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Entry version 155 (07 Apr 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Exosome component 10

Gene

Exosc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
Biological processNonsense-mediated mRNA decay, rRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exosome component 10 (EC:3.1.13.-)
Alternative name(s):
Autoantigen PM/Scl 2 homolog
Polymyositis/scleroderma autoantigen 2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Exosc10
Synonyms:Pmscl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1355322, Exosc10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000871341 – 887Exosome component 10Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki19Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki583Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki583Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei823PhosphoserineBy similarity1
Cross-linki835Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki861Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki875Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P56960

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P56960

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56960

PeptideAtlas

More...
PeptideAtlasi
P56960

PRoteomics IDEntifications database

More...
PRIDEi
P56960

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
275706

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56960

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56960

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000017264, Expressed in undifferentiated genital tubercle and 305 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P56960, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56960, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.

Interacts with C1D and MPHOSPH6 (By similarity).

Interacts with ALYREF/THOC4 (By similarity).

Interacts with MTREX; the interaction mediates the association of MTREX with nuclear RNA exosomes (By similarity).

Interacts with DHX36; this interaction occurs in a RNase-insensitive manner (By similarity).

Interacts with NRDE2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
206151, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-594, Nuclear exosome complex, Dis3-Exosc10 variant
CPX-595, Nucleolar exosome complex, Exosc10 variant
CPX-601, Cytoplasmic exosome complex, Dis3l-Exosc10 variant

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P56960

Protein interaction database and analysis system

More...
IntActi
P56960, 3 interactors

Molecular INTeraction database

More...
MINTi
P56960

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000017408

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P56960, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56960

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini503 – 583HRDCPROSITE-ProRule annotationAdd BLAST81

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2206, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010129_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56960

Database of Orthologous Groups

More...
OrthoDBi
677201at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105991

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR012588, Exosome-assoc_fac_Rrp6_N
IPR010997, HRDC-like_sf
IPR002121, HRDC_dom
IPR012337, RNaseH-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01612, DNA_pol_A_exo1, 1 hit
PF00570, HRDC, 1 hit
PF08066, PMC2NT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00474, 35EXOc, 1 hit
SM00341, HRDC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47819, SSF47819, 1 hit
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50967, HRDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P56960-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPSPREHQ SAPATSATKP DAEMVLPGFP DADSFVKFAL GSVVAVTKAS
60 70 80 90 100
GGLPQFGDEY DFYRSFPAFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR
110 120 130 140 150
SKVTELEDKF DLLVDTNDVI LERVGMLLDE ASGVNKHQQP VLPAGLQVPK
160 170 180 190 200
TIVSSWNRKA GEYGKKAKSE TFRLLHAKNI VRPQLRFREK IDNSNTPFLP
210 220 230 240 250
KIFVKPNARK PLPLALSKER RERPQDRPED LDVPPALADF IHQQRTQQVE
260 270 280 290 300
QDMFAHPYQY ELDHFTPPQS VLQRPKPQLY RAVGETPCHL VSSLDELVEL
310 320 330 340 350
NEKLLGCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFIV DTLELRSDMY
360 370 380 390 400
ILNESLTDPA IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLAR
410 420 430 440 450
HSLDHLLRLY CGVESNKQYQ LADWRIRPLP EEMLSYARDD THYLLYIYDR
460 470 480 490 500
MRLELWERGN HQPVQLQVVW QRSRDICLKK FVKPIFTDES YLELYRKQKK
510 520 530 540 550
HLNSQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI AEELPKEPQG
560 570 580 590 600
IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSENAAGV RKSGPLPSAE
610 620 630 640 650
RLENDLFGPH DCSHAPPDNY QNTSTDGTLP LQKQPSLFTE GKEETSVDAG
660 670 680 690 700
CLLATAVITL FSEPNTEEGG KTPLTVAQKK AQNIMQSFEN PFRMFLPSLE
710 720 730 740 750
HKAHISQAAK FDPSSKIYEI SNRWKLASQV QVQKEPKEAT KKKVAEQTAA
760 770 780 790 800
REEAKEEAAA GVLEQAIPVR QQAALENATK KRERATSDLR TIEQKQEKKR
810 820 830 840 850
LKSSKKAKDP DPPGKDFSPY DYSQSDFRAF AGDSKSKPSS QFDPNKLAPS
860 870 880
GKKGVGAKKC KQSVGNKSMS FAVGKSDRGF RHNWPKR
Length:887
Mass (Da):100,942
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i173164944163620C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8K366Q8K366_MOUSE
Exosc10 protein
Exosc10 p2, p3, p4, PM, PM-Scl
862Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VYQ6F6VYQ6_MOUSE
Exosome component 10
Exosc10
618Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWL4G3UWL4_MOUSE
Exosome component 10
Exosc10
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti792I → V in AAF01779 (PubMed:10708524).Curated1
Sequence conflicti792I → V in AAF01781 (PubMed:10708524).Curated1
Sequence conflicti860C → F in AAF01779 (PubMed:10708524).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF091392 mRNA Translation: AAF01779.1
AF091505 AF092083 Genomic DNA Translation: AAF01781.1
AL606969 Genomic DNA No translation available.
AL713995 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18939.1

NCBI Reference Sequences

More...
RefSeqi
NP_057908.2, NM_016699.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000017408; ENSMUSP00000017408; ENSMUSG00000017264

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50912

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:50912

UCSC genome browser

More...
UCSCi
uc008vut.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091392 mRNA Translation: AAF01779.1
AF091505 AF092083 Genomic DNA Translation: AAF01781.1
AL606969 Genomic DNA No translation available.
AL713995 Genomic DNA No translation available.
CCDSiCCDS18939.1
RefSeqiNP_057908.2, NM_016699.2

3D structure databases

SMRiP56960
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi206151, 2 interactors
ComplexPortaliCPX-594, Nuclear exosome complex, Dis3-Exosc10 variant
CPX-595, Nucleolar exosome complex, Exosc10 variant
CPX-601, Cytoplasmic exosome complex, Dis3l-Exosc10 variant
CORUMiP56960
IntActiP56960, 3 interactors
MINTiP56960
STRINGi10090.ENSMUSP00000017408

PTM databases

iPTMnetiP56960
PhosphoSitePlusiP56960

Proteomic databases

EPDiP56960
MaxQBiP56960
PaxDbiP56960
PeptideAtlasiP56960
PRIDEiP56960
ProteomicsDBi275706

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13683, 183 antibodies

Genome annotation databases

EnsembliENSMUST00000017408; ENSMUSP00000017408; ENSMUSG00000017264
GeneIDi50912
KEGGimmu:50912
UCSCiuc008vut.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5394
MGIiMGI:1355322, Exosc10

Phylogenomic databases

eggNOGiKOG2206, Eukaryota
GeneTreeiENSGT00390000015408
HOGENOMiCLU_010129_1_1_1
InParanoidiP56960
OrthoDBi677201at2759
TreeFamiTF105991

Enzyme and pathway databases

ReactomeiR-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
50912, 18 hits in 51 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Exosc10, mouse

Protein Ontology

More...
PROi
PR:P56960
RNActiP56960, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000017264, Expressed in undifferentiated genital tubercle and 305 other tissues
ExpressionAtlasiP56960, baseline and differential
GenevisibleiP56960, MM

Family and domain databases

InterProiView protein in InterPro
IPR002562, 3'-5'_exonuclease_dom
IPR012588, Exosome-assoc_fac_Rrp6_N
IPR010997, HRDC-like_sf
IPR002121, HRDC_dom
IPR012337, RNaseH-like_sf
PfamiView protein in Pfam
PF01612, DNA_pol_A_exo1, 1 hit
PF00570, HRDC, 1 hit
PF08066, PMC2NT, 1 hit
SMARTiView protein in SMART
SM00474, 35EXOc, 1 hit
SM00341, HRDC, 1 hit
SUPFAMiSSF47819, SSF47819, 1 hit
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50967, HRDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOSX_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56960
Secondary accession number(s): B1ARY9, Q9QYS8, Q9R0B1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: April 7, 2021
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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