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Entry version 158 (17 Jun 2020)
Sequence version 4 (28 Mar 2018)
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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Gene

PIGP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.198 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00196

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (EC:2.4.1.198)
Alternative name(s):
Down syndrome critical region protein 5
Down syndrome critical region protein C
Phosphatidylinositol-glycan biosynthesis class P protein
Short name:
PIG-P
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIGP
Synonyms:DCRC, DSCR5, DSCRC
ORF Names:NPD010
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185808.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3046 PIGP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605938 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P57054

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epileptic encephalopathy, early infantile, 55 (EIEE55)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE55 is an autosomal recessive condition.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07929125M → T in EIEE55; reduced GPI-anchor biosynthetic process; may affect expression of isoform A. 1 PublicationCorresponds to variant dbSNP:rs768633670EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

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DisGeNETi
51227

MalaCards human disease database

More...
MalaCardsi
PIGP
MIMi617599 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000185808

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1934 Early infantile epileptic encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27498

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P57054 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIGP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
425906062

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917831 – 158Phosphatidylinositol N-acetylglucosaminyltransferase subunit PAdd BLAST158

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P57054

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P57054

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P57054

PeptideAtlas

More...
PeptideAtlasi
P57054

PRoteomics IDEntifications database

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PRIDEi
P57054

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56970 [P57054-1]
56971 [P57054-2]
56972 [P57054-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P57054-2 [P57054-2]
P57054-3 [P57054-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P57054

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P57054

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000185808 Expressed in caput epididymis and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P57054 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P57054 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185808 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with PIGA, PIGC, PIGH, PIGQ and DPM2. The latter is not essential for activity.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119391, 7 interactors

Protein interaction database and analysis system

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IntActi
P57054, 19 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000420037

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P57054 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P57054

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIGP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2257 Eukaryota
ENOG41121KH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013771

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_081616_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P57054

KEGG Orthology (KO)

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KOi
K03861

Identification of Orthologs from Complete Genome Data

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OMAi
LYCLWAF

Database of Orthologous Groups

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OrthoDBi
1579862at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P57054

TreeFam database of animal gene trees

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TreeFami
TF323799

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013717 PIG-P
IPR016542 PIG-P_GPI19

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08510 PIG-P, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF008765 PIG-P_GPI19, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: P57054-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPRSTSLTL IVFLFHRLSK APGKMVENSP SPLPERAIYG FVLFLSSQFG
60 70 80 90 100
FILYLVWAFI PESWLNSLGL TYWPQKYWAV ALPVYLLIAI VIGYVLLFGI
110 120 130 140 150
NMMSTSPLDS IHTITDNYAK NQQQKKYQEE AIPALRDISI SEVNQMFFLA

AKELYTKN
Length:158
Mass (Da):18,089
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9309CEAC1DD777CF
GO
Isoform A (identifier: P57054-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:134
Mass (Da):15,408
Checksum:i47A2122FA663EB64
GO
Isoform C (identifier: P57054-3) [UniParc]FASTAAdd to basket
Also known as: DCRC-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     51-52: FI → MV

