UniProtKB - P57059 (SIK1_HUMAN)
Serine/threonine-protein kinase SIK1
SIK1
Functioni
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348).
Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
By similarity5 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 56 | ATPCurated | 1 | |
Active sitei | 149 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 41 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- ATP binding Source: UniProtKB
- cAMP response element binding protein binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cardiac muscle cell differentiation Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- cellular response to glucose starvation Source: GO_Central
- entrainment of circadian clock by photoperiod Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- negative regulation of CREB transcription factor activity Source: UniProtKB
- negative regulation of gluconeogenesis Source: UniProtKB
- negative regulation of triglyceride biosynthetic process Source: UniProtKB
- positive regulation of anoikis Source: BHF-UCL
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of cell differentiation Source: UniProtKB
- regulation of mitotic cell cycle Source: UniProtKB
- regulation of myotube differentiation Source: UniProtKB
- regulation of sodium ion transport Source: UniProtKB
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Biological rhythms, Cell cycle, Differentiation |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P57059 |
Reactomei | R-HSA-400253, Circadian Clock |
SignaLinki | P57059 |
SIGNORi | P57059 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase SIK1 (EC:2.7.11.13 Publications)Alternative name(s): Salt-inducible kinase 1 Short name: SIK-1 Serine/threonine-protein kinase SNF1-like kinase 1 Short name: Serine/threonine-protein kinase SNF1LK |
Gene namesi | Name:SIK1 Synonyms:SIK, SNF1LK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11142, SIK1 |
MIMi | 605705, gene |
neXtProti | NX_P57059 |
VEuPathDBi | HostDB:ENSG00000142178 |
Pathology & Biotechi
Involvement in diseasei
Developmental and epileptic encephalopathy 30 (DEE30)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073701 | 287 | P → T in DEE30; no change in subcellular location. 1 PublicationCorresponds to variant dbSNP:rs786205159EnsemblClinVar. | 1 | |
Natural variantiVAR_073702 | 411 | S → C in DEE30; no change in subcellular location. 1 Publication | 1 | |
Natural variantiVAR_073703 | 636 | G → S in DEE30; no change in subcellular location. 1 PublicationCorresponds to variant dbSNP:rs786205163EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 56 | K → M: Loss of kinase activity. 2 Publications | 1 | |
Mutagenesisi | 135 | S → A: Decreased kinase activity without affecting much autophosphorylation status. 1 Publication | 1 | |
Mutagenesisi | 182 | T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. Reduced inhibition of CRTC3-mediated transcriptional activity. 2 Publications | 1 | |
Mutagenesisi | 186 | S → A, D, C or G: Impaired autophosphorylation and kinase activity. 1 Publication | 1 | |
Mutagenesisi | 186 | S → T: Does not autophosphorylation and kinase activity. 1 Publication | 1 | |
Mutagenesisi | 209 | S → A: Decreased kinase activity without affecting much autophosphorylation status. 1 Publication | 1 | |
Mutagenesisi | 248 | S → A: Decreased kinase activity without affecting much autophosphorylation status. 1 Publication | 1 | |
Mutagenesisi | 473 | T → A: Reduced but still present interaction with 14-3-3 proteins in response to cAMP signaling and, thus, still able to inhibit TORC activity. Resistant to inhibition by cAMP signaling and, thus, still able to inhibit TORC activity; when associated with A-575. 1 Publication | 1 | |
