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Protein

Scorpine

Gene
N/A
Organism
Pandinus imperator (Emperor scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antibacterial activity against B.subtilis and K.pneumoniae and a potent inhibitory effect on the ookinete (ED(50) 0.7 µM) and gamete (ED(50) 10 µM) stages of Plasmodium berghei development.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Toxin

Protein family/group databases

TCDBi1.C.47.3.1 the insect/fungal defensin (insect/fungal defensin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Scorpine
Short name:
Scorpin
Alternative name(s):
Panscorpine
OrganismiPandinus imperator (Emperor scorpion)
Taxonomic identifieri55084 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaePandinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003535520 – 94ScorpineAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 81PROSITE-ProRule annotation
Disulfide bondi68 ↔ 86PROSITE-ProRule annotation
Disulfide bondi72 ↔ 88PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiP56972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 94BetaSPN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST40

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR029237 Long_scorpion_toxin
PfamiView protein in Pfam
PF14866 Toxin_38, 1 hit
PROSITEiView protein in PROSITE
PS51862 BSPN_CSAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56972-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSKLTALIF LGLIAIAYCG WINEEKIQKK IDERMGNTVL GGMAKAIVHK
60 70 80 90
MAKNEFQCMA NMDMLGNCEK HCQTSGEKGY CHGTKCKCGT PLSY
Length:94
Mass (Da):10,394
Last modified:December 1, 2000 - v1
Checksum:i04E57F04BAECC89F
GO

Mass spectrometryi

Molecular mass is 8350 Da from positions 20 - 94. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292361 mRNA Translation: CAB96789.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292361 mRNA Translation: CAB96789.1

3D structure databases

SMRiP56972
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.47.3.1 the insect/fungal defensin (insect/fungal defensin) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR029237 Long_scorpion_toxin
PfamiView protein in Pfam
PF14866 Toxin_38, 1 hit
PROSITEiView protein in PROSITE
PS51862 BSPN_CSAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKBX3_PANIM
AccessioniPrimary (citable) accession number: P56972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 20, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
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Main funding by: National Institutes of Health

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