SOX8

Functionⁱ

May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	102 – 170	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10684944
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein heterodimerization activity Source: Ensembl
RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adipose tissue development Source: UniProtKB
astrocyte fate commitment Source: Ensembl
cell fate commitment Source: UniProtKB
cell maturation Source: Ensembl
central nervous system development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enteric nervous system development Source: UniProtKB
fat cell differentiation Source: UniProtKB
in utero embryonic development Source: UniProtKB
male gonad development Source: UniProtKB
metanephric nephron tubule formation Source: UniProtKB
morphogenesis of a branching epithelium Source: UniProtKB
morphogenesis of an epithelium
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of apoptotic process Source: UniProtKB
negative regulation of myoblast differentiation Source: UniProtKB
negative regulation of photoreceptor cell differentiation Source: Ensembl
negative regulation of transcription, DNA-templated Source: UniProtKB
neural crest cell migration Source: UniProtKB
oligodendrocyte differentiation Source: UniProtKB
osteoblast differentiation Source: UniProtKB
peripheral nervous system development Source: UniProtKB
positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
positive regulation of gliogenesis Source: UniProtKB
positive regulation of kidney development Source: UniProtKB
positive regulation of osteoblast proliferation Source: UniProtKB
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 10662550
regulation of hormone levels Source: UniProtKB
renal vesicle induction Source: UniProtKB
retina development in camera-type eye Source: UniProtKB
retinal rod cell differentiation Source: UniProtKB
Sertoli cell development Source: UniProtKB
signal transduction Source: UniProtKB
skeletal muscle cell differentiation Source: Ensembl
spermatogenesis Source: UniProtKB
ureter morphogenesis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor SOX-8
Gene namesⁱ	Name:SOX8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000005513.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11203 SOX8
MIMⁱ	605923 gene
neXtProtⁱ	NX_P57073

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	30812
Open Targets More...OpenTargetsⁱ	ENSG00000005513
PharmGKBⁱ	PA36040

Polymorphism and mutation databases

BioMutaⁱ	SOX8
DMDMⁱ	10720294

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048733	1 – 446	Transcription factor SOX-8Add BLAST		446

Proteomic databases

EPDⁱ	P57073
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P57073
PaxDbⁱ	P57073
PeptideAtlas More...PeptideAtlasⁱ	P57073
PRIDEⁱ	P57073
ProteomicsDBⁱ	56981

PTM databases

iPTMnetⁱ	P57073
PhosphoSitePlusⁱ	P57073

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000005513 Expressed in 149 organ(s), highest expression level in substantia nigra
CleanExⁱ	HS_SOX8
Genevisibleⁱ	P57073 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041640 HPA058665

HPAⁱ

HPA041640
HPA058665

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119036, 6 interactors
IntActⁱ	P57073, 4 interactors
STRINGⁱ	9606.ENSP00000293894

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P57073
SMRⁱ	P57073
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG0527 Eukaryota ENOG410XT0K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000108876
HOVERGENⁱ	HBG002061
InParanoidⁱ	P57073
KEGG Orthology (KO) More...KOⁱ	K09270
OMAⁱ	NWDQPVY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EKD
PhylomeDBⁱ	P57073

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR031265 SOX-8 IPR022151 Sox_N
PANTHERⁱ	PTHR10270:SF20 PTHR10270:SF20, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit PF12444 Sox_N, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P57073-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLDMSEARSQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGVAVG 
        60         70         80         90        100
GARGDPAEAA DERFPACIRD AVSQVLKGYD WSLVPMPVRG GGGGALKAKP 
       110        120        130        140        150
HVKRPMNAFM VWAQAARRKL ADQYPHLHNA ELSKTLGKLW RLLSESEKRP 
       160        170        180        190        200
FVEEAERLRV QHKKDHPDYK YQPRRRKSAK AGHSDSDSGA ELGPHPGGGA 
       210        220        230        240        250
VYKAEAGLGD GHHHGDHTGQ THGPPTPPTT PKTELQQAGA KPELKLEGRR 
       260        270        280        290        300
PVDSGRQNID FSNVDISELS SEVMGTMDAF DVHEFDQYLP LGGPAPPEPG 
       310        320        330        340        350
QAYGGAYFHA GASPVWAHKS APSASASPTE TGPPRPHIKT EQPSPGHYGD 
       360        370        380        390        400
QPRGSPDYGS CSGQSSATPA APAGPFAGSQ GDYGDLQASS YYGAYPGYAP 
       410        420        430        440 
GLYQYPCFHS PRRPYASPLL NGLALPPAHS PTSHWDQPVY TTLTRP

