UniProtKB - P57071 (PRD15_HUMAN)

BLAST

>sp|P57071|PRD15_HUMAN PR domain zinc finger protein 15 OS=Homo sapiens OX=9606 GN=PRDM15 PE=1 SV=4
MPRRRPPASGAAQFPERIATRSPDPIPLCTFQRQPRAAPVQPPCRLFFVTFAGCGHRWRS
ESKPGWISRSRSGIALRAARPPGSSPPRPAAPRPPPPGGVVAEAPGDVVIPRPRVQPMRV
ARGGPWTPNPAFREAESWSQIGNQRVSEQLLETSLGNEVSDTEPLSPASAGLRRNPALPP
GPFAQNFSWGNQENLPPALGKIANGGGTGAGKAECGYETESHLLEPHEIPLNVNTHKFSD
CEFPYEFCTVCFSPFKLLGMSGVEGVWNQHSRSASMHTFLNHSATGIREAGCRKDMPVSE
MAEDGSEEIMFIWCEDCSQYHDSECPELGPVVMVKDSFVLSRARSWPASGHVHTQAGQGM
RGYEDRDRADPQQLPEAVPAGLVRRLSGQQLPCRSTLTWGRLCHLVAQGRSSLPPNLEIR
RLEDGAEGVFAITQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGHPVCFDTSNEDDC
NWMMLVRPAAEAEHQNLTAYQHGSDVYFTTSRDIPPGTELRVWYAAFYAKKMDKPMLKQA
GSGVHAAGTPENSAPVESEPSQWACKVCSATFLELQLLNEHLLGHLEQAKSLPPGSQSEA
AAPEKEQDTPRGEPPAVPESENVATKEQKKKPRRGRKPKVSKAEQPLVIVEDKEPTEQVA
EIITEVPPDEPVSATPDERIMELVLGKLATTTTDTSSVPKFTHHQNNTITLKRSLILSSR
HGIRRKLIKQLGEHKRVYQCNICSKIFQNSSNLSRHVRSHGDKLFKCEECAKLFSRKESL
KQHVSYKHSRNEVDGEYRYRCGTCEKTFRIESALEFHNCRTDDKTFQCEMCFRFFSTNSN
LSKHKKKHGDKKFACEVCSKMFYRKDVMLDHQRRHLEGVRRVKREDLEAGGENLVRYKKE
PSGCPVCGKVFSCRSNMNKHLLTHGDKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDD
HQREEFIGKIGISSEENDDNSDESADSEPHKYSCKRCQLTFGRGKEYLKHIMEVHKEKGY
GCSICNRRFALKATYHAHMVIHRENLPDPNVQKYIHPCEICGRIFNSIGNLERHKLIHTG
VKSHACEQCGKSFARKDMLKEHMRVHDNVREYLCAECGKGMKTKHALRHHMKLHKGIKEY
ECKECHRRFAQKVNMLKHCKRHTGIKDFMCELCGKTFSERNTMETHKLIHTVGKQWTCSV
CDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLD
HLPETTTIDASSIGIVQPELTLEQEDLAEGKHGKAAKRSHKRKQKPEEEAGAPVPEDATF
SEYSEKETEFTGSVGDETNSAVQSIQQVVVTLGDPNVTTPSSSVGLTNITVTPITTAAAT
QFTNLQPVAVGHLTTPERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIHPQPEASNPQS
VAHFINLTTLVNSITPLGSQLSDQHPLTWRAVPQTDVLPPSQPQAPPQQAAQPQVQAEQQ
QQQMYSY

Align

Format
Add to basket Added to basket
History
Entry version 174 (12 Sep 2018)
Sequence version 4 (28 Nov 2006)
Previous versions | rss
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Protein

