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Entry version 156 (31 Jul 2019)
Sequence version 2 (29 Aug 2003)
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Protein

Sodium/calcium exchanger 3

Gene

SLC8A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the electrogenic exchange of Ca2+ against Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to cellular Ca2+ homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca2+ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca2+ efflux from mitochondria and contributes to mitochondrial Ca2+ ion homeostasis (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Calcium transport is down-regulated by Na+ and stimulated by Ca2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi409Calcium 1By similarity1
Metal bindingi409Calcium 2By similarity1
Metal bindingi409Calcium 3By similarity1
Metal bindingi445Calcium 1By similarity1
Metal bindingi445Calcium 4By similarity1
Metal bindingi470Calcium 2By similarity1
Metal bindingi471Calcium 1By similarity1
Metal bindingi471Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi471Calcium 3By similarity1
Metal bindingi471Calcium 4By similarity1
Metal bindingi473Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi475Calcium 1By similarity1
Metal bindingi475Calcium 3By similarity1
Metal bindingi475Calcium 4By similarity1
Metal bindingi478Calcium 4By similarity1
Metal bindingi525Calcium 3By similarity1
Metal bindingi526Calcium 2By similarity1
Metal bindingi527Calcium 2By similarity1
Metal bindingi527Calcium 3By similarity1
Metal bindingi543Calcium 5By similarity1
Metal bindingi579Calcium 6By similarity1
Metal bindingi606Calcium 6By similarity1
Metal bindingi607Calcium 5; via carbonyl oxygenBy similarity1
Metal bindingi607Calcium 6By similarity1
Metal bindingi672Calcium 5By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processAntiport, Calcium transport, Ion transport, Sodium transport, Transport
LigandCalcium, Metal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-5578775 Ion homeostasis
R-HSA-8949215 Mitochondrial calcium ion transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.19.3.3 the ca(2+):cation antiporter (caca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/calcium exchanger 3
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 3
Solute carrier family 8 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC8A3
Synonyms:NCX3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11070 SLC8A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607991 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57103

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 73ExtracellularSequence analysisAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 147CytoplasmicSequence analysisAdd BLAST53
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169ExtracellularSequence analysis1
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 202CytoplasmicSequence analysisAdd BLAST12
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 230ExtracellularSequence analysis7
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 726CytoplasmicSequence analysisAdd BLAST475
Transmembranei727 – 747HelicalSequence analysisAdd BLAST21
Topological domaini748 – 754ExtracellularSequence analysis7
Transmembranei755 – 775HelicalSequence analysisAdd BLAST21
Topological domaini776 – 778CytoplasmicSequence analysis3
Transmembranei779 – 799HelicalSequence analysisAdd BLAST21
Topological domaini800 – 828ExtracellularSequence analysisAdd BLAST29
Transmembranei829 – 849HelicalSequence analysisAdd BLAST21
Topological domaini850 – 860CytoplasmicSequence analysisAdd BLAST11
Transmembranei861 – 881HelicalSequence analysisAdd BLAST21
Topological domaini882 – 903ExtracellularSequence analysisAdd BLAST22
Transmembranei904 – 924HelicalSequence analysisAdd BLAST21
Topological domaini925 – 927CytoplasmicSequence analysis3

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6547

Open Targets

More...
OpenTargetsi
ENSG00000100678

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA315

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
947

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC8A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395973

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001938431 – 927Sodium/calcium exchanger 3Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi823N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P57103

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P57103

PeptideAtlas

More...
PeptideAtlasi
P57103

PRoteomics IDEntifications database

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PRIDEi
P57103

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56998 [P57103-1]
56999 [P57103-2]
57000 [P57103-3]
57001 [P57103-4]
57002 [P57103-5]
57003 [P57103-6]
77876

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P57103-2 [P57103-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P57103

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P57103

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated during in vitro differentiation of oligodendrocytes (at protein level). Up-regulated during in vitro differentiation of oligodendrocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100678 Expressed in 113 organ(s), highest expression level in quadriceps femoris

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P57103 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P57103 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AKAP1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112437, 8 interactors

Protein interaction database and analysis system

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IntActi
P57103, 2 interactors

