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Protein

Hormonally up-regulated neu tumor-associated kinase

Gene

HUNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91ATPPROSITE-ProRule annotation1
Active sitei186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 76ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP57058

Names & Taxonomyi

Protein namesi
Recommended name:
Hormonally up-regulated neu tumor-associated kinase (EC:2.7.11.1)
Alternative name(s):
B19
Serine/threonine-protein kinase MAK-V
Gene namesi
Name:HUNK
Synonyms:MAKV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000142149.8
HGNCiHGNC:13326 HUNK
MIMi606532 gene
neXtProtiNX_P57058

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi30811
OpenTargetsiENSG00000142149
PharmGKBiPA29563

Chemistry databases

ChEMBLiCHEMBL1795165

Polymorphism and mutation databases

BioMutaiHUNK
DMDMi9973393

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860041 – 714Hormonally up-regulated neu tumor-associated kinaseAdd BLAST714

Proteomic databases

PaxDbiP57058
PeptideAtlasiP57058
PRIDEiP57058
ProteomicsDBi56977
TopDownProteomicsiP57058

PTM databases

iPTMnetiP57058
PhosphoSitePlusiP57058

Expressioni

Gene expression databases

BgeeiENSG00000142149 Expressed in 125 organ(s), highest expression level in forebrain
CleanExiHS_HUNK
ExpressionAtlasiP57058 baseline and differential
GenevisibleiP57058 HS

Organism-specific databases

HPAiHPA027295
HPA027372

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CFL1P235282EBI-3959804,EBI-352733

Protein-protein interaction databases

BioGridi119035, 4 interactors
DIPiDIP-58064N
IntActiP57058, 6 interactors
MINTiP57058
STRINGi9606.ENSP00000270112

Chemistry databases

BindingDBiP57058

Structurei

3D structure databases

ProteinModelPortaliP57058
SMRiP57058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 320Protein kinasePROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00920000149073
HOGENOMiHOG000112978
HOVERGENiHBG006086
InParanoidiP57058
KOiK08797
OMAiDKNLPSH
OrthoDBiEOG091G0I19
PhylomeDBiP57058
TreeFamiTF352373

Family and domain databases

CDDicd14070 STKc_HUNK, 1 hit
InterProiView protein in InterPro
IPR034671 Hunk
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P57058-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAAAGDGLL GEPAAPGGGG GAEDAARPAA ACEGSFLPAW VSGVPRERLR
60 70 80 90 100
DFQHHKRVGN YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK
110 120 130 140 150
DTYVTKNLRR EGQIQQMIRH PNITQLLDIL ETENSYYLVM ELCPGGNLMH
160 170 180 190 200
KIYEKKRLEE SEARRYIRQL ISAVEHLHRA GVVHRDLKIE NLLLDEDNNI
210 220 230 240 250
KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY GPKIDVWSIG
260 270 280 290 300
VNMYAMLTGT LPFTVEPFSL RALYQKMVDK EMNPLPTQLS TGAISFLRSL
310 320 330 340 350
LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH
360 370 380 390 400
MTEKLGYKNS DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSLC
410 420 430 440 450
YKTRLYQIEK YRAPKESYEA SLDTWTRDLE FHAVQDKKPK EQEKRGDFLH
460 470 480 490 500
RPFSKKLDKN LPSHKQPSGS LMTQIQNTKA LLKDRKASKS SFPDKDSFGC
510 520 530 540 550
RNIFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKPEPHQP GPGSTGIPHK
560 570 580 590 600
EDPLMLDMVR SFESVDRDDH VEVLSPSHHY RILNSPVSLA RRNSSERTLS
610 620 630 640 650
PGLPSGSMSP LHTPLHPTLV SFAHEDKNSP PKEEGLCCPP PVPSNGPMQP
660 670 680 690 700
LGSPNCVKSR GRFPMMGIGQ MLRKRHQSLQ PSADRPLEAS LPPLQPLAPV
710
NLAFDMADGV KTQC
Length:714
Mass (Da):79,686
Last modified:December 1, 2000 - v1
Checksum:i87FC85C67D838AA7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3H0H7C3H0_HUMAN
Hormonally up-regulated neu tumor-a...
HUNK
162Annotation score:
H7C2X2H7C2X2_HUMAN
Hormonally up-regulated neu tumor-a...
HUNK
112Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040561157R → W1 PublicationCorresponds to variant dbSNP:rs35133981Ensembl.1
Natural variantiVAR_040562591R → C1 PublicationCorresponds to variant dbSNP:rs10775648Ensembl.1
Natural variantiVAR_040563625E → K1 PublicationCorresponds to variant dbSNP:rs56021554Ensembl.1
Natural variantiVAR_040564648M → T1 PublicationCorresponds to variant dbSNP:rs56240027Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271722 mRNA Translation: CAB71146.1
CCDSiCCDS13610.1
RefSeqiNP_055401.1, NM_014586.1
UniGeneiHs.109437

Genome annotation databases

EnsembliENST00000270112; ENSP00000270112; ENSG00000142149
GeneIDi30811
KEGGihsa:30811
UCSCiuc002yph.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271722 mRNA Translation: CAB71146.1
CCDSiCCDS13610.1
RefSeqiNP_055401.1, NM_014586.1
UniGeneiHs.109437

3D structure databases

ProteinModelPortaliP57058
SMRiP57058
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119035, 4 interactors
DIPiDIP-58064N
IntActiP57058, 6 interactors
MINTiP57058
STRINGi9606.ENSP00000270112

Chemistry databases

BindingDBiP57058
ChEMBLiCHEMBL1795165

PTM databases

iPTMnetiP57058
PhosphoSitePlusiP57058

Polymorphism and mutation databases

BioMutaiHUNK
DMDMi9973393

Proteomic databases

PaxDbiP57058
PeptideAtlasiP57058
PRIDEiP57058
ProteomicsDBi56977
TopDownProteomicsiP57058

Protocols and materials databases

DNASUi30811
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270112; ENSP00000270112; ENSG00000142149
GeneIDi30811
KEGGihsa:30811
UCSCiuc002yph.3 human

Organism-specific databases

CTDi30811
DisGeNETi30811
EuPathDBiHostDB:ENSG00000142149.8
GeneCardsiHUNK
HGNCiHGNC:13326 HUNK
HPAiHPA027295
HPA027372
MIMi606532 gene
neXtProtiNX_P57058
OpenTargetsiENSG00000142149
PharmGKBiPA29563
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00920000149073
HOGENOMiHOG000112978
HOVERGENiHBG006086
InParanoidiP57058
KOiK08797
OMAiDKNLPSH
OrthoDBiEOG091G0I19
PhylomeDBiP57058
TreeFamiTF352373

Enzyme and pathway databases

SignaLinkiP57058

Miscellaneous databases

ChiTaRSiHUNK human
GenomeRNAii30811
PROiPR:P57058
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142149 Expressed in 125 organ(s), highest expression level in forebrain
CleanExiHS_HUNK
ExpressionAtlasiP57058 baseline and differential
GenevisibleiP57058 HS

Family and domain databases

CDDicd14070 STKc_HUNK, 1 hit
InterProiView protein in InterPro
IPR034671 Hunk
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHUNK_HUMAN
AccessioniPrimary (citable) accession number: P57058
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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