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Entry version 189 (07 Oct 2020)
Sequence version 4 (28 Nov 2006)
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Protein

PR domain zinc finger protein 15

Gene

PRDM15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri563 – 585C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 788C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri826 – 848C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri853 – 875C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri902 – 924C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 951C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri992 – 1015C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1020 – 1042C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1056 – 1078C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1084 – 1106C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1112 – 1134C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1140 – 1162C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1168 – 1190C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1196 – 1219C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1225 – 1248C2H2-type 16PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P57071

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 15Curated (EC:2.1.1.-Curated)
Alternative name(s):
PR domain-containing protein 15Curated
Zinc finger protein 298
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM15Imported
Synonyms:C21orf83Imported, ZNF298Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000141956.13

Human Gene Nomenclature Database

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HGNCi
HGNC:13999, PRDM15

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617692, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57071

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
63977

Open Targets

More...
OpenTargetsi
ENSG00000141956

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33713

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P57071, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRDM15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572696

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477721 – 1507PR domain zinc finger protein 15Add BLAST1507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki883Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P57071

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P57071

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P57071

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P57071

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P57071

PeptideAtlas

More...
PeptideAtlasi
P57071

PRoteomics IDEntifications database

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PRIDEi
P57071

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
19680
20018
20339
56980 [P57071-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P57071

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P57071

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in all tissues examined.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000141956, Expressed in sural nerve and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P57071, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P57071, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000141956, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122024, 20 interactors

Protein interaction database and analysis system

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IntActi
P57071, 9 interactors

Molecular INTeraction database

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MINTi
P57071

STRING: functional protein association networks

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STRINGi
9606.ENSP00000269844

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P57071, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P57071

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini415 – 525SETPROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi92 – 97Poly-Pro6
Compositional biasi690 – 695Poly-Thr6
Compositional biasi1499 – 1503Poly-Gln5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri563 – 585C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri738 – 760C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 788C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri826 – 848C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri853 – 875C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri902 – 924C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 951C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri992 – 1015C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1020 – 1042C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1056 – 1078C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1084 – 1106C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1112 – 1134C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1140 – 1162C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1168 – 1190C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1196 – 1219C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1225 – 1248C2H2-type 16PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157890

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P57071

Identification of Orthologs from Complete Genome Data

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OMAi
HGCSICN

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P57071

TreeFam database of animal gene trees

More...
TreeFami
TF331419

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P57071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRRRPPASG AAQFPERIAT RSPDPIPLCT FQRQPRAAPV QPPCRLFFVT
60 70 80 90 100
FAGCGHRWRS ESKPGWISRS RSGIALRAAR PPGSSPPRPA APRPPPPGGV
110 120 130 140 150
VAEAPGDVVI PRPRVQPMRV ARGGPWTPNP AFREAESWSQ IGNQRVSEQL
160 170 180 190 200
LETSLGNEVS DTEPLSPASA GLRRNPALPP GPFAQNFSWG NQENLPPALG
210 220 230 240 250
KIANGGGTGA GKAECGYETE SHLLEPHEIP LNVNTHKFSD CEFPYEFCTV
260 270 280 290 300
CFSPFKLLGM SGVEGVWNQH SRSASMHTFL NHSATGIREA GCRKDMPVSE
310 320 330 340 350
MAEDGSEEIM FIWCEDCSQY HDSECPELGP VVMVKDSFVL SRARSWPASG
360 370 380 390 400
HVHTQAGQGM RGYEDRDRAD PQQLPEAVPA GLVRRLSGQQ LPCRSTLTWG
410 420 430 440 450
RLCHLVAQGR SSLPPNLEIR RLEDGAEGVF AITQLVKRTQ FGPFESRRVA
460 470 480 490 500
KWEKESAFPL KVFQKDGHPV CFDTSNEDDC NWMMLVRPAA EAEHQNLTAY
510 520 530 540 550
QHGSDVYFTT SRDIPPGTEL RVWYAAFYAK KMDKPMLKQA GSGVHAAGTP
560 570 580 590 600
ENSAPVESEP SQWACKVCSA TFLELQLLNE HLLGHLEQAK SLPPGSQSEA
610 620 630 640 650
AAPEKEQDTP RGEPPAVPES ENVATKEQKK KPRRGRKPKV SKAEQPLVIV
660 670 680 690 700
EDKEPTEQVA EIITEVPPDE PVSATPDERI MELVLGKLAT TTTDTSSVPK
710 720 730 740 750
FTHHQNNTIT LKRSLILSSR HGIRRKLIKQ LGEHKRVYQC NICSKIFQNS
760 770 780 790 800
SNLSRHVRSH GDKLFKCEEC AKLFSRKESL KQHVSYKHSR NEVDGEYRYR
810 820 830 840 850
CGTCEKTFRI ESALEFHNCR TDDKTFQCEM CFRFFSTNSN LSKHKKKHGD
860 870 880 890 900
KKFACEVCSK MFYRKDVMLD HQRRHLEGVR RVKREDLEAG GENLVRYKKE
910 920 930 940 950
PSGCPVCGKV FSCRSNMNKH LLTHGDKKYT CEICGRKFFR VDVLRDHIHV
960 970 980 990 1000
HFKDIALMDD HQREEFIGKI GISSEENDDN SDESADSEPH KYSCKRCQLT
1010 1020 1030 1040 1050
FGRGKEYLKH IMEVHKEKGY GCSICNRRFA LKATYHAHMV IHRENLPDPN
1060 1070 1080 1090 1100
VQKYIHPCEI CGRIFNSIGN LERHKLIHTG VKSHACEQCG KSFARKDMLK
1110 1120 1130 1140 1150
EHMRVHDNVR EYLCAECGKG MKTKHALRHH MKLHKGIKEY ECKECHRRFA
1160 1170 1180 1190 1200
QKVNMLKHCK RHTGIKDFMC ELCGKTFSER NTMETHKLIH TVGKQWTCSV
1210 1220 1230 1240 1250
CDKKYVTEYM LQKHVQLTHD KVEAQSCQLC GTKVSTRASM SRHMRRKHPE
1260 1270 1280 1290 1300
VLAVRIDDLD HLPETTTIDA SSIGIVQPEL TLEQEDLAEG KHGKAAKRSH
1310 1320 1330 1340 1350
KRKQKPEEEA GAPVPEDATF SEYSEKETEF TGSVGDETNS AVQSIQQVVV
1360 1370 1380 1390 1400
TLGDPNVTTP SSSVGLTNIT VTPITTAAAT QFTNLQPVAV GHLTTPERQL
1410 1420 1430 1440 1450
QLDNSILTVT FDTVSGSAML HNRQNDVQIH PQPEASNPQS VAHFINLTTL
1460 1470 1480 1490 1500
VNSITPLGSQ LSDQHPLTWR AVPQTDVLPP SQPQAPPQQA AQPQVQAEQQ

