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Protein

Potassium-transporting ATPase ATP-binding subunit

Gene

kdpB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + K+(Out) = ADP + phosphate + K+(In).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3174-aspartylphosphate intermediateUniRule annotation1
Binding sitei354ATPUniRule annotation1
Binding sitei358ATPUniRule annotation1
Binding sitei403ATPUniRule annotation1
Metal bindingi526MagnesiumUniRule annotation1
Metal bindingi530MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi385 – 392ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-1664-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase ATP-binding subunitUniRule annotation (EC:3.6.3.12UniRule annotation)
Alternative name(s):
ATP phosphohydrolase [potassium-transporting] B chainUniRule annotation
Potassium-binding and translocating subunit BUniRule annotation
Potassium-translocating ATPase B chainUniRule annotation
Gene namesi
Name:kdpBUniRule annotation
Ordered Locus Names:PA1634
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1634

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei229 – 249HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei596 – 616HelicalUniRule annotationAdd BLAST21
Transmembranei624 – 644HelicalUniRule annotationAdd BLAST21
Transmembranei662 – 682HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461281 – 690Potassium-transporting ATPase ATP-binding subunitAdd BLAST690

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP57698
PRIDEiP57698

Interactioni

Subunit structurei

The system is composed of three essential subunits: KdpA, KdpB and KdpC.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA1634

Structurei

3D structure databases

ProteinModelPortaliP57698
SMRiP57698
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C8X Bacteria
COG2216 LUCA
HOGENOMiHOG000244113
InParanoidiP57698
KOiK01547
OMAiLQPFAHF
PhylomeDBiP57698

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
HAMAPiMF_00285 KdpB, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006391 P-type_ATPase_bsu_IA
IPR001757 P_typ_ATPase
PANTHERiPTHR43743 PTHR43743, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 2 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
TIGR01497 kdpB, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P57698-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAQTQASKN ALHKSLERRH NASTSLAALW RPALLQAFVK LDPRQLLRSP
60 70 80 90 100
VMLVVELTAV LTTLLCFVPD QAVPTSVALQ IALWLWFTVL FANFAEALAE
110 120 130 140 150
GRGKARADSL KAGSQGLSAN KRRADGSFES VVASSLRKGD VVRVQAGEMI
160 170 180 190 200
PGDGEVIEGV AAVNEAAITG ESAPVIRESG GDRSAVTGNT QVVSDWLLVR
210 220 230 240 250
IGANPGESTL DRMIALVEGA KRQKTPNEVA LDILLIGLTL IFLLVVVTLK
260 270 280 290 300
PFALFAGGNL PLVFLVALLV TLIPTTIGGL LSAIGIAGMD RLVRLNVIAK
310 320 330 340 350
SGRAVEAAGD VHVLLLDKTG TITFGNRRCS ALYAAPGVSG KELAEGALLA
360 370 380 390 400
SLADDTPEGK SIVEYLRILH PIEEPRREEL TPIAFSAETR LSGVDWNGQV
410 420 430 440 450
YRKGAVDAAL RFIDLPREKM PEVLSREVDK IAQSGGTPLL VVANGRLLGA
460 470 480 490 500
IHLKDVVKPG IRERFAELRR LGIRTVMVTG DNPLTAAAIA AEAGVDDVIA
510 520 530 540 550
EATPEKKLAR IRQEQGEGRL VAMCGDGAND APALAQADVG MAMNDGTQAA
560 570 580 590 600
REAANLVDLD SDPTKLLDVV QVGKELLVTR GALTTFSIAN DVAKYFAILP
610 620 630 640 650
ALFVGIYPQL DVLNVMRLQS PQSAILSAIV FNALIIVALI PLALRGVRVQ
660 670 680 690
AADASQLLQR NLLIYGVGGL VAPFLGIKAI DLLLTAVGLA
Length:690
Mass (Da):72,990
Last modified:December 8, 2000 - v1
Checksum:i24F66ED6FCC28057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG05023.1
PIRiA83441
RefSeqiNP_250325.1, NC_002516.2
WP_003097844.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG05023; AAG05023; PA1634
GeneIDi883011
KEGGipae:PA1634
PATRICifig|208964.12.peg.1694

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG05023.1
PIRiA83441
RefSeqiNP_250325.1, NC_002516.2
WP_003097844.1, NC_002516.2

3D structure databases

ProteinModelPortaliP57698
SMRiP57698
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA1634

Proteomic databases

PaxDbiP57698
PRIDEiP57698

Protocols and materials databases

DNASUi883011
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG05023; AAG05023; PA1634
GeneIDi883011
KEGGipae:PA1634
PATRICifig|208964.12.peg.1694

Organism-specific databases

PseudoCAPiPA1634

Phylogenomic databases

eggNOGiENOG4105C8X Bacteria
COG2216 LUCA
HOGENOMiHOG000244113
InParanoidiP57698
KOiK01547
OMAiLQPFAHF
PhylomeDBiP57698

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-1664-MONOMER

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
HAMAPiMF_00285 KdpB, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006391 P-type_ATPase_bsu_IA
IPR001757 P_typ_ATPase
PANTHERiPTHR43743 PTHR43743, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 2 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
TIGR01497 kdpB, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKDPB_PSEAE
AccessioniPrimary (citable) accession number: P57698
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: December 8, 2000
Last modified: October 10, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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