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Protein

RNA-binding protein

Gene

US11

Organism
Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in the inhibition of host immune response. Participates in the inhibition of host autophagy by interacting with and inhibiting host PKR/EIF2AK2. This interaction also prevents the interferon-induced shut down of protein synthesis following viral infection. Downmodulates the host RLR signaling pathway via direct interaction with host DDX58 and IFIH1. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processHost-virus interaction, Inhibition of host autophagy by virus, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MDA5 by virus, Inhibition of host PKR by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein
Alternative name(s):
Vmw21
Gene namesi
Name:US11
OrganismiHuman herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10307 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157411 – 161RNA-binding proteinAdd BLAST161

Post-translational modificationi

May be phosphorylated on Ser residues by host kinases.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP56958

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Associates with RNA derived from the 60S ribosomal subunits. Seems to form large heterogeneous polymers of up to 200 identical subunits in the cytoplasm. Interacts with host EIF2AK2. Interacts with host NCL. Interacts with host DDX58; this interaction prevents DDX58 binding to host MAVS. Interacts with host IFIH1; this interaction prevents host IFH1 binding to MAVS.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati85 – 9016
Repeati91 – 9626
Repeati97 – 10236
Repeati103 – 10846
Repeati109 – 11456
Repeati115 – 12066
Repeati121 – 12676
Repeati127 – 13286
Repeati133 – 13896
Repeati139 – 144106
Repeati145 – 150116
Repeati151 – 156126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 15612 X 6 AA approximate tandem repeatsAdd BLAST72

Domaini

The N-terminal tetrapeptide may be responsible for virion incorporation.By similarity
The C-terminal half, rich in Arg and Pro residues, seems to be responsible for the RNA-binding activity, and for the association with ribosomes and the localization to the nucleolus. This region may adopt a poly-L-proline II helix secondary structure.By similarity

Sequence similaritiesi

Belongs to the simplex virus US11 protein family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiView protein in InterPro
IPR020124 Herpes_US11_RNA-bd_N
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028529 Herpes_US11_RNA-bd_N, 1 hit

Sequencei

Sequence statusi: Complete.

P56958-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQTQPPAPV GPGDPDVYLK GVPSAGMHPR GVHAPRGHPR MISGPPQRGD
60 70 80 90 100
NDQAAGQCGD SGLLRVGADT TISKPSEAVR PPTIPRTPRV PREPRVPRPP
110 120 130 140 150
REPREPRVPR ASRDPRVPRD PRDPRQPRSP REPRSPREPR PPREPRTPRT
160
TREPRTARGA V
Length:161
Mass (Da):17,745
Last modified:December 1, 2000 - v1
Checksum:i1CF68615474462FF
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP56958

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR020124 Herpes_US11_RNA-bd_N
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028529 Herpes_US11_RNA-bd_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNB_HHV1M
AccessioniPrimary (citable) accession number: P56958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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