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Entry version 170 (12 Aug 2020)
Sequence version 2 (16 Aug 2004)
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Protein

T-box transcription factor TBX4

Gene

TBX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi71 – 251T-boxPROSITE-ProRule annotationAdd BLAST181

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P57082

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-box transcription factor TBX4
Short name:
T-box protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121075.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11603, TBX4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601719, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57082

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension (ICPPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant bone disease characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026745248G → V in ICPPS. 1 PublicationCorresponds to variant dbSNP:rs28938474EnsemblClinVar.1
Natural variantiVAR_026746531Q → R in ICPPS. 1 PublicationCorresponds to variant dbSNP:rs28936696Ensembl.1
Amelia, posterior, with pelvic and pulmonary hypoplasia syndrome (PAPPAS)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, lethal embryonic syndrome characterized by absent hindlimbs, pulmonary hypoplasia, severely hypoplastic or absent pelvic bones, hypoplasia of the sacrum, and ambiguous genitalia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083526113 – 545Missing in PAPPAS; also responsible for ischiocoxopodopatellar syndrome in heterozygous carriers; no detectable protein expression in homozygous patient cells. 1 PublicationAdd BLAST433

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9496

MalaCards human disease database

More...
MalaCardsi
TBX4
MIMi147891, phenotype
601360, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000121075

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
261279, 17q23.1q23.2 microdeletion syndrome
1509, Coxopodopatellar syndrome
238578, Familial clubfoot due to 17q23.1q23.2 microduplication
275777, Heritable pulmonary arterial hypertension

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36366

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P57082, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51338786

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001844331 – 545T-box transcription factor TBX4Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei507PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P57082

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P57082

PeptideAtlas

More...
PeptideAtlasi
P57082

PRoteomics IDEntifications database

More...
PRIDEi
P57082

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56994 [P57082-1]
721

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P57082

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P57082

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121075, Expressed in lung and 79 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P57082, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P57082, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000121075, Group enriched (lung, placenta, prostate, smooth muscle, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114875, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P57082, 3 interactors

Molecular INTeraction database

More...
MINTi
P57082

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000240335

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P57082, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P57082

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3585, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158882

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037025_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P57082

KEGG Orthology (KO)

More...
KOi
K10178

Identification of Orthologs from Complete Genome Data

More...
OMAi
PAVCERK

Database of Orthologous Groups

More...
OrthoDBi
344556at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P57082

TreeFam database of animal gene trees

More...
TreeFami
TF106341

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00182, TBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR036960, T-box_sf
IPR001699, TF_T-box
IPR018186, TF_T-box_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11267, PTHR11267, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00907, T-box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00937, TBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00425, TBOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417, SSF49417, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01283, TBOX_1, 1 hit
PS01264, TBOX_2, 1 hit
PS50252, TBOX_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P57082-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQDKGLSES EEAFRAPGPA LGEASAANAP EPALAAPGLS GAALGSPPGP
60 70 80 90 100
GADVVAAAAA EQTIENIKVG LHEKELWKKF HEAGTEMIIT KAGRRMFPSY
110 120 130 140 150
KVKVTGMNPK TKYILLIDIV PADDHRYKFC DNKWMVAGKA EPAMPGRLYV
160 170 180 190 200
HPDSPATGAH WMRQLVSFQK LKLTNNHLDP FGHIILNSMH KYQPRLHIVK
210 220 230 240 250
ADENNAFGSK NTAFCTHVFP ETSFISVTSY QNHKITQLKI ENNPFAKGFR
260 270 280 290 300
GSDDSDLRVA RLQSKEYPVI SKSIMRQRLI SPQLSATPDV GPLLGTHQAL
310 320 330 340 350
QHYQHENGAH SQLAEPQDLP LSTFPTQRDS SLFYHCLKRR DGTRHLDLPC
360 370 380 390 400
KRSYLEAPSS VGEDHYFRSP PPYDQQMLSP SYCSEVTPRE ACMYSGSGPE
410 420 430 440 450
IAGVSGVDDL PPPPLSCNMW TSVSPYTSYS VQTMETVPYQ PFPTHFTATT
460 470 480 490 500
MMPRLPTLSA QSSQPPGNAH FSVYNQLSQS QVRERGPSAS FPRERGLPQG
510 520 530 540
CERKPPSPHL NAANEFLYSQ TFSLSRESSL QYHSGMGTVE NWTDG
Length:545
Mass (Da):60,204
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB822FD05EE98C8CD
GO
Isoform 2 (identifier: P57082-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-340: R → RA

