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Protein

Guanylate kinase

Gene

gmk

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:BU434
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705101 – 207Guanylate kinaseAdd BLAST207

Interactioni

Protein-protein interaction databases

STRINGi107806.BU434.

Structurei

3D structure databases

ProteinModelPortaliP57509.
SMRiP57509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 184Guanylate kinase-likeAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
HOGENOMiHOG000037638.
KOiK00942.
OMAiAGNYYGT.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P57509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGILFIIS APSGTGKSSL IQGLLKSKTL YNTRVSISHT TRIIRPGELH
60 70 80 90 100
GKHYYFISKK EFEIMIKQEY FLEYAKVFSN YYGTSRKYIE KMLFSGIDVF
110 120 130 140 150
LDIDWQGAKQ IKCKMPKSKS IFLLPPSKDT LYKRLRERGQ DSDSVIANRM
160 170 180 190 200
EKAVDEMQHY SEYDYLIIND DFKQAVNDLI TIITAEHLCL FHQKNKHNLL

ISNLLKC
Length:207
Mass (Da):24,092
Last modified:December 1, 2000 - v1
Checksum:i0478657C73697655
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA. Translation: BAB13132.1.
RefSeqiNP_240246.1. NC_002528.1.
WP_009874387.1. NC_002528.1.

Genome annotation databases

EnsemblBacteriaiBAB13132; BAB13132; BAB13132.
GeneIDi1109782.
KEGGibuc:BU434.
PATRICifig|107806.10.peg.443.

Similar proteinsi

Entry informationi

Entry nameiKGUA_BUCAI
AccessioniPrimary (citable) accession number: P57509
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome