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UniProtKB - P57077 (M3KCL_HUMAN)

Entry version 154 (25 May 2022)
Sequence version 2 (07 Oct 2020)
Previous versions | rss
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Protein

MAP3K7 C-terminal-like protein

Gene

MAP3K7CL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P57077

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P57077

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAP3K7 C-terminal-like protein
Alternative name(s):
TAK1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP3K7CL
Synonyms:C21orf7, TAK1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16457, MAP3K7CL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611110, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P57077

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000156265

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56911

Open Targets

More...OpenTargetsi		ENSG00000156265

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25864

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P57077, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAP3K7CL

Domain mapping of disease mutations (DMDM)

More...DMDMi		10719918

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724231 – 142MAP3K7 C-terminal-like proteinAdd BLAST142

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P57077

MaxQB - The MaxQuant DataBase

More...MaxQBi		P57077

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P57077

PeptideAtlas

More...PeptideAtlasi		P57077

PRoteomics IDEntifications database

More...PRIDEi		P57077

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lung and peripheral blood leukocytes. Expressed predominantly in peripheral blood leukocytes and ubiquitously in adult and fetal tissues. Also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000156265, Expressed in monocyte and 160 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P57077, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P57077, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000156265, Tissue enhanced (skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121239, 10 interactors

Protein interaction database and analysis system

More...IntActi		P57077, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P57077, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P57077

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P57077

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S2UX, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00770000120675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_100451_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P57077

Identification of Orthologs from Complete Genome Data

More...OMAi		MAQSQCV

Database for complete collections of gene phylogenies

More...PhylomeDBi		P57077

TreeFam database of animal gene trees

More...TreeFami		TF335499

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042800, Map3k7cl

The PANTHER Classification System

More...PANTHERi		PTHR47140, PTHR47140, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P57077-4) [UniParc]FASTAAdd to basket
Also known as: D1 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISTARVPAD KPVRIAFSLN DASDDTPPED SIPLVFPELD QQLQPLPPCH 
        60         70         80         90        100
DSEESMEVFK QHCQIAEEYH EVKKEITLLE QRKKELIAKL DQAEKEKVDA 
       110        120        130        140 
AELVREFEAL TEENRTLRLA QSQCVEQLEK LRIQYQKRQG SS
Length:142
Mass (Da):16,372
Last modified:October 7, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F9BCBAF69F25444
GO
Isoform 2 (identifier: P57077-1) [UniParc]FASTAAdd to basket
Also known as: A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MISTARVPADKPVRIAFSLNDAS → MVQLIAPLEV...VPVEIPSSPL

Show »
Length:242
Mass (Da):27,248
Checksum:iFFED148FE9AB838C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DFW0B4DFW0_HUMAN
MAP3K7 C-terminal-like protein
MAP3K7CL
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J990C9J990_HUMAN
MAP3K7 C-terminal-like protein
MAP3K7CL
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLK6C9JLK6_HUMAN
MAP3K7 C-terminal-like protein
MAP3K7CL
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF81752 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAF81753 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence CAB90434 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60K → R in CAD28500 (PubMed:17974005).Curated1
Sequence conflicti70H → L in CAD28500 (PubMed:17974005).Curated1
Sequence conflicti95K → E in CAD28500 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: P57077-1)
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083830112I → V. Corresponds to variant dbSNP:rs3746843Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0607591 – 23MISTA…LNDAS → MVQLIAPLEVMWNEAADLKP LALSRRLECSGGIMAHYSPD LLGPEMESRYFAQVGLEHLA SSSPPAFGFLKCLDYSISVL CSATSLAMLEDNPKVSKLAT GDWMLTLKPKSITVPVEIPS SPL in isoform 2. Add BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF269161 mRNA Translation: AAF81751.1
AF269162 mRNA Translation: AAF81752.1 Sequence problems.
AF269163 mRNA Translation: AAF81753.1 Sequence problems.
AF269164 mRNA Translation: AAF81754.1
AY033900 mRNA Translation: AAK68718.1
AY171599 mRNA Translation: AAO16519.1
AL713701 mRNA Translation: CAD28500.1
AL163249 Genomic DNA Translation: CAB90434.1 Sequence problems.
CH471079 Genomic DNA Translation: EAX09921.1
CH471079 Genomic DNA Translation: EAX09923.1
BC008567 mRNA Translation: AAH08567.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13584.1 [P57077-1]
CCDS68182.1 [P57077-4]