Molecular INTeraction database

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MINTi
P57103

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370669

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P57103

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati140 – 180Alpha-1Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini386 – 485Calx-beta 1Add BLAST100
Domaini519 – 619Calx-beta 2Add BLAST101
Repeati796 – 832Alpha-2Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni253 – 272Putative calmodulin-binding regionBy similarityAdd BLAST20

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic Calx-beta domains bind the regulatory Ca2+. The first Calx-beta domain can bind up to four Ca2+ ions. The second domain can bind another two Ca2+ ions that are essential for calcium-regulated ion exchange.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1306 Eukaryota
ENOG410XPJP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157547

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000266971

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P57103

KEGG Orthology (KO)

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KOi
K05849

Identification of Orthologs from Complete Genome Data

More...
OMAi
SRKEMIR

Database of Orthologous Groups

More...
OrthoDBi
490546at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P57103

TreeFam database of animal gene trees

More...
TreeFami
TF314308

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.2030, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR004836 Na_Ca_Ex
IPR032452 Na_Ca_Ex_C-exten
IPR004837 NaCa_Exmemb

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160 Calx-beta, 2 hits
PF01699 Na_Ca_ex, 2 hits
PF16494 Na_Ca_ex_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01259 NACAEXCHNGR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237 Calx_beta, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF141072 SSF141072, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00845 caca, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3 (identifier: P57103-1) [UniParc]FASTAAdd to basket
Also known as: NCX3.3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG
60 70 80 90 100
SSDCKEGVIL PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA
110 120 130 140 150
SIEVITSQER EVTIKKPNGE TSTTTIRVWN ETVSNLTLMA LGSSAPEILL
160 170 180 190 200
SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI IIGICVYVIP DGETRKIKHL
210 220 230 240 250
RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF FPVCVLLAWV
260 270 280 290 300
ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN
310 320 330 340 350
LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS
360 370 380 390 400
RAFYRIQATR MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF
410 420 430 440 450
DPCSYQCLEN CGAVLLTVVR KGGDMSKTMY VDYKTEDGSA NAGADYEFTE
460 470 480 490 500
GTVVLKPGET QKEFSVGIID DDIFEEDEHF FVRLSNVRIE EEQPEEGMPP
510 520 530 540 550
AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH VSESIGVMEV
560 570 580 590 600
KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV
610 620 630 640 650
KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDVTDR KLTMEEEEAK
660 670 680 690 700
RIAEMGKPVL GEHPKLEVII EESYEFKTTV DKLIKKTNLA LVVGTHSWRD
710 720 730 740 750
QFMEAITVSA AGDEDEDESG EERLPSCFDY VMHFLTVFWK VLFACVPPTE
760 770 780 790 800
YCHGWACFAV SILIIGMLTA IIGDLASHFG CTIGLKDSVT AVVFVAFGTS
810 820 830 840 850
VPDTFASKAA ALQDVYADAS IGNVTGSNAV NVFLGIGLAW SVAAIYWALQ
860 870 880 890 900
GQEFHVSAGT LAFSVTLFTI FAFVCISVLL YRRRPHLGGE LGGPRGCKLA
910 920
TTWLFVSLWL LYILFATLEA YCYIKGF
Length:927
Mass (Da):103,010
Last modified:August 29, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B43CB6A9D77615E
GO
Isoform 2 (identifier: P57103-2) [UniParc]FASTAAdd to basket
Also known as: NCX3.2

The sequence of this isoform differs from the canonical sequence as follows:
     630-635: Missing.

Show »
Length:921
Mass (Da):102,415
Checksum:i9E7E932E8EAE13F7
GO
Isoform 4 (identifier: P57103-3) [UniParc]FASTAAdd to basket
Also known as: NCX3.4

The sequence of this isoform differs from the canonical sequence as follows:
     596-620: KTIRVKIVDEEEYERQENFFIALGE → CDRQEADYGRRGGQEDSRDGKASIG
     621-927: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:620
Mass (Da):68,947
Checksum:i0FBEC381D196FD7C
GO
Isoform 5 (identifier: P57103-4) [UniParc]FASTAAdd to basket
Also known as: NCX3-tN.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-643: Missing.

Note: Expressed in fetal brain.
Show »
Length:284
Mass (Da):31,142
Checksum:i14B4A98B3DE17144
GO
Isoform 6 (identifier: P57103-5) [UniParc]FASTAAdd to basket
Also known as: NCX3-tN.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     630-635: Missing.

Note: Expressed in fetal brain.
Show »
Length:298
Mass (Da):32,745
Checksum:i6B91455189B786D7
GO
Isoform 7 (identifier: P57103-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-638: Missing.

Show »
Length:924
Mass (Da):102,694
Checksum:iA0A556B753998A07
GO
Isoform 8 (identifier: P57103-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     599-638: RVKIVDEEEY...SALLLSPDVT → HIKVIDDEAY...SFQKALLLSP

Show »
Length:925
Mass (Da):102,804
Checksum:i0CCF8DA0881C4FDA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z391F2Z391_HUMAN
Sodium/calcium exchanger 3
SLC8A3
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036463612E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0431251 – 643Missing in isoform 5. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_0431261 – 623Missing in isoform 6. 2 PublicationsAdd BLAST623
Alternative sequenceiVSP_008117596 – 620KTIRV…IALGE → CDRQEADYGRRGGQEDSRDG KASIG in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_044502599 – 638RVKIV…SPDVT → HIKVIDDEAYEKNKNYFIEM MGPRMVDMSFQKALLLSP in isoform 8. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_008118621 – 927Missing in isoform 4. 1 PublicationAdd BLAST307
Alternative sequenceiVSP_008116630 – 635Missing in isoform 2 and isoform 6. 3 Publications6
Alternative sequenceiVSP_043850636 – 638Missing in isoform 7. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF510501 mRNA Translation: AAN60790.1
AF510502 mRNA Translation: AAN60791.1
AF510503 mRNA Translation: AAN60792.1
AF508982 Genomic DNA Translation: AAM90955.1
AJ304852 mRNA Translation: CAC40984.1
AJ304853 mRNA Translation: CAC40985.1
AJ745101 mRNA Translation: CAG33739.1
AJ745102 mRNA Translation: CAG33740.1
AL135747 Genomic DNA No translation available.
AL160191 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81019.1
CH471061 Genomic DNA Translation: EAW81021.1
CH471061 Genomic DNA Translation: EAW81026.1
BC142969 mRNA Translation: AAI42970.1
X93017 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35498.1 [P57103-1]
CCDS41967.1 [P57103-4]
CCDS45131.1 [P57103-5]
CCDS53904.1 [P57103-6]
CCDS9799.1 [P57103-7]
CCDS9800.1 [P57103-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001123889.1, NM_001130417.2 [P57103-5]
NP_150287.1, NM_033262.4 [P57103-7]
NP_489479.1, NM_058240.3 [P57103-6]
NP_891977.1, NM_182932.2 [P57103-2]
NP_891981.1, NM_182936.2 [P57103-4]
NP_892114.1, NM_183002.2 [P57103-1]
XP_016877095.1, XM_017021606.1 [P57103-1]
XP_016877097.1, XM_017021608.1 [P57103-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216568; ENSP00000216568; ENSG00000100678 [P57103-5]
ENST00000356921; ENSP00000349392; ENSG00000100678 [P57103-2]
ENST00000357887; ENSP00000350560; ENSG00000100678 [P57103-7]
ENST00000381269; ENSP00000370669; ENSG00000100678 [P57103-1]
ENST00000394330; ENSP00000377863; ENSG00000100678 [P57103-4]
ENST00000494208; ENSP00000436332; ENSG00000100678 [P57103-3]
ENST00000528359; ENSP00000433531; ENSG00000100678 [P57103-7]
ENST00000534137; ENSP00000436688; ENSG00000100678 [P57103-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6547

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6547

UCSC genome browser

More...
UCSCi
uc001xlu.5 human [P57103-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510501 mRNA Translation: AAN60790.1
AF510502 mRNA Translation: AAN60791.1
AF510503 mRNA Translation: AAN60792.1
AF508982 Genomic DNA Translation: AAM90955.1
AJ304852 mRNA Translation: CAC40984.1
AJ304853 mRNA Translation: CAC40985.1
AJ745101 mRNA Translation: CAG33739.1
AJ745102 mRNA Translation: CAG33740.1
AL135747 Genomic DNA No translation available.
AL160191 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81019.1
CH471061 Genomic DNA Translation: EAW81021.1
CH471061 Genomic DNA Translation: EAW81026.1
BC142969 mRNA Translation: AAI42970.1
X93017 Genomic DNA No translation available.
CCDSiCCDS35498.1 [P57103-1]
CCDS41967.1 [P57103-4]
CCDS45131.1 [P57103-5]
CCDS53904.1 [P57103-6]
CCDS9799.1 [P57103-7]
CCDS9800.1 [P57103-2]
RefSeqiNP_001123889.1, NM_001130417.2 [P57103-5]
NP_150287.1, NM_033262.4 [P57103-7]
NP_489479.1, NM_058240.3 [P57103-6]
NP_891977.1, NM_182932.2 [P57103-2]
NP_891981.1, NM_182936.2 [P57103-4]
NP_892114.1, NM_183002.2 [P57103-1]
XP_016877095.1, XM_017021606.1 [P57103-1]
XP_016877097.1, XM_017021608.1 [P57103-2]

3D structure databases

SMRiP57103
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112437, 8 interactors
IntActiP57103, 2 interactors
MINTiP57103
STRINGi9606.ENSP00000370669

Chemistry databases

GuidetoPHARMACOLOGYi947

Protein family/group databases

TCDBi2.A.19.3.3 the ca(2+):cation antiporter (caca) family

PTM databases

iPTMnetiP57103
PhosphoSitePlusiP57103

Polymorphism and mutation databases

BioMutaiSLC8A3
DMDMi34395973

Proteomic databases

EPDiP57103
PaxDbiP57103
PeptideAtlasiP57103
PRIDEiP57103
ProteomicsDBi56998 [P57103-1]
56999 [P57103-2]
57000 [P57103-3]
57001 [P57103-4]
57002 [P57103-5]
57003 [P57103-6]
77876
TopDownProteomicsiP57103-2 [P57103-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6547
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216568; ENSP00000216568; ENSG00000100678 [P57103-5]
ENST00000356921; ENSP00000349392; ENSG00000100678 [P57103-2]
ENST00000357887; ENSP00000350560; ENSG00000100678 [P57103-7]
ENST00000381269; ENSP00000370669; ENSG00000100678 [P57103-1]
ENST00000394330; ENSP00000377863; ENSG00000100678 [P57103-4]
ENST00000494208; ENSP00000436332; ENSG00000100678 [P57103-3]
ENST00000528359; ENSP00000433531; ENSG00000100678 [P57103-7]
ENST00000534137; ENSP00000436688; ENSG00000100678 [P57103-6]
GeneIDi6547
KEGGihsa:6547
UCSCiuc001xlu.5 human [P57103-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6547
DisGeNETi6547

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC8A3
HGNCiHGNC:11070 SLC8A3
MIMi607991 gene
neXtProtiNX_P57103
OpenTargetsiENSG00000100678
PharmGKBiPA315

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1306 Eukaryota
ENOG410XPJP LUCA
GeneTreeiENSGT00940000157547
HOGENOMiHOG000266971
InParanoidiP57103
KOiK05849
OMAiSRKEMIR
OrthoDBi490546at2759
PhylomeDBiP57103
TreeFamiTF314308

Enzyme and pathway databases

ReactomeiR-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-5578775 Ion homeostasis
R-HSA-8949215 Mitochondrial calcium ion transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC8A3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6547

Protein Ontology

More...
PROi
PR:P57103

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100678 Expressed in 113 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiP57103 baseline and differential
GenevisibleiP57103 HS

Family and domain databases

Gene3Di2.60.40.2030, 2 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR004836 Na_Ca_Ex
IPR032452 Na_Ca_Ex_C-exten
IPR004837 NaCa_Exmemb
PfamiView protein in Pfam
PF03160 Calx-beta, 2 hits
PF01699 Na_Ca_ex, 2 hits
PF16494 Na_Ca_ex_C, 1 hit
PRINTSiPR01259 NACAEXCHNGR
SMARTiView protein in SMART
SM00237 Calx_beta, 2 hits
SUPFAMiSSF141072 SSF141072, 2 hits
TIGRFAMsiTIGR00845 caca, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57103
Secondary accession number(s): Q5K3P6
, Q5K3P7, Q8IUE9, Q8IUF0, Q8NFI7, Q96QG1, Q96QG2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 29, 2003
Last modified: July 31, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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