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Entry version 98 (11 Dec 2019)
Sequence version 1 (01 Dec 2000)
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Protein

RecBCD enzyme subunit RecC

Gene

recC

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.UniRule annotation EC:3.1.11.5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Exonuclease, Helicase, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RecBCD enzyme subunit RecCUniRule annotation (EC:3.1.11.5UniRule annotation)
Alternative name(s):
Exonuclease V subunit RecCUniRule annotation
Short name:
ExoV subunit RecCUniRule annotation
Helicase/nuclease RecBCD subunit RecCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:recCUniRule annotation
Ordered Locus Names:BU453
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri107806 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001806 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000871171 – 1070RecBCD enzyme subunit RecCAdd BLAST1070

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P57528

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
107806.10039117

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RecC family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DSY Bacteria
COG1330 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085880

KEGG Orthology (KO)

More...
KOi
K03583

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCPDIET

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.160, 1 hit

HAMAP database of protein families

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HAMAPi
MF_01486 RecC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013986 DExx_box_DNA_helicase_dom_sf
IPR027417 P-loop_NTPase
IPR006697 RecC
IPR041500 RecC_C
IPR011335 Restrct_endonuc-II-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17946 RecC_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000980 RecC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF52980 SSF52980, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01450 recC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P57528-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTIYKSNSL NTLLLKAYHI IEEKPFSNIF EKEIFIYDNK VLFQYLNIFI
60 70 80 90 100
AEKKGISANF KFYHPNDFIW KLFKIILSKK ELKNIFTHSM IIWEIIKILD
110 120 130 140 150
NKKFFENCSK KKDMIKKFKF SFLMASIFKK YILYRPEWIN QWEIEKNISI
160 170 180 190 200
FDKNEQWQIK LWMEIIHNTK KINQSSDHFA NLFYNIQKII KEKKIKKKYL
210 220 230 240 250
PKRFFIISSF SMNPSYIKIF QNISIYTDIY FLYITPFKKN IFNFIQDNKI
260 270 280 290 300
FTDIKIEKKN ILNDSLITLW GQYEEIYYFY ILKSKKNKVI NCFKKNKNKS
310 320 330 340 350
LLSQIKNNFF NDSEFTRKKR FLEISDHSIS INICFNKKNE IEVLYEKLLI
360 370 380 390 400
FLNENSSIKP GDIVVTSFSL DTYISSINLI FQSIDNKKTI PFFIAKKSSK
410 420 430 440 450
TTEIMLWSFK KILNLSNSRF ENEEILELLD VPEIAEKFNF SEEEIKILYH
460 470 480 490 500
WIEETNIRWG INEKHKNYLL FPKNKQNTWF YGIEKLLLSY AMNDTEKIWN
510 520 530 540 550
GVLSCSFING SRSELIGKLI SFIKILEKWQ KKLSKLQYLT YWRSLYSDLV
560 570 580 590 600
SDFFQNNTKI EKSIQIIQKK WIEIIDDSLS SNYLKKISIN ILKKIFFYKY
610 620 630 640 650
YDNNHEIFLP GVVNFCYPDS VCYIPFKVIC MIGTDHTSIP KTNYLDNFNL
660 670 680 690 700
LKKYPLIGDI NLYQKYSYLF VQSLSCAEKY FYISYIGYSV KDESKVHPSI
710 720 730 740 750
LVDQLLNYIT LNFCFIGDQN LSYKENSKKI TKYLCKKHKK QFFYETKNIE
760 770 780 790 800
SFIQDDIKND FKHTEKNISH KNLLKKNTDN EINLKDLINF WKHPIRYFYN
810 820 830 840 850
SHLKIKIRQK KQKINTTETF LVNPLNSFKI KNKLLDYIIH NKNITKLYQH
860 870 880 890 900
YLLSGKLPYH FFGEIFWIKN IKEMKLIANK VMQYRIEKEE KKINLNIEKY
910 920 930 940 950
QIYGVLSEIQ STGLLRWKTS SIRYSDRIAL WLEHLIYSIL GGCGKSKIIG
960 970 980 990 1000
YKSQIWSFSS LNSHRAHSYL LEYIKGYIKG MKEPLFLTKS GASWLDQVYD
1010 1020 1030 1040 1050
ERNNCIKNDY YTKIKAYKKL LYTWKGDNYT EGEQEDYYLK KTITISNKKN
1060 1070
IKKICESAEK WLIPILKNKG
Length:1,070
Mass (Da):128,579
Last modified:December 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F644C84877981AF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB13151.1

NCBI Reference Sequences

More...
RefSeqi
NP_240265.1, NC_002528.1
WP_010896125.1, NC_002528.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAB13151; BAB13151; BAB13151

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1109801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
buc:BU453

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|107806.10.peg.463

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB13151.1
RefSeqiNP_240265.1, NC_002528.1
WP_010896125.1, NC_002528.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi107806.10039117

Proteomic databases

PRIDEiP57528

Genome annotation databases

EnsemblBacteriaiBAB13151; BAB13151; BAB13151
GeneIDi1109801
KEGGibuc:BU453
PATRICifig|107806.10.peg.463

Phylogenomic databases

eggNOGiENOG4105DSY Bacteria
COG1330 LUCA
HOGENOMiHOG000085880
KOiK03583
OMAiMCPDIET

Family and domain databases

Gene3Di1.10.10.160, 1 hit
HAMAPiMF_01486 RecC, 1 hit
InterProiView protein in InterPro
IPR013986 DExx_box_DNA_helicase_dom_sf
IPR027417 P-loop_NTPase
IPR006697 RecC
IPR041500 RecC_C
IPR011335 Restrct_endonuc-II-like
PfamiView protein in Pfam
PF17946 RecC_C, 1 hit
PIRSFiPIRSF000980 RecC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF52980 SSF52980, 1 hit
TIGRFAMsiTIGR01450 recC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRECC_BUCAI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57528
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: December 11, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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