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Entry version 158 (07 Apr 2021)
Sequence version 1 (01 Dec 2000)
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Protein

RWD domain-containing protein 2B

Gene

RWDD2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P57060

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RWD domain-containing protein 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RWDD2B
Synonyms:C21orf6
ORF Names:GL011
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1302, RWDD2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617843, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57060

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000156253.6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10069

Open Targets

More...
OpenTargetsi
ENSG00000156253

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402318

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P57060, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RWDD2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
9972769

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000795041 – 319RWD domain-containing protein 2BAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei275PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P57060

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P57060

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P57060

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P57060

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P57060

PeptideAtlas

More...
PeptideAtlasi
P57060

PRoteomics IDEntifications database

More...
PRIDEi
P57060

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56979

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P57060

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P57060

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156253, Expressed in muscle of leg and 220 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P57060, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000156253, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115380, 28 interactors

Protein interaction database and analysis system

More...
IntActi
P57060, 23 interactors

Molecular INTeraction database

More...
MINTi
P57060

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000418693

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P57060, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P57060

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P57060

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P57060

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 165RWDPROSITE-ProRule annotationAdd BLAST125

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR2G, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007224

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_046295_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P57060

Identification of Orthologs from Complete Genome Data

More...
OMAi
VIFTRLW

Database of Orthologous Groups

More...
OrthoDBi
1387276at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P57060

TreeFam database of animal gene trees

More...
TreeFami
TF324344

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010541, DUF1115
IPR006575, RWD-domain
IPR016135, UBQ-conjugating_enzyme/RWD
IPR017359, UCP038021_RWD

The PANTHER Classification System

More...
PANTHERi
PTHR15955, PTHR15955, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06544, DUF1115, 1 hit
PF05773, RWD, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038021, UCP038021_RWDD2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00591, RWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54495, SSF54495, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50908, RWD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P57060-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIELSMQPW NPGYSSEGAT AQETYTCPKM IEMEQAEAQL AELDLLASMF
60 70 80 90 100
PGENELIVND QLAVAELKDC IEKKTMEGRS SKVYFTINMN LDVSDEKMAM
110 120 130 140 150
FSLACILPFK YPAVLPEITV RSVLLSRSQQ TQLNTDLTAF LQKHCHGDVC
160 170 180 190 200
ILNATEWVRE HASGYVSRDT SSSPTTGSTV QSVDLIFTRL WIYSHHIYNK
210 220 230 240 250
CKRKNILEWA KELSLSGFSM PGKPGVVCVE GPQSACEEFW SRLRKLNWKR
260 270 280 290 300
ILIRHREDIP FDGTNDETER QRKFSIFEEK VFSVNGARGN HMDFGQLYQF
310
LNTKGCGDVF QMFFGVEGQ
Length:319
Mass (Da):36,332
Last modified:December 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E04418893C889B4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y19009 mRNA Translation: CAB88085.1
AF212232 mRNA Translation: AAK14918.1
AK000056 mRNA Translation: BAA90913.1
AL163249 Genomic DNA Translation: CAB90431.1
BC012546 mRNA Translation: AAH12546.1
BC017912 mRNA Translation: AAH17912.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13582.1

NCBI Reference Sequences

More...
RefSeqi
NP_058636.1, NM_016940.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000493196; ENSP00000418693; ENSG00000156253

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10069

UCSC genome browser

More...
UCSCi
uc002yms.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19009 mRNA Translation: CAB88085.1
AF212232 mRNA Translation: AAK14918.1
AK000056 mRNA Translation: BAA90913.1
AL163249 Genomic DNA Translation: CAB90431.1
BC012546 mRNA Translation: AAH12546.1
BC017912 mRNA Translation: AAH17912.1
CCDSiCCDS13582.1
RefSeqiNP_058636.1, NM_016940.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAXNMR-A34-172[»]
BMRBiP57060
SMRiP57060
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115380, 28 interactors
IntActiP57060, 23 interactors
MINTiP57060
STRINGi9606.ENSP00000418693

PTM databases

iPTMnetiP57060
PhosphoSitePlusiP57060

Genetic variation databases

BioMutaiRWDD2B
DMDMi9972769

Proteomic databases

EPDiP57060
jPOSTiP57060
MassIVEiP57060
MaxQBiP57060
PaxDbiP57060
PeptideAtlasiP57060
PRIDEiP57060
ProteomicsDBi56979

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
6351, 12 antibodies

The DNASU plasmid repository

More...
DNASUi
10069

Genome annotation databases

EnsembliENST00000493196; ENSP00000418693; ENSG00000156253
GeneIDi10069
KEGGihsa:10069
UCSCiuc002yms.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10069
DisGeNETi10069

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RWDD2B
HGNCiHGNC:1302, RWDD2B
HPAiENSG00000156253, Tissue enhanced (pancreas)
MIMi617843, gene
neXtProtiNX_P57060
OpenTargetsiENSG00000156253
PharmGKBiPA162402318
VEuPathDBiHostDB:ENSG00000156253.6

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QR2G, Eukaryota
GeneTreeiENSGT00390000007224
HOGENOMiCLU_046295_1_0_1
InParanoidiP57060
OMAiVIFTRLW
OrthoDBi1387276at2759
PhylomeDBiP57060
TreeFamiTF324344

Enzyme and pathway databases

PathwayCommonsiP57060

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10069, 5 hits in 1000 CRISPR screens
EvolutionaryTraceiP57060

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RWDD2B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10069
PharosiP57060, Tdark

Protein Ontology

More...
PROi
PR:P57060
RNActiP57060, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156253, Expressed in muscle of leg and 220 other tissues
GenevisibleiP57060, HS

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR010541, DUF1115
IPR006575, RWD-domain
IPR016135, UBQ-conjugating_enzyme/RWD
IPR017359, UCP038021_RWD
PANTHERiPTHR15955, PTHR15955, 1 hit
PfamiView protein in Pfam
PF06544, DUF1115, 1 hit
PF05773, RWD, 1 hit
PIRSFiPIRSF038021, UCP038021_RWDD2, 1 hit
SMARTiView protein in SMART
SM00591, RWD, 1 hit
SUPFAMiSSF54495, SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50908, RWD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRWD2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57060
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 7, 2021
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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