PR domain zinc finger protein 15

Gene

PRDM15

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	563 – 585	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	738 – 760	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	765 – 788	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	826 – 848	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	853 – 875	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	902 – 924	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	929 – 951	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	992 – 1015	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	1020 – 1042	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1056 – 1078	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1084 – 1106	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1112 – 1134	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1140 – 1162	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1168 – 1190	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1196 – 1219	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	1225 – 1248	C2H2-type 16PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
methyltransferase activity Source: UniProtKB-KW
promoter-specific chromatin binding Source: UniProtKB
RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW
negative regulation of MAPK cascade Source: UniProtKB
positive regulation of canonical Wnt signaling pathway Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: UniProtKB
regulation of stem cell division Source: UniProtKB
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Methyltransferase, Repressor, Transferase
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PR domain zinc finger protein 15Curated (EC:2.1.1.-Curated) Alternative name(s): PR domain-containing protein 15Curated Zinc finger protein 298
Gene namesⁱ	Name:PRDM15Imported Synonyms:C21orf83Imported, ZNF298Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141956.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13999 PRDM15
MIMⁱ	617692 gene
neXtProtⁱ	NX_P57071

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	63977
Open Targets More...OpenTargetsⁱ	ENSG00000141956
PharmGKBⁱ	PA33713

Polymorphism and mutation databases

BioMutaⁱ	PRDM15
DMDMⁱ	118572696

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047772	1 – 1507	PR domain zinc finger protein 15Add BLAST		1507

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	883	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P57071
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P57071
PaxDbⁱ	P57071
PeptideAtlas More...PeptideAtlasⁱ	P57071
PRIDEⁱ	P57071
ProteomicsDBⁱ	56980

PTM databases

iPTMnetⁱ	P57071
PhosphoSitePlusⁱ	P57071

Expressionⁱ

Tissue specificityⁱ

Detected in all tissues examined.1 Publication

Developmental stageⁱ

Expressed in fetal tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000141956 Expressed in 168 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_PRDM15
ExpressionAtlasⁱ	P57071 baseline and differential
Genevisibleⁱ	P57071 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024268 HPA029255 HPA029256

HPAⁱ

HPA024268
HPA029255
HPA029256

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122024, 19 interactors
IntActⁱ	P57071, 1 interactor
Molecular INTeraction database More...MINTⁱ	P57071
STRINGⁱ	9606.ENSP00000269844

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P57071
SMRⁱ	P57071
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	415 – 525	SETPROSITE-ProRule annotationAdd BLAST		111

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	92 – 97	Poly-Pro	6
Compositional biasⁱ	690 – 695	Poly-Thr	6
Compositional biasⁱ	1499 – 1503	Poly-Gln	5

Sequence similaritiesⁱ

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	563 – 585	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	738 – 760	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	765 – 788	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	826 – 848	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	853 – 875	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	902 – 924	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	929 – 951	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	992 – 1015	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	1020 – 1042	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1056 – 1078	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1084 – 1106	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1112 – 1134	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1140 – 1162	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1168 – 1190	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1196 – 1219	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	1225 – 1248	C2H2-type 16PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149092
HOGENOMⁱ	HOG000115685
HOVERGENⁱ	HBG053669
InParanoidⁱ	P57071
OMAⁱ	HGCSICN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P57071
TreeFamⁱ	TF331419

