230 240 250
RKSCQACRLR KCYEVGMMKG GIRKDRGGRS VRRERRRSSN EDRDKSSSDQ
260 270 280 290 300
CSRAGVRTTG PQDKRKKRSG GVVSTLCMSP DQVLLLLLGA EPPAVCSRQK
310 320 330 340 350
HSRPYTEITM MSLLTNMADK ELVHMIAWAK KVPGFQDLSL HDQVQLLESS
360 370 380 390 400
WLEVLMIGLI WRSIHSPGKL IFAQDLILDR SEGECVEGMA EIFDMLLATV
410 420 430 440 450
ARFRSLKLKL EEFVCLKAII LINSGAFSFC SSPVEPLMDN FMVQCMLDNI
460 470 480 490 500
TDALIYCISK SGASLQLQSR RQAQLLLLLS HIRHMSNKGM EHLYRMKCKN
510 520 530 540 550
RVPLYDLLLE MLDAQRFQSS GKVQRVWSQS EKNPPSTPTT SSSSSNNSPR
560
GGAAAIQSNG ACHSHSPDP
Length:569
Mass (Da):62,846
Last modified:April 4, 2003 - v2
Checksum:iCFA0C1AD4376A53C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31T → A in BAB16893 (Ref. 1) Curated1
Sequence conflicti279S → P in BAB16893 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037185 mRNA Translation: BAB16893.1
AF349412 mRNA Translation: AAK16740.1
RefSeqiNP_694491.1, NM_152959.1
UniGeneiDr.79999

Genome annotation databases

GeneIDi259252
KEGGidre:259252

Similar proteinsi

Entry informationi

Entry nameiESR1_DANRE
AccessioniPrimary (citable) accession number: P57717
Secondary accession number(s): Q98SM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 4, 2003
Last modified: June 20, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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