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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:BU205
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
Taxonomic identifieri107806 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001806 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622401 – 887Pyruvate dehydrogenase E1 componentAdd BLAST887

Proteomic databases

PRIDEiP57301

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi107806.BU205

Structurei

3D structure databases

ProteinModelPortaliP57301
SMRiP57301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105DAQ Bacteria
COG2609 LUCA
HOGENOMiHOG000115215
KOiK00163
OMAiREPWFPG

Family and domain databases

CDDicd02017 TPP_E1_EcPDC_like, 1 hit
Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR004660 2-oxoA_DH_E1
IPR035807 PDC_E1_N
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N
PANTHERiPTHR43825:SF3 PTHR43825:SF3, 1 hit
PfamiView protein in Pfam
PF00456 Transketolase_N, 1 hit
PIRSFiPIRSF000156 Pyruvate_dh_E1, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00759 aceE, 1 hit

Sequencei

Sequence statusi: Complete.

P57301-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSENLYNDVD PIETRDWVQA IESVIRREGH KRAHFLIEQV LKTAKINRKE
60 70 80 90 100
FFRSSFTSDY INTISREDEY EYPGNLILEK RIRSAIRWNA IMMVLRASKK
110 120 130 140 150
NLELGGHLSS FQSSATIYEV CFNHFFQAKN HKDGGDLVYF QGHISPGIYA
160 170 180 190 200
RSFLEGRLSE EQIDNFRQEV DGIGLSSYPH PKLMPNFWQF PTVSMGLGPL
210 220 230 240 250
CAIYQAKFLK YLHNRELKNT SKQIVYAFLG DGEMDEPESK GAISIAVREK
260 270 280 290 300
LDNLIFIINC NLQRLDGPVV GNGKIVNELE SFFYGAGWKV IKVIWGSRWD
310 320 330 340 350
CLLKKDTSGK LIQLMNETVD GDYQTFKSKD GAYVRKYFFG KYKETYDLVK
360 370 380 390 400
DMTDEEIWKL NRGGHDPKKM FNALKKAKET KYKPTVILAH TVKGYGMGVI
410 420 430 440 450
AEGKNIAHQI KKININGIIH IRDRFNIPVS NDEINKLPYV TFKKNSEEYC
460 470 480 490 500
YIHSQRKKLG GYIPFRLSSF TGKLILPKLI DFQSLLEEQK KDISTTVAFI
510 520 530 540 550
RVLNIILKNN SIKHLIVPII ADEARTFGME GLFRKIGIYS SSGQKYTPQD
560 570 580 590 600
REQLAYYKEE KKGQILQEGI NELGAASSWL AAATSYSTND FPMILFYIYY
610 620 630 640 650
SIFGFQRIGD LFWAAGDQQA RGFLIGGTSG RTTLNGEGLQ HEDGHSHIQS
660 670 680 690 700
LTIPNCISYD PAFAYEVAVI IQDGLRRMYG PSQENIYYYI TTINENYYMP
710 720 730 740 750
AMPIGVEEGI CKGIYKLKTL HGTTSKVQLI GSGAILRSVC EAAEILLKDY
760 770 780 790 800
SITTDIYSVT SFTELARNGE DCERWNMLHP NEKNKIAYVK QIMNKNPTVA
810 820 830 840 850
ATDYMKLFAE QIRHYIPSQE YHVLGTDGFG RSDSRDKLRD HFEVNAYYIV
860 870 880
IAALNLLANI NDIKKKVVED AIMKFNIDAN KINPRLS
Length:887
Mass (Da):101,396
Last modified:December 1, 2000 - v1
Checksum:iB6AB82C012826105
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB12922.1
RefSeqiNP_240036.1, NC_002528.1
WP_010896002.1, NC_002528.1

Genome annotation databases

EnsemblBacteriaiBAB12922; BAB12922; BAB12922
GeneIDi1109648
KEGGibuc:BU205
PATRICifig|107806.10.peg.216

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000003 Genomic DNA Translation: BAB12922.1
RefSeqiNP_240036.1, NC_002528.1
WP_010896002.1, NC_002528.1

3D structure databases

ProteinModelPortaliP57301
SMRiP57301
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi107806.BU205

Proteomic databases

PRIDEiP57301

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB12922; BAB12922; BAB12922
GeneIDi1109648
KEGGibuc:BU205
PATRICifig|107806.10.peg.216

Phylogenomic databases

eggNOGiENOG4105DAQ Bacteria
COG2609 LUCA
HOGENOMiHOG000115215
KOiK00163
OMAiREPWFPG

Family and domain databases

CDDicd02017 TPP_E1_EcPDC_like, 1 hit
Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR004660 2-oxoA_DH_E1
IPR035807 PDC_E1_N
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N
PANTHERiPTHR43825:SF3 PTHR43825:SF3, 1 hit
PfamiView protein in Pfam
PF00456 Transketolase_N, 1 hit
PIRSFiPIRSF000156 Pyruvate_dh_E1, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00759 aceE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiODP1_BUCAI
AccessioniPrimary (citable) accession number: P57301
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 22, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Buchnera aphidicola (subsp. Acyrthosiphon pisum)
    Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names
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