Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 136 (12 Aug 2020)
Sequence version 1 (30 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Claudin-18

Gene

Cldn18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.H.1.1.8, the claudin tight junction (claudin1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Claudin-18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cldn18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929209, Cldn18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 80ExtracellularSequence analysisAdd BLAST53
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 122CytoplasmicSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 176ExtracellularSequence analysisAdd BLAST33
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 264CytoplasmicSequence analysisAdd BLAST67

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447801 – 264Claudin-18Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei217PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P56857

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56857

PRoteomics IDEntifications database

More...
PRIDEi
P56857

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56857

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56857

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform A1.1: Expressed in lung (PubMed:11585919). Isoform A1.2: Expressed in lung (PubMed:11585919). Isoform A2.1: Expressed in stomach (PubMed:11585919). Isoform A2.2: Expressed in stomach (PubMed:11585919).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032473, Expressed in lung and 55 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56857, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-48956N

Protein interaction database and analysis system

More...
IntActi
P56857, 3 interactors

Molecular INTeraction database

More...
MINTi
P56857

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035048

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P56857, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTRB, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158655

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076370_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56857

KEGG Orthology (KO)

More...
KOi
K06087

Identification of Orthologs from Complete Genome Data

More...
OMAi
QYQGLWR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56857

TreeFam database of animal gene trees

More...
TreeFami
TF331936

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006187, Claudin
IPR003928, Claudin18
IPR017974, Claudin_CS
IPR004031, PMP22/EMP/MP20/Claudin

The PANTHER Classification System

More...
PANTHERi
PTHR12002, PTHR12002, 1 hit
PTHR12002:SF9, PTHR12002:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00822, PMP22_Claudin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01448, CLAUDIN18

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01346, CLAUDIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A1.1 (identifier: P56857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TAVFQYEGLW
60 70 80 90 100
RSCVQQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA
110 120 130 140 150
LKCIRIGSMD DSAKAKMTLT SGILFIISGI CAIIGVSVFA NMLVTNFWMS
160 170 180 190 200
TANMYSGMGG MGGMVQTVQT RYTFGAALFV GWVAGGLTLI GGVMMCIACR
210 220 230 240 250
GLTPDDSNFK AVSYHASGQN VAYRPGGFKA STGFGSNTRN KKIYDGGART
260
EDDEQSHPTK YDYV
Length:264
Mass (Da):28,122
Last modified:May 30, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CA0D441C4705653
GO
Isoform A1.2 (identifier: P56857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-208: N → K
     209-264: Missing.

Show »
Length:208
Mass (Da):21,978
Checksum:iFA9E7DA70D7E7ADE
GO
Isoform A2.1 (identifier: P56857-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MATTTCQVVG...FTECRPYFTI → MSVTACQGLG...FTECRGYFTL

Show »
Length:264
Mass (Da):28,144
Checksum:iAEA19430E157E831
GO
Isoform A2.2 (identifier: P56857-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MATTTCQVVG...FTECRPYFTI → MSVTACQGLG...FTECRGYFTL
     208-208: N → K
     209-264: Missing.

Show »
Length:208
Mass (Da):22,000
Checksum:i03FAA247911BCD6C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0011031 – 69MATTT…PYFTI → MSVTACQGLGFVVSLIGFAG IIAATCMDQWSTQDLYNNPV TAVFNYQGLWRSCVRESSGF TECRGYFTL in isoform A2.1 and isoform A2.2. CuratedAdd BLAST69
Alternative sequenceiVSP_001104208N → K in isoform A1.2 and isoform A2.2. Curated1
Alternative sequenceiVSP_001105209 – 264Missing in isoform A1.2 and isoform A2.2. CuratedAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF221068 mRNA Translation: AAF26447.1
AF349450 mRNA Translation: AAL15635.1
AF349451 mRNA Translation: AAL15636.1
AF349453 mRNA Translation: AAL15638.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23437.1 [P56857-1]
CCDS57692.1 [P56857-2]
CCDS57693.1 [P56857-4]
CCDS57694.1 [P56857-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001181850.1, NM_001194921.1 [P56857-3]
NP_001181851.1, NM_001194922.1 [P56857-2]
NP_001181852.1, NM_001194923.1 [P56857-4]
NP_062789.1, NM_019815.3 [P56857-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035048; ENSMUSP00000035048; ENSMUSG00000032473 [P56857-1]
ENSMUST00000112882; ENSMUSP00000108503; ENSMUSG00000032473 [P56857-3]
ENSMUST00000131922; ENSMUSP00000117382; ENSMUSG00000032473 [P56857-4]
ENSMUST00000136429; ENSMUSP00000115782; ENSMUSG00000032473 [P56857-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56492

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56492

UCSC genome browser

More...
UCSCi
uc009rep.2, mouse [P56857-1]
uc009req.2, mouse [P56857-2]
uc009rer.2, mouse [P56857-4]
uc009res.2, mouse [P56857-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221068 mRNA Translation: AAF26447.1
AF349450 mRNA Translation: AAL15635.1
AF349451 mRNA Translation: AAL15636.1
AF349453 mRNA Translation: AAL15638.1
CCDSiCCDS23437.1 [P56857-1]
CCDS57692.1 [P56857-2]
CCDS57693.1 [P56857-4]
CCDS57694.1 [P56857-3]
RefSeqiNP_001181850.1, NM_001194921.1 [P56857-3]
NP_001181851.1, NM_001194922.1 [P56857-2]
NP_001181852.1, NM_001194923.1 [P56857-4]
NP_062789.1, NM_019815.3 [P56857-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-48956N
IntActiP56857, 3 interactors
MINTiP56857
STRINGi10090.ENSMUSP00000035048

Protein family/group databases

TCDBi1.H.1.1.8, the claudin tight junction (claudin1) family

PTM databases

iPTMnetiP56857
PhosphoSitePlusiP56857

Proteomic databases

MaxQBiP56857
PaxDbiP56857
PRIDEiP56857

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4575, 193 antibodies

The DNASU plasmid repository

More...
DNASUi
56492

Genome annotation databases

EnsembliENSMUST00000035048; ENSMUSP00000035048; ENSMUSG00000032473 [P56857-1]
ENSMUST00000112882; ENSMUSP00000108503; ENSMUSG00000032473 [P56857-3]
ENSMUST00000131922; ENSMUSP00000117382; ENSMUSG00000032473 [P56857-4]
ENSMUST00000136429; ENSMUSP00000115782; ENSMUSG00000032473 [P56857-2]
GeneIDi56492
KEGGimmu:56492
UCSCiuc009rep.2, mouse [P56857-1]
uc009req.2, mouse [P56857-2]
uc009rer.2, mouse [P56857-4]
uc009res.2, mouse [P56857-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51208
MGIiMGI:1929209, Cldn18

Phylogenomic databases

eggNOGiENOG502QTRB, Eukaryota
GeneTreeiENSGT00940000158655
HOGENOMiCLU_076370_2_1_1
InParanoidiP56857
KOiK06087
OMAiQYQGLWR
PhylomeDBiP56857
TreeFamiTF331936

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
56492, 0 hits in 18 CRISPR screens

Protein Ontology

More...
PROi
PR:P56857
RNActiP56857, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032473, Expressed in lung and 55 other tissues
GenevisibleiP56857, MM

Family and domain databases

InterProiView protein in InterPro
IPR006187, Claudin
IPR003928, Claudin18
IPR017974, Claudin_CS
IPR004031, PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002, PTHR12002, 1 hit
PTHR12002:SF9, PTHR12002:SF9, 1 hit
PfamiView protein in Pfam
PF00822, PMP22_Claudin, 1 hit
PRINTSiPR01448, CLAUDIN18
PROSITEiView protein in PROSITE
PS01346, CLAUDIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLD18_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56857
Secondary accession number(s): Q91ZY9, Q91ZZ0, Q91ZZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: August 12, 2020
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again