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Protein

Potassium-transporting ATPase ATP-binding subunit

Gene

kdpB

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + K+(Out) = ADP + phosphate + K+(In).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2954-aspartylphosphate intermediateUniRule annotation1
Binding sitei332ATPUniRule annotation1
Binding sitei336ATPUniRule annotation1
Binding sitei382ATPUniRule annotation1
Metal bindingi501MagnesiumUniRule annotation1
Metal bindingi505MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi364 – 371ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDAi3.6.3.12 6324

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase ATP-binding subunitUniRule annotation (EC:3.6.3.12UniRule annotation)
Alternative name(s):
ATP phosphohydrolase [potassium-transporting] B chainUniRule annotation
Potassium-binding and translocating subunit BUniRule annotation
Potassium-translocating ATPase B chainUniRule annotation
Gene namesi
Name:kdpBUniRule annotation
Ordered Locus Names:Ta1309
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei56 – 76HelicalUniRule annotationAdd BLAST21
Transmembranei207 – 227HelicalUniRule annotationAdd BLAST21
Transmembranei244 – 264HelicalUniRule annotationAdd BLAST21
Transmembranei570 – 590HelicalUniRule annotationAdd BLAST21
Transmembranei596 – 616HelicalUniRule annotationAdd BLAST21
Transmembranei644 – 664HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461521 – 665Potassium-transporting ATPase ATP-binding subunitAdd BLAST665

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

The system is composed of three essential subunits: KdpA, KdpB and KdpC.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta1309

Structurei

3D structure databases

ProteinModelPortaliP57700
SMRiP57700
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG01577 Archaea
COG2216 LUCA
HOGENOMiHOG000244113
KOiK01547
OMAiILWLWFT
OrthoDBiPOG093Z00WB

Family and domain databases

CDDicd02078 P-type_ATPase_K, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
HAMAPiMF_00285 KdpB, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006391 P-type_ATPase_bsu_IA
IPR001757 P_typ_ATPase
PANTHERiPTHR43743 PTHR43743, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
TIGR01497 kdpB, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P57700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFMKVYEEF LLTLKNMRPD VIIHNPVMFL TEMSLFLSVF IYAFPGFFGV
60 70 80 90 100
PSSTTYLQFY LAVVILLFLT VFFSSMSTAM SEGKSKAITD SLKKFKTEVT
110 120 130 140 150
AHVIRDGNPV DVKSTDLRKG DIIVVYRDEI IPIDGEVIEG SGYVDESNVT
160 170 180 190 200
GESRAVMKVI GDTVTGSTRL VTDKIKIRAT ADPGSTFIDK MIDLVNRATR
210 220 230 240 250
EKTPNEIALT VFLSGLTLIF LIITASIFSI SHYYGRTANV MMLIVLLIAL
260 270 280 290 300
IPTTIGALLP AIGIAAINKV SEYNIIAKSG RAIENAGDID TIILDKTGTI
310 320 330 340 350
TIGERQAVRM YPNKGVDDKE FYRMCALASF YDQTKEGISI LNLARSNGIT
360 370 380 390 400
VSEEDLRGYS FIPFSSETKY SGLESDSDYI IKGSLHALKE KFHVADEFIE
410 420 430 440 450
ALCKEISMRG GTAIPVVHNG KFAGVIELQD LIKPGIKERI AEIKNMDIKT
460 470 480 490 500
VMCTGDDEVT AQYISAQVGL DEYIANSKPI DKYNVVIREK ERQRMVAMVG
510 520 530 540 550
DGTNDAPALA KADVGLAMNN GTQAAKEAAN MIDLDSNPTK LMDVIFLGKQ
560 570 580 590 600
ILITRGALTT FSIANDISKY FVIIPAIFYM FPSLSMVNVL DLTDPIVAVT
610 620 630 640 650
SALIFNTIII VFLIPLALGG VKYKPTSISD LLKRNIMIYG LGGVVVPFIA
660
IKLIYMLLVA LGVVW
Length:665
Mass (Da):73,016
Last modified:December 8, 2000 - v1
Checksum:i96C72CFA612435EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445067 Genomic DNA Translation: CAC12430.1

Genome annotation databases

EnsemblBacteriaiCAC12430; CAC12430; CAC12430
KEGGitac:Ta1309

Similar proteinsi

Entry informationi

Entry nameiKDPB_THEAC
AccessioniPrimary (citable) accession number: P57700
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: December 8, 2000
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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