Mutagenesisi | 473 | T → E: Reduced but still present interaction with 14-3-3 proteins in response to cAMP signaling and, thus, still able to inhibit TORC activity. 1 Publication | 1 | |
Mutagenesisi | 575 | S → A: Loss of interaction with 14-3-3 proteins in response to cAMP signaling and, thus, still able to inhibit TORC activity. Resistant to inhibition by cAMP signaling and, thus, still able to inhibit TORC activity; when associated with A-473. 1 Publication | 1 | |
Mutagenesisi | 575 | S → E: Strongly reduced but still present interaction with 14-3-3 proteins in response to cAMP signaling and, thus, still able to inhibit TORC activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Epilepsy, Tumor suppressorOrganism-specific databases
DisGeNETi | 102724428 150094 |
MalaCardsi | SIK1 |
MIMi | 616341, phenotype |
OpenTargetsi | ENSG00000142178 |
Orphaneti | 1934, Early infantile epileptic encephalopathy 1935, Early myoclonic encephalopathy 3451, Infantile spasms syndrome |
PharmGKBi | PA164725717 |
Miscellaneous databases
Pharosi | P57059, Tchem |
Chemistry databases
ChEMBLi | CHEMBL6082 |
DrugBanki | DB08912, Dabrafenib DB12010, Fostamatinib |
DrugCentrali | P57059 |
GuidetoPHARMACOLOGYi | 2197 |
Genetic variation databases
BioMutai | SIK1 |
DMDMi | 59803093 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086659 | 1 – 783 | Serine/threonine-protein kinase SIK1Add BLAST | 783 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 182 | Phosphothreonine; by LKB1 and GSK3-beta2 Publications | 1 | |
Modified residuei | 186 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 322 | Phosphothreonine; by CaMK1By similarity | 1 | |
Modified residuei | 473 | Phosphothreonine; by PKA1 Publication | 1 | |
Modified residuei | 575 | Phosphoserine; by PKABy similarity1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P57059 |
jPOSTi | P57059 |
MassIVEi | P57059 |
MaxQBi | P57059 |
PaxDbi | P57059 |
PeptideAtlasi | P57059 |
PRIDEi | P57059 |
ProteomicsDBi | 56978 |
PTM databases
iPTMneti | P57059 |
PhosphoSitePlusi | P57059 |
Expressioni
Gene expression databases
Bgeei | ENSG00000142178, Expressed in adipose tissue and 111 other tissues |
ExpressionAtlasi | P57059, baseline and differential |
Genevisiblei | P57059, HS |
Organism-specific databases
HPAi | ENSG00000142178, Tissue enhanced (skin) |
Interactioni
Subunit structurei
Interacts with ATP1A1 (By similarity).
Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ (PubMed:16306228).
Interacts (when phosphorylated at Thr-473 and/or Ser-575) with 14-3-3 proteins; the interaction inhibits kinase activity towards TORCs (PubMed:29211348). There is a cooperative effect of the phosphorylation sites in 14-3-3 binding as the interaction is stronger when both Thr-473 and Ser-575 are modified (PubMed:29211348).
By similarity2 PublicationsBinary interactionsi
P57059
With | #Exp. | IntAct |
---|---|---|
YWHAZ [P63104] | 5 | EBI-1181640,EBI-347088 |
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- cAMP response element binding protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 127260, 42 interactors 3195539, 6 interactors |
IntActi | P57059, 28 interactors |
MINTi | P57059 |
STRINGi | 9606.ENSP00000270162 |
Chemistry databases
BindingDBi | P57059 |
Miscellaneous databases
RNActi | P57059, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 278 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 303 – 343 | UBAPROSITE-ProRule annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 353 – 377 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 449 – 477 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 583 – 612 | RK-rich region; required for cAMP responsiveness and nuclear localization1 PublicationAdd BLAST | 30 | |
Regioni | 619 – 643 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 457 – 477 | Polar residuesSequence analysisAdd BLAST | 21 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000154989 |
HOGENOMi | CLU_000288_87_2_1 |
InParanoidi | P57059 |
OMAi | LHISAGP |
OrthoDBi | 1127668at2759 |
PhylomeDBi | P57059 |
TreeFami | TF315213 |
Family and domain databases
CDDi | cd14071, STKc_SIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR017090, Ser/Thr_kinase_SIK1/2 IPR034672, SIK IPR015940, UBA |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037014, Ser/Thr_PK_SNF1-like, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MVIMSEFSAD PAGQGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK
60 70 80 90 100
TQVAIKIIDK TRLDSSNLEK IYREVQLMKL LNHPHIIKLY QVMETKDMLY
110 120 130 140 150
IVTEFAKNGE MFDYLTSNGH LSENEARKKF WQILSAVEYC HDHHIVHRDL
160 170 180 190 200
KTENLLLDGN MDIKLADFGF GNFYKSGEPL STWCGSPPYA APEVFEGKEY
210 220 230 240 250
EGPQLDIWSL GVVLYVLVCG SLPFDGPNLP TLRQRVLEGR FRIPFFMSQD
260 270 280 290 300
CESLIRRMLV VDPARRITIA QIRQHRWMRA EPCLPGPACP AFSAHSYTSN
310 320 330 340 350
LGDYDEQALG IMQTLGVDRQ RTVESLQNSS YNHFAAIYYL LLERLKEYRN
360 370 380 390 400
AQCARPGPAR QPRPRSSDLS GLEVPQEGLS TDPFRPALLC PQPQTLVQSV
410 420 430 440 450
LQAEMDCELQ SSLQWPLFFP VDASCSGVFR PRPVSPSSLL DTAISEEARQ
460 470 480 490 500
GPGLEEEQDT QESLPSSTGR RHTLAEVSTR LSPLTAPCIV VSPSTTASPA
510 520 530 540 550
EGTSSDSCLT FSASKSPAGL SGTPATQGLL GACSPVRLAS PFLGSQSATP
560 570 580 590 600
VLQAQGGLGG AVLLPVSFQE GRRASDTSLT QGLKAFRQQL RKTTRTKGFL
610 620 630 640 650
GLNKIKGLAR QVCQAPASRA SRGGLSPFHA PAQSPGLHGG AAGSREGWSL
660 670 680 690 700
LEEVLEQQRL LQLQHHPAAA PGCSQAPQPA PAPFVIAPCD GPGAAPLPST
710 720 730 740 750
LLTSGLPLLP PPLLQTGASP VASAAQLLDT HLHIGTGPTA LPAVPPPRLA
760 770 780
RLAPGCEPLG LLQGDCEMED LMPCSLGTFV LVQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y6E4 | A0A2R8Y6E4_HUMAN | Serine/threonine-protein kinase SIK... | SIK1 | 153 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 166 | A → AGTE in BAA95536 (PubMed:10830953).Curated | 1 | |
Sequence conflicti | 489 – 490 | IV → KF in BAA95536 (PubMed:10830953).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041087 | 15 | G → S1 PublicationCorresponds to variant dbSNP:rs3746951EnsemblClinVar. | 1 | |
Natural variantiVAR_041088 | 142 | D → N1 PublicationCorresponds to variant dbSNP:rs45491503EnsemblClinVar. | 1 | |
Natural variantiVAR_041089 | 211 | G → S in a glioblastoma multiforme sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_073701 | 287 | P → T in DEE30; no change in subcellular location. 1 PublicationCorresponds to variant dbSNP:rs786205159EnsemblClinVar. | 1 | |
Natural variantiVAR_073702 | 411 | S → C in DEE30; no change in subcellular location. 1 Publication | 1 | |
Natural variantiVAR_033910 | 430 | R → W. Corresponds to variant dbSNP:rs34164089EnsemblClinVar. | 1 | |
Natural variantiVAR_041090 | 469 | G → D in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_021255 | 615 | A → V3 PublicationsCorresponds to variant dbSNP:rs430554EnsemblClinVar. | 1 | |
Natural variantiVAR_073703 | 636 | G → S in DEE30; no change in subcellular location. 1 PublicationCorresponds to variant dbSNP:rs786205163EnsemblClinVar. | 1 | |
Natural variantiVAR_041091 | 696 | P → L1 PublicationCorresponds to variant dbSNP:rs56386767EnsemblClinVar. | 1 | |
Natural variantiVAR_041092 | 725 | A → V1 PublicationCorresponds to variant dbSNP:rs35596465EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB047786 mRNA Translation: BAD74070.1 AP001751 Genomic DNA Translation: BAA95536.1 BC038504 mRNA Translation: AAH38504.1 AK131076 mRNA Translation: BAC85126.1 |