Family and domain databases

InterProⁱ	View protein in InterPro IPR001214 SET_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 17 hits
SUPFAMⁱ	SSF57667 SSF57667, 8 hits
PROSITEⁱ	View protein in PROSITE PS50280 SET, 1 hit PS00028 ZINC_FINGER_C2H2_1, 16 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P57071-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQPRAAPV QPPCRLFFVT 
        60         70         80         90        100
FAGCGHRWRS ESKPGWISRS RSGIALRAAR PPGSSPPRPA APRPPPPGGV 
       110        120        130        140        150
VAEAPGDVVI PRPRVQPMRV ARGGPWTPNP AFREAESWSQ IGNQRVSEQL 
       160        170        180        190        200
LETSLGNEVS DTEPLSPASA GLRRNPALPP GPFAQNFSWG NQENLPPALG 
       210        220        230        240        250
KIANGGGTGA GKAECGYETE SHLLEPHEIP LNVNTHKFSD CEFPYEFCTV 
       260        270        280        290        300
CFSPFKLLGM SGVEGVWNQH SRSASMHTFL NHSATGIREA GCRKDMPVSE 
       310        320        330        340        350
MAEDGSEEIM FIWCEDCSQY HDSECPELGP VVMVKDSFVL SRARSWPASG 
       360        370        380        390        400
HVHTQAGQGM RGYEDRDRAD PQQLPEAVPA GLVRRLSGQQ LPCRSTLTWG 
       410        420        430        440        450
RLCHLVAQGR SSLPPNLEIR RLEDGAEGVF AITQLVKRTQ FGPFESRRVA 
       460        470        480        490        500
KWEKESAFPL KVFQKDGHPV CFDTSNEDDC NWMMLVRPAA EAEHQNLTAY 
       510        520        530        540        550
QHGSDVYFTT SRDIPPGTEL RVWYAAFYAK KMDKPMLKQA GSGVHAAGTP 
       560        570        580        590        600
ENSAPVESEP SQWACKVCSA TFLELQLLNE HLLGHLEQAK SLPPGSQSEA 
       610        620        630        640        650
AAPEKEQDTP RGEPPAVPES ENVATKEQKK KPRRGRKPKV SKAEQPLVIV 
       660        670        680        690        700
EDKEPTEQVA EIITEVPPDE PVSATPDERI MELVLGKLAT TTTDTSSVPK 
       710        720        730        740        750
FTHHQNNTIT LKRSLILSSR HGIRRKLIKQ LGEHKRVYQC NICSKIFQNS 
       760        770        780        790        800
SNLSRHVRSH GDKLFKCEEC AKLFSRKESL KQHVSYKHSR NEVDGEYRYR 
       810        820        830        840        850
CGTCEKTFRI ESALEFHNCR TDDKTFQCEM CFRFFSTNSN LSKHKKKHGD 
       860        870        880        890        900
KKFACEVCSK MFYRKDVMLD HQRRHLEGVR RVKREDLEAG GENLVRYKKE 
       910        920        930        940        950
PSGCPVCGKV FSCRSNMNKH LLTHGDKKYT CEICGRKFFR VDVLRDHIHV 
       960        970        980        990       1000
HFKDIALMDD HQREEFIGKI GISSEENDDN SDESADSEPH KYSCKRCQLT 
      1010       1020       1030       1040       1050
FGRGKEYLKH IMEVHKEKGY GCSICNRRFA LKATYHAHMV IHRENLPDPN 
      1060       1070       1080       1090       1100
VQKYIHPCEI CGRIFNSIGN LERHKLIHTG VKSHACEQCG KSFARKDMLK 
      1110       1120       1130       1140       1150
EHMRVHDNVR EYLCAECGKG MKTKHALRHH MKLHKGIKEY ECKECHRRFA 
      1160       1170       1180       1190       1200
QKVNMLKHCK RHTGIKDFMC ELCGKTFSER NTMETHKLIH TVGKQWTCSV 
      1210       1220       1230       1240       1250
CDKKYVTEYM LQKHVQLTHD KVEAQSCQLC GTKVSTRASM SRHMRRKHPE 
      1260       1270       1280       1290       1300
VLAVRIDDLD HLPETTTIDA SSIGIVQPEL TLEQEDLAEG KHGKAAKRSH 
      1310       1320       1330       1340       1350
KRKQKPEEEA GAPVPEDATF SEYSEKETEF TGSVGDETNS AVQSIQQVVV 
      1360       1370       1380       1390       1400
TLGDPNVTTP SSSVGLTNIT VTPITTAAAT QFTNLQPVAV GHLTTPERQL 
      1410       1420       1430       1440       1450
QLDNSILTVT FDTVSGSAML HNRQNDVQIH PQPEASNPQS VAHFINLTTL 
      1460       1470       1480       1490       1500
VNSITPLGSQ LSDQHPLTWR AVPQTDVLPP SQPQAPPQQA AQPQVQAEQQ 

QQQMYSY

Length:1,507

Mass (Da):169,269

Last modified:November 28, 2006 - v4

Checksum:ⁱE980A7EDB97239D0

Isoform 2 (identifier: P57071-2) [UniParc]FASTA Add to basket

Also known as: ZNF298b

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     821-821: T → TGLIAHPGEGGPGGSRLRDLP

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        10         20         30         40         50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQVSEMAE DGSEEIMFIW 
        60         70         80         90        100
CEDCSQYHDS ECPELGPVVM VKDSFVLSRA RSSLPPNLEI RRLEDGAEGV 
       110        120        130        140        150
FAITQLVKRT QFGPFESRRV AKWEKESAFP LKVFQKDGHP VCFDTSNEDD 
       160        170        180        190        200
CNWMMLVRPA AEAEHQNLTA YQHGSDVYFT TSRDIPPGTE LRVWYAAFYA 
       210        220        230        240        250
KKMDKPMLKQ AGSGVHAAGT PENSAPVESE PSQWACKVCS ATFLELQLLN 
       260        270        280        290        300
EHLLGHLEQA KSLPPGSQSE AAAPEKEQDT PRGEPPAVPE SENVATKEQK 
       310        320        330        340        350
KKPRRGRKPK VSKAEQPLVI VEDKEPTEQV AEIITEVPPD EPVSATPDER 
       360        370        380        390        400
IMELVLGKLA TTTTDTSSVP KFTHHQNNTI TLKRSLILSS RHGIRRKLIK 
       410        420        430        440        450
QLGEHKRVYQ CNICSKIFQN SSNLSRHVRS HGDKLFKCEE CAKLFSRKES 
       460        470        480        490        500
LKQHVSYKHS RNEVDGEYRY RCGTCEKTFR IESALEFHNC RTGLIAHPGE 
       510        520        530        540        550
GGPGGSRLRD LPDDKTFQCE MCFRFFSTNS NLSKHKKKHG DKKFACEVCS 
       560        570        580        590        600
KMFYRKDVML DHQRRHLEGV RRVKREDLEA GGENLVRYKK EPSGCPVCGK 
       610        620        630        640        650
VFSCRSNMNK HLLTHGDKKY TCEICGRKFF RVDVLRDHIH VHFKDIALMD 
       660        670        680        690        700
DHQREEFIGK IGISSEENDD NSDESADSEP HKYSCKRCQL TFGRGKEYLK 
       710        720        730        740        750
HIMEVHKEKG YGCSICNRRF ALKATYHAHM VIHRENLPDP NVQKYIHPCE 
       760        770        780        790        800
ICGRIFNSIG NLERHKLIHT GVKSHACEQC GKSFARKDML KEHMRVHDNV 
       810        820        830        840        850
REYLCAECGK GMKTKHALRH HMKLHKGIKE YECKECHRRF AQKVNMLKHC 
       860        870        880        890        900
KRHTGIKDFM CELCGKTFSE RNTMETHKLI HTVGKQWTCS VCDKKYVTEY 
       910        920        930        940        950
MLQKHVQLTH DKVEAQSCQL CGTKVSTRAS MSRHMRRKHP EVLAVRIDDL 
       960        970        980        990       1000
DHLPETTTID ASSIGIVQPE LTLEQEDLAE GKHGKAAKRS HKRKQKPEEE 
      1010       1020       1030       1040       1050
AGAPVPEDAT FSEYSEKETE FTGSVGDETN SAVQSIQQVV VTLGDPNVTT 
      1060       1070       1080       1090       1100
PSSSVGLTNI TVTPITTAAA TQFTNLQPVA VGHLTTPERQ LQLDNSILTV 
      1110       1120       1130       1140       1150
TFDTVSGSAM LHNRQNDVQI HPQPEASNPQ SVAHFINLTT LVNSITPLGS 
      1160       1170       1180       1190 
QLSDQHPLTW RAVPQTDVLP PSQPQAPPQQ AAQPQVQAEQ QQQQMYSY

Show »

Length:1,198

Mass (Da):135,670

Checksum:ⁱ6EEA445CDDCA07A7

Isoform 3 (identifier: P57071-3) [UniParc]FASTA Add to basket

Also known as: ZNF298a

The sequence of this isoform differs from the canonical sequence as follows:
35-297: Missing.
344-409: Missing.

« Hide

        10         20         30         40         50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQVSEMAE DGSEEIMFIW 
        60         70         80         90        100
CEDCSQYHDS ECPELGPVVM VKDSFVLSRA RSSLPPNLEI RRLEDGAEGV 
       110        120        130        140        150
FAITQLVKRT QFGPFESRRV AKWEKESAFP LKVFQKDGHP VCFDTSNEDD 
       160        170        180        190        200
CNWMMLVRPA AEAEHQNLTA YQHGSDVYFT TSRDIPPGTE LRVWYAAFYA 
       210        220        230        240        250
KKMDKPMLKQ AGSGVHAAGT PENSAPVESE PSQWACKVCS ATFLELQLLN 
       260        270        280        290        300
EHLLGHLEQA KSLPPGSQSE AAAPEKEQDT PRGEPPAVPE SENVATKEQK 
       310        320        330        340        350
KKPRRGRKPK VSKAEQPLVI VEDKEPTEQV AEIITEVPPD EPVSATPDER 
       360        370        380        390        400
IMELVLGKLA TTTTDTSSVP KFTHHQNNTI TLKRSLILSS RHGIRRKLIK 
       410        420        430        440        450
QLGEHKRVYQ CNICSKIFQN SSNLSRHVRS HGDKLFKCEE CAKLFSRKES 
       460        470        480        490        500
LKQHVSYKHS RNEVDGEYRY RCGTCEKTFR IESALEFHNC RTDDKTFQCE 
       510        520        530        540        550
MCFRFFSTNS NLSKHKKKHG DKKFACEVCS KMFYRKDVML DHQRRHLEGV 
       560        570        580        590        600
RRVKREDLEA GGENLVRYKK EPSGCPVCGK VFSCRSNMNK HLLTHGDKKY 
       610        620        630        640        650
TCEICGRKFF RVDVLRDHIH VHFKDIALMD DHQREEFIGK IGISSEENDD 
       660        670        680        690        700
NSDESADSEP HKYSCKRCQL TFGRGKEYLK HIMEVHKEKG YGCSICNRRF 
       710        720        730        740        750
ALKATYHAHM VIHRENLPDP NVQKYIHPCE ICGRIFNSIG NLERHKLIHT 
       760        770        780        790        800
GVKSHACEQC GKSFARKDML KEHMRVHDNV REYLCAECGK GMKTKHALRH 
       810        820        830        840        850
HMKLHKGIKE YECKECHRRF AQKVNMLKHC KRHTGIKDFM CELCGKTFSE 
       860        870        880        890        900
RNTMETHKLI HTVGKQWTCS VCDKKYVTEY MLQKHVQLTH DKVEAQSCQL 
       910        920        930        940        950
CGTKVSTRAS MSRHMRRKHP EVLAVRIDDL DHLPETTTID ASSIGIVQPE 
       960        970        980        990       1000
LTLEQEDLAE GKHGKAAKRS HKRKQKPEEE AGAPVPEDAT FSEYSEKETE 
      1010       1020       1030       1040       1050
FTGSVGDETN SAVQSIQQVV VTLGDPNVTT PSSSVGLTNI TVTPITTAAA 
      1060       1070       1080       1090       1100
TQFTNLQPVA VGHLTTPERQ LQLDNSILTV TFDTVSGSAM LHNRQNDVQI 
      1110       1120       1130       1140       1150
HPQPEASNPQ SVAHFINLTT LVNSITPLGS QLSDQHPLTW RAVPQTDVLP 
      1160       1170 
PSQPQAPPQQ AAQPQVQAEQ QQQQMYSY

Show »

Length:1,178

Mass (Da):133,732

Checksum:ⁱ6F51396D6B31F50B

Isoform 4 (identifier: P57071-5) [UniParc]FASTA Add to basket

Also known as: ZNF298c

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     822-884: DDKTFQCEMC...HLEGVRRVKR → GLIAHPGEGG...SAGTWKECGE
     885-1507: Missing.

« Hide

        10         20         30         40         50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQVSEMAE DGSEEIMFIW 
        60         70         80         90        100
CEDCSQYHDS ECPELGPVVM VKDSFVLSRA RSSLPPNLEI RRLEDGAEGV 
       110        120        130        140        150
FAITQLVKRT QFGPFESRRV AKWEKESAFP LKVFQKDGHP VCFDTSNEDD 
       160        170        180        190        200
CNWMMLVRPA AEAEHQNLTA YQHGSDVYFT TSRDIPPGTE LRVWYAAFYA 
       210        220        230        240        250
KKMDKPMLKQ AGSGVHAAGT PENSAPVESE PSQWACKVCS ATFLELQLLN 
       260        270        280        290        300
EHLLGHLEQA KSLPPGSQSE AAAPEKEQDT PRGEPPAVPE SENVATKEQK 
       310        320        330        340        350
KKPRRGRKPK VSKAEQPLVI VEDKEPTEQV AEIITEVPPD EPVSATPDER 
       360        370        380        390        400
IMELVLGKLA TTTTDTSSVP KFTHHQNNTI TLKRSLILSS RHGIRRKLIK 
       410        420        430        440        450
QLGEHKRVYQ CNICSKIFQN SSNLSRHVRS HGDKLFKCEE CAKLFSRKES 
       460        470        480        490        500
LKQHVSYKHS RNEVDGEYRY RCGTCEKTFR IESALEFHNC RTGLIAHPGE 
       510        520        530        540        550
GGPGGSRLRD LPATSPSTRR STATRSLPVR SAARCSTART SCWTTSAGTW 

KECGE

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:555

Mass (Da):62,097

Checksum:ⁱ7676D13685BAC4C8

Isoform 5 (identifier: P57071-6) [UniParc]FASTA Add to basket

Also known as: ZNF298d

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     701-720: Missing.
     822-864: DDKTFQCEMC...CEVCSKMFYR → ATSPSTRRST...SAGTWKECGE
     865-1507: Missing.

« Hide

        10         20         30         40         50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQVSEMAE DGSEEIMFIW 
        60         70         80         90        100
CEDCSQYHDS ECPELGPVVM VKDSFVLSRA RSSLPPNLEI RRLEDGAEGV 
       110        120        130        140        150
FAITQLVKRT QFGPFESRRV AKWEKESAFP LKVFQKDGHP VCFDTSNEDD 
       160        170        180        190        200
CNWMMLVRPA AEAEHQNLTA YQHGSDVYFT TSRDIPPGTE LRVWYAAFYA 
       210        220        230        240        250
KKMDKPMLKQ AGSGVHAAGT PENSAPVESE PSQWACKVCS ATFLELQLLN 
       260        270        280        290        300
EHLLGHLEQA KSLPPGSQSE AAAPEKEQDT PRGEPPAVPE SENVATKEQK 
       310        320        330        340        350
KKPRRGRKPK VSKAEQPLVI VEDKEPTEQV AEIITEVPPD EPVSATPDER 
       360        370        380        390        400
IMELVLGKLA TTTTDTSSVP KHGIRRKLIK QLGEHKRVYQ CNICSKIFQN 
       410        420        430        440        450
SSNLSRHVRS HGDKLFKCEE CAKLFSRKES LKQHVSYKHS RNEVDGEYRY 
       460        470        480        490        500
RCGTCEKTFR IESALEFHNC RTATSPSTRR STATRSLPVR SAARCSTART 
       510 
SCWTTSAGTW KECGE

