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Protein

Claudin-18

Gene

Cldn18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

TCDBi1.H.1.1.8 the claudin tight junction (claudin1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-18
Gene namesi
Name:Cldn18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1929209 Cldn18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 80ExtracellularSequence analysisAdd BLAST53
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 122CytoplasmicSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 176ExtracellularSequence analysisAdd BLAST33
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 264CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447801 – 264Claudin-18Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP56857
PaxDbiP56857
PRIDEiP56857

PTM databases

iPTMnetiP56857
PhosphoSitePlusiP56857

Expressioni

Gene expression databases

BgeeiENSMUSG00000032473 Expressed in 37 organ(s), highest expression level in lung
CleanExiMM_CLDN18
GenevisibleiP56857 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-48956N
IntActiP56857, 3 interactors
MINTiP56857
STRINGi10090.ENSMUSP00000035048

Structurei

3D structure databases

ProteinModelPortaliP56857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG28 Eukaryota
ENOG410XPD1 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG102991
InParanoidiP56857
KOiK06087
OMAiVQSHPSK
OrthoDBiEOG091G0MX2
PhylomeDBiP56857
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003928 Claudin18
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF9 PTHR12002:SF9, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01448 CLAUDIN18
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A1.1 (identifier: P56857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW
60 70 80 90 100
RSCVQQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA
110 120 130 140 150
LKCIRIGSMD DSAKAKMTLT SGILFIISGI CAIIGVSVFA NMLVTNFWMS
160 170 180 190 200
TANMYSGMGG MGGMVQTVQT RYTFGAALFV GWVAGGLTLI GGVMMCIACR
210 220 230 240 250
GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN KKIYDGGART
260
EDDEQSHPTK YDYV
Length:264
Mass (Da):28,122
Last modified:May 30, 2000 - v1
Checksum:i3CA0D441C4705653
GO
Isoform A1.2 (identifier: P56857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-208: N → K
     209-264: Missing.

Show »
Length:208
Mass (Da):21,978
Checksum:iFA9E7DA70D7E7ADE
GO
Isoform A2.1 (identifier: P56857-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MATTTCQVVG...FTECRPYFTI → MSVTACQGLG...FTECRGYFTL

Show »
Length:264
Mass (Da):28,144
Checksum:iAEA19430E157E831
GO
Isoform A2.2 (identifier: P56857-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MATTTCQVVG...FTECRPYFTI → MSVTACQGLG...FTECRGYFTL
     208-208: N → K
     209-264: Missing.

Show »
Length:208
Mass (Da):22,000
Checksum:i03FAA247911BCD6C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0011031 – 69MATTT…PYFTI → MSVTACQGLGFVVSLIGFAG IIAATCMDQWSTQDLYNNPV TAVFNYQGLWRSCVRESSGF TECRGYFTL in isoform A2.1 and isoform A2.2. CuratedAdd BLAST69
Alternative sequenceiVSP_001104208N → K in isoform A1.2 and isoform A2.2. Curated1
Alternative sequenceiVSP_001105209 – 264Missing in isoform A1.2 and isoform A2.2. CuratedAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221068 mRNA Translation: AAF26447.1
AF349450 mRNA Translation: AAL15635.1
AF349451 mRNA Translation: AAL15636.1
AF349453 mRNA Translation: AAL15638.1
CCDSiCCDS23437.1 [P56857-1]
CCDS57692.1 [P56857-2]
CCDS57693.1 [P56857-4]
CCDS57694.1 [P56857-3]
RefSeqiNP_001181850.1, NM_001194921.1 [P56857-3]
NP_001181851.1, NM_001194922.1 [P56857-2]
NP_001181852.1, NM_001194923.1 [P56857-4]
NP_062789.1, NM_019815.3 [P56857-1]
UniGeneiMm.386784

Genome annotation databases

EnsembliENSMUST00000035048; ENSMUSP00000035048; ENSMUSG00000032473 [P56857-1]
ENSMUST00000112882; ENSMUSP00000108503; ENSMUSG00000032473 [P56857-3]
ENSMUST00000131922; ENSMUSP00000117382; ENSMUSG00000032473 [P56857-4]
ENSMUST00000136429; ENSMUSP00000115782; ENSMUSG00000032473 [P56857-2]
GeneIDi56492
KEGGimmu:56492
UCSCiuc009rep.2 mouse [P56857-1]
uc009req.2 mouse [P56857-2]
uc009rer.2 mouse [P56857-4]
uc009res.2 mouse [P56857-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221068 mRNA Translation: AAF26447.1
AF349450 mRNA Translation: AAL15635.1
AF349451 mRNA Translation: AAL15636.1
AF349453 mRNA Translation: AAL15638.1
CCDSiCCDS23437.1 [P56857-1]
CCDS57692.1 [P56857-2]
CCDS57693.1 [P56857-4]
CCDS57694.1 [P56857-3]
RefSeqiNP_001181850.1, NM_001194921.1 [P56857-3]
NP_001181851.1, NM_001194922.1 [P56857-2]
NP_001181852.1, NM_001194923.1 [P56857-4]
NP_062789.1, NM_019815.3 [P56857-1]
UniGeneiMm.386784

3D structure databases

ProteinModelPortaliP56857
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48956N
IntActiP56857, 3 interactors
MINTiP56857
STRINGi10090.ENSMUSP00000035048

Protein family/group databases

TCDBi1.H.1.1.8 the claudin tight junction (claudin1) family

PTM databases

iPTMnetiP56857
PhosphoSitePlusiP56857

Proteomic databases

MaxQBiP56857
PaxDbiP56857
PRIDEiP56857

Protocols and materials databases

DNASUi56492
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035048; ENSMUSP00000035048; ENSMUSG00000032473 [P56857-1]
ENSMUST00000112882; ENSMUSP00000108503; ENSMUSG00000032473 [P56857-3]
ENSMUST00000131922; ENSMUSP00000117382; ENSMUSG00000032473 [P56857-4]
ENSMUST00000136429; ENSMUSP00000115782; ENSMUSG00000032473 [P56857-2]
GeneIDi56492
KEGGimmu:56492
UCSCiuc009rep.2 mouse [P56857-1]
uc009req.2 mouse [P56857-2]
uc009rer.2 mouse [P56857-4]
uc009res.2 mouse [P56857-3]

Organism-specific databases

CTDi51208
MGIiMGI:1929209 Cldn18

Phylogenomic databases

eggNOGiENOG410IG28 Eukaryota
ENOG410XPD1 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG102991
InParanoidiP56857
KOiK06087
OMAiVQSHPSK
OrthoDBiEOG091G0MX2
PhylomeDBiP56857
TreeFamiTF331936

Miscellaneous databases

PROiPR:P56857
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032473 Expressed in 37 organ(s), highest expression level in lung
CleanExiMM_CLDN18
GenevisibleiP56857 MM

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003928 Claudin18
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF9 PTHR12002:SF9, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01448 CLAUDIN18
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD18_MOUSE
AccessioniPrimary (citable) accession number: P56857
Secondary accession number(s): Q91ZY9, Q91ZZ0, Q91ZZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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