UniProtKB - P57073 (SOX8_HUMAN)
Protein
Transcription factor SOX-8
Gene
SOX8
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 102 – 170 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: GO_Central
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: Ensembl
GO - Biological processi
- adipose tissue development Source: UniProtKB
- astrocyte fate commitment Source: Ensembl
- cell fate commitment Source: UniProtKB
- cell maturation Source: Ensembl
- enteric nervous system development Source: UniProtKB
- fat cell differentiation Source: UniProtKB
- in utero embryonic development Source: UniProtKB
- male gonad development Source: UniProtKB
- metanephric nephron tubule formation Source: UniProtKB
- morphogenesis of a branching epithelium Source: UniProtKB
- morphogenesis of an epithelium Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of myoblast differentiation Source: UniProtKB
- negative regulation of photoreceptor cell differentiation Source: Ensembl
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- neural crest cell development Source: GO_Central
- neural crest cell migration Source: UniProtKB
- oligodendrocyte differentiation Source: UniProtKB
- osteoblast differentiation Source: UniProtKB
- peripheral nervous system development Source: UniProtKB
- positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
- positive regulation of gliogenesis Source: UniProtKB
- positive regulation of kidney development Source: UniProtKB
- positive regulation of osteoblast proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of hormone levels Source: UniProtKB
- renal vesicle induction Source: UniProtKB
- retina development in camera-type eye Source: UniProtKB
- retinal rod cell differentiation Source: UniProtKB
- Sertoli cell development Source: UniProtKB
- signal transduction Source: UniProtKB
- skeletal muscle cell differentiation Source: Ensembl
- spermatogenesis Source: UniProtKB
- ureter morphogenesis Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P57073 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SOX-8 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11203, SOX8 |
MIMi | 605923, gene |
neXtProti | NX_P57073 |
VEuPathDBi | HostDB:ENSG00000005513.9 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 30812 |
OpenTargetsi | ENSG00000005513 |
PharmGKBi | PA36040 |
Miscellaneous databases
Pharosi | P57073, Tbio |
Genetic variation databases
BioMutai | SOX8 |
DMDMi | 10720294 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048733 | 1 – 446 | Transcription factor SOX-8Add BLAST | 446 |
Proteomic databases
jPOSTi | P57073 |
MassIVEi | P57073 |
MaxQBi | P57073 |
PaxDbi | P57073 |
PeptideAtlasi | P57073 |
PRIDEi | P57073 |
ProteomicsDBi | 56981 |
PTM databases
iPTMneti | P57073 |
PhosphoSitePlusi | P57073 |
Expressioni
Gene expression databases
Bgeei | ENSG00000005513, Expressed in substantia nigra and 160 other tissues |
Genevisiblei | P57073, HS |
Organism-specific databases
HPAi | ENSG00000005513, Tissue enriched (brain) |
Interactioni
GO - Molecular functioni
- transcription factor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 119036, 6 interactors |
IntActi | P57073, 4 interactors |
STRINGi | 9606.ENSP00000293894 |
Miscellaneous databases
RNActi | P57073, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 58 – 100 | Dimerization (DIM)1 PublicationAdd BLAST | 43 | |
Regioni | 224 – 298 | Transactivation domain (TAM)1 PublicationAdd BLAST | 75 | |
Regioni | 335 – 446 | Transactivation domain (TAC)1 PublicationAdd BLAST | 112 |
Domaini
The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.By similarity
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000159920 |
HOGENOMi | CLU_031800_0_0_1 |
InParanoidi | P57073 |
OMAi | SIYQYPY |
OrthoDBi | 782373at2759 |
