UniProtKB - P57071 (PRD15_HUMAN)
PR domain zinc finger protein 15
PRDM15
Functioni
Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity).
Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 563 – 585 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 738 – 760 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 765 – 788 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 826 – 848 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 853 – 875 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 902 – 924 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 929 – 951 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 992 – 1015 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1020 – 1042 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1056 – 1078 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1084 – 1106 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1112 – 1134 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1140 – 1162 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1168 – 1190 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1196 – 1219 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1225 – 1248 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- methyltransferase activity Source: UniProtKB-KW
- promoter-specific chromatin binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- methylation Source: UniProtKB-KW
- negative regulation of MAPK cascade Source: UniProtKB
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of stem cell division Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding, Methyltransferase, Repressor, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, S-adenosyl-L-methionine, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P57071 |
SignaLinki | P57071 |
Names & Taxonomyi
Protein namesi | Recommended name: PR domain zinc finger protein 15Curated (EC:2.1.1.-Curated)Alternative name(s): PR domain-containing protein 15Curated Zinc finger protein 298 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13999, PRDM15 |
MIMi | 617692, gene |
neXtProti | NX_P57071 |
VEuPathDBi | HostDB:ENSG00000141956 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 63977 |
PharmGKBi | PA33713 |
Miscellaneous databases
Pharosi | P57071, Tbio |
Genetic variation databases
BioMutai | PRDM15 |
DMDMi | 118572696 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047772 | 1 – 1507 | PR domain zinc finger protein 15Add BLAST | 1507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 883 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P57071 |
jPOSTi | P57071 |
MassIVEi | P57071 |
MaxQBi | P57071 |
PaxDbi | P57071 |
PeptideAtlasi | P57071 |
PRIDEi | P57071 |
ProteomicsDBi | 19680 20018 20339 56980 [P57071-1] |
PTM databases
iPTMneti | P57071 |
PhosphoSitePlusi | P57071 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000141956, Expressed in sural nerve and 186 other tissues |
ExpressionAtlasi | P57071, baseline and differential |
Genevisiblei | P57071, HS |
Organism-specific databases
HPAi | ENSG00000141956, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122024, 74 interactors |
IntActi | P57071, 10 interactors |
MINTi | P57071 |
STRINGi | 9606.ENSP00000269844 |
Miscellaneous databases
RNActi | P57071, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 415 – 525 | SETPROSITE-ProRule annotationAdd BLAST | 111 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 77 – 105 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 590 – 649 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 970 – 989 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1288 – 1339 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1474 – 1507 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 82 – 101 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1488 – 1507 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 563 – 585 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 738 – 760 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 765 – 788 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 826 – 848 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 853 – 875 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 902 – 924 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 929 – 951 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 992 – 1015 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1020 – 1042 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1056 – 1078 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1084 – 1106 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1112 – 1134 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1140 – 1162 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1168 – 1190 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1196 – 1219 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1225 – 1248 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | P57071 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P57071 |
TreeFami | TF331419 |
Family and domain databases
CDDi | cd19199, PR-SET_PRDM15, 1 hit |
InterProi | View protein in InterPro IPR044409, PRDM15_PR-SET IPR001214, SET_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 17 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit PS00028, ZINC_FINGER_C2H2_1, 16 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQPRAAPV QPPCRLFFVT
60 70 80 90 100
FAGCGHRWRS ESKPGWISRS RSGIALRAAR PPGSSPPRPA APRPPPPGGV
110 120 130 140 150
VAEAPGDVVI PRPRVQPMRV ARGGPWTPNP AFREAESWSQ IGNQRVSEQL
160 170 180 190 200
LETSLGNEVS DTEPLSPASA GLRRNPALPP GPFAQNFSWG NQENLPPALG
210 220 230 240 250
KIANGGGTGA GKAECGYETE SHLLEPHEIP LNVNTHKFSD CEFPYEFCTV
260 270 280 290 300
CFSPFKLLGM SGVEGVWNQH SRSASMHTFL NHSATGIREA GCRKDMPVSE
310 320 330 340 350
MAEDGSEEIM FIWCEDCSQY HDSECPELGP VVMVKDSFVL SRARSWPASG
360 370 380 390 400
HVHTQAGQGM RGYEDRDRAD PQQLPEAVPA GLVRRLSGQQ LPCRSTLTWG
410 420 430 440 450
RLCHLVAQGR SSLPPNLEIR RLEDGAEGVF AITQLVKRTQ FGPFESRRVA
460 470 480 490 500
KWEKESAFPL KVFQKDGHPV CFDTSNEDDC NWMMLVRPAA EAEHQNLTAY
510 520 530 540 550
QHGSDVYFTT SRDIPPGTEL RVWYAAFYAK KMDKPMLKQA GSGVHAAGTP
560 570 580 590 600
ENSAPVESEP SQWACKVCSA TFLELQLLNE HLLGHLEQAK SLPPGSQSEA
610 620 630 640 650
AAPEKEQDTP RGEPPAVPES ENVATKEQKK KPRRGRKPKV SKAEQPLVIV
660 670 680 690 700
EDKEPTEQVA EIITEVPPDE PVSATPDERI MELVLGKLAT TTTDTSSVPK
710 720 730 740 750
FTHHQNNTIT LKRSLILSSR HGIRRKLIKQ LGEHKRVYQC NICSKIFQNS
760 770 780 790 800
SNLSRHVRSH GDKLFKCEEC AKLFSRKESL KQHVSYKHSR NEVDGEYRYR
810 820 830 840 850
CGTCEKTFRI ESALEFHNCR TDDKTFQCEM CFRFFSTNSN LSKHKKKHGD
860 870 880 890 900
KKFACEVCSK MFYRKDVMLD HQRRHLEGVR RVKREDLEAG GENLVRYKKE
910 920 930 940 950
PSGCPVCGKV FSCRSNMNKH LLTHGDKKYT CEICGRKFFR VDVLRDHIHV
960 970 980 990 1000
HFKDIALMDD HQREEFIGKI GISSEENDDN SDESADSEPH KYSCKRCQLT
1010 1020 1030 1040 1050
FGRGKEYLKH IMEVHKEKGY GCSICNRRFA LKATYHAHMV IHRENLPDPN
1060 1070 1080 1090 1100
VQKYIHPCEI CGRIFNSIGN LERHKLIHTG VKSHACEQCG KSFARKDMLK
1110 1120 1130 1140 1150
EHMRVHDNVR EYLCAECGKG MKTKHALRHH MKLHKGIKEY ECKECHRRFA
1160 1170 1180 1190 1200
QKVNMLKHCK RHTGIKDFMC ELCGKTFSER NTMETHKLIH TVGKQWTCSV
1210 1220 1230 1240 1250
CDKKYVTEYM LQKHVQLTHD KVEAQSCQLC GTKVSTRASM SRHMRRKHPE
1260 1270 1280 1290 1300
VLAVRIDDLD HLPETTTIDA SSIGIVQPEL TLEQEDLAEG KHGKAAKRSH
1310 1320 1330 1340 1350
KRKQKPEEEA GAPVPEDATF SEYSEKETEF TGSVGDETNS AVQSIQQVVV
1360 1370 1380 1390 1400
TLGDPNVTTP SSSVGLTNIT VTPITTAAAT QFTNLQPVAV GHLTTPERQL
1410 1420 1430 1440 1450
QLDNSILTVT FDTVSGSAML HNRQNDVQIH PQPEASNPQS VAHFINLTTL
1460 1470 1480 1490 1500
VNSITPLGSQ LSDQHPLTWR AVPQTDVLPP SQPQAPPQQA AQPQVQAEQQ
QQQMYSY
The sequence of this isoform differs from the canonical sequence as follows:
35-297: Missing.
344-409: Missing.
822-884: DDKTFQCEMC...HLEGVRRVKR → GLIAHPGEGG...SAGTWKECGE
885-1507: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
35-297: Missing.
344-409: Missing.
701-720: Missing.
822-864: DDKTFQCEMC...CEVCSKMFYR → ATSPSTRRST...SAGTWKECGE
865-1507: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ER26 | E7ER26_HUMAN | PR domain zinc finger protein 15 | PRDM15 | 1,141 | Annotation score: | ||
Q4W8S1 | Q4W8S1_HUMAN | PR domain zinc finger protein 15 | PRDM15 ZNF298 | 478 | Annotation score: | ||
A0A6Q8PFK1 | A0A6Q8PFK1_HUMAN | PR domain zinc finger protein 15 | PRDM15 | 173 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1147 | R → G in AAL60596 (PubMed:12036297).Curated | 1 | |
Sequence conflicti | 1167 | D → I in AAL60596 (PubMed:12036297).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014992 | 1342 | V → I. Corresponds to variant dbSNP:rs3819158Ensembl. | 1 | |
Natural variantiVAR_014993 | 1376 | T → S. Corresponds to variant dbSNP:rs2236695Ensembl. | 1 | |
Natural variantiVAR_014994 | 1481 | S → P3 PublicationsCorresponds to variant dbSNP:rs3850706Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055110 | 35 – 297 | Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST | 263 | |
Alternative sequenceiVSP_055111 | 344 – 409 | Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_055112 | 701 – 720 | Missing in isoform 5. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_055113 | 821 | T → TGLIAHPGEGGPGGSRLRDL P in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_055114 | 822 – 884 | DDKTF…RRVKR → GLIAHPGEGGPGGSRLRDLP ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 4. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_055115 | 822 – 864 | DDKTF…KMFYR → ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 5. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_055116 | 865 – 1507 | Missing in isoform 5. 1 PublicationAdd BLAST | 643 | |
Alternative sequenceiVSP_055117 | 885 – 1507 | Missing in isoform 4. 1 PublicationAdd BLAST | 623 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY078498 mRNA Translation: AAL85487.2 AB051812 mRNA Translation: BAD99015.1 Different initiation. AB051813 mRNA Translation: BAD99016.1 Different initiation. AB051814 mRNA Translation: BAD99017.1 Different initiation. AB051814 mRNA Translation: BAD99018.1 Sequence problems. AB051815 mRNA Translation: BAD99020.1 Sequence problems. AB126081 Genomic DNA No translation available. AP001580 Genomic DNA No translation available. AP001618 Genomic DNA No translation available. AP001619 Genomic DNA No translation available. AP001745 Genomic DNA Translation: BAA95527.1 Sequence problems. AP002955 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09585.1 AF276513 mRNA Translation: AAF78093.1 AY063456 mRNA Translation: AAL60596.1 Different initiation. AF426259 mRNA Translation: AAM53515.1 Sequence problems. AF426260 mRNA Translation: AAM53516.1 Sequence problems. |
RefSeqi | NP_001035514.1, NM_001040424.2 NP_001269863.1, NM_001282934.1 NP_071398.3, NM_022115.4 |
Genome annotation databases
Ensembli | ENST00000269844; ENSP00000269844; ENSG00000141956 ENST00000398548; ENSP00000381556; ENSG00000141956 ENST00000422911; ENSP00000408592; ENSG00000141956 ENST00000449395; ENSP00000396943; ENSG00000141956 |
GeneIDi | 63977 |
KEGGi | hsa:63977 |
UCSCi | uc002yzo.4, human [P57071-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY078498 mRNA Translation: AAL85487.2 AB051812 mRNA Translation: BAD99015.1 Different initiation. AB051813 mRNA Translation: BAD99016.1 Different initiation. AB051814 mRNA Translation: BAD99017.1 Different initiation. AB051814 mRNA Translation: BAD99018.1 Sequence problems. AB051815 mRNA Translation: BAD99020.1 Sequence problems. AB126081 Genomic DNA No translation available. AP001580 Genomic DNA No translation available. AP001618 Genomic DNA No translation available. AP001619 Genomic DNA No translation available. AP001745 Genomic DNA Translation: BAA95527.1 Sequence problems. AP002955 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09585.1 AF276513 mRNA Translation: AAF78093.1 AY063456 mRNA Translation: AAL60596.1 Different initiation. AF426259 mRNA Translation: AAM53515.1 Sequence problems. AF426260 mRNA Translation: AAM53516.1 Sequence problems. |
RefSeqi | NP_001035514.1, NM_001040424.2 NP_001269863.1, NM_001282934.1 NP_071398.3, NM_022115.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122024, 74 interactors |
IntActi | P57071, 10 interactors |
MINTi | P57071 |
STRINGi | 9606.ENSP00000269844 |
PTM databases
iPTMneti | P57071 |
PhosphoSitePlusi | P57071 |
Genetic variation databases
BioMutai | PRDM15 |
DMDMi | 118572696 |
Proteomic databases
EPDi | P57071 |
jPOSTi | P57071 |
MassIVEi | P57071 |
MaxQBi | P57071 |
PaxDbi | P57071 |
PeptideAtlasi | P57071 |
PRIDEi | P57071 |
ProteomicsDBi | 19680 20018 20339 56980 [P57071-1] |
Protocols and materials databases
Antibodypediai | 9262, 102 antibodies from 20 providers |
DNASUi | 63977 |
Genome annotation databases
Ensembli | ENST00000269844; ENSP00000269844; ENSG00000141956 ENST00000398548; ENSP00000381556; ENSG00000141956 ENST00000422911; ENSP00000408592; ENSG00000141956 ENST00000449395; ENSP00000396943; ENSG00000141956 |
GeneIDi | 63977 |
KEGGi | hsa:63977 |
UCSCi | uc002yzo.4, human [P57071-1] |
Organism-specific databases
CTDi | 63977 |
DisGeNETi | 63977 |
GeneCardsi | PRDM15 |
HGNCi | HGNC:13999, PRDM15 |
HPAi | ENSG00000141956, Low tissue specificity |
MIMi | 617692, gene |
neXtProti | NX_P57071 |
PharmGKBi | PA33713 |
VEuPathDBi | HostDB:ENSG00000141956 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | P57071 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P57071 |
TreeFami | TF331419 |
Enzyme and pathway databases
PathwayCommonsi | P57071 |
SignaLinki | P57071 |
Miscellaneous databases
BioGRID-ORCSi | 63977, 22 hits in 1071 CRISPR screens |
ChiTaRSi | PRDM15, human |
GenomeRNAii | 63977 |
Pharosi | P57071, Tbio |
PROi | PR:P57071 |
RNActi | P57071, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141956, Expressed in sural nerve and 186 other tissues |
ExpressionAtlasi | P57071, baseline and differential |
Genevisiblei | P57071, HS |
Family and domain databases
CDDi | cd19199, PR-SET_PRDM15, 1 hit |
InterProi | View protein in InterPro IPR044409, PRDM15_PR-SET IPR001214, SET_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 17 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit PS00028, ZINC_FINGER_C2H2_1, 16 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PRD15_HUMAN | |
Accessioni | P57071Primary (citable) accession number: P57071 Secondary accession number(s): E9PDJ6 Q9NQV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 28, 2006 | |
Last modified: | February 23, 2022 | |
This is version 195 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families