Show »
Length:108
Mass (Da):12,510
Checksum:iCF1E65158429EE48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JKT1C9JKT1_HUMAN
Phosphatidylinositol N-acetylglucos...
PIGP
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3P → S in BAA96872 (PubMed:10814524).Curated1
Sequence conflicti90I → V in BAA96873 (PubMed:10814524).Curated1
Sequence conflicti90I → V in AAF32289 (PubMed:10907851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0615219T → A. Corresponds to variant dbSNP:rs2507733Ensembl.1
Natural variantiVAR_07929125M → T in EIEE55; reduced GPI-anchor biosynthetic process; may affect expression of isoform A. 1 PublicationCorresponds to variant dbSNP:rs768633670EnsemblClinVar.1
Natural variantiVAR_050538118Y → C. Corresponds to variant dbSNP:rs16994704Ensembl.1
Natural variantiVAR_050539136R → S. Corresponds to variant dbSNP:rs2276231Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0042031 – 50Missing in isoform C. 3 PublicationsAdd BLAST50
Alternative sequenceiVSP_0042021 – 24Missing in isoform A. 5 PublicationsAdd BLAST24
Alternative sequenceiVSP_00420451 – 52FI → MV in isoform C. 3 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB037162 mRNA Translation: BAA96871.1
AB037163 mRNA Translation: BAA96872.1
AB037164 mRNA Translation: BAA96873.1
AB035742 mRNA Translation: BAA95633.1
AB035743 mRNA Translation: BAA95634.1
AB035744 mRNA Translation: BAA95635.1
AB035745 mRNA Translation: BAA95636.1
AF216305 mRNA Translation: AAF32289.1
AB039659 mRNA Translation: BAB12395.1
AF237812 mRNA Translation: AAG09757.1
BT007053 mRNA Translation: AAP35702.1
AK314457 mRNA Translation: BAG37065.1
AK316609 mRNA Translation: BAG38196.1
AB451328 mRNA Translation: BAG70142.1
AB451472 mRNA Translation: BAG70286.1
AP000704 Genomic DNA No translation available.
AP001429 Genomic DNA No translation available.
AP001431 Genomic DNA No translation available.
AP001727 Genomic DNA Translation: BAA95512.1
KC877872 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09724.1
CH471079 Genomic DNA Translation: EAX09725.1
CH471079 Genomic DNA Translation: EAX09727.1
CH471079 Genomic DNA Translation: EAX09726.1
CH471079 Genomic DNA Translation: EAX09728.1
BC005180 mRNA Translation: AAH05180.1
BC011007 mRNA Translation: AAH11007.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13649.1 [P57054-1]
CCDS13650.1 [P57054-2]
CCDS82670.1 [P57054-3]

Protein sequence database of the Protein Information Resource

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PIRi
JC7301
JC7302

NCBI Reference Sequences

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RefSeqi
NP_001307409.1, NM_001320480.1 [P57054-2]
NP_057514.2, NM_016430.3 [P57054-3]
NP_710148.1, NM_153681.2 [P57054-1]
NP_710149.1, NM_153682.2 [P57054-2]
XP_005261047.1, XM_005260990.4
XP_011527898.1, XM_011529596.2
XP_016883853.1, XM_017028364.1
XP_016883854.1, XM_017028365.1 [P57054-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360525; ENSP00000353719; ENSG00000185808 [P57054-2]
ENST00000399098; ENSP00000382049; ENSG00000185808 [P57054-3]
ENST00000399102; ENSP00000382053; ENSG00000185808 [P57054-2]
ENST00000399103; ENSP00000382054; ENSG00000185808 [P57054-2]
ENST00000464265; ENSP00000420037; ENSG00000185808 [P57054-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51227

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51227

UCSC genome browser

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UCSCi
uc002yvw.2 human [P57054-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037162 mRNA Translation: BAA96871.1
AB037163 mRNA Translation: BAA96872.1
AB037164 mRNA Translation: BAA96873.1
AB035742 mRNA Translation: BAA95633.1
AB035743 mRNA Translation: BAA95634.1
AB035744 mRNA Translation: BAA95635.1
AB035745 mRNA Translation: BAA95636.1
AF216305 mRNA Translation: AAF32289.1
AB039659 mRNA Translation: BAB12395.1
AF237812 mRNA Translation: AAG09757.1
BT007053 mRNA Translation: AAP35702.1
AK314457 mRNA Translation: BAG37065.1
AK316609 mRNA Translation: BAG38196.1
AB451328 mRNA Translation: BAG70142.1
AB451472 mRNA Translation: BAG70286.1
AP000704 Genomic DNA No translation available.
AP001429 Genomic DNA No translation available.
AP001431 Genomic DNA No translation available.
AP001727 Genomic DNA Translation: BAA95512.1
KC877872 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09724.1
CH471079 Genomic DNA Translation: EAX09725.1
CH471079 Genomic DNA Translation: EAX09727.1
CH471079 Genomic DNA Translation: EAX09726.1
CH471079 Genomic DNA Translation: EAX09728.1
BC005180 mRNA Translation: AAH05180.1
BC011007 mRNA Translation: AAH11007.1
CCDSiCCDS13649.1 [P57054-1]
CCDS13650.1 [P57054-2]
CCDS82670.1 [P57054-3]
PIRiJC7301
JC7302
RefSeqiNP_001307409.1, NM_001320480.1 [P57054-2]
NP_057514.2, NM_016430.3 [P57054-3]
NP_710148.1, NM_153681.2 [P57054-1]
NP_710149.1, NM_153682.2 [P57054-2]
XP_005261047.1, XM_005260990.4
XP_011527898.1, XM_011529596.2
XP_016883853.1, XM_017028364.1
XP_016883854.1, XM_017028365.1 [P57054-3]