PhylomeDBi | P57073 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR031265, SOX-8 IPR022151, Sox_N |
PANTHERi | PTHR45803:SF2, PTHR45803:SF2, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12444, Sox_N, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P57073-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDMSEARSQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGVAVG
60 70 80 90 100
GARGDPAEAA DERFPACIRD AVSQVLKGYD WSLVPMPVRG GGGGALKAKP
110 120 130 140 150
HVKRPMNAFM VWAQAARRKL ADQYPHLHNA ELSKTLGKLW RLLSESEKRP
160 170 180 190 200
FVEEAERLRV QHKKDHPDYK YQPRRRKSAK AGHSDSDSGA ELGPHPGGGA
210 220 230 240 250
VYKAEAGLGD GHHHGDHTGQ THGPPTPPTT PKTELQQAGA KPELKLEGRR
260 270 280 290 300
PVDSGRQNID FSNVDISELS SEVMGTMDAF DVHEFDQYLP LGGPAPPEPG
310 320 330 340 350
QAYGGAYFHA GASPVWAHKS APSASASPTE TGPPRPHIKT EQPSPGHYGD
360 370 380 390 400
QPRGSPDYGS CSGQSSATPA APAGPFAGSQ GDYGDLQASS YYGAYPGYAP
410 420 430 440
GLYQYPCFHS PRRPYASPLL NGLALPPAHS PTSHWDQPVY TTLTRP
Sequence cautioni
The sequence CAB75612 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF226675 mRNA Translation: AAF35886.1 AE006465 Genomic DNA Translation: AAK61260.1 Z99757 Genomic DNA Translation: CAB75612.1 Different initiation. BC031797 mRNA Translation: AAH31797.1 AF164104 mRNA Translation: AAF37424.1 |
CCDSi | CCDS10428.1 |
RefSeqi | NP_055402.2, NM_014587.4 |
Genome annotation databases
Ensembli | ENST00000293894; ENSP00000293894; ENSG00000005513 |
GeneIDi | 30812 |
KEGGi | hsa:30812 |
UCSCi | uc002ckn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF226675 mRNA Translation: AAF35886.1 AE006465 Genomic DNA Translation: AAK61260.1 Z99757 Genomic DNA Translation: CAB75612.1 Different initiation. BC031797 mRNA Translation: AAH31797.1 AF164104 mRNA Translation: AAF37424.1 |
CCDSi | CCDS10428.1 |
RefSeqi | NP_055402.2, NM_014587.4 |
3D structure databases
SMRi | P57073 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119036, 6 interactors |
IntActi | P57073, 4 interactors |
STRINGi | 9606.ENSP00000293894 |
PTM databases
iPTMneti | P57073 |
PhosphoSitePlusi | P57073 |
Genetic variation databases
BioMutai | SOX8 |
DMDMi | 10720294 |
Proteomic databases
jPOSTi | P57073 |
MassIVEi | P57073 |
MaxQBi | P57073 |
PaxDbi | P57073 |
PeptideAtlasi | P57073 |
PRIDEi | P57073 |
ProteomicsDBi | 56981 |
Protocols and materials databases
Antibodypediai | 9438, 338 antibodies |
Genome annotation databases
Ensembli | ENST00000293894; ENSP00000293894; ENSG00000005513 |
GeneIDi | 30812 |
KEGGi | hsa:30812 |
UCSCi | uc002ckn.3, human |
Organism-specific databases
CTDi | 30812 |
DisGeNETi | 30812 |
GeneCardsi | SOX8 |
HGNCi | HGNC:11203, SOX8 |
HPAi | ENSG00000005513, Tissue enriched (brain) |
MIMi | 605923, gene |
neXtProti | NX_P57073 |
OpenTargetsi | ENSG00000005513 |
PharmGKBi | PA36040 |
VEuPathDBi | HostDB:ENSG00000005513.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000159920 |
HOGENOMi | CLU_031800_0_0_1 |
InParanoidi | P57073 |
OMAi | SIYQYPY |
OrthoDBi | 782373at2759 |
PhylomeDBi | P57073 |
Enzyme and pathway databases
PathwayCommonsi | P57073 |
Miscellaneous databases
BioGRID-ORCSi | 30812, 4 hits in 894 CRISPR screens |
ChiTaRSi | SOX8, human |
GeneWikii | SOX8 |
GenomeRNAii | 30812 |
Pharosi | P57073, Tbio |
PROi | PR:P57073 |
RNActi | P57073, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000005513, Expressed in substantia nigra and 160 other tissues |
Genevisiblei | P57073, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR031265, SOX-8 IPR022151, Sox_N |
PANTHERi | PTHR45803:SF2, PTHR45803:SF2, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12444, Sox_N, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOX8_HUMAN | |
Accessioni | P57073Primary (citable) accession number: P57073 Secondary accession number(s): Q9NZW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM