Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P56817 (BACE1_HUMAN)

Entry version 219 (22 Apr 2020)
Sequence version 3 (07 Jun 2017)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Beta-secretase 1

Gene

BACE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by RTN3 and RTN4.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.67 sec(-1) and 2.45 sec(-1) for APP cleaved by PSEN1 and APP Swedish variant, respectively (PubMed:10677483).1 Publication
  1. KM=15.2 mM for APP cleaved by PSEN1 (at pH4)1 Publication
  2. KM=1 mM for APP Swedish variant (at pH4)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei93PROSITE-ProRule annotation1
    Active sitei289PROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:ENSG00000160610-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.4.23.46 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-977225 Amyloid fiber formation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P56817

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		P56817

    Protein family/group databases

    MEROPS protease database

    More...    MEROPSi    		A01.004

    Transport Classification Database

    More...    TCDBi    		8.A.32.1.1 the Beta-amyloid cleaving enzyme (bace1) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Beta-secretase 1Curated (EC:3.4.23.461 Publication)
    Alternative name(s):
    Aspartyl protease 21 Publication
    Short name:
    ASP21 Publication
    Short name:
    Asp 21 Publication
    Beta-site amyloid precursor protein cleaving enzyme 1
    Short name:
    Beta-site APP cleaving enzyme 1
    Memapsin-22 Publications
    Membrane-associated aspartic protease 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:BACE1Imported
    Synonyms:BACE, KIAA1149
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:933 BACE1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		604252 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P56817

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 457ExtracellularSequence analysisAdd BLAST436
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
    Topological domaini479 – 501CytoplasmicSequence analysisAdd BLAST23

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi93D → N: Decreases beta-cleaved soluble APP production. 1 Publication1
    Mutagenesisi284D → N: Almost abolishes beta-cleaved soluble APP production. 1 Publication1
    Mutagenesisi498S → A: No effect on endocytosis from the cell surface. Increases recycling from endosomes to the cell surface. 2 Publications1
    Mutagenesisi498S → D: No effect on endocytosis form the cell surface. Decreases recycling from endosomes to the cell surface. 1 Publication1
    Mutagenesisi499 – 500LL → AA: Impairs endocytosis and produces a delayed retrograde transport to the trans-Golgi network and delivery to the lysosmes, decreasinf its degradation. Disrupts location to late endosomes and lysosomes. Locates mainly at the cell surface. No effect on degradation regulated by GGA3. Effects on protein stability and defective internalization increases; when associated with R-501. 4 Publications2
    Mutagenesisi501K → R: Inhibits ubiquitination. No effect on endocytosis rate. Induced protein stability and acculmulation in early and late endosomes, lysosomes and cell membrane. Effects on protein stability and defective internalization increases; when associated with A-499-500-A. 3 Publications1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		23621

    Open Targets

    More...    OpenTargetsi    		ENSG00000186318

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA25232

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P56817 Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4822

    Drug and drug target database

    More...    DrugBanki    		DB07573 (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol
    DB07736 (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
    DB07737 (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
    DB07519 (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
    DB07874 (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
    DB07535 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
    DB08749 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
    DB07345 4-(2-aminoethyl)-2-cyclohexylphenol
    DB07346 4-(2-aminoethyl)-2-ethylphenol
    DB07110 4-(4-FLUOROBENZYL)PIPERIDINE
    DB07415 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine
    DB07206 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE
    DB07245 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE
    DB06073 CTS-21166
    DB02378 MMI-175
    DB07734 N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
    DB07019 N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
    DB07735 N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
    DB07738 N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
    DB06930 N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
    DB07089 N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
    DB07175 N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide
    DB07284 N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
    DB07993 N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE
    DB07303 N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
    DB07994 N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE
    DB07281 N~3~-BENZYLPYRIDINE-2,3-DIAMINE
    DB12285 Verubecestat

    DrugCentral

    More...    DrugCentrali    		P56817

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		2330

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		BACE1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		296434407

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002593922 – 451 PublicationAdd BLAST24
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002594046 – 501Beta-secretase 1Add BLAST456

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126N6-acetyllysine2 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi216 ↔ 4201 Publication
    Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
    Modified residuei275N6-acetyllysine2 Publications1
    Disulfide bondi278 ↔ 4431 Publication
    Modified residuei279N6-acetyllysine2 Publications1
    Modified residuei285N6-acetyllysine2 Publications1
    Modified residuei299N6-acetyllysine2 Publications1
    Modified residuei300N6-acetyllysine2 Publications1
    Modified residuei307N6-acetyllysine2 Publications1
    Disulfide bondi330 ↔ 3801 Publication
    Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi474S-palmitoyl cysteineBy similarity1
    Lipidationi478S-palmitoyl cysteineBy similarity1
    Lipidationi482S-palmitoyl cysteineBy similarity1
    Lipidationi485S-palmitoyl cysteineBy similarity1
    Modified residuei498Phosphoserine1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki501Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-Glycosylated (PubMed:11083922, PubMed:17425515). Addition of a bisecting N-acetylglucosamine by MGAT3 blocks lysosomal targeting, further degradation and is required for maintaining stability under stress conditions (By similarity).By similarity2 Publications
    Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein.2 Publications
    Palmitoylation mediates lipid raft localization.By similarity
    Ubiquitinated at Lys-501, ubiquitination leads to lysosomal degradation (PubMed:27302062, PubMed:16033761, PubMed:20484053, PubMed:23109336). Monoubiquitinated and 'Lys-63'-linked polyubitinated (PubMed:20484053). Deubiquitnated by USP8; inhibits lysosomal degradation (PubMed:27302062).4 Publications
    Phosphorylation at Ser-498 is required for interaction with GGA1 and retrograded transport from endosomal compartments to the trans-Golgi network. Non-phosphorylated BACE1 enters a direct recycling route to the cell surface.1 Publication

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation, Zymogen

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P56817

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P56817

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P56817

    PeptideAtlas

    More...    PeptideAtlasi    		P56817

    PRoteomics IDEntifications database

    More...    PRIDEi    		P56817

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		19820
    43307
    56947 [P56817-1]
    56948 [P56817-2]
    56949 [P56817-3]
    56950 [P56817-4]

    PTM databases

    GlyConnect protein glycosylation platform

    More...    GlyConnecti    		71
    72

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P56817

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P56817

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P56817

    UniCarbKB; an annotated and curated database of glycan structures

    More...    UniCarbKBi    		P56817

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.2 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by the Ca2+-regulated transcription factor NFATC4.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000186318 Expressed in C1 segment of cervical spinal cord and 222 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P56817 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P56817 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000186318 Group enriched (brain, pancreas)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    Interacts (via DXXLL motif) with GGA1, GGA2 and GGA3 (via their VHS domain); the interaction highly increases when BACE1 is phosphorylated at Ser-498 (PubMed:14567678, PubMed:15886016).

    Interacts with RTN3 and RTN4 (PubMed:15286784, PubMed:16965550, PubMed:16979658).

    Interacts with SNX6 (PubMed:20354142).

    Interacts with PCSK9 (PubMed:18660751).

    Interacts with NAT8 and NAT8B (PubMed:19011241).

    Interacts with BIN1 (PubMed:27179792).

    Interacts (via extracellular domain) with ADAM10 (via extracellular domain) (By similarity).

    Interacts with SORL1; this interaction may affect binding with APP and hence reduce APP cleavage (PubMed:16407538).

    By similarity10 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Show more details

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		117154, 22 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...    CORUMi    		P56817

    Database of interacting proteins

    More...    DIPi    		DIP-41388N

    Protein interaction database and analysis system

    More...    IntActi    		P56817, 40 interactors

    Molecular INTeraction database

    More...    MINTi    		P56817

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000318585

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P56817

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P56817 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1501
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P56817

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P56817

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 416Peptidase A1PROSITE-ProRule annotationAdd BLAST342

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni479 – 501Interaction with RTN3Add BLAST23

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi496 – 500DXXLL1 Publication5

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    DXXLL motif is required for a proper endocytosis and retrograde transport to the trans-Golgi network, as well as for regulation of lysosomal degradation.1 Publication
    The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.1 Publication

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1339 Eukaryota
    ENOG410XNV7 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000157786

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_039009_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P56817

    KEGG Orthology (KO)

    More...    KOi    		K04521

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		ELEDCGY

    Database of Orthologous Groups

    More...    OrthoDBi    		429758at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P56817

    TreeFam database of animal gene trees

    More...    TreeFami    		TF329595

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd05473 beta_secretase_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		2.40.70.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR001461 Aspartic_peptidase_A1
    IPR001969 Aspartic_peptidase_AS
    IPR009119 BACE
    IPR009120 BACE1
    IPR033874 Memapsin-like
    IPR033121 PEPTIDASE_A1
    IPR021109 Peptidase_aspartic_dom_sf

    The PANTHER Classification System

    More...    PANTHERi    		PTHR13683 PTHR13683, 1 hit
    PTHR13683:SF245 PTHR13683:SF245, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00026 Asp, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR01815 BACEFAMILY
    PR00792 PEPSIN

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF50630 SSF50630, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00141 ASP_PROTEASE, 1 hit
    PS51767 PEPTIDASE_A1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform A (identifier: P56817-1) [UniParc]FASTAAdd to basket
    Also known as: BACE-1A, BAC-501

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPLG LRLPRETDEE 
            60         70         80         90        100
    PEEPGRRGSF VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA 
           110        120        130        140        150
    VGAAPHPFLH RYYQRQLSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH 
           160        170        180        190        200
    GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARP DDSLEPFFDS 
           210        220        230        240        250
    LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI DHSLYTGSLW 
           260        270        280        290        300
    YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK 
           310        320        330        340        350
    VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG 
           360        370        380        390        400
    EVTNQSFRIT ILPQQYLRPV EDVATSQDDC YKFAISQSST GTVMGAVIME 
           410        420        430        440        450
    GFYVVFDRAR KRIGFAVSAC HVHDEFRTAA VEGPFVTLDM EDCGYNIPQT 
           460        470        480        490        500
    DESTLMTIAY VMAAICALFM LPLCLMVCQW RCLRCLRQQH DDFADDISLL 

    K
    Length:501
    Mass (Da):55,764
    Last modified:June 7, 2017 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i377CE4C824ACEF05
    GO
    Isoform B (identifier: P56817-2) [UniParc]FASTAAdd to basket
    Also known as: BACE-1B, BACE-I-476

    The sequence of this isoform differs from the canonical sequence as follows:
         190-214: Missing.

    Show »
    Length:476
    Mass (Da):52,908
    Checksum:i6C8C87F8A953AF66
    GO
    Isoform C (identifier: P56817-3) [UniParc]FASTAAdd to basket
    Also known as: BACE-1C, BACE-I-457

    The sequence of this isoform differs from the canonical sequence as follows:
         146-189: Missing.

    Show »
    Length:457
    Mass (Da):51,068
    Checksum:iC794C9A9E85FE7A2
    GO
    Isoform D (identifier: P56817-4) [UniParc]FASTAAdd to basket
    Also known as: BACE-1D, BACE-I-432

    The sequence of this isoform differs from the canonical sequence as follows:
         146-189: Missing.
         190-214: Missing.

    Show »
    Length:432
    Mass (Da):48,212
    Checksum:i96FC81E6F0EED01B
    GO
    Isoform 5 (identifier: P56817-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MAQALPWLLLWMGAGVLPAH → MVPFIYLQAHFTLCSGWSST
         21-120: Missing.

    Show »
    Length:401
    Mass (Da):45,017
    Checksum:iA8D5B1113A78C521
    GO
    Isoform 6 (identifier: P56817-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MAQALPWLLLWMGAGVLPAH → MVPFIYLQAHFTLCSGWSST
         21-120: Missing.
         190-214: Missing.

    Show »
    Length:376
    Mass (Da):42,160
    Checksum:i93E4D8C553E23716
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    E9PJG7E9PJG7_HUMAN
    Beta-secretase 1
    BACE1
    		467Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    U3KPS1U3KPS1_HUMAN
    Beta-secretase 1
    BACE1
    		51Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YDX0H0YDX0_HUMAN
    Beta-secretase 1
    BACE1
    		40Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA86463 differs from that shown. Reason: Frameshift.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060692265V → A1 PublicationCorresponds to variant dbSNP:rs28989503Ensembl.1
    Natural variantiVAR_051509481R → C. Corresponds to variant dbSNP:rs539765Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470921 – 20MAQAL…VLPAH → MVPFIYLQAHFTLCSGWSST in isoform 5 and isoform 6. CuratedAdd BLAST20
    Alternative sequenceiVSP_04709321 – 120Missing in isoform 5 and isoform 6. CuratedAdd BLAST100
    Alternative sequenceiVSP_005222146 – 189Missing in isoform C and isoform D. 2 PublicationsAdd BLAST44
    Alternative sequenceiVSP_005223190 – 214Missing in isoform B, isoform D and isoform 6. 2 PublicationsAdd BLAST25