3D structure databases

SMRiP57054
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119391, 7 interactors
IntActiP57054, 19 interactors
STRINGi9606.ENSP00000420037

PTM databases

iPTMnetiP57054
PhosphoSitePlusiP57054

Polymorphism and mutation databases

BioMutaiPIGP
DMDMi425906062

Proteomic databases

EPDiP57054
MassIVEiP57054
PaxDbiP57054
PeptideAtlasiP57054
PRIDEiP57054
ProteomicsDBi56970 [P57054-1]
56971 [P57054-2]
56972 [P57054-3]
TopDownProteomicsiP57054-2 [P57054-2]
P57054-3 [P57054-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8411 117 antibodies

The DNASU plasmid repository

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DNASUi
51227

Genome annotation databases

EnsembliENST00000360525; ENSP00000353719; ENSG00000185808 [P57054-2]
ENST00000399098; ENSP00000382049; ENSG00000185808 [P57054-3]
ENST00000399102; ENSP00000382053; ENSG00000185808 [P57054-2]
ENST00000399103; ENSP00000382054; ENSG00000185808 [P57054-2]
ENST00000464265; ENSP00000420037; ENSG00000185808 [P57054-1]
GeneIDi51227
KEGGihsa:51227
UCSCiuc002yvw.2 human [P57054-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51227
DisGeNETi51227
EuPathDBiHostDB:ENSG00000185808.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PIGP
HGNCiHGNC:3046 PIGP
HPAiENSG00000185808 Low tissue specificity
MalaCardsiPIGP
MIMi605938 gene
617599 phenotype
neXtProtiNX_P57054
OpenTargetsiENSG00000185808
Orphaneti1934 Early infantile epileptic encephalopathy
PharmGKBiPA27498

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2257 Eukaryota
ENOG41121KH LUCA
GeneTreeiENSGT00390000013771
HOGENOMiCLU_081616_2_1_1
InParanoidiP57054
KOiK03861
OMAiLYCLWAF
OrthoDBi1579862at2759
PhylomeDBiP57054
TreeFamiTF323799

Enzyme and pathway databases

UniPathwayiUPA00196
BRENDAi2.4.1.198 2681
ReactomeiR-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51227 5 hits in 781 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIGP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PIGP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51227
PharosiP57054 Tbio

Protein Ontology

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PROi
PR:P57054
RNActiP57054 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185808 Expressed in caput epididymis and 234 other tissues
ExpressionAtlasiP57054 baseline and differential
GenevisibleiP57054 HS

Family and domain databases

InterProiView protein in InterPro
IPR013717 PIG-P
IPR016542 PIG-P_GPI19
PfamiView protein in Pfam
PF08510 PIG-P, 1 hit
PIRSFiPIRSF008765 PIG-P_GPI19, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIGP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P57054
Secondary accession number(s): A0A0C4DH71
, B2RB18, B2RE99, B5BU92, D3DSG7, J3KR75, Q53Y28, Q96KI1, Q9NZA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 28, 2018
Last modified: June 17, 2020
This is version 158 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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