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UniProtKB - P57057 (G6PT2_HUMAN)
Protein
Glucose-6-phosphate exchanger SLC37A1
Gene
SLC37A1
Organism
Homo sapiens (Human)
Status
Functioni
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
1 PublicationActivity regulationi
Inhibited by vanadate but not by chlorogenic acid.1 Publication
GO - Molecular functioni
- glucose 6-phosphate:inorganic phosphate antiporter activity Source: UniProtKB
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- glucose-6-phosphate transport Source: UniProtKB
- phosphate ion transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Antiport, Sugar transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P57057 |
Reactomei | R-HSA-70263, Gluconeogenesis |
SignaLinki | P57057 |
Protein family/group databases
TCDBi | 2.A.1.4.7, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate exchanger SLC37A11 PublicationAlternative name(s): Glycerol-3-phosphate permease1 Publication Short name: G-3-P permease1 Publication Solute carrier family 37 member 1Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11024, SLC37A1 |
MIMi | 608094, gene |
neXtProti | NX_P57057 |
VEuPathDBi | HostDB:ENSG00000160190 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
- integral component of endoplasmic reticulum membrane Source: UniProtKB
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 242 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 304 – 324 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 394 – 414 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 423 – 443 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 466 – 486 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 490 – 510 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54020 |
OpenTargetsi | ENSG00000160190 |
PharmGKBi | PA35892 |
Miscellaneous databases
Pharosi | P57057, Tbio |
Genetic variation databases
BioMutai | SLC37A1 |
DMDMi | 317373359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000199890 | 1 – 533 | Glucose-6-phosphate exchanger SLC37A1Add BLAST | 533 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 263 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | P57057 |
MassIVEi | P57057 |
MaxQBi | P57057 |
PaxDbi | P57057 |
PeptideAtlasi | P57057 |
PRIDEi | P57057 |
ProteomicsDBi | 56976 |
PTM databases
GlyGeni | P57057, 2 sites |
iPTMneti | P57057 |
PhosphoSitePlusi | P57057 |
Expressioni
Tissue specificityi
Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.2 Publications
Gene expression databases
Bgeei | ENSG00000160190, Expressed in adenohypophysis and 175 other tissues |
ExpressionAtlasi | P57057, baseline and differential |
Genevisiblei | P57057, HS |
Organism-specific databases
HPAi | ENSG00000160190, Tissue enhanced (intestine) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119832, 6 interactors |
IntActi | P57057, 4 interactors |
MINTi | P57057 |
STRINGi | 9606.ENSP00000344648 |
Miscellaneous databases
RNActi | P57057, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2533, Eukaryota |
GeneTreei | ENSGT00940000159245 |
HOGENOMi | CLU_001265_31_6_1 |
InParanoidi | P57057 |
OMAi | IQKELQC |
OrthoDBi | 964162at2759 |
PhylomeDBi | P57057 |
TreeFami | TF314991 |
Family and domain databases
CDDi | cd17344, MFS_SLC37A1_2, 1 hit |
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR044740, SLC37A1_2 IPR000849, Sugar_P_transporter |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PIRSFi | PIRSF002808, Hexose_phosphate_transp, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P57057-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARLPAGIRF IISFSRDQWY RAFIFILTFL LYASFHLSRK PISIVKGELH
60 70 80 90 100
KYCTAWDEAD VRFSSQNRKS GSAAPHQLPD NETDCGWAPF DKNNYQQLLG
110 120 130 140 150
ALDYSFLCAY AVGMYLSGII GERLPIRYYL TFGMLASGAF TALFGLGYFY
160 170 180 190 200
NIHSFGFYVV TQVINGLVQT TGWPSVVTCL GNWFGKGRRG LIMGVWNSHT
210 220 230 240 250
SVGNILGSLI AGYWVSTCWG LSFVVPGAIV AAMGIVCFLF LIEHPNDVRC
260 270 280 290 300
SSTLVTHSKG YENGTNRLRL QKQILKSEKN KPLDPEMQCL LLSDGKGSIH
310 320 330 340 350
PNHVVILPGD GGSGTAAISF TGALKIPGVI EFSLCLLFAK LVSYTFLFWL
360 370 380 390 400
PLYITNVDHL DAKKAGELST LFDVGGIFGG ILAGVISDRL EKRASTCGLM
410 420 430 440 450
LLLAAPTLYI FSTVSKMGLE ATIAMLLLSG ALVSGPYTLI TTAVSADLGT
460 470 480 490 500
HKSLKGNAHA LSTVTAIIDG TGSVGAALGP LLAGLLSPSG WSNVFYMLMF
510 520 530
