Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - P57094 (AXIN1_DANRE)

Entry version 147 (23 Feb 2022)
Sequence version 2 (22 Jul 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Axin-1

Gene

axin1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:17681137).

Controls dorsoventral patterning via two opposing effects: down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:17681137, PubMed:30467143).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-195253, Degradation of beta-catenin by the destruction complex
R-DRE-196299, Beta-catenin phosphorylation cascade
R-DRE-201681, TCF dependent signaling in response to WNT
R-DRE-4641257, Degradation of AXIN
R-DRE-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-DRE-5689880, Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:axin1
Synonyms:axin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-000403-1, axin1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002208931 – 835Axin-1Add BLAST835

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated by tankyrase tnks and tnks2. Poly-ADP-ribosylated protein is recognized by rnf146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway.1 Publication
Ubiquitinated by rnf146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway.1 Publication

Keywords - PTMi

ADP-ribosylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P57094

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with dixdc1 (PubMed:12526749).

Interacts with hwa; leading to promote the tankyrase-mediated degradation of axin1 (PubMed:30467143).

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		78941, 3 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P57094

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000036978

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P57094

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 214RGSPROSITE-ProRule annotationAdd BLAST123
Domaini753 – 835DIXPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 60DisorderedSequence analysisAdd BLAST45
Regioni318 – 349DisorderedSequence analysisAdd BLAST32
Regioni351 – 436Interaction with GSK3BBy similarityAdd BLAST86
Regioni437 – 512Interaction with beta-cateninBy similarityAdd BLAST76
Regioni485 – 530DisorderedSequence analysisAdd BLAST46
Regioni602 – 627DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 60Polar residuesSequence analysisAdd BLAST21
Compositional biasi318 – 342Polar residuesSequence analysisAdd BLAST25
Compositional biasi612 – 627Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DIX domain mediates interaction with dixdc1.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3589, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P57094

Database for complete collections of gene phylogenies

More...PhylomeDBi		P57094

Family and domain databases

Conserved Domains Database

More...CDDi		cd11582, Axin_TNKS_binding, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.167.10, 1 hit
1.10.196.10, 2 hits
2.40.240.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043581, Axin-like
IPR029797, AXIN1
IPR014936, Axin_b-cat-bd
IPR032101, Axin_TNKS-bd
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
IPR044926, RGS_subdomain_2
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR46102, PTHR46102, 1 hit
PTHR46102:SF3, PTHR46102:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16646, AXIN1_TNKS_BD, 1 hit
PF08833, Axin_b-cat_bind, 1 hit
PF00778, DIX, 1 hit
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01301, RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00021, DAX, 1 hit
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097, SSF48097, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50841, DIX, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P57094-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMSVNEKGI CYLPDLGSSF TEDAPRPPVP GEEGDLVSSD GRQYNHSFYS 
        60         70         80         90        100
SKSDSLKNEA SIATPRRPDL DLGYEPEGSA SPTPPYLKWA ESLHSLLDDQ 
       110        120        130        140        150
DGIHLFRTFL KQEECADMLD FWFACSGFRK QEANDGNEKM LKLAKAIYKK 
       160        170        180        190        200
YILDNNGIVS RQIKPATKSF IKDCVTKLHI DPAMFDQAQT EIQTMMEENT 
       210        220        230        240        250
YPLFLKSDIY LEYTRTGGES PKLFSDQSSV SGNGKVLPGY LPTVIEDVEW 
       260        270        280        290        300
RCDQEEEQIA ESDPTPSNRL TQKLPLETVP QRVANSKRYQ DNREYRHASW 
       310        320        330        340        350
REPVNPYYVN SGYALAPATS ANDSEQQSMS SDADTLSLTD SSVDGVPPYR 
       360        370        380        390        400
YRKPHRREIH ESAKVNGRVP LPHIPRTNRI PKDIHVEPEK FAAELISRLE 
       410        420        430        440        450
GVLREREAQE KLEERLKRVR LEEEGDDADI STGPSLANHR VPPAVHVQHY 
       460        470        480        490        500
GGRYSEMSYN GLQLRDAHEE NPESILDEHV QRVMKTPGCQ SPGTGRHSPK 
       510        520        530        540        550
SRSPDGLPAG KIPGLMMPLS GGQGKHQARQ GPKGEAAHLH HHKHIHHTHY 
       560        570        580        590        600
AAAGKPKEQA EAEAARMHGG FAWNTEQHHY GPKSRNYADG MSVGPNTMDP 
       610        620        630        640        650
MGYSSKGSTL SKRPVRKGED GRNFEMREPL PADDMERNQK ILQWMMEGEK 
       660        670        680        690        700
EAGRYKRGPY GSISGPKKAQ GHEPARPSSV ERLGAVHPWV TAQLRNNVQP 
       710        720        730        740        750
SHPFIQDPTM PPNPAPNPLT QLEEARRRLE EERRKSGTLQ AKQRHKNMKK 
       760        770        780        790        800
QPCENITVAY YFRGEPIPYR TSVKGRIVTL GQFKELLTKK GSYKYYFKKV 
       810        820        830 
SYEFDCGVVF EEVREDDAIL PIFEEKIIGK VEKVD
Length:835
Mass (Da):94,329
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7ABEE52E1DE2FAB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4II61A0A0R4II61_DANRE
Axin-1
axin1
835Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176T → M in BAA92439 (PubMed:10704853).Curated1
Sequence conflicti275P → L in BAA92439 (PubMed:10704853).Curated1
Sequence conflicti658G → S in BAA92439 (PubMed:10704853).Curated1
Sequence conflicti763R → C in BAA92439 (PubMed:10704853).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB032262 mRNA Translation: BAA92439.1
BC099991 mRNA Translation: AAH99991.1

