BCAR1

Functionⁱ

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.2 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization
Source: UniProtKB
Inferred from direct assayⁱ
- 16105984
actin filament reorganization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
antigen receptor-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 10587647
B cell receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 9020138
cell adhesion Source: UniProtKB-KW
cell chemotaxis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21245381
cell division
Source: UniProtKB
Non-traceable author statementⁱ
- 10675905
cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 9425168
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10639512
cellular response to hepatocyte growth factor stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21245381
epidermal growth factor receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
hepatocyte growth factor receptor signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21245381
insulin receptor signaling pathway Source: UniProtKB
integrin-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 8649368
neurotrophin TRK receptor signaling pathway Source: UniProtKB
platelet-derived growth factor receptor signaling pathway Source: UniProtKB
positive regulation of cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 9472046
positive regulation of endothelial cell migration
Source: BHF-UCL
Inferred from direct assayⁱ
- 21245381
regulation of apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 11607844
regulation of cell growth
Source: UniProtKB
Traceable author statementⁱ
- 11607844
T cell receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 9295052
vascular endothelial growth factor receptor signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21245381

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-186763 Downstream signal transduction R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkⁱ	P56945
SIGNORⁱ	P56945

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Breast cancer anti-estrogen resistance protein 1 Alternative name(s): CRK-associated substrate Cas scaffolding protein family member 1 p130cas
Gene namesⁱ	Name:BCAR1 Synonyms:CAS, CASS1, CRKAS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000050820.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:971 BCAR1
MIMⁱ	602941 gene
neXtProtⁱ	NX_P56945

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9564
Open Targets More...OpenTargetsⁱ	ENSG00000050820
PharmGKBⁱ	PA25281

Polymorphism and mutation databases

BioMutaⁱ	BCAR1
DMDMⁱ	288558806

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064854	1 – 870	Breast cancer anti-estrogen resistance protein 1Add BLAST		870

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine1 Publication	1
Modified residueⁱ	128	Phosphotyrosine; by SRC1 Publication	1
Modified residueⁱ	134	PhosphoserineCombined sources	1
Modified residueⁱ	139	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	234	PhosphotyrosineBy similarity	1
Modified residueⁱ	249	Phosphotyrosine; by ABL1By similarity	1
Modified residueⁱ	269	PhosphothreonineCombined sources	1
Modified residueⁱ	292	PhosphoserineCombined sources	1
Modified residueⁱ	362	PhosphotyrosineBy similarity	1
Modified residueⁱ	372	PhosphotyrosineBy similarity	1
Modified residueⁱ	410	PhosphotyrosineBy similarity	1
Modified residueⁱ	428	PhosphoserineCombined sources	1
Modified residueⁱ	437	Phosphoserine1 Publication	1
Modified residueⁱ	639	PhosphoserineCombined sources1 Publication	1

Post-translational modificationⁱ

PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.4 Publications

Dephosphorylated by PTPN14 at Tyr-128.

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P56945
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P56945
PaxDbⁱ	P56945
PeptideAtlas More...PeptideAtlasⁱ	P56945
PRIDEⁱ	P56945
ProteomicsDBⁱ	56960 56961 [P56945-2]

PTM databases

iPTMnetⁱ	P56945
PhosphoSitePlusⁱ	P56945

Expressionⁱ

Tissue specificityⁱ

Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.

Gene expression databases

Bgeeⁱ	ENSG00000050820 Expressed in 181 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_BCAR1
ExpressionAtlasⁱ	P56945 baseline and differential
Genevisibleⁱ	P56945 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000443 HPA042282

HPAⁱ

CAB000443
HPA042282

Interactionⁱ

Subunit structureⁱ

Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation. Interacts with NPHP1 and SH2D3C. Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with TNK2 via SH3 domains. Interacts with PTK2B/PYK2.8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BCAR3	O75815-1	3	EBI-702093,EBI-15953103
CRK	P46108	5	EBI-702093,EBI-886
FYN	P06241	3	EBI-702093,EBI-515315
INPPL1	O15357	2	EBI-702093,EBI-1384248
IQGAP1	P46940	4	EBI-702093,EBI-297509
MMP14	P50281	3	EBI-702093,EBI-992788
PEAK1	Q9H792	3	EBI-702093,EBI-2609701
PTK2	Q05397	2	EBI-702093,EBI-702142
PTPN1	P18031	5	EBI-702093,EBI-968788
PTPN12	Q05209	4	EBI-702093,EBI-2266035
SH2D3C	Q8N5H7-2	8	EBI-702093,EBI-15952996
SRC	P12931	3	EBI-702093,EBI-621482
SRCIN1	Q9C0H9	3	EBI-702093,EBI-1393949
Srcin1	Q9QWI6	3	EBI-702093,EBI-775592	From Mus musculus.
TNK2	Q07912	5	EBI-702093,EBI-603457
TNS	Q04205	2	EBI-702093,EBI-2607590	From Gallus gallus.
TNS3	Q68CZ2	8	EBI-702093,EBI-1220488

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114934, 73 interactors
CORUMⁱ	P56945
Database of interacting proteins More...DIPⁱ	DIP-33855N
ELMⁱ	P56945
IntActⁱ	P56945, 261 interactors
Molecular INTeraction database More...MINTⁱ	P56945
STRINGⁱ	9606.ENSP00000391669

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 12	Combined sources	8
Beta strandⁱ	29 – 34	Combined sources	6
Helixⁱ	37 – 39	Combined sources	3
Beta strandⁱ	43 – 48	Combined sources	6
Beta strandⁱ	51 – 56	Combined sources	6
Helixⁱ	57 – 59	Combined sources	3
Beta strandⁱ	60 – 68	Combined sources	9
Helixⁱ	740 – 770	Combined sources	31
Helixⁱ	775 – 801	Combined sources	27
Helixⁱ	806 – 835	Combined sources	30
Helixⁱ	840 – 870	Combined sources	31

Show more details

3D structure databases

ProteinModelPortalⁱ	P56945
SMRⁱ	P56945
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P56945

EvolutionaryTraceⁱ

P56945

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 65	SH3PROSITE-ProRule annotationAdd BLAST		63

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	115 – 416	Substrate for kinasesBy similarityAdd BLAST		302
Regionⁱ	746 – 796	Divergent helix-loop-helix motifAdd BLAST		51

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	635 – 643	SH3-bindingSequence analysis		9

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	74 – 87	Pro-richAdd BLAST		14
Compositional biasⁱ	422 – 614	Ser-richAdd BLAST		193

Domainⁱ

Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).By similarity

A serine-rich region promotes activation of the serum response element (SRE).

The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11.

Sequence similaritiesⁱ

Belongs to the CAS family.Curated

Keywords - Domainⁱ

SH3 domain, SH3-binding

Phylogenomic databases

eggNOGⁱ	ENOG410IEDD Eukaryota ENOG410ZSUM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00490000043324
HOGENOMⁱ	HOG000261698
HOVERGENⁱ	HBG004354
InParanoidⁱ	P56945
KEGG Orthology (KO) More...KOⁱ	K05726
OMAⁱ	TVEHNQP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RVA
PhylomeDBⁱ	P56945
TreeFamⁱ	TF328782

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12001 SH3_BCAR1, 1 hit
Gene3Dⁱ	1.20.120.830, 1 hit
InterProⁱ	View protein in InterPro IPR028848 BCAR1 IPR035745 BCAR1_SH3 IPR021901 CAS_C IPR037362 CAS_fam IPR014928 Serine_rich_dom IPR038319 Serine_rich_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR10654 PTHR10654, 1 hit PTHR10654:SF15 PTHR10654:SF15, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12026 DUF3513, 1 hit PF08824 Serine_rich, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002 SH3, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 8 described isoforms and 17 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P56945-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHLNVLAKA LYDNVAESPD ELSFRKGDIM TVLEQDTQGL DGWWLCSLHG 
        60         70         80         90        100
RQGIVPGNRL KILVGMYDKK PAGPGPGPPA TPAQPQPGLH APAPPASQYT 
       110        120        130        140        150
PMLPNTYQPQ PDSVYLVPTP SKAQQGLYQV PGPSPQFQSP PAKQTSTFSK 
       160        170        180        190        200
QTPHHPFPSP ATDLYQVPPG PGGPAQDIYQ VPPSAGMGHD IYQVPPSMDT 
       210        220        230        240        250
RSWEGTKPPA KVVVPTRVGQ GYVYEAAQPE QDEYDIPRHL LAPGPQDIYD 
       260        270        280        290        300
VPPVRGLLPS QYGQEVYDTP PMAVKGPNGR DPLLEVYDVP PSVEKGLPPS 
       310        320        330        340        350
NHHAVYDVPP SVSKDVPDGP LLREETYDVP PAFAKAKPFD PARTPLVLAA 
       360        370        380        390        400
PPPDSPPAED VYDVPPPAPD LYDVPPGLRR PGPGTLYDVP RERVLPPEVA 
       410        420        430        440        450
DGGVVDSGVY AVPPPAEREA PAEGKRLSAS STGSTRSSQS ASSLEVAGPG 
       460        470        480        490        500
REPLELEVAV EALARLQQGV SATVAHLLDL AGSAGATGSW RSPSEPQEPL 
       510        520        530        540        550
VQDLQAAVAA VQSAVHELLE FARSAVGNAA HTSDRALHAK LSRQLQKMED 
       560        570        580        590        600
VHQTLVAHGQ ALDAGRGGSG ATLEDLDRLV ACSRAVPEDA KQLASFLHGN 
       610        620        630        640        650
ASLLFRRTKA TAPGPEGGGT LHPNPTDKTS SIQSRPLPSP PKFTSQDSPD 
       660        670        680        690        700
GQYENSEGGW MEDYDYVHLQ GKEEFEKTQK ELLEKGSITR QGKSQLELQQ 
       710        720        730        740        750
LKQFERLEQE VSRPIDHDLA NWTPAQPLAP GRTGGLGPSD RQLLLFYLEQ 
       760        770        780        790        800
CEANLTTLTN AVDAFFTAVA TNQPPKIFVA HSKFVILSAH KLVFIGDTLS 
       810        820        830        840        850
RQAKAADVRS QVTHYSNLLC DLLRGIVATT KAAALQYPSP SAAQDMVERV 
       860        870
KELGHSTQQF RRVLGQLAAA

Length:870

Mass (Da):93,372

Last modified:February 9, 2010 - v2

Checksum:ⁱB81EC3430049E795

GO

Isoform 2 (identifier: P56945-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-4: MNHL → MLTHRPQEAEQRGRTPGPSFEW

« Hide

        10         20         30         40         50
MLTHRPQEAE QRGRTPGPSF EWNVLAKALY DNVAESPDEL SFRKGDIMTV 
        60         70         80         90        100
LEQDTQGLDG WWLCSLHGRQ GIVPGNRLKI LVGMYDKKPA GPGPGPPATP 
       110        120        130        140        150
AQPQPGLHAP APPASQYTPM LPNTYQPQPD SVYLVPTPSK AQQGLYQVPG 
       160        170        180        190        200
PSPQFQSPPA KQTSTFSKQT PHHPFPSPAT DLYQVPPGPG GPAQDIYQVP 
       210        220        230        240        250
PSAGMGHDIY QVPPSMDTRS WEGTKPPAKV VVPTRVGQGY VYEAAQPEQD 
       260        270        280        290        300
EYDIPRHLLA PGPQDIYDVP PVRGLLPSQY GQEVYDTPPM AVKGPNGRDP 
       310        320        330        340        350
LLEVYDVPPS VEKGLPPSNH HAVYDVPPSV SKDVPDGPLL REETYDVPPA 
       360        370        380        390        400
FAKAKPFDPA RTPLVLAAPP PDSPPAEDVY DVPPPAPDLY DVPPGLRRPG 
       410        420        430        440        450
PGTLYDVPRE RVLPPEVADG GVVDSGVYAV PPPAEREAPA EGKRLSASST 
       460        470        480        490        500
GSTRSSQSAS SLEVAGPGRE PLELEVAVEA LARLQQGVSA TVAHLLDLAG 
       510        520        530        540        550
SAGATGSWRS PSEPQEPLVQ DLQAAVAAVQ SAVHELLEFA RSAVGNAAHT 
       560        570        580        590        600
SDRALHAKLS RQLQKMEDVH QTLVAHGQAL DAGRGGSGAT LEDLDRLVAC 
       610        620        630        640        650
SRAVPEDAKQ LASFLHGNAS LLFRRTKATA PGPEGGGTLH PNPTDKTSSI 
       660        670        680        690        700
QSRPLPSPPK FTSQDSPDGQ YENSEGGWME DYDYVHLQGK EEFEKTQKEL 
       710        720        730        740        750
LEKGSITRQG KSQLELQQLK QFERLEQEVS RPIDHDLANW TPAQPLAPGR 
       760        770        780        790        800
TGGLGPSDRQ LLLFYLEQCE ANLTTLTNAV DAFFTAVATN QPPKIFVAHS 
       810        820        830        840        850
KFVILSAHKL VFIGDTLSRQ AKAADVRSQV THYSNLLCDL LRGIVATTKA 
       860        870        880 
AALQYPSPSA AQDMVERVKE LGHSTQQFRR VLGQLAAA

Note: No experimental confirmation available.

Show »

Length:888

Mass (Da):95,469

Checksum:ⁱ4CA6EC5C8EFE3DA6

GO

Isoform 3 (identifier: P56945-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
304-304: A → AVSKCQGNARARLRLWGVW

« Hide

        10         20         30         40         50
MNHLNVLAKA LYDNVAESPD ELSFRKGDIM TVLEQDTQGL DGWWLCSLHG 
        60         70         80         90        100
RQGIVPGNRL KILVGMYDKK PAGPGPGPPA TPAQPQPGLH APAPPASQYT 
       110        120        130        140        150
PMLPNTYQPQ PDSVYLVPTP SKAQQGLYQV PGPSPQFQSP PAKQTSTFSK 
       160        170        180        190        200
QTPHHPFPSP ATDLYQVPPG PGGPAQDIYQ VPPSAGMGHD IYQVPPSMDT 
       210        220        230        240        250
RSWEGTKPPA KVVVPTRVGQ GYVYEAAQPE QDEYDIPRHL LAPGPQDIYD 
       260        270        280        290        300
VPPVRGLLPS QYGQEVYDTP PMAVKGPNGR DPLLEVYDVP PSVEKGLPPS 
       310        320        330        340        350
NHHAVSKCQG NARARLRLWG VWVYDVPPSV SKDVPDGPLL REETYDVPPA 
       360        370        380        390        400
FAKAKPFDPA RTPLVLAAPP PDSPPAEDVY DVPPPAPDLY DVPPGLRRPG 
       410        420        430        440        450
PGTLYDVPRE RVLPPEVADG GVVDSGVYAV PPPAEREAPA EGKRLSASST 
       460        470        480        490        500
GSTRSSQSAS SLEVAGPGRE PLELEVAVEA LARLQQGVSA TVAHLLDLAG 
       510        520        530        540        550
SAGATGSWRS PSEPQEPLVQ DLQAAVAAVQ SAVHELLEFA RSAVGNAAHT 
       560        570        580        590        600
SDRALHAKLS RQLQKMEDVH QTLVAHGQAL DAGRGGSGAT LEDLDRLVAC 
       610        620        630        640        650
SRAVPEDAKQ LASFLHGNAS LLFRRTKATA PGPEGGGTLH PNPTDKTSSI 
       660        670        680        690        700
QSRPLPSPPK FTSQDSPDGQ YENSEGGWME DYDYVHLQGK EEFEKTQKEL 
       710        720        730        740        750
LEKGSITRQG KSQLELQQLK QFERLEQEVS RPIDHDLANW TPAQPLAPGR 
       760        770        780        790        800
TGGLGPSDRQ LLLFYLEQCE ANLTTLTNAV DAFFTAVATN QPPKIFVAHS 
       810        820        830        840        850
KFVILSAHKL VFIGDTLSRQ AKAADVRSQV THYSNLLCDL LRGIVATTKA 
       860        870        880 
AALQYPSPSA AQDMVERVKE LGHSTQQFRR VLGQLAAA

Show »

Length:888

Mass (Da):95,454

Checksum:ⁱFF81642D11EB93AC

GO

Isoform 4 (identifier: P56945-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-4: MNHL → MQGK
64-211: Missing.

« Hide

        10         20         30         40         50
MQGKNVLAKA LYDNVAESPD ELSFRKGDIM TVLEQDTQGL DGWWLCSLHG 
        60         70         80         90        100
RQGIVPGNRL KILVVVPTRV GQGYVYEAAQ PEQDEYDIPR HLLAPGPQDI 
       110        120        130        140        150
YDVPPVRGLL PSQYGQEVYD TPPMAVKGPN GRDPLLEVYD VPPSVEKGLP 
       160        170        180        190        200
PSNHHAVYDV PPSVSKDVPD GPLLREETYD VPPAFAKAKP FDPARTPLVL 
       210        220        230        240        250
AAPPPDSPPA EDVYDVPPPA PDLYDVPPGL RRPGPGTLYD VPRERVLPPE 
       260        270        280        290        300
VADGGVVDSG VYAVPPPAER EAPAEGKRLS ASSTGSTRSS QSASSLEVAG 
       310        320        330        340        350
PGREPLELEV AVEALARLQQ GVSATVAHLL DLAGSAGATG SWRSPSEPQE 
       360        370        380        390        400
PLVQDLQAAV AAVQSAVHEL LEFARSAVGN AAHTSDRALH AKLSRQLQKM 
       410        420        430        440        450
EDVHQTLVAH GQALDAGRGG SGATLEDLDR LVACSRAVPE DAKQLASFLH 
       460        470        480        490        500
GNASLLFRRT KATAPGPEGG GTLHPNPTDK TSSIQSRPLP SPPKFTSQDS 
       510        520        530        540        550
PDGQYENSEG GWMEDYDYVH LQGKEEFEKT QKELLEKGSI TRQGKSQLEL 
       560        570        580        590        600
QQLKQFERLE QEVSRPIDHD LANWTPAQPL APGRTGGLGP SDRQLLLFYL 
       610        620        630        640        650
EQCEANLTTL TNAVDAFFTA VATNQPPKIF VAHSKFVILS AHKLVFIGDT 
       660        670        680        690        700
LSRQAKAADV RSQVTHYSNL LCDLLRGIVA TTKAAALQYP SPSAAQDMVE 
       710        720 
RVKELGHSTQ QFRRVLGQLA AA

Note: No experimental confirmation available.

Show »

Length:722

Mass (Da):77,731

Checksum:ⁱ2537ED6C3BEBE512

GO

Isoform 5 (identifier: P56945-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-4: MNHL → ME

« Hide

        10         20         30         40         50
MENVLAKALY DNVAESPDEL SFRKGDIMTV LEQDTQGLDG WWLCSLHGRQ 
        60         70         80         90        100
GIVPGNRLKI LVGMYDKKPA GPGPGPPATP AQPQPGLHAP APPASQYTPM 
       110        120        130        140        150
LPNTYQPQPD SVYLVPTPSK AQQGLYQVPG PSPQFQSPPA KQTSTFSKQT 
       160        170        180        190        200
PHHPFPSPAT DLYQVPPGPG GPAQDIYQVP PSAGMGHDIY QVPPSMDTRS 
       210        220        230        240        250
WEGTKPPAKV VVPTRVGQGY VYEAAQPEQD EYDIPRHLLA PGPQDIYDVP 
       260        270        280        290        300
PVRGLLPSQY GQEVYDTPPM AVKGPNGRDP LLEVYDVPPS VEKGLPPSNH 
       310        320        330        340        350
HAVYDVPPSV SKDVPDGPLL REETYDVPPA FAKAKPFDPA RTPLVLAAPP 
       360        370        380        390        400
PDSPPAEDVY DVPPPAPDLY DVPPGLRRPG PGTLYDVPRE RVLPPEVADG 
       410        420        430        440        450
GVVDSGVYAV PPPAEREAPA EGKRLSASST GSTRSSQSAS SLEVAGPGRE 
       460        470        480        490        500
PLELEVAVEA LARLQQGVSA TVAHLLDLAG SAGATGSWRS PSEPQEPLVQ 
       510        520        530        540        550
DLQAAVAAVQ SAVHELLEFA RSAVGNAAHT SDRALHAKLS RQLQKMEDVH 
       560        570        580        590        600
QTLVAHGQAL DAGRGGSGAT LEDLDRLVAC SRAVPEDAKQ LASFLHGNAS 
       610        620        630        640        650
LLFRRTKATA PGPEGGGTLH PNPTDKTSSI QSRPLPSPPK FTSQDSPDGQ 
       660        670        680        690        700
YENSEGGWME DYDYVHLQGK EEFEKTQKEL LEKGSITRQG KSQLELQQLK 
       710        720        730        740        750
QFERLEQEVS RPIDHDLANW TPAQPLAPGR TGGLGPSDRQ LLLFYLEQCE 
       760        770        780        790        800
ANLTTLTNAV DAFFTAVATN QPPKIFVAHS KFVILSAHKL VFIGDTLSRQ 
       810        820        830        840        850
AKAADVRSQV THYSNLLCDL LRGIVATTKA AALQYPSPSA AQDMVERVKE 
       860 
LGHSTQQFRR VLGQLAAA

Note: No experimental confirmation available.