ADACALLFLI RLIHKELSCP GSATGDQVPF KEQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG69 | A0A0C4DG69_HUMAN | Glucose-6-phosphate exchanger SLC37... | SLC37A1 | 18 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 223 | F → L in AAG29853 (Ref. 2) Curated | 1 | |
Sequence conflicti | 303 | H → Q in AAG29853 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017110 | 247 | D → N1 PublicationCorresponds to variant dbSNP:rs768541152Ensembl. | 1 | |
Natural variantiVAR_017111 | 414 | V → I1 PublicationCorresponds to variant dbSNP:rs228104Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ269529 mRNA Translation: CAB87248.1 AJ277912 mRNA Translation: CAB91985.1 AJ277913 mRNA Translation: CAB91986.1 AF311320 mRNA Translation: AAG29853.1 AP001625 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09552.1 CH471079 Genomic DNA Translation: EAX09553.1 |
CCDSi | CCDS13689.1 |
RefSeqi | NP_001307466.1, NM_001320537.1 NP_061837.3, NM_018964.3 XP_016883866.1, XM_017028377.1 XP_016883867.1, XM_017028378.1 XP_016883868.1, XM_017028379.1 XP_016883869.1, XM_017028380.1 |
Genome annotation databases
Ensembli | ENST00000352133; ENSP00000344648; ENSG00000160190 ENST00000398341; ENSP00000381383; ENSG00000160190 |
GeneIDi | 54020 |
KEGGi | hsa:54020 |
MANE-Selecti | ENST00000352133.3; ENSP00000344648.2; NM_001320537.2; NP_001307466.1 |
UCSCi | uc002zbi.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ269529 mRNA Translation: CAB87248.1 AJ277912 mRNA Translation: CAB91985.1 AJ277913 mRNA Translation: CAB91986.1 AF311320 mRNA Translation: AAG29853.1 AP001625 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09552.1 CH471079 Genomic DNA Translation: EAX09553.1 |
CCDSi | CCDS13689.1 |
RefSeqi | NP_001307466.1, NM_001320537.1 NP_061837.3, NM_018964.3 XP_016883866.1, XM_017028377.1 XP_016883867.1, XM_017028378.1 XP_016883868.1, XM_017028379.1 XP_016883869.1, XM_017028380.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119832, 6 interactors |
IntActi | P57057, 4 interactors |
MINTi | P57057 |
STRINGi | 9606.ENSP00000344648 |
Protein family/group databases
TCDBi | 2.A.1.4.7, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | P57057, 2 sites |
iPTMneti | P57057 |
PhosphoSitePlusi | P57057 |
Genetic variation databases
BioMutai | SLC37A1 |
DMDMi | 317373359 |
Proteomic databases
EPDi | P57057 |
MassIVEi | P57057 |
MaxQBi | P57057 |
PaxDbi | P57057 |
PeptideAtlasi | P57057 |
PRIDEi | P57057 |
ProteomicsDBi | 56976 |
Protocols and materials databases
Antibodypediai | 23842, 82 antibodies from 19 providers |
DNASUi | 54020 |
Genome annotation databases
Ensembli | ENST00000352133; ENSP00000344648; ENSG00000160190 ENST00000398341; ENSP00000381383; ENSG00000160190 |
GeneIDi | 54020 |
KEGGi | hsa:54020 |
MANE-Selecti | ENST00000352133.3; ENSP00000344648.2; NM_001320537.2; NP_001307466.1 |
UCSCi | uc002zbi.3, human |
Organism-specific databases
CTDi | 54020 |
DisGeNETi | 54020 |
GeneCardsi | SLC37A1 |
HGNCi | HGNC:11024, SLC37A1 |
HPAi | ENSG00000160190, Tissue enhanced (intestine) |
MIMi | 608094, gene |
neXtProti | NX_P57057 |
OpenTargetsi | ENSG00000160190 |
PharmGKBi | PA35892 |
VEuPathDBi | HostDB:ENSG00000160190 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2533, Eukaryota |
GeneTreei | ENSGT00940000159245 |
HOGENOMi | CLU_001265_31_6_1 |
InParanoidi | P57057 |
OMAi | IQKELQC |
OrthoDBi | 964162at2759 |
PhylomeDBi | P57057 |
TreeFami | TF314991 |
Enzyme and pathway databases
PathwayCommonsi | P57057 |
Reactomei | R-HSA-70263, Gluconeogenesis |
SignaLinki | P57057 |
Miscellaneous databases
BioGRID-ORCSi | 54020, 5 hits in 1045 CRISPR screens |
ChiTaRSi | SLC37A1, human |
GenomeRNAii | 54020 |
Pharosi | P57057, Tbio |
PROi | PR:P57057 |
RNActi | P57057, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160190, Expressed in adenohypophysis and 175 other tissues |
ExpressionAtlasi | P57057, baseline and differential |
Genevisiblei | P57057, HS |
Family and domain databases
CDDi | cd17344, MFS_SLC37A1_2, 1 hit |
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR044740, SLC37A1_2 IPR000849, Sugar_P_transporter |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PIRSFi | PIRSF002808, Hexose_phosphate_transp, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G6PT2_HUMAN | |
Accessioni | P57057Primary (citable) accession number: P57057 Secondary accession number(s): D3DSJ7, Q9HAQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families