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Protein

Claudin-18

Gene

CLDN18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-18
Gene namesi
Name:CLDN18
ORF Names:UNQ778/PRO1572
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000066405.12
HGNCiHGNC:2039 CLDN18
MIMi609210 gene
neXtProtiNX_P56856

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 80ExtracellularSequence analysisAdd BLAST53
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 122CytoplasmicSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 174ExtracellularSequence analysisAdd BLAST31
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 261CytoplasmicSequence analysisAdd BLAST66

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi51208
OpenTargetsiENSG00000066405
PharmGKBiPA26565

Chemistry databases

ChEMBLiCHEMBL3712859

Polymorphism and mutation databases

BioMutaiCLDN18
DMDMi7387578

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447791 – 261Claudin-18Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP56856
PeptideAtlasiP56856
PRIDEiP56856
ProteomicsDBi56953
56954 [P56856-2]

PTM databases

iPTMnetiP56856
PhosphoSitePlusiP56856

Expressioni

Tissue specificityi

Concentrated at the cell-cell borders of epithelial cells.

Gene expression databases

BgeeiENSG00000066405 Expressed in 115 organ(s), highest expression level in pylorus
CleanExiHS_CLDN18
ExpressionAtlasiP56856 baseline and differential
GenevisibleiP56856 HS

Organism-specific databases

HPAiCAB013010
CAB013243
HPA018446

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119381, 2 interactors
DIPiDIP-48955N
IntActiP56856, 4 interactors
STRINGi9606.ENSP00000183605

Structurei

3D structure databases

ProteinModelPortaliP56856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG28 Eukaryota
ENOG410XPD1 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG102991
InParanoidiP56856
KOiK06087
OMAiVQSHPSK
OrthoDBiEOG091G0MX2
PhylomeDBiP56856
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003928 Claudin18
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF9 PTHR12002:SF9, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01448 CLAUDIN18
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A1 (identifier: P56856-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTTTCQVVA FLLSILGLAG CIAATGMDMW STQDLYDNPV TSVFQYEGLW
60 70 80 90 100
RSCVRQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG AIGLLVSIFA
110 120 130 140 150
LKCIRIGSME DSAKANMTLT SGIMFIVSGL CAIAGVSVFA NMLVTNFWMS
160 170 180 190 200
TANMYTGMGG MVQTVQTRYT FGAALFVGWV AGGLTLIGGV MMCIACRGLA
210 220 230 240 250
PEETNYKAVS YHASGHSVAY KPGGFKASTG FGSNTKNKKI YDGGARTEDE
260
VQSYPSKHDY V
Length:261
Mass (Da):27,856
Last modified:May 30, 2000 - v1
Checksum:i4362B590D3C2B387
GO
Isoform A2 (identifier: P56856-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MSTTTCQVVA...FTECRPYFTI → MAVTACQGLG...FTECRGYFTL

Show »
Length:261
Mass (Da):27,720
Checksum:iDA519D1E57FDFCA7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEY4F8WEY4_HUMAN
Claudin
CLDN18
146Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033775149M → L. Corresponds to variant dbSNP:rs17204075Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0011021 – 69MSTTT…PYFTI → MAVTACQGLGFVVSLIGIAG IIAATCMDQWSTQDLYNNPV TAVFNYQGLWRSCVRESSGF TECRGYFTL in isoform A2. CuratedAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221069 mRNA Translation: AAF26448.1
AF349452 mRNA Translation: AAL15637.1
AY358479 mRNA Translation: AAQ88843.1
CH471052 Genomic DNA Translation: EAW79092.1
BC142708 mRNA Translation: AAI42709.1
BC146668 mRNA Translation: AAI46669.1
CCDSiCCDS3095.1 [P56856-1]
CCDS33862.1 [P56856-2]
RefSeqiNP_001002026.1, NM_001002026.2 [P56856-2]
NP_057453.1, NM_016369.3 [P56856-1]
UniGeneiHs.655324

Genome annotation databases

EnsembliENST00000183605; ENSP00000183605; ENSG00000066405 [P56856-1]
ENST00000343735; ENSP00000340939; ENSG00000066405 [P56856-2]
GeneIDi51208
KEGGihsa:51208
UCSCiuc003ero.2 human [P56856-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221069 mRNA Translation: AAF26448.1
AF349452 mRNA Translation: AAL15637.1
AY358479 mRNA Translation: AAQ88843.1
CH471052 Genomic DNA Translation: EAW79092.1
BC142708 mRNA Translation: AAI42709.1
BC146668 mRNA Translation: AAI46669.1
CCDSiCCDS3095.1 [P56856-1]
CCDS33862.1 [P56856-2]
RefSeqiNP_001002026.1, NM_001002026.2 [P56856-2]
NP_057453.1, NM_016369.3 [P56856-1]
UniGeneiHs.655324

3D structure databases

ProteinModelPortaliP56856
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119381, 2 interactors
DIPiDIP-48955N
IntActiP56856, 4 interactors
STRINGi9606.ENSP00000183605

Chemistry databases

ChEMBLiCHEMBL3712859

PTM databases

iPTMnetiP56856
PhosphoSitePlusiP56856

Polymorphism and mutation databases

BioMutaiCLDN18
DMDMi7387578

Proteomic databases

PaxDbiP56856
PeptideAtlasiP56856
PRIDEiP56856
ProteomicsDBi56953
56954 [P56856-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000183605; ENSP00000183605; ENSG00000066405 [P56856-1]
ENST00000343735; ENSP00000340939; ENSG00000066405 [P56856-2]
GeneIDi51208
KEGGihsa:51208
UCSCiuc003ero.2 human [P56856-1]

Organism-specific databases

CTDi51208
DisGeNETi51208
EuPathDBiHostDB:ENSG00000066405.12
GeneCardsiCLDN18
H-InvDBiHIX0003711
HGNCiHGNC:2039 CLDN18
HPAiCAB013010
CAB013243
HPA018446
MIMi609210 gene
neXtProtiNX_P56856
OpenTargetsiENSG00000066405
PharmGKBiPA26565
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG28 Eukaryota
ENOG410XPD1 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG102991
InParanoidiP56856
KOiK06087
OMAiVQSHPSK
OrthoDBiEOG091G0MX2
PhylomeDBiP56856
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

ChiTaRSiCLDN18 human
GeneWikiiCLDN18
GenomeRNAii51208
PROiPR:P56856
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000066405 Expressed in 115 organ(s), highest expression level in pylorus
CleanExiHS_CLDN18
ExpressionAtlasiP56856 baseline and differential
GenevisibleiP56856 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003928 Claudin18
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF9 PTHR12002:SF9, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01448 CLAUDIN18
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD18_HUMAN
AccessioniPrimary (citable) accession number: P56856
Secondary accession number(s): A5PL21, Q96PH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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