Show »

Length:868

Mass (Da):93,137

Checksum:ⁱDB6B70B2AB1926CD

GO

Isoform 6 (identifier: P56945-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-4: MNHL → MPAKPFLSSVLLSWKVLDFSGPGPQGTGQPCSCGHWAEGQGGPPEPAGGP

« Hide

        10         20         30         40         50
MPAKPFLSSV LLSWKVLDFS GPGPQGTGQP CSCGHWAEGQ GGPPEPAGGP 
        60         70         80         90        100
NVLAKALYDN VAESPDELSF RKGDIMTVLE QDTQGLDGWW LCSLHGRQGI 
       110        120        130        140        150
VPGNRLKILV GMYDKKPAGP GPGPPATPAQ PQPGLHAPAP PASQYTPMLP 
       160        170        180        190        200
NTYQPQPDSV YLVPTPSKAQ QGLYQVPGPS PQFQSPPAKQ TSTFSKQTPH 
       210        220        230        240        250
HPFPSPATDL YQVPPGPGGP AQDIYQVPPS AGMGHDIYQV PPSMDTRSWE 
       260        270        280        290        300
GTKPPAKVVV PTRVGQGYVY EAAQPEQDEY DIPRHLLAPG PQDIYDVPPV 
       310        320        330        340        350
RGLLPSQYGQ EVYDTPPMAV KGPNGRDPLL EVYDVPPSVE KGLPPSNHHA 
       360        370        380        390        400
VYDVPPSVSK DVPDGPLLRE ETYDVPPAFA KAKPFDPART PLVLAAPPPD 
       410        420        430        440        450
SPPAEDVYDV PPPAPDLYDV PPGLRRPGPG TLYDVPRERV LPPEVADGGV 
       460        470        480        490        500
VDSGVYAVPP PAEREAPAEG KRLSASSTGS TRSSQSASSL EVAGPGREPL 
       510        520        530        540        550
ELEVAVEALA RLQQGVSATV AHLLDLAGSA GATGSWRSPS EPQEPLVQDL 
       560        570        580        590        600
QAAVAAVQSA VHELLEFARS AVGNAAHTSD RALHAKLSRQ LQKMEDVHQT 
       610        620        630        640        650
LVAHGQALDA GRGGSGATLE DLDRLVACSR AVPEDAKQLA SFLHGNASLL 
       660        670        680        690        700
FRRTKATAPG PEGGGTLHPN PTDKTSSIQS RPLPSPPKFT SQDSPDGQYE 
       710        720        730        740        750
NSEGGWMEDY DYVHLQGKEE FEKTQKELLE KGSITRQGKS QLELQQLKQF 
       760        770        780        790        800
ERLEQEVSRP IDHDLANWTP AQPLAPGRTG GLGPSDRQLL LFYLEQCEAN 
       810        820        830        840        850
LTTLTNAVDA FFTAVATNQP PKIFVAHSKF VILSAHKLVF IGDTLSRQAK 
       860        870        880        890        900
AADVRSQVTH YSNLLCDLLR GIVATTKAAA LQYPSPSAAQ DMVERVKELG 
       910 
HSTQQFRRVL GQLAAA

Note: No experimental confirmation available.

Show »

Length:916

Mass (Da):97,877

Checksum:ⁱ3A5FDEB4BA15527B

GO

Isoform 7 (identifier: P56945-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-4: MNHL → MHCPGEAPLAAPRPTPKDPCLR

« Hide

        10         20         30         40         50
MHCPGEAPLA APRPTPKDPC LRNVLAKALY DNVAESPDEL SFRKGDIMTV 
        60         70         80         90        100
LEQDTQGLDG WWLCSLHGRQ GIVPGNRLKI LVGMYDKKPA GPGPGPPATP 
       110        120        130        140        150
AQPQPGLHAP APPASQYTPM LPNTYQPQPD SVYLVPTPSK AQQGLYQVPG 
       160        170        180        190        200
PSPQFQSPPA KQTSTFSKQT PHHPFPSPAT DLYQVPPGPG GPAQDIYQVP 
       210        220        230        240        250
PSAGMGHDIY QVPPSMDTRS WEGTKPPAKV VVPTRVGQGY VYEAAQPEQD 
       260        270        280        290        300
EYDIPRHLLA PGPQDIYDVP PVRGLLPSQY GQEVYDTPPM AVKGPNGRDP 
       310        320        330        340        350
LLEVYDVPPS VEKGLPPSNH HAVYDVPPSV SKDVPDGPLL REETYDVPPA 
       360        370        380        390        400
FAKAKPFDPA RTPLVLAAPP PDSPPAEDVY DVPPPAPDLY DVPPGLRRPG 
       410        420        430        440        450
PGTLYDVPRE RVLPPEVADG GVVDSGVYAV PPPAEREAPA EGKRLSASST 
       460        470        480        490        500
GSTRSSQSAS SLEVAGPGRE PLELEVAVEA LARLQQGVSA TVAHLLDLAG 
       510        520        530        540        550
SAGATGSWRS PSEPQEPLVQ DLQAAVAAVQ SAVHELLEFA RSAVGNAAHT 
       560        570        580        590        600
SDRALHAKLS RQLQKMEDVH QTLVAHGQAL DAGRGGSGAT LEDLDRLVAC 
       610        620        630        640        650
SRAVPEDAKQ LASFLHGNAS LLFRRTKATA PGPEGGGTLH PNPTDKTSSI 
       660        670        680        690        700
QSRPLPSPPK FTSQDSPDGQ YENSEGGWME DYDYVHLQGK EEFEKTQKEL 
       710        720        730        740        750
LEKGSITRQG KSQLELQQLK QFERLEQEVS RPIDHDLANW TPAQPLAPGR 
       760        770        780        790        800
TGGLGPSDRQ LLLFYLEQCE ANLTTLTNAV DAFFTAVATN QPPKIFVAHS 
       810        820        830        840        850
KFVILSAHKL VFIGDTLSRQ AKAADVRSQV THYSNLLCDL LRGIVATTKA 
       860        870        880 
AALQYPSPSA AQDMVERVKE LGHSTQQFRR VLGQLAAA

Note: No experimental confirmation available.

