UniProtKB - P57077 (M3KCL_HUMAN)
Protein
MAP3K7 C-terminal-like protein
Gene
MAP3K7CL
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: MAP3K7 C-terminal-like proteinAlternative name(s): TAK1-like protein |
Gene namesi | Name:MAP3K7CL Synonyms:C21orf7, TAK1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16457, MAP3K7CL |
MIMi | 611110, gene |
neXtProti | NX_P57077 |
VEuPathDBi | HostDB:ENSG00000156265.15 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56911 |
OpenTargetsi | ENSG00000156265 |
PharmGKBi | PA25864 |
Miscellaneous databases
Pharosi | P57077, Tdark |
Genetic variation databases
BioMutai | MAP3K7CL |
DMDMi | 10719918 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072423 | 1 – 142 | MAP3K7 C-terminal-like proteinAdd BLAST | 142 |
Proteomic databases
MassIVEi | P57077 |
MaxQBi | P57077 |
PaxDbi | P57077 |
PeptideAtlasi | P57077 |
PRIDEi | P57077 |
ProteomicsDBi | 56985 [P57077-1] 56988 [P57077-4] |
Expressioni
Tissue specificityi
Detected in lung and peripheral blood leukocytes. Expressed predominantly in peripheral blood leukocytes and ubiquitously in adult and fetal tissues. Also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.1 Publication
Gene expression databases
Bgeei | ENSG00000156265, Expressed in monocyte and 160 other tissues |
ExpressionAtlasi | P57077, baseline and differential |
Genevisiblei | P57077, HS |
Organism-specific databases
HPAi | ENSG00000156265, Tissue enhanced (blood, skeletal muscle, tongue) |
Interactioni
Binary interactionsi
Hide detailsP57077
With | #Exp. | IntAct |
---|---|---|
GPS2 [Q13227] | 2 | EBI-748831,EBI-713355 |
Isoform 1 [P57077-4]
Protein-protein interaction databases
BioGRIDi | 121239, 10 interactors |
IntActi | P57077, 9 interactors |
STRINGi | 9606.ENSP00000382828 |
Miscellaneous databases
RNActi | P57077, protein |
Family & Domainsi
Domaini
Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
Phylogenomic databases
eggNOGi | ENOG502S2UX, Eukaryota |
GeneTreei | ENSGT00770000120675 |
HOGENOMi | CLU_100451_0_0_1 |
InParanoidi | P57077 |
OMAi | GSGAHMI |
PhylomeDBi | P57077 |
TreeFami | TF335499 |
Family and domain databases
InterProi | View protein in InterPro IPR042800, Map3k7cl |
PANTHERi | PTHR47140, PTHR47140, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P57077-4) [UniParc]FASTAAdd to basket
Also known as: D1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MISTARVPAD KPVRIAFSLN DASDDTPPED SIPLVFPELD QQLQPLPPCH
60 70 80 90 100
DSEESMEVFK QHCQIAEEYH EVKKEITLLE QRKKELIAKL DQAEKEKVDA
110 120 130 140
AELVREFEAL TEENRTLRLA QSQCVEQLEK LRIQYQKRQG SS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DFW0 | B4DFW0_HUMAN | MAP3K7 C-terminal-like protein | MAP3K7CL | 136 | Annotation score: | ||
C9J990 | C9J990_HUMAN | MAP3K7 C-terminal-like protein | MAP3K7CL | 94 | Annotation score: | ||
C9JLK6 | C9JLK6_HUMAN | MAP3K7 C-terminal-like protein | MAP3K7CL | 44 | Annotation score: |
Sequence cautioni
The sequence AAF81752 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAF81753 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence CAB90434 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | K → R in CAD28500 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 70 | H → L in CAD28500 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 95 | K → E in CAD28500 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: P57077-1) | |||||