QQQMYSY
Length:1,507
Mass (Da):169,269
Last modified:November 28, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE980A7EDB97239D0
GO
Isoform 2 (identifier: P57071-2) [UniParc]FASTAAdd to basket
Also known as: ZNF298b

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     821-821: T → TGLIAHPGEGGPGGSRLRDLP

Show »
Length:1,198
Mass (Da):135,670
Checksum:i6EEA445CDDCA07A7
GO
Isoform 3 (identifier: P57071-3) [UniParc]FASTAAdd to basket
Also known as: ZNF298a

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.

Show »
Length:1,178
Mass (Da):133,732
Checksum:i6F51396D6B31F50B
GO
Isoform 4 (identifier: P57071-5) [UniParc]FASTAAdd to basket
Also known as: ZNF298c

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     822-884: DDKTFQCEMC...HLEGVRRVKR → GLIAHPGEGG...SAGTWKECGE
     885-1507: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:555
Mass (Da):62,097
Checksum:i7676D13685BAC4C8
GO
Isoform 5 (identifier: P57071-6) [UniParc]FASTAAdd to basket
Also known as: ZNF298d

The sequence of this isoform differs from the canonical sequence as follows:
     35-297: Missing.
     344-409: Missing.
     701-720: Missing.
     822-864: DDKTFQCEMC...CEVCSKMFYR → ATSPSTRRST...SAGTWKECGE
     865-1507: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
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Length:515
Mass (Da):57,810
Checksum:i44CC7B8E12AE587A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ER26E7ER26_HUMAN
PR domain zinc finger protein 15
PRDM15
1,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4W8S1Q4W8S1_HUMAN
PR domain zinc finger protein 15
PRDM15 ZNF298
478Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL60596 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAM53515 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence AAM53516 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence BAA95527 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD99015 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD99016 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD99017 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD99018 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated
The sequence BAD99020 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1147R → G in AAL60596 (PubMed:12036297).Curated1
Sequence conflicti1167D → I in AAL60596 (PubMed:12036297).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0149921342V → I. Corresponds to variant dbSNP:rs3819158Ensembl.1
Natural variantiVAR_0149931376T → S. Corresponds to variant dbSNP:rs2236695Ensembl.1
Natural variantiVAR_0149941481S → P3 PublicationsCorresponds to variant dbSNP:rs3850706Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05511035 – 297Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST263
Alternative sequenceiVSP_055111344 – 409Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_055112701 – 720Missing in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_055113821T → TGLIAHPGEGGPGGSRLRDL P in isoform 2. 1 Publication1
Alternative sequenceiVSP_055114822 – 884DDKTF…RRVKR → GLIAHPGEGGPGGSRLRDLP ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 4. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_055115822 – 864DDKTF…KMFYR → ATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKE CGE in isoform 5. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_055116865 – 1507Missing in isoform 5. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_055117885 – 1507Missing in isoform 4. 1 PublicationAdd BLAST623

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY078498 mRNA Translation: AAL85487.2
AB051812 mRNA Translation: BAD99015.1 Different initiation.
AB051813 mRNA Translation: BAD99016.1 Different initiation.
AB051814 mRNA Translation: BAD99017.1 Different initiation.
AB051814 mRNA Translation: BAD99018.1 Sequence problems.
AB051815 mRNA Translation: BAD99020.1 Sequence problems.
AB126081 Genomic DNA No translation available.
AP001580 Genomic DNA No translation available.
AP001618 Genomic DNA No translation available.
AP001619 Genomic DNA No translation available.
AP001745 Genomic DNA Translation: BAA95527.1 Sequence problems.
AP002955 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09585.1
AF276513 mRNA Translation: AAF78093.1
AY063456 mRNA Translation: AAL60596.1 Different initiation.
AF426259 mRNA Translation: AAM53515.1 Sequence problems.
AF426260 mRNA Translation: AAM53516.1 Sequence problems.

