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Protein

Transcription factor SOX-8

Gene

SOX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi102 – 170HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-8
Gene namesi
Name:SOX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000005513.9
HGNCiHGNC:11203 SOX8
MIMi605923 gene
neXtProtiNX_P57073

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi30812
OpenTargetsiENSG00000005513
PharmGKBiPA36040

Polymorphism and mutation databases

BioMutaiSOX8
DMDMi10720294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487331 – 446Transcription factor SOX-8Add BLAST446

Proteomic databases

EPDiP57073
MaxQBiP57073
PaxDbiP57073
PeptideAtlasiP57073
PRIDEiP57073
ProteomicsDBi56981

PTM databases

iPTMnetiP57073
PhosphoSitePlusiP57073

Expressioni

Gene expression databases

BgeeiENSG00000005513 Expressed in 149 organ(s), highest expression level in substantia nigra
CleanExiHS_SOX8
GenevisibleiP57073 HS

Organism-specific databases

HPAiHPA041640
HPA058665

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119036, 6 interactors
IntActiP57073, 4 interactors
STRINGi9606.ENSP00000293894

Structurei

3D structure databases

ProteinModelPortaliP57073
SMRiP57073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000108876
HOVERGENiHBG002061
InParanoidiP57073
KOiK09270
OMAiNWDQPVY
OrthoDBiEOG091G0EKD
PhylomeDBiP57073

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR031265 SOX-8
IPR022151 Sox_N
PANTHERiPTHR10270:SF20 PTHR10270:SF20, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12444 Sox_N, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P57073-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDMSEARSQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGVAVG
60 70 80 90 100
GARGDPAEAA DERFPACIRD AVSQVLKGYD WSLVPMPVRG GGGGALKAKP
110 120 130 140 150
HVKRPMNAFM VWAQAARRKL ADQYPHLHNA ELSKTLGKLW RLLSESEKRP
160 170 180 190 200
FVEEAERLRV QHKKDHPDYK YQPRRRKSAK AGHSDSDSGA ELGPHPGGGA
210 220 230 240 250
VYKAEAGLGD GHHHGDHTGQ THGPPTPPTT PKTELQQAGA KPELKLEGRR
260 270 280 290 300
PVDSGRQNID FSNVDISELS SEVMGTMDAF DVHEFDQYLP LGGPAPPEPG
310 320 330 340 350
QAYGGAYFHA GASPVWAHKS APSASASPTE TGPPRPHIKT EQPSPGHYGD
360 370 380 390 400
QPRGSPDYGS CSGQSSATPA APAGPFAGSQ GDYGDLQASS YYGAYPGYAP
410 420 430 440
GLYQYPCFHS PRRPYASPLL NGLALPPAHS PTSHWDQPVY TTLTRP
Length:446
Mass (Da):47,314
Last modified:December 1, 2000 - v1
Checksum:iAE453359051A6DB3
GO

Sequence cautioni

The sequence CAB75612 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226675 mRNA Translation: AAF35886.1
AE006465 Genomic DNA Translation: AAK61260.1
Z99757 Genomic DNA Translation: CAB75612.1 Different initiation.
BC031797 mRNA Translation: AAH31797.1
AF164104 mRNA Translation: AAF37424.1
CCDSiCCDS10428.1
RefSeqiNP_055402.2, NM_014587.4
UniGeneiHs.243678

Genome annotation databases

EnsembliENST00000293894; ENSP00000293894; ENSG00000005513
GeneIDi30812
KEGGihsa:30812
UCSCiuc002ckn.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226675 mRNA Translation: AAF35886.1
AE006465 Genomic DNA Translation: AAK61260.1
Z99757 Genomic DNA Translation: CAB75612.1 Different initiation.
BC031797 mRNA Translation: AAH31797.1
AF164104 mRNA Translation: AAF37424.1
CCDSiCCDS10428.1
RefSeqiNP_055402.2, NM_014587.4
UniGeneiHs.243678

3D structure databases

ProteinModelPortaliP57073
SMRiP57073
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119036, 6 interactors
IntActiP57073, 4 interactors
STRINGi9606.ENSP00000293894

PTM databases

iPTMnetiP57073
PhosphoSitePlusiP57073

Polymorphism and mutation databases

BioMutaiSOX8
DMDMi10720294

Proteomic databases

EPDiP57073
MaxQBiP57073
PaxDbiP57073
PeptideAtlasiP57073
PRIDEiP57073
ProteomicsDBi56981

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293894; ENSP00000293894; ENSG00000005513
GeneIDi30812
KEGGihsa:30812
UCSCiuc002ckn.3 human

Organism-specific databases

CTDi30812
DisGeNETi30812
EuPathDBiHostDB:ENSG00000005513.9
GeneCardsiSOX8
HGNCiHGNC:11203 SOX8
HPAiHPA041640
HPA058665
MIMi605923 gene
neXtProtiNX_P57073
OpenTargetsiENSG00000005513
PharmGKBiPA36040
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000108876
HOVERGENiHBG002061
InParanoidiP57073
KOiK09270
OMAiNWDQPVY
OrthoDBiEOG091G0EKD
PhylomeDBiP57073

Miscellaneous databases

ChiTaRSiSOX8 human
GeneWikiiSOX8
GenomeRNAii30812
PROiPR:P57073
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000005513 Expressed in 149 organ(s), highest expression level in substantia nigra
CleanExiHS_SOX8
GenevisibleiP57073 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR031265 SOX-8
IPR022151 Sox_N
PANTHERiPTHR10270:SF20 PTHR10270:SF20, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12444 Sox_N, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX8_HUMAN
AccessioniPrimary (citable) accession number: P57073
Secondary accession number(s): Q9NZW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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