Natural variantiVAR_083830 | 112 | I → V. Corresponds to variant dbSNP:rs3746843Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060759 | 1 – 23 | MISTA…LNDAS → MVQLIAPLEVMWNEAADLKP LALSRRLECSGGIMAHYSPD LLGPEMESRYFAQVGLEHLA SSSPPAFGFLKCLDYSISVL CSATSLAMLEDNPKVSKLAT GDWMLTLKPKSITVPVEIPS SPL in isoform 2. Add BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF269161 mRNA Translation: AAF81751.1 AF269162 mRNA Translation: AAF81752.1 Sequence problems. AF269163 mRNA Translation: AAF81753.1 Sequence problems. AF269164 mRNA Translation: AAF81754.1 AY033900 mRNA Translation: AAK68718.1 AY171599 mRNA Translation: AAO16519.1 AL713701 mRNA Translation: CAD28500.1 AL163249 Genomic DNA Translation: CAB90434.1 Sequence problems. CH471079 Genomic DNA Translation: EAX09921.1 CH471079 Genomic DNA Translation: EAX09923.1 BC008567 mRNA Translation: AAH08567.1 |
CCDSi | CCDS13584.1 [P57077-1] CCDS68182.1 [P57077-4] |
RefSeqi | NP_001273546.1, NM_001286617.1 [P57077-4] NP_001273547.1, NM_001286618.1 [P57077-4] NP_001273548.1, NM_001286619.1 [P57077-4] NP_001273549.1, NM_001286620.1 [P57077-4] NP_001273551.1, NM_001286622.1 NP_001273553.1, NM_001286624.1 NP_001273563.1, NM_001286634.1 [P57077-1] NP_064537.1, NM_020152.3 [P57077-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF269161 mRNA Translation: AAF81751.1 AF269162 mRNA Translation: AAF81752.1 Sequence problems. AF269163 mRNA Translation: AAF81753.1 Sequence problems. AF269164 mRNA Translation: AAF81754.1 AY033900 mRNA Translation: AAK68718.1 AY171599 mRNA Translation: AAO16519.1 AL713701 mRNA Translation: CAD28500.1 AL163249 Genomic DNA Translation: CAB90434.1 Sequence problems. CH471079 Genomic DNA Translation: EAX09921.1 CH471079 Genomic DNA Translation: EAX09923.1 BC008567 mRNA Translation: AAH08567.1 |
CCDSi | CCDS13584.1 [P57077-1] CCDS68182.1 [P57077-4] |
RefSeqi | NP_001273546.1, NM_001286617.1 [P57077-4] NP_001273547.1, NM_001286618.1 [P57077-4] NP_001273548.1, NM_001286619.1 [P57077-4] NP_001273549.1, NM_001286620.1 [P57077-4] NP_001273551.1, NM_001286622.1 NP_001273553.1, NM_001286624.1 NP_001273563.1, NM_001286634.1 [P57077-1] NP_064537.1, NM_020152.3 [P57077-1] |
3D structure databases
SMRi | P57077 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121239, 10 interactors |
IntActi | P57077, 9 interactors |
STRINGi | 9606.ENSP00000382828 |
Genetic variation databases
BioMutai | MAP3K7CL |
DMDMi | 10719918 |
Proteomic databases
MassIVEi | P57077 |
MaxQBi | P57077 |
PaxDbi | P57077 |
PeptideAtlasi | P57077 |
PRIDEi | P57077 |
ProteomicsDBi | 56985 [P57077-1] 56988 [P57077-4] |
Protocols and materials databases
Antibodypediai | 6479, 151 antibodies |
DNASUi | 56911 |
Genome annotation databases
Organism-specific databases
CTDi | 56911 |
DisGeNETi | 56911 |
GeneCardsi | MAP3K7CL |
HGNCi | HGNC:16457, MAP3K7CL |
HPAi | ENSG00000156265, Tissue enhanced (blood, skeletal muscle, tongue) |
MIMi | 611110, gene |
neXtProti | NX_P57077 |
OpenTargetsi | ENSG00000156265 |
PharmGKBi | PA25864 |
VEuPathDBi | HostDB:ENSG00000156265.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2UX, Eukaryota |
GeneTreei | ENSGT00770000120675 |
HOGENOMi | CLU_100451_0_0_1 |
InParanoidi | P57077 |
OMAi | GSGAHMI |
PhylomeDBi | P57077 |
TreeFami | TF335499 |
Enzyme and pathway databases
PathwayCommonsi | P57077 |
Miscellaneous databases
BioGRID-ORCSi | 56911, 11 hits in 981 CRISPR screens |
ChiTaRSi | MAP3K7CL, human |
GeneWikii | C21orf7 |
GenomeRNAii | 56911 |
Pharosi | P57077, Tdark |
PROi | PR:P57077 |
RNActi | P57077, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156265, Expressed in monocyte and 160 other tissues |
ExpressionAtlasi | P57077, baseline and differential |
Genevisiblei | P57077, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042800, Map3k7cl |
PANTHERi | PTHR47140, PTHR47140, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M3KCL_HUMAN | |
Accessioni | P57077Primary (citable) accession number: P57077 Secondary accession number(s): D3DSE0, Q8TCL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | October 7, 2020 | |
Last modified: | April 7, 2021 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot