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UniProtKB - P57071 (PRD15_HUMAN)

Protein

PR domain zinc finger protein 15

Gene

PRDM15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri563 – 585C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 788C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri826 – 848C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri853 – 875C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri902 – 924C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 951C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri992 – 1015C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1020 – 1042C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1056 – 1078C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1084 – 1106C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1112 – 1134C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1140 – 1162C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1168 – 1190C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1196 – 1219C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1225 – 1248C2H2-type 16PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 15Curated (EC:2.1.1.-Curated)
Alternative name(s):
PR domain-containing protein 15Curated
Zinc finger protein 298
Gene namesi
Name:PRDM15Imported
Synonyms:C21orf83Imported, ZNF298Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000141956.13
HGNCiHGNC:13999 PRDM15
MIMi617692 gene
neXtProtiNX_P57071

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi63977
OpenTargetsiENSG00000141956
PharmGKBiPA33713

Polymorphism and mutation databases

BioMutaiPRDM15
DMDMi118572696

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477721 – 1507PR domain zinc finger protein 15Add BLAST1507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki883Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP57071
MaxQBiP57071
PaxDbiP57071
PeptideAtlasiP57071
PRIDEiP57071
ProteomicsDBi56980

PTM databases

iPTMnetiP57071
PhosphoSitePlusiP57071

Expressioni

Tissue specificityi

Detected in all tissues examined.1 Publication

Developmental stagei

Expressed in fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000141956 Expressed in 168 organ(s), highest expression level in cerebellum
CleanExiHS_PRDM15
ExpressionAtlasiP57071 baseline and differential
GenevisibleiP57071 HS

Organism-specific databases

HPAiHPA024268
HPA029255
HPA029256

Interactioni

Protein-protein interaction databases

BioGridi122024, 19 interactors
IntActiP57071, 1 interactor
MINTiP57071
STRINGi9606.ENSP00000269844

Structurei

3D structure databases

ProteinModelPortaliP57071
SMRiP57071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini415 – 525SETPROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 97Poly-Pro6
Compositional biasi690 – 695Poly-Thr6
Compositional biasi1499 – 1503Poly-Gln5

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri563 – 585C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 788C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri826 – 848C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri853 – 875C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri902 – 924C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 951C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri992 – 1015C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1020 – 1042C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1056 – 1078C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1084 – 1106C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1112 – 1134C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1140 – 1162C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1168 – 1190C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1196 – 1219C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1225 – 1248C2H2-type 16PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149092
HOGENOMiHOG000115685
HOVERGENiHBG093153
InParanoidiP57071
OMAiHGCSICN
OrthoDBiEOG091G02KC
PhylomeDBiP57071
TreeFamiTF331419

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P57071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQPRAAPV QPPCRLFFVT 
        60         70         80         90        100
FAGCGHRWRS ESKPGWISRS RSGIALRAAR PPGSSPPRPA APRPPPPGGV 
       110        120        130        140        150
VAEAPGDVVI PRPRVQPMRV ARGGPWTPNP AFREAESWSQ IGNQRVSEQL 
       160        170        180        190        200
LETSLGNEVS DTEPLSPASA GLRRNPALPP GPFAQNFSWG NQENLPPALG 
       210        220        230        240        250
KIANGGGTGA GKAECGYETE SHLLEPHEIP LNVNTHKFSD CEFPYEFCTV 
       260        270        280        290        300
CFSPFKLLGM SGVEGVWNQH SRSASMHTFL NHSATGIREA GCRKDMPVSE 
       310        320        330        340        350
MAEDGSEEIM FIWCEDCSQY HDSECPELGP VVMVKDSFVL SRARSWPASG 
       360        370        380        390        400
HVHTQAGQGM RGYEDRDRAD PQQLPEAVPA GLVRRLSGQQ LPCRSTLTWG 
       410        420        430        440        450
RLCHLVAQGR SSLPPNLEIR RLEDGAEGVF AITQLVKRTQ FGPFESRRVA 
       460        470        480        490        500
KWEKESAFPL KVFQKDGHPV CFDTSNEDDC NWMMLVRPAA EAEHQNLTAY 
       510        520        530        540        550
QHGSDVYFTT SRDIPPGTEL RVWYAAFYAK KMDKPMLKQA GSGVHAAGTP 
       560        570        580        590        600
ENSAPVESEP SQWACKVCSA TFLELQLLNE HLLGHLEQAK SLPPGSQSEA 
       610        620        630        640        650
AAPEKEQDTP RGEPPAVPES ENVATKEQKK KPRRGRKPKV SKAEQPLVIV 
       660        670        680        690        700
EDKEPTEQVA EIITEVPPDE PVSATPDERI MELVLGKLAT TTTDTSSVPK 
       710        720        730        740        750
FTHHQNNTIT LKRSLILSSR HGIRRKLIKQ LGEHKRVYQC NICSKIFQNS 
       760        770        780        790        800
SNLSRHVRSH GDKLFKCEEC AKLFSRKESL KQHVSYKHSR NEVDGEYRYR 
       810        820        830        840        850
CGTCEKTFRI ESALEFHNCR TDDKTFQCEM CFRFFSTNSN LSKHKKKHGD 
       860        870        880        890        900
KKFACEVCSK MFYRKDVMLD HQRRHLEGVR RVKREDLEAG GENLVRYKKE 
       910        920        930        940        950
PSGCPVCGKV FSCRSNMNKH LLTHGDKKYT CEICGRKFFR VDVLRDHIHV 
       960        970        980        990       1000
HFKDIALMDD HQREEFIGKI GISSEENDDN SDESADSEPH KYSCKRCQLT 
      1010       1020       1030       1040       1050
FGRGKEYLKH IMEVHKEKGY GCSICNRRFA LKATYHAHMV IHRENLPDPN 
      1060       1070       1080       1090       1100
VQKYIHPCEI CGRIFNSIGN LERHKLIHTG VKSHACEQCG KSFARKDMLK 
      1110       1120       1130       1140       1150
EHMRVHDNVR EYLCAECGKG MKTKHALRHH MKLHKGIKEY ECKECHRRFA 
      1160       1170       1180       1190       1200
QKVNMLKHCK RHTGIKDFMC ELCGKTFSER NTMETHKLIH TVGKQWTCSV 
      1210       1220       1230       1240       1250
CDKKYVTEYM LQKHVQLTHD KVEAQSCQLC GTKVSTRASM SRHMRRKHPE 
      1260       1270       1280       1290       1300
VLAVRIDDLD HLPETTTIDA SSIGIVQPEL TLEQEDLAEG KHGKAAKRSH 
      1310       1320       1330       1340       1350
KRKQKPEEEA GAPVPEDATF SEYSEKETEF TGSVGDETNS AVQSIQQVVV 
      1360       1370       1380       1390       1400
TLGDPNVTTP SSSVGLTNIT VTPITTAAAT QFTNLQPVAV GHLTTPERQL 
      1410       1420       1430       1440       1450
QLDNSILTVT FDTVSGSAML HNRQNDVQIH PQPEASNPQS VAHFINLTTL 
      1460       1470       1480       1490       1500
VNSITPLGSQ LSDQHPLTWR AVPQTDVLPP SQPQAPPQQA AQPQVQAEQQ 

QQQMYSY
Length:1,507
Mass (Da):169,269
Last modified:November 28, 2006 - v4
Checksum:iE980A7EDB97239D0
GO
Isoform 2 (identifier: P57071-2) [UniParc]FASTAAdd to basket
Also known as: ZNF298b

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     821-821: T → TGLIAHPGEGGPGGSRLRDLP

Show »
Length:1,198
Mass (Da):135,670
Checksum:i6EEA445CDDCA07A7
GO
Isoform 3 (identifier: P57071-3) [UniParc]FASTAAdd to basket
Also known as: ZNF298a

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.

Show »
Length:1,178
Mass (Da):133,732
Checksum:i6F51396D6B31F50B
GO
Isoform 4 (identifier: P57071-5) [UniParc]FASTAAdd to basket
Also known as: ZNF298c

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     822-884: DDKTFQCEMC...HLEGVRRVKR → GLIAHPGEGG...SAGTWKECGE
     885-1507: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:555
Mass (Da):62,097
Checksum:i7676D13685BAC4C8
GO
Isoform 5 (identifier: P57071-6) [UniParc]FASTAAdd to basket
Also known as: ZNF298d

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     701-720: Missing.
     822-864: DDKTFQCEMC...CEVCSKMFYR → ATSPSTRRST...SAGTWKECGE
     865-1507: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:515
Mass (Da):57,810
Checksum:i44CC7B8E12AE587A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ER26E7ER26_HUMAN
PR domain zinc finger protein 15
PRDM15
1,141Annotation score:
Q4W8S1Q4W8S1_HUMAN
PR domain zinc finger protein 15
PRDM15 ZNF298
478Annotation score:

Sequence cautioni

The sequence AAL60596 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAM53515 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence AAM53516 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence BAA95527 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD99015 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD99016 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD99017 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD99018 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence BAD99020 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1147R → G in AAL60596 (PubMed:12036297).Curated1
Sequence conflicti1167D → I in AAL60596 (PubMed:12036297).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0149921342V → I. Corresponds to variant dbSNP:rs3819158Ensembl.1
Natural variantiVAR_0149931376T → S. Corresponds to variant dbSNP:rs2236695Ensembl.1
Natural variantiVAR_0149941481S → P3 PublicationsCorresponds to variant dbSNP:rs3850706Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05511035 – 297Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST263
Alternative sequenceiVSP_055111344 – 409Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_055112701 – 720Missing in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_055113821T → TGLIAHPGEGGPGGSRLRDL P in isoform 2. 1 Publication1
Alternative sequenceiVSP_055114822 – 884DDKTF…RRVKR → GLIAHPGEGGPGGSRLRDLP ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 4. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_055115822 – 864DDKTF…KMFYR → ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 5. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_055116865 – 1507Missing in isoform 5. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_055117885 – 1507Missing in isoform 4. 1 PublicationAdd BLAST623

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078498 mRNA Translation: AAL85487.2
AB051812 mRNA Translation: BAD99015.1 Different initiation.
AB051813 mRNA Translation: BAD99016.1 Different initiation.
AB051814 mRNA Translation: BAD99017.1 Different initiation.
AB051814 mRNA Translation: BAD99018.1 Sequence problems.
AB051815 mRNA Translation: BAD99020.1 Sequence problems.
AB126081 Genomic DNA No translation available.
AP001580 Genomic DNA No translation available.
AP001618 Genomic DNA No translation available.
AP001619 Genomic DNA No translation available.
AP001745 Genomic DNA Translation: BAA95527.1 Sequence problems.
AP002955 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09585.1
AF276513 mRNA Translation: AAF78093.1
AY063456 mRNA Translation: AAL60596.1 Different initiation.
AF426259 mRNA Translation: AAM53515.1 Sequence problems.
AF426260 mRNA Translation: AAM53516.1 Sequence problems.
CCDSiCCDS13676.1 [P57071-1]
CCDS42932.1 [P57071-3]
CCDS63370.1 [P57071-2]
RefSeqiNP_001035514.1, NM_001040424.2 [P57071-3]
NP_001269863.1, NM_001282934.1 [P57071-2]
NP_071398.3, NM_022115.4 [P57071-1]
UniGeneiHs.473893
Hs.726680