NCBI Reference Sequences

More...RefSeqi		NP_571578.2, NM_131503.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57931

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:57931

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032262 mRNA Translation: BAA92439.1
BC099991 mRNA Translation: AAH99991.1
RefSeqiNP_571578.2, NM_131503.2

3D structure databases

SMRiP57094
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi78941, 3 interactors
ELMiP57094
STRINGi7955.ENSDARP00000036978

Proteomic databases

PaxDbiP57094

Genome annotation databases

GeneIDi57931
KEGGidre:57931

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8312
ZFINiZDB-GENE-000403-1, axin1

Phylogenomic databases

eggNOGiKOG3589, Eukaryota
InParanoidiP57094
PhylomeDBiP57094

Enzyme and pathway databases

ReactomeiR-DRE-195253, Degradation of beta-catenin by the destruction complex
R-DRE-196299, Beta-catenin phosphorylation cascade
R-DRE-201681, TCF dependent signaling in response to WNT
R-DRE-4641257, Degradation of AXIN
R-DRE-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-DRE-5689880, Ub-specific processing proteases

Miscellaneous databases

Protein Ontology

More...PROi		PR:P57094

Family and domain databases

CDDicd11582, Axin_TNKS_binding, 1 hit
Gene3Di1.10.167.10, 1 hit
1.10.196.10, 2 hits
2.40.240.130, 1 hit
InterProiView protein in InterPro
IPR043581, Axin-like
IPR029797, AXIN1
IPR014936, Axin_b-cat-bd
IPR032101, Axin_TNKS-bd
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
IPR044926, RGS_subdomain_2
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR46102, PTHR46102, 1 hit
PTHR46102:SF3, PTHR46102:SF3, 1 hit
PfamiView protein in Pfam
PF16646, AXIN1_TNKS_BD, 1 hit
PF08833, Axin_b-cat_bind, 1 hit
PF00778, DIX, 1 hit
PF00615, RGS, 1 hit
PRINTSiPR01301, RGSPROTEIN
SMARTiView protein in SMART
SM00021, DAX, 1 hit
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841, DIX, 1 hit
PS50132, RGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAXIN1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57094
Secondary accession number(s): Q499B7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 22, 2008
Last modified: February 23, 2022
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again