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:515

Mass (Da):57,810

Checksum:ⁱ44CC7B8E12AE587A

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	E7ER26	E7ER26_HUMAN		PR domain zinc finger protein 15 PR domain zinc finger protein 15	PRDM15	1,141	Annotation score:
	Q4W8S1	Q4W8S1_HUMAN		PR domain zinc finger protein 15 PR domain zinc finger protein 15 (Zinc finger protein ZNF298d)	PRDM15 ZNF298	478	Annotation score:

Sequence cautionⁱ

The sequence AAL60596 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAM53515 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated

The sequence AAM53516 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated

The sequence BAA95527 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence BAD99015 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAD99016 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAD99017 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAD99018 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated

The sequence BAD99020 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1147	R → G in AAL60596 (PubMed:12036297).Curated		1
Sequence conflictⁱ	1167	D → I in AAL60596 (PubMed:12036297).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014992	1342	V → I. Corresponds to variant dbSNP:rs3819158Ensembl.	1
Natural variantⁱVAR_014993	1376	T → S. Corresponds to variant dbSNP:rs2236695Ensembl.	1
Natural variantⁱVAR_014994	1481	S → P3 PublicationsCorresponds to variant dbSNP:rs3850706Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055110	35 – 297	Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST	263
Alternative sequenceⁱVSP_055111	344 – 409	Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST	66
Alternative sequenceⁱVSP_055112	701 – 720	Missing in isoform 5. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_055113	821	T → TGLIAHPGEGGPGGSRLRDL P in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_055114	822 – 884	DDKTF…RRVKR → GLIAHPGEGGPGGSRLRDLP ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 4. 1 PublicationAdd BLAST	63
Alternative sequenceⁱVSP_055115	822 – 864	DDKTF…KMFYR → ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 5. 1 PublicationAdd BLAST	43
Alternative sequenceⁱVSP_055116	865 – 1507	Missing in isoform 5. 1 PublicationAdd BLAST	643
Alternative sequenceⁱVSP_055117	885 – 1507	Missing in isoform 4. 1 PublicationAdd BLAST	623

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY078498 mRNA Translation: AAL85487.2 AB051812 mRNA Translation: BAD99015.1 Different initiation. AB051813 mRNA Translation: BAD99016.1 Different initiation. AB051814 mRNA Translation: BAD99017.1 Different initiation. AB051814 mRNA Translation: BAD99018.1 Sequence problems. AB051815 mRNA Translation: BAD99020.1 Sequence problems. AB126081 Genomic DNA No translation available. AP001580 Genomic DNA No translation available. AP001618 Genomic DNA No translation available. AP001619 Genomic DNA No translation available. AP001745 Genomic DNA Translation: BAA95527.1 Sequence problems. AP002955 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09585.1 AF276513 mRNA Translation: AAF78093.1 AY063456 mRNA Translation: AAL60596.1 Different initiation. AF426259 mRNA Translation: AAM53515.1 Sequence problems. AF426260 mRNA Translation: AAM53516.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13676.1 [P57071-1] CCDS42932.1 [P57071-3] CCDS63370.1 [P57071-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035514.1, NM_001040424.2 [P57071-3] NP_001269863.1, NM_001282934.1 [P57071-2] NP_071398.3, NM_022115.4 [P57071-1]
UniGeneⁱ	Hs.473893 Hs.726680