Show »
Length:546
Mass (Da):60,275
Checksum:iFBBD5B47E298A2CA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPY2K7EPY2_HUMAN
T-box transcription factor TBX4
TBX4
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0202516G → A2 PublicationsCorresponds to variant dbSNP:rs3744448EnsemblClinVar.1
Natural variantiVAR_02677235A → V1 PublicationCorresponds to variant dbSNP:rs148424252EnsemblClinVar.1
Natural variantiVAR_083526113 – 545Missing in PAPPAS; also responsible for ischiocoxopodopatellar syndrome in heterozygous carriers; no detectable protein expression in homozygous patient cells. 1 PublicationAdd BLAST433
Natural variantiVAR_026745248G → V in ICPPS. 1 PublicationCorresponds to variant dbSNP:rs28938474EnsemblClinVar.1
Natural variantiVAR_078493282P → T1 Publication1
Natural variantiVAR_021983314A → V. Corresponds to variant dbSNP:rs3744438EnsemblClinVar.1
Natural variantiVAR_026746531Q → R in ICPPS. 1 PublicationCorresponds to variant dbSNP:rs28936696Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054002340R → RA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF188703 mRNA Translation: AAF68854.1
AC005901 Genomic DNA No translation available.
BC136403 mRNA Translation: AAI36404.1
BC142620 mRNA Translation: AAI42621.1
BC144062 mRNA Translation: AAI44063.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11629.1 [P57082-1]
CCDS82180.1 [P57082-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001308049.1, NM_001321120.1 [P57082-2]
NP_060958.2, NM_018488.3 [P57082-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000240335; ENSP00000240335; ENSG00000121075 [P57082-1]
ENST00000642491; ENSP00000495714; ENSG00000121075 [P57082-2]
ENST00000644296; ENSP00000495986; ENSG00000121075 [P57082-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9496

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9496

UCSC genome browser

More...
UCSCi
uc002izi.3, human [P57082-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188703 mRNA Translation: AAF68854.1
AC005901 Genomic DNA No translation available.
BC136403 mRNA Translation: AAI36404.1
BC142620 mRNA Translation: AAI42621.1
BC144062 mRNA Translation: AAI44063.1
CCDSiCCDS11629.1 [P57082-1]
CCDS82180.1 [P57082-2]
RefSeqiNP_001308049.1, NM_001321120.1 [P57082-2]
NP_060958.2, NM_018488.3 [P57082-1]

3D structure databases

SMRiP57082
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114875, 3 interactors
IntActiP57082, 3 interactors
MINTiP57082
STRINGi9606.ENSP00000240335

PTM databases

iPTMnetiP57082
PhosphoSitePlusiP57082

Polymorphism and mutation databases

BioMutaiTBX4
DMDMi51338786

Proteomic databases

MassIVEiP57082
PaxDbiP57082
PeptideAtlasiP57082
PRIDEiP57082
ProteomicsDBi56994 [P57082-1]
721

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P57082, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18589, 140 antibodies

Genome annotation databases

EnsembliENST00000240335; ENSP00000240335; ENSG00000121075 [P57082-1]
ENST00000642491; ENSP00000495714; ENSG00000121075 [P57082-2]
ENST00000644296; ENSP00000495986; ENSG00000121075 [P57082-2]
GeneIDi9496
KEGGihsa:9496
UCSCiuc002izi.3, human [P57082-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9496
DisGeNETi9496
EuPathDBiHostDB:ENSG00000121075.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TBX4
HGNCiHGNC:11603, TBX4
HPAiENSG00000121075, Group enriched (lung, placenta, prostate, smooth muscle, urinary bladder)
MalaCardsiTBX4
MIMi147891, phenotype
601360, phenotype
601719, gene
neXtProtiNX_P57082
OpenTargetsiENSG00000121075
Orphaneti261279, 17q23.1q23.2 microdeletion syndrome
1509, Coxopodopatellar syndrome
238578, Familial clubfoot due to 17q23.1q23.2 microduplication
275777, Heritable pulmonary arterial hypertension
PharmGKBiPA36366

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3585, Eukaryota
GeneTreeiENSGT00940000158882
HOGENOMiCLU_037025_1_0_1
InParanoidiP57082
KOiK10178
OMAiPAVCERK
OrthoDBi344556at2759
PhylomeDBiP57082
TreeFamiTF106341

Enzyme and pathway databases

PathwayCommonsiP57082

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9496, 7 hits in 893 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBX4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9496
PharosiP57082, Tbio

Protein Ontology

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PROi
PR:P57082
RNActiP57082, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000121075, Expressed in lung and 79 other tissues
ExpressionAtlasiP57082, baseline and differential
GenevisibleiP57082, HS

Family and domain databases

CDDicd00182, TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967, p53-like_TF_DNA-bd
IPR036960, T-box_sf
IPR001699, TF_T-box
IPR018186, TF_T-box_CS
PANTHERiPTHR11267, PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907, T-box, 1 hit
PRINTSiPR00937, TBOX
SMARTiView protein in SMART
SM00425, TBOX, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283, TBOX_1, 1 hit
PS01264, TBOX_2, 1 hit
PS50252, TBOX_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57082
Secondary accession number(s): A5PKU7, B2RMT1, B7ZLV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 16, 2004
Last modified: August 12, 2020
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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