Genome annotation databases

EnsembliENST00000269844; ENSP00000269844; ENSG00000141956 [P57071-1]
ENST00000398548; ENSP00000381556; ENSG00000141956 [P57071-3]
ENST00000422911; ENSP00000408592; ENSG00000141956 [P57071-2]
ENST00000433067; ENSP00000415471; ENSG00000141956 [P57071-1]
ENST00000449395; ENSP00000396943; ENSG00000141956 [P57071-5]
GeneIDi63977
KEGGihsa:63977
UCSCiuc002yzo.4 human [P57071-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078498 mRNA Translation: AAL85487.2
AB051812 mRNA Translation: BAD99015.1 Different initiation.
AB051813 mRNA Translation: BAD99016.1 Different initiation.
AB051814 mRNA Translation: BAD99017.1 Different initiation.
AB051814 mRNA Translation: BAD99018.1 Sequence problems.
AB051815 mRNA Translation: BAD99020.1 Sequence problems.
AB126081 Genomic DNA No translation available.
AP001580 Genomic DNA No translation available.
AP001618 Genomic DNA No translation available.
AP001619 Genomic DNA No translation available.
AP001745 Genomic DNA Translation: BAA95527.1 Sequence problems.
AP002955 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09585.1
AF276513 mRNA Translation: AAF78093.1
AY063456 mRNA Translation: AAL60596.1 Different initiation.
AF426259 mRNA Translation: AAM53515.1 Sequence problems.
AF426260 mRNA Translation: AAM53516.1 Sequence problems.
CCDSiCCDS13676.1 [P57071-1]
CCDS42932.1 [P57071-3]
CCDS63370.1 [P57071-2]
RefSeqiNP_001035514.1, NM_001040424.2 [P57071-3]
NP_001269863.1, NM_001282934.1 [P57071-2]
NP_071398.3, NM_022115.4 [P57071-1]
UniGeneiHs.473893
Hs.726680

3D structure databases

ProteinModelPortaliP57071
SMRiP57071
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122024, 19 interactors
IntActiP57071, 1 interactor
MINTiP57071
STRINGi9606.ENSP00000269844

PTM databases

iPTMnetiP57071
PhosphoSitePlusiP57071

Polymorphism and mutation databases

BioMutaiPRDM15
DMDMi118572696

Proteomic databases

EPDiP57071
MaxQBiP57071
PaxDbiP57071
PeptideAtlasiP57071
PRIDEiP57071
ProteomicsDBi56980

Protocols and materials databases

DNASUi63977
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269844; ENSP00000269844; ENSG00000141956 [P57071-1]
ENST00000398548; ENSP00000381556; ENSG00000141956 [P57071-3]
ENST00000422911; ENSP00000408592; ENSG00000141956 [P57071-2]
ENST00000433067; ENSP00000415471; ENSG00000141956 [P57071-1]
ENST00000449395; ENSP00000396943; ENSG00000141956 [P57071-5]
GeneIDi63977
KEGGihsa:63977
UCSCiuc002yzo.4 human [P57071-1]

Organism-specific databases

CTDi63977
DisGeNETi63977
EuPathDBiHostDB:ENSG00000141956.13
GeneCardsiPRDM15
HGNCiHGNC:13999 PRDM15
HPAiHPA024268
HPA029255
HPA029256
MIMi617692 gene
neXtProtiNX_P57071
OpenTargetsiENSG00000141956
PharmGKBiPA33713
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149092
HOGENOMiHOG000115685
HOVERGENiHBG093153
InParanoidiP57071
OMAiHGCSICN
OrthoDBiEOG091G02KC
PhylomeDBiP57071
TreeFamiTF331419

Miscellaneous databases

GenomeRNAii63977
PROiPR:P57071
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141956 Expressed in 168 organ(s), highest expression level in cerebellum
CleanExiHS_PRDM15
ExpressionAtlasiP57071 baseline and differential
GenevisibleiP57071 HS

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPRD15_HUMAN
AccessioniPrimary (citable) accession number: P57071
Secondary accession number(s): E9PDJ6
, E9PF37, E9PGL3, Q4W8S0, Q4W8S3, Q4W8S4, Q4W8S5, Q8N0X3, Q8NEX0, Q9NQV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 28, 2006
Last modified: November 7, 2018
This is version 176 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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