UniProtKB - P56945 (BCAR1_HUMAN)
Breast cancer anti-estrogen resistance protein 1
BCAR1
Functioni
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB-KW
GO - Biological processi
- actin filament organization Source: UniProtKB
- actin filament reorganization Source: GO_Central
- antigen receptor-mediated signaling pathway Source: UniProtKB
- B cell receptor signaling pathway Source: UniProtKB
- cell adhesion Source: UniProtKB-KW
- cell chemotaxis Source: BHF-UCL
- cell division Source: UniProtKB
- cell migration Source: UniProtKB
- cellular response to hepatocyte growth factor stimulus Source: BHF-UCL
- epidermal growth factor receptor signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: UniProtKB
- hepatocyte growth factor receptor signaling pathway Source: BHF-UCL
- insulin receptor signaling pathway Source: UniProtKB
- integrin-mediated signaling pathway Source: UniProtKB
- neurotrophin TRK receptor signaling pathway Source: UniProtKB
- platelet-derived growth factor receptor signaling pathway Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of endothelial cell migration Source: BHF-UCL
- regulation of apoptotic process Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- T cell receptor signaling pathway Source: UniProtKB
- vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-HSA-186763 Downstream signal transduction R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
SignaLinki | P56945 |
SIGNORi | P56945 |
Names & Taxonomyi
Protein namesi | Recommended name: Breast cancer anti-estrogen resistance protein 1Alternative name(s): CRK-associated substrate Cas scaffolding protein family member 1 p130cas |
Gene namesi | Name:BCAR1 Synonyms:CAS, CASS1, CRKAS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:971 BCAR1 |
MIMi | 602941 gene |
neXtProti | NX_P56945 |
Subcellular locationi
Other locations
- focal adhesion 1 Publication
- Cytoplasm 1 Publication
Note: Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.By similarity
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Cytosol
- cytosol Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: BHF-UCL
- lamellipodium Source: Ensembl
- ruffle Source: UniProtKB
Keywords - Cellular componenti
Cell junction, CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 9564 |
OpenTargetsi | ENSG00000050820 |
PharmGKBi | PA25281 |
Miscellaneous databases
Pharosi | P56945 |
Polymorphism and mutation databases
BioMutai | BCAR1 |
DMDMi | 288558806 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064854 | 1 – 870 | Breast cancer anti-estrogen resistance protein 1Add BLAST | 870 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 128 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 134 | PhosphoserineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 234 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 249 | Phosphotyrosine; by ABL1By similarity | 1 | |
Modified residuei | 269 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 292 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 372 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 410 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 428 | PhosphoserineCombined sources | 1 | |
Modified residuei | 437 | Phosphoserine1 Publication | 1 | |
Modified residuei | 639 | PhosphoserineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P56945 |
jPOSTi | P56945 |
MassIVEi | P56945 |
MaxQBi | P56945 |
PaxDbi | P56945 |
PeptideAtlasi | P56945 |
PRIDEi | P56945 |
ProteomicsDBi | 19466 19521 24360 24539 27632 30445 56960 [P56945-1] 56961 [P56945-2] |
PTM databases
iPTMneti | P56945 |
PhosphoSitePlusi | P56945 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000050820 Expressed in 181 organ(s), highest expression level in cerebellum |
ExpressionAtlasi | P56945 baseline and differential |
Genevisiblei | P56945 HS |
Organism-specific databases
HPAi | CAB000443 HPA042282 |
Interactioni
Subunit structurei
Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9.
Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation.
Interacts with NPHP1 and SH2D3C.
Interacts with activated CSPG4.
Interacts with BMX, INPPL1/SHIP2 and PEAK1.
Part of a collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas.
Interacts with TNK2 via SH3 domains.
Interacts with PTK2B/PYK2.
8 PublicationsBinary interactionsi
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGridi | 114934, 80 interactors |
CORUMi | P56945 |
DIPi | DIP-33855N |
ELMi | P56945 |
IntActi | P56945, 261 interactors |
MINTi | P56945 |
STRINGi | 9606.ENSP00000391669 |
Structurei
Secondary structure
3D structure databases
SMRi | P56945 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P56945 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 65 | SH3PROSITE-ProRule annotationAdd BLAST | 63 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 115 – 416 | Substrate for kinasesBy similarityAdd BLAST | 302 | |
Regioni | 746 – 796 | Divergent helix-loop-helix motifAdd BLAST | 51 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 635 – 643 | SH3-bindingSequence analysis | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 74 – 87 | Pro-richAdd BLAST | 14 | |
Compositional biasi | 422 – 614 | Ser-richAdd BLAST | 193 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH3 domain, SH3-bindingPhylogenomic databases
eggNOGi | ENOG410IEDD Eukaryota ENOG410ZSUM LUCA |
GeneTreei | ENSGT00950000183008 |
HOGENOMi | HOG000261698 |
InParanoidi | P56945 |
KOi | K05726 |
OMAi | NYADTPD |
OrthoDBi | 1086228at2759 |
PhylomeDBi | P56945 |
TreeFami | TF328782 |
Family and domain databases
CDDi | cd12001 SH3_BCAR1, 1 hit |
Gene3Di | 1.20.120.830, 1 hit |
InterProi | View protein in InterPro IPR028848 BCAR1 IPR035745 BCAR1_SH3 IPR021901 CAS_C IPR037362 CAS_fam IPR014928 Serine_rich_dom IPR038319 Serine_rich_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain |
PANTHERi | PTHR10654 PTHR10654, 1 hit PTHR10654:SF15 PTHR10654:SF15, 1 hit |
Pfami | View protein in Pfam PF12026 CAS_C, 1 hit PF08824 Serine_rich, 1 hit PF00018 SH3_1, 1 hit |
PRINTSi | PR00452 SH3DOMAIN |
SMARTi | View protein in SMART SM00326 SH3, 1 hit |
SUPFAMi | SSF50044 SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002 SH3, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNHLNVLAKA LYDNVAESPD ELSFRKGDIM TVLEQDTQGL DGWWLCSLHG
60 70 80 90 100
RQGIVPGNRL KILVGMYDKK PAGPGPGPPA TPAQPQPGLH APAPPASQYT
110 120 130 140 150
PMLPNTYQPQ PDSVYLVPTP SKAQQGLYQV PGPSPQFQSP PAKQTSTFSK
160 170 180 190 200
QTPHHPFPSP ATDLYQVPPG PGGPAQDIYQ VPPSAGMGHD IYQVPPSMDT
210 220 230 240 250
RSWEGTKPPA KVVVPTRVGQ GYVYEAAQPE QDEYDIPRHL LAPGPQDIYD
260 270 280 290 300
VPPVRGLLPS QYGQEVYDTP PMAVKGPNGR DPLLEVYDVP PSVEKGLPPS
310 320 330 340 350
NHHAVYDVPP SVSKDVPDGP LLREETYDVP PAFAKAKPFD PARTPLVLAA
360 370 380 390 400
PPPDSPPAED VYDVPPPAPD LYDVPPGLRR PGPGTLYDVP RERVLPPEVA
410 420 430 440 450
DGGVVDSGVY AVPPPAEREA PAEGKRLSAS STGSTRSSQS ASSLEVAGPG
460 470 480 490 500
REPLELEVAV EALARLQQGV SATVAHLLDL AGSAGATGSW RSPSEPQEPL
510 520 530 540 550
VQDLQAAVAA VQSAVHELLE FARSAVGNAA HTSDRALHAK LSRQLQKMED
560 570 580 590 600
VHQTLVAHGQ ALDAGRGGSG ATLEDLDRLV ACSRAVPEDA KQLASFLHGN
610 620 630 640 650
ASLLFRRTKA TAPGPEGGGT LHPNPTDKTS SIQSRPLPSP PKFTSQDSPD
660 670 680 690 700
GQYENSEGGW MEDYDYVHLQ GKEEFEKTQK ELLEKGSITR QGKSQLELQQ
710 720 730 740 750
LKQFERLEQE VSRPIDHDLA NWTPAQPLAP GRTGGLGPSD RQLLLFYLEQ
760 770 780 790 800
CEANLTTLTN AVDAFFTAVA TNQPPKIFVA HSKFVILSAH KLVFIGDTLS
810 820 830 840 850
RQAKAADVRS QVTHYSNLLC DLLRGIVATT KAAALQYPSP SAAQDMVERV
860 870
KELGHSTQQF RRVLGQLAAA
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y596 | A0A2R8Y596_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 916 | Annotation score: | ||
H3BQJ7 | H3BQJ7_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 133 | Annotation score: | ||
H3BSB2 | H3BSB2_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 135 | Annotation score: | ||
H3BSY4 | H3BSY4_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 128 | Annotation score: | ||
H3BU42 | H3BU42_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 80 | Annotation score: | ||
H3BVF0 | H3BVF0_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 120 | Annotation score: | ||
H3BTB0 | H3BTB0_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 58 | Annotation score: | ||
H3BN62 | H3BN62_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 238 | Annotation score: | ||
A0A2R8Y4C2 | A0A2R8Y4C2_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 870 | Annotation score: | ||
A0A2R8Y5C9 | A0A2R8Y5C9_HUMAN | Breast cancer anti-estrogen resista... | BCAR1 | 888 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | L → S in BAB55230 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 236 | I → T in AAF27527 (Ref. 2) Curated | 1 | |
Sequence conflicti | 254 | V → I in BAG54099 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 349 | A → G in AAF27527 (Ref. 2) Curated | 1 | |
Sequence conflicti | 363 | D → Y in AAF27527 (Ref. 2) Curated | 1 | |
Sequence conflicti | 385 | T → A in AAS48631 (Ref. 4) Curated | 1 | |
Sequence conflicti | 428 | S → P in BAB55230 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 471 | S → G in BAB55230 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 600 | N → S in AAS48631 (Ref. 4) Curated | 1 | |
Sequence conflicti | 700 | Q → R in BAH13763 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 714 | P → L in BAG54099 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 740 | D → G in AAS48631 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058970 | 76 | P → S4 PublicationsCorresponds to variant dbSNP:rs1035539Ensembl. | 1 | |
Natural variantiVAR_035798 | 407 | S → T in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_057820 | 491 | R → L. Corresponds to variant dbSNP:rs16957558Ensembl. | 1 | |
Natural variantiVAR_057821 | 558 | H → R. Corresponds to variant dbSNP:rs16957552Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043559 | 1 – 4 | MNHL → MLTHRPQEAEQRGRTPGPSF EW in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_046127 | 1 – 4 | MNHL → MQGK in isoform 4. 1 Publication | 4 | |
Alternative sequenceiVSP_046748 | 1 – 4 | MNHL → ME in isoform 5. 1 Publication | 4 | |
Alternative sequenceiVSP_046749 | 1 – 4 | MNHL → MPAKPFLSSVLLSWKVLDFS GPGPQGTGQPCSCGHWAEGQ GGPPEPAGGP in isoform 6. 1 Publication | 4 | |
Alternative sequenceiVSP_046750 | 1 – 4 | MNHL → MHCPGEAPLAAPRPTPKDPC LR in isoform 7. 1 Publication | 4 | |
Alternative sequenceiVSP_046751 | 1 – 4 | MNHL → MSVP in isoform 8. 1 Publication | 4 | |
Alternative sequenceiVSP_046128 | 64 – 211 | Missing in isoform 4. 1 PublicationAdd BLAST | 148 | |
Alternative sequenceiVSP_045355 | 304 | A → AVSKCQGNARARLRLWGVW in isoform 3. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WYX | X-ray | 1.14 | A/B | 3-71 | [»] | |
3T6G | X-ray | 2.50 | B/D | 645-870 | [»] | |
5O2M | NMR | - | A | 4-73 | [»] | |
5O2P | NMR | - | A | 4-73 | [»] | |
5O2Q | NMR | - | A | 4-73 | [»] | |
SMRi | P56945 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 114934, 80 interactors |
CORUMi | P56945 |
DIPi | DIP-33855N |
ELMi | P56945 |
IntActi | P56945, 261 interactors |
MINTi | P56945 |
STRINGi | 9606.ENSP00000391669 |
PTM databases
iPTMneti | P56945 |
PhosphoSitePlusi | P56945 |
Polymorphism and mutation databases
BioMutai | BCAR1 |
DMDMi | 288558806 |
Proteomic databases
EPDi | P56945 |
jPOSTi | P56945 |
MassIVEi | P56945 |
MaxQBi | P56945 |
PaxDbi | P56945 |
PeptideAtlasi | P56945 |
PRIDEi | P56945 |
ProteomicsDBi | 19466 19521 24360 24539 27632 30445 56960 [P56945-1] 56961 [P56945-2] |
Protocols and materials databases
DNASUi | 9564 |
Genome annotation databases
Organism-specific databases
CTDi | 9564 |
DisGeNETi | 9564 |
GeneCardsi | BCAR1 |
HGNCi | HGNC:971 BCAR1 |
HPAi | CAB000443 HPA042282 |
MIMi | 602941 gene |
neXtProti | NX_P56945 |
OpenTargetsi | ENSG00000050820 |
PharmGKBi | PA25281 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IEDD Eukaryota ENOG410ZSUM LUCA |
GeneTreei | ENSGT00950000183008 |
HOGENOMi | HOG000261698 |
InParanoidi | P56945 |
KOi | K05726 |
OMAi | NYADTPD |
OrthoDBi | 1086228at2759 |
PhylomeDBi | P56945 |
TreeFami | TF328782 |
Enzyme and pathway databases
Reactomei | R-HSA-186763 Downstream signal transduction R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
SignaLinki | P56945 |
SIGNORi | P56945 |
Miscellaneous databases
ChiTaRSi | BCAR1 human |
EvolutionaryTracei | P56945 |
GeneWikii | BCAR1 |
GenomeRNAii | 9564 |
Pharosi | P56945 |
PROi | PR:P56945 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000050820 Expressed in 181 organ(s), highest expression level in cerebellum |
ExpressionAtlasi | P56945 baseline and differential |
Genevisiblei | P56945 HS |
Family and domain databases
CDDi | cd12001 SH3_BCAR1, 1 hit |
Gene3Di | 1.20.120.830, 1 hit |
InterProi | View protein in InterPro IPR028848 BCAR1 IPR035745 BCAR1_SH3 IPR021901 CAS_C IPR037362 CAS_fam IPR014928 Serine_rich_dom IPR038319 Serine_rich_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain |
PANTHERi | PTHR10654 PTHR10654, 1 hit PTHR10654:SF15 PTHR10654:SF15, 1 hit |
Pfami | View protein in Pfam PF12026 CAS_C, 1 hit PF08824 Serine_rich, 1 hit PF00018 SH3_1, 1 hit |
PRINTSi | PR00452 SH3DOMAIN |
SMARTi | View protein in SMART SM00326 SH3, 1 hit |
SUPFAMi | SSF50044 SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002 SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCAR1_HUMAN | |
Accessioni | P56945Primary (citable) accession number: P56945 Secondary accession number(s): B3KWD7 Q6QEF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 9, 2010 | |
Last modified: | October 16, 2019 | |
This is version 196 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references