UniProtKB - P57105 (SYJ2B_HUMAN)
Synaptojanin-2-binding protein
SYNJ2BP
Functioni
Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.
By similarityGO - Biological processi
- cell-cell adhesion Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- negative regulation of angiogenesis Source: UniProtKB
- negative regulation of endothelial cell migration Source: UniProtKB
- negative regulation of endothelial cell proliferation Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- negative regulation of sprouting angiogenesis Source: UniProtKB
- protein targeting Source: Ensembl
- receptor clustering Source: GO_Central
- receptor localization to synapse Source: GO_Central
- regulation of endocytosis Source: Ensembl
- regulation of Notch signaling pathway Source: UniProtKB
- Rho protein signal transduction Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P57105 |
SignaLinki | P57105 |
Protein family/group databases
TCDBi | 8.A.24.1.5, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptojanin-2-binding proteinAlternative name(s): Mitochondrial outer membrane protein 25 |
Gene namesi | Name:SYNJ2BP Synonyms:OMP251 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18955, SYNJ2BP |
MIMi | 609411, gene |
neXtProti | NX_P57105 |
VEuPathDBi | HostDB:ENSG00000213463 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication
Mitochondrion
- integral component of mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: UniProtKB
Plasma Membrane
- basolateral plasma membrane Source: GO_Central
- postsynaptic density membrane Source: GO_Central
Other locations
- cell junction Source: GO_Central
- neuromuscular junction Source: GO_Central
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 117 | CytoplasmicSequence analysisAdd BLAST | 117 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 145 | Mitochondrial intermembraneSequence analysis | 7 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55333 |
OpenTargetsi | ENSG00000213463 |
PharmGKBi | PA38768 |
Miscellaneous databases
Pharosi | P57105, Tbio |
Genetic variation databases
BioMutai | SYNJ2BP |
DMDMi | 22261816 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072383 | 1 – 145 | Synaptojanin-2-binding proteinAdd BLAST | 145 |
Proteomic databases
EPDi | P57105 |
jPOSTi | P57105 |
MassIVEi | P57105 |
MaxQBi | P57105 |
PaxDbi | P57105 |
PeptideAtlasi | P57105 |
PRIDEi | P57105 |
ProteomicsDBi | 57004 |
TopDownProteomicsi | P57105 |
PTM databases
iPTMneti | P57105 |
PhosphoSitePlusi | P57105 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213463, Expressed in renal medulla and 250 other tissues |
ExpressionAtlasi | P57105, baseline and differential |
Genevisiblei | P57105, HS |
Organism-specific databases
HPAi | ENSG00000213463, Low tissue specificity |
Interactioni
Subunit structurei
Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (By similarity).
Interacts (via C-terminus) with RALBP1.
Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus).
Forms a ternary complex with ACVR2A and RALBP1 (By similarity).
Interacts with MAPK12 (By similarity).
Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells (PubMed:24025447).
