UniProtKB - P57105 (SYJ2B_HUMAN)
Protein
Synaptojanin-2-binding protein
Gene
SYNJ2BP
Organism
Homo sapiens (Human)
Status
Functioni
Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.By similarity
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- negative regulation of angiogenesis Source: UniProtKB
- negative regulation of endothelial cell migration Source: UniProtKB
- negative regulation of endothelial cell proliferation Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- negative regulation of sprouting angiogenesis Source: UniProtKB
- receptor clustering Source: GO_Central
- receptor localization to synapse Source: GO_Central
- regulation of Notch signaling pathway Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P57105 |
Protein family/group databases
TCDBi | 8.A.24.1.5, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptojanin-2-binding proteinAlternative name(s): Mitochondrial outer membrane protein 25 |
Gene namesi | Name:SYNJ2BP Synonyms:OMP251 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18955, SYNJ2BP |
MIMi | 609411, gene |
neXtProti | NX_P57105 |
VEuPathDBi | HostDB:ENSG00000213463.4 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Plasma Membrane
- basolateral plasma membrane Source: GO_Central
- postsynaptic density membrane Source: GO_Central
Other locations
- cell junction Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- neuromuscular junction Source: GO_Central
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 117 | CytoplasmicSequence analysisAdd BLAST | 117 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 145 | Mitochondrial intermembraneSequence analysis | 7 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55333 |
OpenTargetsi | ENSG00000213463 |
PharmGKBi | PA38768 |
Miscellaneous databases
Pharosi | P57105, Tbio |
Genetic variation databases
BioMutai | SYNJ2BP |
DMDMi | 22261816 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072383 | 1 – 145 | Synaptojanin-2-binding proteinAdd BLAST | 145 |
Proteomic databases
EPDi | P57105 |
jPOSTi | P57105 |
MassIVEi | P57105 |
MaxQBi | P57105 |
PaxDbi | P57105 |
PeptideAtlasi | P57105 |
PRIDEi | P57105 |
ProteomicsDBi | 57004 |
TopDownProteomicsi | P57105 |
PTM databases
iPTMneti | P57105 |
PhosphoSitePlusi | P57105 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213463, Expressed in renal medulla and 249 other tissues |
ExpressionAtlasi | P57105, baseline and differential |
Genevisiblei | P57105, HS |
Organism-specific databases
HPAi | ENSG00000213463, Low tissue specificity |
Interactioni
Subunit structurei
Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (By similarity).
Interacts (via C-terminus) with RALBP1.
Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus).
Forms a ternary complex with ACVR2A and RALBP1 (By similarity).
Interacts with MAPK12 (By similarity).
Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells (PubMed:24025447).
By similarity1 PublicationBinary interactionsi
Hide detailsP57105
Protein-protein interaction databases
BioGRIDi | 120614, 102 interactors |
IntActi | P57105, 28 interactors |
STRINGi | 9606.ENSP00000256366 |
Miscellaneous databases
RNActi | P57105, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P57105 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P57105 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 100 | PDZPROSITE-ProRule annotationAdd BLAST | 88 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00830000128402 |
HOGENOMi | CLU_149433_1_0_1 |
InParanoidi | P57105 |
OrthoDBi | 1502481at2759 |
PhylomeDBi | P57105 |
TreeFami | TF318964 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
P57105-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN
60 70 80 90 100
GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL
110 120 130 140
QVQNGPIGHR GEGDPSGIPI FMVLVPVFAL TMVAAWAFMR YRQQL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | V → A in BAA92098 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051394 | 9 | V → I. Corresponds to variant dbSNP:rs4356408Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY534623 mRNA Translation: AAT01566.1 AK002133 mRNA Translation: BAA92098.1 CH471061 Genomic DNA Translation: EAW81032.1 BC007704 mRNA Translation: AAH07704.1 |
CCDSi | CCDS9803.1 |
RefSeqi | NP_060843.2, NM_018373.2 |
Genome annotation databases
Ensembli | ENST00000256366; ENSP00000256366; ENSG00000213463 |
GeneIDi | 55333 |
KEGGi | hsa:55333 |
UCSCi | uc001xmc.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY534623 mRNA Translation: AAT01566.1 AK002133 mRNA Translation: BAA92098.1 CH471061 Genomic DNA Translation: EAW81032.1 BC007704 mRNA Translation: AAH07704.1 |
CCDSi | CCDS9803.1 |
RefSeqi | NP_060843.2, NM_018373.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ENO | NMR | - | A | 1-107 | [»] | |
2JIK | X-ray | 1.35 | A/B | 6-100 | [»] | |
2JIN | X-ray | 1.50 | A | 4-99 | [»] | |
SMRi | P57105 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120614, 102 interactors |
IntActi | P57105, 28 interactors |
STRINGi | 9606.ENSP00000256366 |
Protein family/group databases
TCDBi | 8.A.24.1.5, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
PTM databases
iPTMneti | P57105 |
PhosphoSitePlusi | P57105 |
Genetic variation databases
BioMutai | SYNJ2BP |
DMDMi | 22261816 |
Proteomic databases
EPDi | P57105 |
jPOSTi | P57105 |
MassIVEi | P57105 |
MaxQBi | P57105 |
PaxDbi | P57105 |
PeptideAtlasi | P57105 |
PRIDEi | P57105 |
ProteomicsDBi | 57004 |
TopDownProteomicsi | P57105 |
Protocols and materials databases
Antibodypediai | 46, 114 antibodies |
Genome annotation databases
Ensembli | ENST00000256366; ENSP00000256366; ENSG00000213463 |
GeneIDi | 55333 |
KEGGi | hsa:55333 |
UCSCi | uc001xmc.5, human |
Organism-specific databases
CTDi | 55333 |
DisGeNETi | 55333 |
GeneCardsi | SYNJ2BP |
HGNCi | HGNC:18955, SYNJ2BP |
HPAi | ENSG00000213463, Low tissue specificity |
MIMi | 609411, gene |
neXtProti | NX_P57105 |
OpenTargetsi | ENSG00000213463 |
PharmGKBi | PA38768 |
VEuPathDBi | HostDB:ENSG00000213463.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00830000128402 |
HOGENOMi | CLU_149433_1_0_1 |
InParanoidi | P57105 |
OrthoDBi | 1502481at2759 |
PhylomeDBi | P57105 |
TreeFami | TF318964 |
Enzyme and pathway databases
PathwayCommonsi | P57105 |
Miscellaneous databases
BioGRID-ORCSi | 55333, 2 hits in 872 CRISPR screens |
EvolutionaryTracei | P57105 |
GeneWikii | SYNJ2BP |
GenomeRNAii | 55333 |
Pharosi | P57105, Tbio |
PROi | PR:P57105 |
RNActi | P57105, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213463, Expressed in renal medulla and 249 other tissues |
ExpressionAtlasi | P57105, baseline and differential |
Genevisiblei | P57105, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYJ2B_HUMAN | |
Accessioni | P57105Primary (citable) accession number: P57105 Secondary accession number(s): Q49SH3, Q96IA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | August 13, 2002 | |
Last modified: | February 10, 2021 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references