Length:446

Mass (Da):47,314

Last modified:December 1, 2000 - v1

Checksum:ⁱAE453359051A6DB3

GO

Sequence cautionⁱ

The sequence CAB75612 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF226675 mRNA Translation: AAF35886.1 AE006465 Genomic DNA Translation: AAK61260.1 Z99757 Genomic DNA Translation: CAB75612.1 Different initiation. BC031797 mRNA Translation: AAH31797.1 AF164104 mRNA Translation: AAF37424.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10428.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055402.2, NM_014587.4
UniGeneⁱ	Hs.243678

Genome annotation databases

Ensemblⁱ	ENST00000293894; ENSP00000293894; ENSG00000005513
GeneIDⁱ	30812
KEGGⁱ	hsa:30812
UCSC genome browser More...UCSCⁱ	uc002ckn.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P57073	SRY-box 8		CHLSB		446	UniRef90_P57073
Uncharacterized protein		MACMU		141
Uncharacterized protein		MACFA		141
SOX8 isoform 1		PANTR		446
Uncharacterized protein		Cebus capucinus imitator		446
+18

Protein	Similar proteins		Species	Score	Length	Source
P57073	SOX8 isoform 1		PONAB		446	UniRef50_P57073
Uncharacterized protein		Cebus capucinus imitator		446
SRY-box 8		GORGO		446
Uncharacterized protein		AOTNA		446
Uncharacterized protein		PAPAN		446
+38

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF226675 mRNA Translation: AAF35886.1 AE006465 Genomic DNA Translation: AAK61260.1 Z99757 Genomic DNA Translation: CAB75612.1 Different initiation. BC031797 mRNA Translation: AAH31797.1 AF164104 mRNA Translation: AAF37424.1
CCDSⁱ	CCDS10428.1
RefSeqⁱ	NP_055402.2, NM_014587.4
UniGeneⁱ	Hs.243678

3D structure databases

ProteinModelPortalⁱ	P57073
SMRⁱ	P57073
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119036, 6 interactors
IntActⁱ	P57073, 4 interactors
STRINGⁱ	9606.ENSP00000293894

PTM databases

iPTMnetⁱ	P57073
PhosphoSitePlusⁱ	P57073

Polymorphism and mutation databases

BioMutaⁱ	SOX8
DMDMⁱ	10720294

Proteomic databases

EPDⁱ	P57073
MaxQBⁱ	P57073
PaxDbⁱ	P57073
PeptideAtlasⁱ	P57073
PRIDEⁱ	P57073
ProteomicsDBⁱ	56981

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000293894; ENSP00000293894; ENSG00000005513
GeneIDⁱ	30812
KEGGⁱ	hsa:30812
UCSCⁱ	uc002ckn.3 human

Organism-specific databases

CTDⁱ	30812
DisGeNETⁱ	30812
EuPathDBⁱ	HostDB:ENSG00000005513.9
GeneCardsⁱ	SOX8
HGNCⁱ	HGNC:11203 SOX8
HPAⁱ	HPA041640 HPA058665
MIMⁱ	605923 gene
neXtProtⁱ	NX_P57073
OpenTargetsⁱ	ENSG00000005513
PharmGKBⁱ	PA36040
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0527 Eukaryota ENOG410XT0K LUCA
GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000108876
HOVERGENⁱ	HBG002061
InParanoidⁱ	P57073
KOⁱ	K09270
OMAⁱ	NWDQPVY
OrthoDBⁱ	EOG091G0EKD
PhylomeDBⁱ	P57073

Miscellaneous databases

ChiTaRSⁱ	SOX8 human
GeneWikiⁱ	SOX8
GenomeRNAiⁱ	30812
Protein Ontology More...PROⁱ	PR:P57073
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000005513 Expressed in 149 organ(s), highest expression level in substantia nigra
CleanExⁱ	HS_SOX8
Genevisibleⁱ	P57073 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR031265 SOX-8 IPR022151 Sox_N
PANTHERⁱ	PTHR10270:SF20 PTHR10270:SF20, 1 hit
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit PF12444 Sox_N, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOX8_HUMAN
Accessionⁱ	P57073Primary (citable) accession number: P57073 Secondary accession number(s): Q9NZW2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P57073 (SOX8_HUMAN)

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Transcription factor SOX-8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