CCDSi | CCDS33575.1 |
RefSeqi | NP_001307572.1, NM_001320643.2 NP_775490.2, NM_173354.4 |
Genome annotation databases
Ensembli | ENST00000270162.8; ENSP00000270162.6; ENSG00000142178.9 |
GeneIDi | 102724428 150094 |
KEGGi | hsa:102724428 hsa:150094 |
MANE-Selecti | ENST00000270162.8; ENSP00000270162.6; NM_173354.5; NP_775490.2 |
UCSCi | uc002zdf.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB047786 mRNA Translation: BAD74070.1 AP001751 Genomic DNA Translation: BAA95536.1 BC038504 mRNA Translation: AAH38504.1 AK131076 mRNA Translation: BAC85126.1 |
CCDSi | CCDS33575.1 |
RefSeqi | NP_001307572.1, NM_001320643.2 NP_775490.2, NM_173354.4 |
3D structure databases
AlphaFoldDBi | P57059 |
SMRi | P57059 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127260, 42 interactors 3195539, 6 interactors |
IntActi | P57059, 28 interactors |
MINTi | P57059 |
STRINGi | 9606.ENSP00000270162 |
Chemistry databases
BindingDBi | P57059 |
ChEMBLi | CHEMBL6082 |
DrugBanki | DB08912, Dabrafenib DB12010, Fostamatinib |
DrugCentrali | P57059 |
GuidetoPHARMACOLOGYi | 2197 |
PTM databases
iPTMneti | P57059 |
PhosphoSitePlusi | P57059 |
Genetic variation databases
BioMutai | SIK1 |
DMDMi | 59803093 |
Proteomic databases
EPDi | P57059 |
jPOSTi | P57059 |
MassIVEi | P57059 |
MaxQBi | P57059 |
PaxDbi | P57059 |
PeptideAtlasi | P57059 |
PRIDEi | P57059 |
ProteomicsDBi | 56978 |
Protocols and materials databases
Antibodypediai | 9946, 316 antibodies from 36 providers |
DNASUi | 150094 |
Genome annotation databases
Ensembli | ENST00000270162.8; ENSP00000270162.6; ENSG00000142178.9 |
GeneIDi | 102724428 150094 |
KEGGi | hsa:102724428 hsa:150094 |
MANE-Selecti | ENST00000270162.8; ENSP00000270162.6; NM_173354.5; NP_775490.2 |
UCSCi | uc002zdf.4, human |
Organism-specific databases
CTDi | 150094 |
DisGeNETi | 102724428 150094 |
GeneCardsi | SIK1 |
HGNCi | HGNC:11142, SIK1 |
HPAi | ENSG00000142178, Tissue enhanced (skin) |
MalaCardsi | SIK1 |
MIMi | 605705, gene 616341, phenotype |
neXtProti | NX_P57059 |
OpenTargetsi | ENSG00000142178 |
Orphaneti | 1934, Early infantile epileptic encephalopathy 1935, Early myoclonic encephalopathy 3451, Infantile spasms syndrome |
PharmGKBi | PA164725717 |
VEuPathDBi | HostDB:ENSG00000142178 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000154989 |
HOGENOMi | CLU_000288_87_2_1 |
InParanoidi | P57059 |
OMAi | LHISAGP |
OrthoDBi | 1127668at2759 |
PhylomeDBi | P57059 |
TreeFami | TF315213 |
Enzyme and pathway databases
PathwayCommonsi | P57059 |
Reactomei | R-HSA-400253, Circadian Clock |
SignaLinki | P57059 |
SIGNORi | P57059 |
Miscellaneous databases
BioGRID-ORCSi | 102724428, 0 hits in 4 CRISPR screens 150094, 14 hits in 1110 CRISPR screens |
ChiTaRSi | SIK1, human |
GeneWikii | SNF1LK |
Pharosi | P57059, Tchem |
PROi | PR:P57059 |
RNActi | P57059, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142178, Expressed in adipose tissue and 111 other tissues |
ExpressionAtlasi | P57059, baseline and differential |
Genevisiblei | P57059, HS |
Family and domain databases
CDDi | cd14071, STKc_SIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR017090, Ser/Thr_kinase_SIK1/2 IPR034672, SIK IPR015940, UBA |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037014, Ser/Thr_PK_SNF1-like, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SIK1_HUMAN | |
Accessioni | P57059Primary (citable) accession number: P57059 Secondary accession number(s): A6NC84 Q86YJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | February 15, 2005 | |
Last modified: | May 25, 2022 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families