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Protein

Claudin-20

Gene

CLDN20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-20
Gene namesi
Name:CLDN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000171217.5
HGNCiHGNC:2042 CLDN20
neXtProtiNX_P56880

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 118CytoplasmicSequence analysisAdd BLAST16
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 160ExtracellularSequence analysisAdd BLAST21
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 219CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171217
PharmGKBiPA26568

Polymorphism and mutation databases

BioMutaiCLDN20
DMDMi7387580

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447841 – 219Claudin-20Add BLAST219

Proteomic databases

PaxDbiP56880
PRIDEiP56880
ProteomicsDBi56955

Expressioni

Gene expression databases

BgeeiENSG00000171217 Expressed in 88 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_CLDN20
ExpressionAtlasiP56880 baseline and differential
GenevisibleiP56880 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119070, 3 interactors
STRINGi9606.ENSP00000356133

Structurei

3D structure databases

ProteinModelPortaliP56880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJXC Eukaryota
ENOG410XTF5 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiP56880
KOiK06087
OMAiCTLKYSI
OrthoDBiEOG091G0MX2
PhylomeDBiP56880
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

P56880-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAGLQLLA FILALSGVSG VLTATLLPNW KVNVDVDSNI ITAIVQLHGL
60 70 80 90 100
WMDCTWYSTG MFSCALKHSI LSLPIHVQAA RATMVLACVL SALGICTSTV
110 120 130 140 150
GMKCTRLGGD RETKSHASFA GGVCFMSAGI SSLISTVWYT KEIIANFLDL
160 170 180 190 200
TVPESNKHEP GGAIYIGFIS AMLLFISGMI FCTSCIKRNP EARLDPPTQQ
210
PISNTQLENN STHNLKDYV
Length:219
Mass (Da):23,515
Last modified:May 30, 2000 - v1
Checksum:iD2F5FAD2AAB66306
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139101 Genomic DNA No translation available.
BC020838 mRNA Translation: AAH20838.1
CCDSiCCDS5249.1
RefSeqiNP_001001346.1, NM_001001346.3
XP_011534150.1, XM_011535848.2
UniGeneiHs.567491

Genome annotation databases

EnsembliENST00000367165; ENSP00000356133; ENSG00000171217
GeneIDi49861
KEGGihsa:49861
UCSCiuc003qql.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139101 Genomic DNA No translation available.
BC020838 mRNA Translation: AAH20838.1
CCDSiCCDS5249.1
RefSeqiNP_001001346.1, NM_001001346.3
XP_011534150.1, XM_011535848.2
UniGeneiHs.567491

3D structure databases

ProteinModelPortaliP56880
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119070, 3 interactors
STRINGi9606.ENSP00000356133

Polymorphism and mutation databases

BioMutaiCLDN20
DMDMi7387580

Proteomic databases

PaxDbiP56880
PRIDEiP56880
ProteomicsDBi56955

Protocols and materials databases

DNASUi49861
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367165; ENSP00000356133; ENSG00000171217
GeneIDi49861
KEGGihsa:49861
UCSCiuc003qql.2 human

Organism-specific databases

CTDi49861
EuPathDBiHostDB:ENSG00000171217.5
GeneCardsiCLDN20
HGNCiHGNC:2042 CLDN20
neXtProtiNX_P56880
OpenTargetsiENSG00000171217
PharmGKBiPA26568
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJXC Eukaryota
ENOG410XTF5 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiP56880
KOiK06087
OMAiCTLKYSI
OrthoDBiEOG091G0MX2
PhylomeDBiP56880
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

GeneWikiiCLDN20
GenomeRNAii49861
PROiPR:P56880

Gene expression databases

BgeeiENSG00000171217 Expressed in 88 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_CLDN20
ExpressionAtlasiP56880 baseline and differential
GenevisibleiP56880 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD20_HUMAN
AccessioniPrimary (citable) accession number: P56880
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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