Genome annotation databases

Ensemblⁱ	ENST00000269844; ENSP00000269844; ENSG00000141956 [P57071-1] ENST00000398548; ENSP00000381556; ENSG00000141956 [P57071-3] ENST00000422911; ENSP00000408592; ENSG00000141956 [P57071-2] ENST00000433067; ENSP00000415471; ENSG00000141956 [P57071-1] ENST00000449395; ENSP00000396943; ENSG00000141956 [P57071-5]
GeneIDⁱ	63977
KEGGⁱ	hsa:63977
UCSC genome browser More...UCSCⁱ	uc002yzo.4 human [P57071-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P57071	PRDM15 isoform 10		PANTR		1519	UniRef90_P57071
PRDM15 isoform 10		PONAB		1517
PR/SET domain 15		PANPA		1469
PR/SET domain 15		MANLE		1384
PR/SET domain 15		GORGO		1368
+1
P57071-2	PR/SET domain 15		Cebus capucinus imitator		1201	UniRef90_P57071-2
PR/SET domain 15		PANTR		1197
PR/SET domain 15		PANPA		1163
PRDM15 isoform 8		PONAB		1197
PR/SET domain 15		CERAT		1197
+38
P57071-3	PR/SET domain 15		Cebus capucinus imitator		1181	UniRef90_P57071-3
PRDM15 isoform 3		PONAB		1177
PR/SET domain 15		PANTR		1177
PR/SET domain 15		PANPA		1140
PR/SET domain 15		MACFA		1177
+33
P57071-5	PRDM15 isoform 6		PANTR		555	UniRef90_A0A2J8M872
PRDM15 isoform 6		PONAB		555
UPI000732A165		MACMU		513
P57071-6	PR domain zinc finger protein 15		HUMAN		478	UniRef90_Q4W8S1
PRDM15 isoform 1		PANTR		478
PR/SET domain 15		COLAP		484
PRDM15 isoform 1		PONAB		478
Uncharacterized protein		MACMU		460

Protein	Similar proteins		Species	Score	Length	Source
P57071	PRDM15 isoform 10		PANTR		1519	UniRef50_P57071
PRDM15 isoform 10		PONAB		1517
PR/SET domain 15		PANPA		1469
PR/SET domain 15		MANLE		1384
PR/SET domain 15		GORGO		1368
+4
P57071-2	PR/SET domain 15		Cebus capucinus imitator		1201	UniRef50_P57071-2
PR/SET domain 15		PAPAN		1197
PR/SET domain 15		PANTR		1197
PR/SET domain 15		PANPA		1163
PRDM15 isoform 8		PONAB		1197
+40
P57071-3	PR domain zinc finger protein 15		MOUSE		1174	UniRef50_P57071-3
PR/SET domain 15		Cebus capucinus imitator		1181
PR/SET domain 15		PANTR		1177
PR/SET domain 15		PANPA		1140
PRDM15 isoform 3		PONAB		1177
+256
P57071-5	PR domain zinc finger protein 15		MOUSE		474	UniRef50_D6RIL7
Uncharacterized protein		MACMU		460
PR/SET domain 15		COLAP		484
PRDM15 isoform 1		PONAB		478
PR domain zinc finger protein 15		HUMAN		478
+5
P57071-6	PR domain zinc finger protein 15		MOUSE		474	UniRef50_D6RIL7
Uncharacterized protein		MACMU		460
PR/SET domain 15		COLAP		484
PRDM15 isoform 1		PONAB		478
PR domain zinc finger protein 15		HUMAN		478
+5

Entry informationⁱ

Entry nameⁱ	PRD15_HUMAN
Accessionⁱ	P57071Primary (citable) accession number: P57071 Secondary accession number(s): E9PDJ6 Q9NQV3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 28, 2006
	Last modified:	September 12, 2018
	This is version 174 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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Supporting data

UniProtKB - P57071 (PRD15_HUMAN)

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PR domain zinc finger protein 15

PRDM15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