By similarity1 PublicationBinary interactionsi
P57105
Protein-protein interaction databases
BioGRIDi | 120614, 130 interactors |
IntActi | P57105, 28 interactors |
STRINGi | 9606.ENSP00000256366 |
Miscellaneous databases
RNActi | P57105, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P57105 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P57105 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 100 | PDZPROSITE-ProRule annotationAdd BLAST | 88 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00830000128402 |
HOGENOMi | CLU_149433_1_0_1 |
InParanoidi | P57105 |
OMAi | WILLRYR |
OrthoDBi | 1502481at2759 |
PhylomeDBi | P57105 |
TreeFami | TF318964 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN
60 70 80 90 100
GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL
110 120 130 140
QVQNGPIGHR GEGDPSGIPI FMVLVPVFAL TMVAAWAFMR YRQQL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | V → A in BAA92098 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051394 | 9 | V → I. Corresponds to variant dbSNP:rs4356408Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY534623 mRNA Translation: AAT01566.1 AK002133 mRNA Translation: BAA92098.1 CH471061 Genomic DNA Translation: EAW81032.1 BC007704 mRNA Translation: AAH07704.1 |
CCDSi | CCDS9803.1 |
RefSeqi | NP_060843.2, NM_018373.2 |
Genome annotation databases
Ensembli | ENST00000256366; ENSP00000256366; ENSG00000213463 |
GeneIDi | 55333 |
KEGGi | hsa:55333 |
MANE-Selecti | ENST00000256366.6; ENSP00000256366.4; NM_018373.3; NP_060843.2 |
UCSCi | uc001xmc.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY534623 mRNA Translation: AAT01566.1 AK002133 mRNA Translation: BAA92098.1 CH471061 Genomic DNA Translation: EAW81032.1 BC007704 mRNA Translation: AAH07704.1 |
CCDSi | CCDS9803.1 |
RefSeqi | NP_060843.2, NM_018373.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ENO | NMR | - | A | 1-107 | [»] | |
2JIK | X-ray | 1.35 | A/B | 6-100 | [»] | |
2JIN | X-ray | 1.50 | A | 4-99 | [»] | |
SMRi | P57105 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120614, 130 interactors |
IntActi | P57105, 28 interactors |
STRINGi | 9606.ENSP00000256366 |
Protein family/group databases
TCDBi | 8.A.24.1.5, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
PTM databases
iPTMneti | P57105 |
PhosphoSitePlusi | P57105 |
Genetic variation databases
BioMutai | SYNJ2BP |
DMDMi | 22261816 |
Proteomic databases
EPDi | P57105 |
jPOSTi | P57105 |
MassIVEi | P57105 |
MaxQBi | P57105 |
PaxDbi | P57105 |
PeptideAtlasi | P57105 |
PRIDEi | P57105 |
ProteomicsDBi | 57004 |
TopDownProteomicsi | P57105 |
Protocols and materials databases
Antibodypediai | 46, 124 antibodies from 21 providers |
DNASUi | 55333 |
Genome annotation databases
Ensembli | ENST00000256366; ENSP00000256366; ENSG00000213463 |
GeneIDi | 55333 |
KEGGi | hsa:55333 |
MANE-Selecti | ENST00000256366.6; ENSP00000256366.4; NM_018373.3; NP_060843.2 |
UCSCi | uc001xmc.5, human |
Organism-specific databases
CTDi | 55333 |
DisGeNETi | 55333 |
GeneCardsi | SYNJ2BP |
HGNCi | HGNC:18955, SYNJ2BP |
HPAi | ENSG00000213463, Low tissue specificity |
MIMi | 609411, gene |
neXtProti | NX_P57105 |
OpenTargetsi | ENSG00000213463 |
PharmGKBi | PA38768 |
VEuPathDBi | HostDB:ENSG00000213463 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00830000128402 |
HOGENOMi | CLU_149433_1_0_1 |
InParanoidi | P57105 |
OMAi | WILLRYR |
OrthoDBi | 1502481at2759 |
PhylomeDBi | P57105 |
TreeFami | TF318964 |
Enzyme and pathway databases
PathwayCommonsi | P57105 |
SignaLinki | P57105 |
Miscellaneous databases
BioGRID-ORCSi | 55333, 5 hits in 1036 CRISPR screens |
EvolutionaryTracei | P57105 |
GeneWikii | SYNJ2BP |
GenomeRNAii | 55333 |
Pharosi | P57105, Tbio |
PROi | PR:P57105 |
RNActi | P57105, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213463, Expressed in renal medulla and 250 other tissues |
ExpressionAtlasi | P57105, baseline and differential |
Genevisiblei | P57105, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYJ2B_HUMAN | |
Accessioni | P57105Primary (citable) accession number: P57105 Secondary accession number(s): Q49SH3, Q96IA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | August 13, 2002 | |
Last modified: | February 23, 2022 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references