NCBI Reference Sequences

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RefSeqi
NP_001035514.1, NM_001040424.2
NP_001269863.1, NM_001282934.1
NP_071398.3, NM_022115.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000269844; ENSP00000269844; ENSG00000141956 [P57071-1]
ENST00000398548; ENSP00000381556; ENSG00000141956 [P57071-3]
ENST00000422911; ENSP00000408592; ENSG00000141956 [P57071-2]
ENST00000433067; ENSP00000415471; ENSG00000141956 [P57071-1]
ENST00000449395; ENSP00000396943; ENSG00000141956 [P57071-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
63977

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:63977

UCSC genome browser

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UCSCi
uc002yzo.4, human [P57071-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078498 mRNA Translation: AAL85487.2
AB051812 mRNA Translation: BAD99015.1 Different initiation.
AB051813 mRNA Translation: BAD99016.1 Different initiation.
AB051814 mRNA Translation: BAD99017.1 Different initiation.
AB051814 mRNA Translation: BAD99018.1 Sequence problems.
AB051815 mRNA Translation: BAD99020.1 Sequence problems.
AB126081 Genomic DNA No translation available.
AP001580 Genomic DNA No translation available.
AP001618 Genomic DNA No translation available.
AP001619 Genomic DNA No translation available.
AP001745 Genomic DNA Translation: BAA95527.1 Sequence problems.
AP002955 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09585.1
AF276513 mRNA Translation: AAF78093.1
AY063456 mRNA Translation: AAL60596.1 Different initiation.
AF426259 mRNA Translation: AAM53515.1 Sequence problems.
AF426260 mRNA Translation: AAM53516.1 Sequence problems.
RefSeqiNP_001035514.1, NM_001040424.2
NP_001269863.1, NM_001282934.1
NP_071398.3, NM_022115.4

3D structure databases

SMRiP57071
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122024, 20 interactors
IntActiP57071, 9 interactors
MINTiP57071
STRINGi9606.ENSP00000269844

PTM databases

iPTMnetiP57071
PhosphoSitePlusiP57071

Polymorphism and mutation databases

BioMutaiPRDM15
DMDMi118572696

Proteomic databases

EPDiP57071
jPOSTiP57071
MassIVEiP57071
MaxQBiP57071
PaxDbiP57071
PeptideAtlasiP57071
PRIDEiP57071
ProteomicsDBi19680
20018
20339
56980 [P57071-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
9262, 101 antibodies

The DNASU plasmid repository

More...
DNASUi
63977

Genome annotation databases

EnsembliENST00000269844; ENSP00000269844; ENSG00000141956 [P57071-1]
ENST00000398548; ENSP00000381556; ENSG00000141956 [P57071-3]
ENST00000422911; ENSP00000408592; ENSG00000141956 [P57071-2]
ENST00000433067; ENSP00000415471; ENSG00000141956 [P57071-1]
ENST00000449395; ENSP00000396943; ENSG00000141956 [P57071-5]
GeneIDi63977
KEGGihsa:63977
UCSCiuc002yzo.4, human [P57071-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63977
DisGeNETi63977
EuPathDBiHostDB:ENSG00000141956.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PRDM15
HGNCiHGNC:13999, PRDM15
HPAiENSG00000141956, Low tissue specificity
MIMi617692, gene
neXtProtiNX_P57071
OpenTargetsiENSG00000141956
PharmGKBiPA33713

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000157890
InParanoidiP57071
OMAiHGCSICN
OrthoDBi1318335at2759
PhylomeDBiP57071
TreeFamiTF331419

Enzyme and pathway databases

PathwayCommonsiP57071

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
63977, 17 hits in 895 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PRDM15, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
63977
PharosiP57071, Tdark

Protein Ontology

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PROi
PR:P57071
RNActiP57071, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141956, Expressed in sural nerve and 185 other tissues
ExpressionAtlasiP57071, baseline and differential
GenevisibleiP57071, HS

Family and domain databases

InterProiView protein in InterPro
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 17 hits
SUPFAMiSSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 16 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRD15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57071
Secondary accession number(s): E9PDJ6
, E9PF37, E9PGL3, Q4W8S0, Q4W8S3, Q4W8S4, Q4W8S5, Q8N0X3, Q8NEX0, Q9NQV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 28, 2006
Last modified: October 7, 2020
This is version 189 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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