NCBI Reference Sequences

More...RefSeqi		NP_001273546.1, NM_001286617.1 [P57077-4]
NP_001273547.1, NM_001286618.1 [P57077-4]
NP_001273548.1, NM_001286619.1 [P57077-4]
NP_001273549.1, NM_001286620.1 [P57077-4]
NP_001273551.1, NM_001286622.1
NP_001273553.1, NM_001286624.1
NP_001273563.1, NM_001286634.1 [P57077-1]
NP_064537.1, NM_020152.3 [P57077-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000286791.9; ENSP00000286791.6; ENSG00000156265.16 [P57077-1]
ENST00000339024.8; ENSP00000345777.4; ENSG00000156265.16
ENST00000341618.8; ENSP00000343212.4; ENSG00000156265.16 [P57077-1]
ENST00000399925.5; ENSP00000382809.1; ENSG00000156265.16
ENST00000399926.5; ENSP00000382810.1; ENSG00000156265.16
ENST00000399928.6; ENSP00000382812.1; ENSG00000156265.16
ENST00000399934.5; ENSP00000382816.1; ENSG00000156265.16
ENST00000399935.6; ENSP00000382817.2; ENSG00000156265.16
ENST00000399947.6; ENSP00000382828.2; ENSG00000156265.16 [P57077-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56911

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000399928.6; ENSP00000382812.1; NM_001286620.2; NP_001273549.1

UCSC genome browser

More...UCSCi		uc002ynd.5, human [P57077-4]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269161 mRNA Translation: AAF81751.1
AF269162 mRNA Translation: AAF81752.1 Sequence problems.
AF269163 mRNA Translation: AAF81753.1 Sequence problems.
AF269164 mRNA Translation: AAF81754.1
AY033900 mRNA Translation: AAK68718.1
AY171599 mRNA Translation: AAO16519.1
AL713701 mRNA Translation: CAD28500.1
AL163249 Genomic DNA Translation: CAB90434.1 Sequence problems.
CH471079 Genomic DNA Translation: EAX09921.1
CH471079 Genomic DNA Translation: EAX09923.1
BC008567 mRNA Translation: AAH08567.1
CCDSiCCDS13584.1 [P57077-1]
CCDS68182.1 [P57077-4]
RefSeqiNP_001273546.1, NM_001286617.1 [P57077-4]
NP_001273547.1, NM_001286618.1 [P57077-4]
NP_001273548.1, NM_001286619.1 [P57077-4]
NP_001273549.1, NM_001286620.1 [P57077-4]
NP_001273551.1, NM_001286622.1
NP_001273553.1, NM_001286624.1
NP_001273563.1, NM_001286634.1 [P57077-1]
NP_064537.1, NM_020152.3 [P57077-1]

3D structure databases

AlphaFoldDBiP57077
SMRiP57077
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121239, 10 interactors
IntActiP57077, 9 interactors
STRINGi9606.ENSP00000382828

Genetic variation databases

BioMutaiMAP3K7CL
DMDMi10719918

Proteomic databases

MassIVEiP57077
MaxQBiP57077
PaxDbiP57077
PeptideAtlasiP57077
PRIDEiP57077

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6479, 153 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		56911

Genome annotation databases

EnsembliENST00000286791.9; ENSP00000286791.6; ENSG00000156265.16 [P57077-1]
ENST00000339024.8; ENSP00000345777.4; ENSG00000156265.16
ENST00000341618.8; ENSP00000343212.4; ENSG00000156265.16 [P57077-1]
ENST00000399925.5; ENSP00000382809.1; ENSG00000156265.16
ENST00000399926.5; ENSP00000382810.1; ENSG00000156265.16
ENST00000399928.6; ENSP00000382812.1; ENSG00000156265.16
ENST00000399934.5; ENSP00000382816.1; ENSG00000156265.16
ENST00000399935.6; ENSP00000382817.2; ENSG00000156265.16
ENST00000399947.6; ENSP00000382828.2; ENSG00000156265.16 [P57077-1]
GeneIDi56911
KEGGihsa:56911
MANE-SelectiENST00000399928.6; ENSP00000382812.1; NM_001286620.2; NP_001273549.1
UCSCiuc002ynd.5, human [P57077-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56911
DisGeNETi56911

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAP3K7CL
HGNCiHGNC:16457, MAP3K7CL
HPAiENSG00000156265, Tissue enhanced (skeletal muscle, tongue)
MIMi611110, gene
neXtProtiNX_P57077
OpenTargetsiENSG00000156265
PharmGKBiPA25864
VEuPathDBiHostDB:ENSG00000156265

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S2UX, Eukaryota
GeneTreeiENSGT00770000120675
HOGENOMiCLU_100451_0_0_1
InParanoidiP57077
OMAiMAQSQCV
PhylomeDBiP57077
TreeFamiTF335499

Enzyme and pathway databases

PathwayCommonsiP57077
SignaLinkiP57077

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56911, 20 hits in 1064 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAP3K7CL, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		C21orf7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56911
PharosiP57077, Tdark

Protein Ontology

More...PROi		PR:P57077
RNActiP57077, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000156265, Expressed in monocyte and 160 other tissues
ExpressionAtlasiP57077, baseline and differential
GenevisibleiP57077, HS

Family and domain databases

InterProiView protein in InterPro
IPR042800, Map3k7cl
PANTHERiPTHR47140, PTHR47140, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3KCL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57077
Secondary accession number(s): D3DSE0, Q8TCL9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 7, 2020
Last modified: May 25, 2022
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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