Show »

Length:888

Mass (Da):95,216

Checksum:ⁱCD3BA8494536FC76

GO

Isoform 8 (identifier: P56945-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-4: MNHL → MSVP

« Hide

        10         20         30         40         50
MSVPNVLAKA LYDNVAESPD ELSFRKGDIM TVLEQDTQGL DGWWLCSLHG 
        60         70         80         90        100
RQGIVPGNRL KILVGMYDKK PAGPGPGPPA TPAQPQPGLH APAPPASQYT 
       110        120        130        140        150
PMLPNTYQPQ PDSVYLVPTP SKAQQGLYQV PGPSPQFQSP PAKQTSTFSK 
       160        170        180        190        200
QTPHHPFPSP ATDLYQVPPG PGGPAQDIYQ VPPSAGMGHD IYQVPPSMDT 
       210        220        230        240        250
RSWEGTKPPA KVVVPTRVGQ GYVYEAAQPE QDEYDIPRHL LAPGPQDIYD 
       260        270        280        290        300
VPPVRGLLPS QYGQEVYDTP PMAVKGPNGR DPLLEVYDVP PSVEKGLPPS 
       310        320        330        340        350
NHHAVYDVPP SVSKDVPDGP LLREETYDVP PAFAKAKPFD PARTPLVLAA 
       360        370        380        390        400
PPPDSPPAED VYDVPPPAPD LYDVPPGLRR PGPGTLYDVP RERVLPPEVA 
       410        420        430        440        450
DGGVVDSGVY AVPPPAEREA PAEGKRLSAS STGSTRSSQS ASSLEVAGPG 
       460        470        480        490        500
REPLELEVAV EALARLQQGV SATVAHLLDL AGSAGATGSW RSPSEPQEPL 
       510        520        530        540        550
VQDLQAAVAA VQSAVHELLE FARSAVGNAA HTSDRALHAK LSRQLQKMED 
       560        570        580        590        600
VHQTLVAHGQ ALDAGRGGSG ATLEDLDRLV ACSRAVPEDA KQLASFLHGN 
       610        620        630        640        650
ASLLFRRTKA TAPGPEGGGT LHPNPTDKTS SIQSRPLPSP PKFTSQDSPD 
       660        670        680        690        700
GQYENSEGGW MEDYDYVHLQ GKEEFEKTQK ELLEKGSITR QGKSQLELQQ 
       710        720        730        740        750
LKQFERLEQE VSRPIDHDLA NWTPAQPLAP GRTGGLGPSD RQLLLFYLEQ 
       760        770        780        790        800
CEANLTTLTN AVDAFFTAVA TNQPPKIFVA HSKFVILSAH KLVFIGDTLS 
       810        820        830        840        850
RQAKAADVRS QVTHYSNLLC DLLRGIVATT KAAALQYPSP SAAQDMVERV 
       860        870
KELGHSTQQF RRVLGQLAAA

Note: No experimental confirmation available.

Show »

