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Entry version 195 (02 Jun 2021)
Sequence version 1 (30 May 2000)
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Protein

3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Gene

HSD17B7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030).

Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193).

Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030).

6 Publications

Does not have enzymatic activities toward E1 and DHT.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Estradiol 17-beta-dehydrogenase and dihydrotestosterone oxidoreductase activities are selectively inhibited by 4-methyl-4-aza-5alpha-androstane derivatives, such as 17beta-[(N-Heptyl)methylamino]-4-aza-5r-androstan-3-one and 17beta-(N-Decylformamido)-4-aza-5r-androstan-3-one.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.25 µM for estrone1 Publication
  2. KM=2.60 µM for 17beta-hydroxy-5alpha-androstan-3-one1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: estrogen biosynthesis

    This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.3 Publications
    View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

    Pathwayi: zymosterol biosynthesis

    This protein is involved in step 5 of the subpathway that synthesizes zymosterol from lanosterol.2 Publications This subpathway is part of the pathway zymosterol biosynthesis, which is itself part of Steroid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol, the pathway zymosterol biosynthesis and in Steroid biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei171SubstrateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei193Proton acceptorBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi8 – 15NADSequence analysis8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
    LigandNAD, NADP

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS05604-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.1.1.270, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P56937

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-191273, Cholesterol biosynthesis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P56937

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00769
    UPA00770;UER00758

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001214

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7Curated
    Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase 7
    Short name:
    17-beta-HSD 7
    3-keto-steroid reductase (EC:1.1.1.2703 Publications)
    Dihydrotestosterone oxidoreductase (EC:1.1.1.2103 Publications)
    Estradiol 17-beta-dehydrogenase 7 (EC:1.1.1.623 Publications)
    Short chain dehydrogenase/reductase family 37C member 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HSD17B7
    Synonyms:17HSD71 Publication, SDR37C1
    ORF Names:UNQ2563/PRO6243
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:5215, HSD17B7

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606756, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P56937

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000132196.13

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 229ExtracellularSequence analysisAdd BLAST229
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
    Topological domaini251 – 341CytoplasmicSequence analysisAdd BLAST91

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    51478

    Open Targets

    More...
    OpenTargetsi
    ENSG00000132196

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA29483

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P56937, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5999

    Drug and drug target database

    More...
    DrugBanki
    DB00157, NADH

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    HSD17B7

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    8134404

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000545861 – 3413-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7Add BLAST341

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P56937

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P56937

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P56937

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P56937

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P56937

    PeptideAtlas

    More...
    PeptideAtlasi
    P56937

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P56937

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    56957 [P56937-1]
    56958 [P56937-2]
    56959 [P56937-3]

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    P56937, 3 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P56937

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P56937

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P56937

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested.1 Publication
    Expressed in eye ciliary epithelial cells and neuroendocrine cells.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000132196, Expressed in left adrenal gland and 131 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P56937, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P56937, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000132196, Tissue enhanced (blood, liver)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Binds to the short form of prolactin receptor.

    By similarity

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    119563, 23 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P56937, 14 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000254521

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P56937

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P56937, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1478, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000013340

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_029944_2_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P56937

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ASYEGSK

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P56937

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105433

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd08941, 3KS_SDR_c, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR042829, HSD17B7/Erg27
    IPR036291, NAD(P)-bd_dom_sf
    IPR002347, SDR_fam

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00106, adh_short, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00081, GDHRDH

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51735, SSF51735, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P56937-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA
    60 70 80 90 100
    SHPTAEVTIV QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN
    110 120 130 140 150
    IKALFFGLFS RKVIHMFSTA EGLLTQGDKI TADGLQEVFE TNVFGHFILI
    160 170 180 190 200
    RELEPLLCHS DNPSQLIWTS SRSARKSNFS LEDFQHSKGK EPYSSSKYAT
    210 220 230 240 250
    DLLSVALNRN FNQQGLYSNV ACPGTALTNL TYGILPPFIW TLLMPAILLL
    260 270 280 290 300
    RFFANAFTLT PYNGTEALVW LFHQKPESLN PLIKYLSATT GFGRNYIMTQ
    310 320 330 340
    KMDLDEDTAE KFYQKLLELE KHIRVTIQKT DNQARLSGSC L
    Length:341
    Mass (Da):38,206
    Last modified:May 30, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE4892B2602F549B
    GO
    Isoform 2 (identifier: P56937-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         112-119: Missing.

    Show »
    Length:333
    Mass (Da):37,262
    Checksum:i187F2F8818D93869
    GO
    Isoform 3 (identifier: P56937-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         215-249: Missing.

    Show »
    Length:306
    Mass (Da):34,476
    Checksum:i61F696BEDA3B9EAE
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    Q5T249Q5T249_HUMAN
    3-keto-steroid reductase/17-beta-hy...
    HSD17B7 hCG_2024989
    84Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F2Z2C2F2Z2C2_HUMAN
    3-keto-steroid reductase/17-beta-hy...
    HSD17B7
    109Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V9GYN3V9GYN3_HUMAN
    3-keto-steroid reductase/17-beta-hy...
    HSD17B7
    62Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52 – 53HP → PT in AAF14537 (PubMed:10544267).Curated2
    Sequence conflicti61Q → P in AAF14537 (PubMed:10544267).Curated1
    Sequence conflicti86C → R in CAC88111 (PubMed:12732193).Curated1
    Sequence conflicti105F → L in CAC88111 (PubMed:12732193).Curated1
    Sequence conflicti135L → F in AAP97275 (Ref. 4) Curated1
    Sequence conflicti273 – 276HQKP → PPKA in AAP97275 (Ref. 4) Curated4
    Sequence conflicti288 – 295ATTGFGRN → GTTALEEI in AAP97275 (Ref. 4) Curated8

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006029112 – 119Missing in isoform 2. 1 Publication8
    Alternative sequenceiVSP_012766215 – 249Missing in isoform 3. 1 PublicationAdd BLAST35

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF098786 mRNA Translation: AAF09266.2
    AF162767 AF162766 Genomic DNA Translation: AAF14537.1
    AJ249179 mRNA Translation: CAC20418.1
    AJ250550 AJ250558 Genomic DNA Translation: CAC88111.1
    AF145023 mRNA Translation: AAP97275.1
    AY358962 mRNA Translation: AAQ89321.1
    AK290741 mRNA Translation: BAF83430.1
    BT007075 mRNA Translation: AAP35738.1
    AL392003 Genomic DNA No translation available.
    AL445197 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW90716.1
    BC007068 mRNA Translation: AAH07068.1
    BC065246 mRNA Translation: AAH65246.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1242.1 [P56937-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001291441.1, NM_001304512.1
    NP_001291442.1, NM_001304513.1
    NP_057455.1, NM_016371.3 [P56937-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000254521; ENSP00000254521; ENSG00000132196 [P56937-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    51478

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:51478

    UCSC genome browser

    More...
    UCSCi
    uc001gci.4, human [P56937-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF098786 mRNA Translation: AAF09266.2
    AF162767 AF162766 Genomic DNA Translation: AAF14537.1
    AJ249179 mRNA Translation: CAC20418.1
    AJ250550 AJ250558 Genomic DNA Translation: CAC88111.1
    AF145023 mRNA Translation: AAP97275.1
    AY358962 mRNA Translation: AAQ89321.1
    AK290741 mRNA Translation: BAF83430.1
    BT007075 mRNA Translation: AAP35738.1
    AL392003 Genomic DNA No translation available.
    AL445197 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW90716.1
    BC007068 mRNA Translation: AAH07068.1
    BC065246 mRNA Translation: AAH65246.1
    CCDSiCCDS1242.1 [P56937-1]
    RefSeqiNP_001291441.1, NM_001304512.1
    NP_001291442.1, NM_001304513.1
    NP_057455.1, NM_016371.3 [P56937-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi119563, 23 interactors
    IntActiP56937, 14 interactors
    STRINGi9606.ENSP00000254521

    Chemistry databases

    BindingDBiP56937
    ChEMBLiCHEMBL5999
    DrugBankiDB00157, NADH
    SwissLipidsiSLP:000001214

    PTM databases

    GlyGeniP56937, 3 sites
    iPTMnetiP56937
    PhosphoSitePlusiP56937
    SwissPalmiP56937

    Genetic variation databases

    BioMutaiHSD17B7
    DMDMi8134404

    Proteomic databases

    EPDiP56937
    jPOSTiP56937
    MassIVEiP56937
    MaxQBiP56937
    PaxDbiP56937
    PeptideAtlasiP56937
    PRIDEiP56937
    ProteomicsDBi56957 [P56937-1]
    56958 [P56937-2]
    56959 [P56937-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    34324, 157 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    51478

    Genome annotation databases

    EnsembliENST00000254521; ENSP00000254521; ENSG00000132196 [P56937-1]
    GeneIDi51478
    KEGGihsa:51478
    UCSCiuc001gci.4, human [P56937-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    51478
    DisGeNETi51478

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    HSD17B7
    HGNCiHGNC:5215, HSD17B7
    HPAiENSG00000132196, Tissue enhanced (blood, liver)
    MIMi606756, gene
    neXtProtiNX_P56937
    OpenTargetsiENSG00000132196
    PharmGKBiPA29483
    VEuPathDBiHostDB:ENSG00000132196.13

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1478, Eukaryota
    GeneTreeiENSGT00390000013340
    HOGENOMiCLU_029944_2_0_1
    InParanoidiP56937
    OMAiASYEGSK
    PhylomeDBiP56937
    TreeFamiTF105433

    Enzyme and pathway databases

    UniPathwayiUPA00769
    UPA00770;UER00758
    BioCyciMetaCyc:HS05604-MONOMER
    BRENDAi1.1.1.270, 2681
    PathwayCommonsiP56937
    ReactomeiR-HSA-191273, Cholesterol biosynthesis
    SABIO-RKiP56937

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    51478, 20 hits in 964 CRISPR screens

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    HSD17B7

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    51478
    PharosiP56937, Tchem

    Protein Ontology

    More...
    PROi
    PR:P56937
    RNActiP56937, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000132196, Expressed in left adrenal gland and 131 other tissues
    ExpressionAtlasiP56937, baseline and differential
    GenevisibleiP56937, HS

    Family and domain databases

    CDDicd08941, 3KS_SDR_c, 1 hit
    InterProiView protein in InterPro
    IPR042829, HSD17B7/Erg27
    IPR036291, NAD(P)-bd_dom_sf
    IPR002347, SDR_fam
    PfamiView protein in Pfam
    PF00106, adh_short, 1 hit
    PRINTSiPR00081, GDHRDH
    SUPFAMiSSF51735, SSF51735, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHB7_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56937
    Secondary accession number(s): Q5T246
    , Q7Z4V9, Q8WWS2, Q9UF00
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: June 2, 2021
    This is version 195 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families
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