Length:870

Mass (Da):93,291

Checksum:ⁱ2262F3718326A675

GO

Computationally mapped potential isoform sequencesⁱ

There are 17 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A2R8Y596	A0A2R8Y596_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	916	Annotation score:
	F5H855	F5H855_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	57	Annotation score:
	H3BVF0	H3BVF0_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	120	Annotation score:
	H3BQJ7	H3BQJ7_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	133	Annotation score:
	H3BTL5	H3BTL5_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	50	Annotation score:
	H3BSB2	H3BSB2_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	135	Annotation score:
	H3BSY4	H3BSY4_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	128	Annotation score:
	H3BU42	H3BU42_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	80	Annotation score:
	H3BTB0	H3BTB0_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	58	Annotation score:
	H3BN62	H3BN62_HUMAN	Breast cancer anti-estrogen resista... Breast cancer anti-estrogen resistance protein 1	BCAR1	238	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	63	L → S in BAB55230 (PubMed:14702039).Curated	1
Sequence conflictⁱ	236	I → T in AAF27527 (Ref. 2) Curated	1
Sequence conflictⁱ	254	V → I in BAG54099 (PubMed:14702039).Curated	1
Sequence conflictⁱ	349	A → G in AAF27527 (Ref. 2) Curated	1
Sequence conflictⁱ	363	D → Y in AAF27527 (Ref. 2) Curated	1
Sequence conflictⁱ	385	T → A in AAS48631 (Ref. 4) Curated	1
Sequence conflictⁱ	428	S → P in BAB55230 (PubMed:14702039).Curated	1
Sequence conflictⁱ	471	S → G in BAB55230 (PubMed:14702039).Curated	1
Sequence conflictⁱ	600	N → S in AAS48631 (Ref. 4) Curated	1
Sequence conflictⁱ	700	Q → R in BAH13763 (PubMed:14702039).Curated	1
Sequence conflictⁱ	714	P → L in BAG54099 (PubMed:14702039).Curated	1
Sequence conflictⁱ	740	D → G in AAS48631 (Ref. 4) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_058970	76	P → S4 PublicationsCorresponds to variant dbSNP:rs1035539Ensembl.	1
Natural variantⁱVAR_035798	407	S → T in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_057820	491	R → L. Corresponds to variant dbSNP:rs16957558Ensembl.	1
Natural variantⁱVAR_057821	558	H → R. Corresponds to variant dbSNP:rs16957552Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043559	1 – 4	MNHL → MLTHRPQEAEQRGRTPGPSF EW in isoform 2. 1 Publication	4
Alternative sequenceⁱVSP_046127	1 – 4	MNHL → MQGK in isoform 4. 1 Publication	4
Alternative sequenceⁱVSP_046748	1 – 4	MNHL → ME in isoform 5. 1 Publication	4
Alternative sequenceⁱVSP_046749	1 – 4	MNHL → MPAKPFLSSVLLSWKVLDFS GPGPQGTGQPCSCGHWAEGQ GGPPEPAGGP in isoform 6. 1 Publication	4
Alternative sequenceⁱVSP_046750	1 – 4	MNHL → MHCPGEAPLAAPRPTPKDPC LR in isoform 7. 1 Publication	4
Alternative sequenceⁱVSP_046751	1 – 4	MNHL → MSVP in isoform 8. 1 Publication	4
Alternative sequenceⁱVSP_046128	64 – 211	Missing in isoform 4. 1 PublicationAdd BLAST	148
Alternative sequenceⁱVSP_045355	304	A → AVSKCQGNARARLRLWGVW in isoform 3. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ242987 mRNA Translation: CAB75875.2 AF218451 mRNA Translation: AAF27527.1 AB040024 mRNA Translation: BAA92711.1 AY545071 mRNA Translation: AAS48631.1 AK027608 mRNA Translation: BAB55230.1 AK124815 mRNA Translation: BAG54099.1 AK293808 mRNA Translation: BAG57215.1 AK294513 mRNA Translation: BAG57726.1 AK295809 mRNA Translation: BAG58627.1 AK302617 mRNA Translation: BAH13763.1 AC009078 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10915.1 [P56945-1] CCDS54037.1 [P56945-5] CCDS54038.1 [P56945-3] CCDS54039.1 [P56945-4] CCDS54040.1 [P56945-6] CCDS54041.1 [P56945-8] CCDS54042.1 [P56945-2] CCDS54043.1 [P56945-7]
NCBI Reference Sequences More...RefSeqⁱ	NP_001164185.1, NM_001170714.1 [P56945-6] NP_001164186.1, NM_001170715.1 [P56945-7] NP_001164187.1, NM_001170716.1 [P56945-2] NP_001164188.1, NM_001170717.1 [P56945-3] NP_001164189.1, NM_001170718.1 [P56945-8] NP_001164190.1, NM_001170719.1 [P56945-5] NP_001164191.1, NM_001170720.1 [P56945-4] NP_055382.2, NM_014567.3 [P56945-1] XP_016879386.1, XM_017023897.1 [P56945-6]
UniGeneⁱ	Hs.479747

Genome annotation databases

Ensemblⁱ	ENST00000162330; ENSP00000162330; ENSG00000050820 [P56945-1] ENST00000393420; ENSP00000377072; ENSG00000050820 [P56945-3] ENST00000393422; ENSP00000377074; ENSG00000050820 [P56945-7] ENST00000418647; ENSP00000391669; ENSG00000050820 [P56945-6] ENST00000420641; ENSP00000392708; ENSG00000050820 [P56945-2] ENST00000535626; ENSP00000440370; ENSG00000050820 [P56945-4] ENST00000538440; ENSP00000443841; ENSG00000050820 [P56945-8] ENST00000542031; ENSP00000440415; ENSG00000050820 [P56945-5]
GeneIDⁱ	9564
KEGGⁱ	hsa:9564
UCSC genome browser More...UCSCⁱ	uc002fdv.4 human [P56945-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P56945	Breast cancer anti-estrogen resistance protein 1	)	MOUSE		874	UniRef90_P56945
BCAR1, Cas family scaffold protein		OTOGA		920
BCAR1 isoform 5		PANTR		916
Uncharacterized protein		PANPA		916
Uncharacterized protein		PROCO		902
+293
P56945-4	breast cancer anti-estrogen resistance protein 1		TURTR		730	UniRef90_P56945-4
Breast cancer anti-estrogen resistance protein 1		HUMAN		722
BCAR1 isoform 6		PANTR		722
Uncharacterized protein		PANPA		722
BCAR1, Cas family scaffold protein		SAIBB		722
+12
P56945-6	cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA		HUMAN		684	UniRef90_P56945-6
Uncharacterized protein		CALJA		920
Uncharacterized protein		AOTNA		920
BCAR1, Cas family scaffold protein		SAIBB		917
BCAR1 isoform 9 (Fragment)		PANTR		135
+50

Protein	Similar proteins		Species	Score	Length	Source
P56945	Breast cancer anti-estrogen resistance protein 1	)	MOUSE		874	UniRef50_P56945
Breast cancer anti-estrogen resistance protein 1	)	RAT		968
BCAR1, Cas family scaffold protein		OTOGA		920
BCAR1 isoform 5		PANTR		916
Uncharacterized protein		PANPA		916
+516
P56945-4	breast cancer anti-estrogen resistance protein 1		TURTR		730	UniRef50_P56945-4
BCAR1, Cas family scaffold protein		SAIBB		722
BCAR1 isoform 11		PONAB		722
Uncharacterized protein		RHIRO		722
BCAR1, Cas family scaffold protein		GORGO		722
+27

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ242987 mRNA Translation: CAB75875.2 AF218451 mRNA Translation: AAF27527.1 AB040024 mRNA Translation: BAA92711.1 AY545071 mRNA Translation: AAS48631.1 AK027608 mRNA Translation: BAB55230.1 AK124815 mRNA Translation: BAG54099.1 AK293808 mRNA Translation: BAG57215.1 AK294513 mRNA Translation: BAG57726.1 AK295809 mRNA Translation: BAG58627.1 AK302617 mRNA Translation: BAH13763.1 AC009078 Genomic DNA No translation available.
CCDSⁱ	CCDS10915.1 [P56945-1] CCDS54037.1 [P56945-5] CCDS54038.1 [P56945-3] CCDS54039.1 [P56945-4] CCDS54040.1 [P56945-6] CCDS54041.1 [P56945-8] CCDS54042.1 [P56945-2] CCDS54043.1 [P56945-7]
RefSeqⁱ	NP_001164185.1, NM_001170714.1 [P56945-6] NP_001164186.1, NM_001170715.1 [P56945-7] NP_001164187.1, NM_001170716.1 [P56945-2] NP_001164188.1, NM_001170717.1 [P56945-3] NP_001164189.1, NM_001170718.1 [P56945-8] NP_001164190.1, NM_001170719.1 [P56945-5] NP_001164191.1, NM_001170720.1 [P56945-4] NP_055382.2, NM_014567.3 [P56945-1] XP_016879386.1, XM_017023897.1 [P56945-6]
UniGeneⁱ	Hs.479747

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WYX	X-ray	1.14	A/B	3-71	[»]
	3T6G	X-ray	2.50	B/D	645-870	[»]
	5O2M	NMR	-	A	4-73	[»]
	5O2P	NMR	-	A	4-73	[»]
	5O2Q	NMR	-	A	4-73	[»]
ProteinModelPortalⁱ	P56945
SMRⁱ	P56945
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114934, 73 interactors
CORUMⁱ	P56945
DIPⁱ	DIP-33855N
ELMⁱ	P56945
IntActⁱ	P56945, 261 interactors
MINTⁱ	P56945
STRINGⁱ	9606.ENSP00000391669

PTM databases

iPTMnetⁱ	P56945
PhosphoSitePlusⁱ	P56945

Polymorphism and mutation databases

BioMutaⁱ	BCAR1
DMDMⁱ	288558806

Proteomic databases

EPDⁱ	P56945
MaxQBⁱ	P56945
PaxDbⁱ	P56945
PeptideAtlasⁱ	P56945
PRIDEⁱ	P56945
ProteomicsDBⁱ	56960 56961 [P56945-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9564
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000162330; ENSP00000162330; ENSG00000050820 [P56945-1] ENST00000393420; ENSP00000377072; ENSG00000050820 [P56945-3] ENST00000393422; ENSP00000377074; ENSG00000050820 [P56945-7] ENST00000418647; ENSP00000391669; ENSG00000050820 [P56945-6] ENST00000420641; ENSP00000392708; ENSG00000050820 [P56945-2] ENST00000535626; ENSP00000440370; ENSG00000050820 [P56945-4] ENST00000538440; ENSP00000443841; ENSG00000050820 [P56945-8] ENST00000542031; ENSP00000440415; ENSG00000050820 [P56945-5]
GeneIDⁱ	9564
KEGGⁱ	hsa:9564
UCSCⁱ	uc002fdv.4 human [P56945-1]

Organism-specific databases

CTDⁱ	9564
DisGeNETⁱ	9564
EuPathDBⁱ	HostDB:ENSG00000050820.16
GeneCardsⁱ	BCAR1
H-InvDBⁱ	HIX0173293
HGNCⁱ	HGNC:971 BCAR1
HPAⁱ	CAB000443 HPA042282
MIMⁱ	602941 gene
neXtProtⁱ	NX_P56945
OpenTargetsⁱ	ENSG00000050820
PharmGKBⁱ	PA25281
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEDD Eukaryota ENOG410ZSUM LUCA
GeneTreeⁱ	ENSGT00490000043324
HOGENOMⁱ	HOG000261698
HOVERGENⁱ	HBG004354
InParanoidⁱ	P56945
KOⁱ	K05726
OMAⁱ	TVEHNQP
OrthoDBⁱ	EOG091G0RVA
PhylomeDBⁱ	P56945
TreeFamⁱ	TF328782

Enzyme and pathway databases

Reactomeⁱ	R-HSA-186763 Downstream signal transduction R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SignaLinkⁱ	P56945
SIGNORⁱ	P56945

Miscellaneous databases

ChiTaRSⁱ	BCAR1 human
EvolutionaryTraceⁱ	P56945
GeneWikiⁱ	BCAR1
GenomeRNAiⁱ	9564
Protein Ontology More...PROⁱ	PR:P56945
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000050820 Expressed in 181 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_BCAR1
ExpressionAtlasⁱ	P56945 baseline and differential
Genevisibleⁱ	P56945 HS

Family and domain databases

CDDⁱ	cd12001 SH3_BCAR1, 1 hit
Gene3Dⁱ	1.20.120.830, 1 hit
InterProⁱ	View protein in InterPro IPR028848 BCAR1 IPR035745 BCAR1_SH3 IPR021901 CAS_C IPR037362 CAS_fam IPR014928 Serine_rich_dom IPR038319 Serine_rich_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR10654 PTHR10654, 1 hit PTHR10654:SF15 PTHR10654:SF15, 1 hit
Pfamⁱ	View protein in Pfam PF12026 DUF3513, 1 hit PF08824 Serine_rich, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BCAR1_HUMAN
Accessionⁱ	P56945Primary (citable) accession number: P56945 Secondary accession number(s): B3KWD7 Q6QEF7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	February 9, 2010
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P56945 (BCAR1_HUMAN)

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Breast cancer anti-estrogen resistance protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