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF190725 mRNA Translation: AAF04142.1
    AF201468 mRNA Translation: AAF18982.1
    AF200343 mRNA Translation: AAF17079.1
    AF204943 mRNA Translation: AAF26367.1
    AF338816 mRNA Translation: AAK38374.1
    AF338817 mRNA Translation: AAK38375.1
    AB050436 mRNA Translation: BAB40931.1
    AB050437 mRNA Translation: BAB40932.1
    AB050438 mRNA Translation: BAB40933.1
    AB032975 mRNA Translation: BAA86463.2 Frameshift.
    DQ007053 Genomic DNA Translation: AAY16982.1
    EF444940 Genomic DNA Translation: ACA05927.1
    AP000892 Genomic DNA No translation available.
    CH471065 Genomic DNA Translation: EAW67313.1
    BC065492 mRNA Translation: AAH65492.1
    AF200193 mRNA Translation: AAF13715.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS44739.1 [P56817-2]
    CCDS44740.1 [P56817-3]
    CCDS44741.1 [P56817-4]
    CCDS55786.1 [P56817-6]
    CCDS55787.1 [P56817-5]
    CCDS8383.1 [P56817-1]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A59090

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001193978.1, NM_001207049.1 [P56817-6]
    NP_036236.1, NM_012104.4 [P56817-1]
    NP_620427.1, NM_138971.3 [P56817-3]
    NP_620428.1, NM_138972.3 [P56817-2]
    NP_620429.1, NM_138973.3 [P56817-4]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000313005; ENSP00000318585; ENSG00000186318 [P56817-1]
    ENST00000392937; ENSP00000475405; ENSG00000186318 [P56817-5]
    ENST00000428381; ENSP00000402228; ENSG00000186318 [P56817-4]
    ENST00000445823; ENSP00000403685; ENSG00000186318 [P56817-3]
    ENST00000510630; ENSP00000422461; ENSG00000186318 [P56817-6]
    ENST00000513780; ENSP00000424536; ENSG00000186318 [P56817-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		23621

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:23621

    UCSC genome browser

    More...    UCSCi    		uc001pqw.4 human [P56817-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF190725 mRNA Translation: AAF04142.1
    AF201468 mRNA Translation: AAF18982.1
    AF200343 mRNA Translation: AAF17079.1
    AF204943 mRNA Translation: AAF26367.1
    AF338816 mRNA Translation: AAK38374.1
    AF338817 mRNA Translation: AAK38375.1
    AB050436 mRNA Translation: BAB40931.1
    AB050437 mRNA Translation: BAB40932.1
    AB050438 mRNA Translation: BAB40933.1
    AB032975 mRNA Translation: BAA86463.2 Frameshift.
    DQ007053 Genomic DNA Translation: AAY16982.1
    EF444940 Genomic DNA Translation: ACA05927.1
    AP000892 Genomic DNA No translation available.
    CH471065 Genomic DNA Translation: EAW67313.1
    BC065492 mRNA Translation: AAH65492.1
    AF200193 mRNA Translation: AAF13715.1
    CCDSiCCDS44739.1 [P56817-2]
    CCDS44740.1 [P56817-3]
    CCDS44741.1 [P56817-4]
    CCDS55786.1 [P56817-6]
    CCDS55787.1 [P56817-5]
    CCDS8383.1 [P56817-1]
    PIRiA59090
    RefSeqiNP_001193978.1, NM_001207049.1 [P56817-6]
    NP_036236.1, NM_012104.4 [P56817-1]
    NP_620427.1, NM_138971.3 [P56817-3]
    NP_620428.1, NM_138972.3 [P56817-2]
    NP_620429.1, NM_138973.3 [P56817-4]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1FKNX-ray1.90A/B56-446[»]
    1M4HX-ray2.10A/B56-446[»]
    1PY1X-ray2.60E/F/G/H494-501[»]
    1SGZX-ray2.00A/B/C/D58-446[»]
    1TQFX-ray1.80A43-446[»]
    1UJJX-ray2.60C490-501[»]
    1UJKX-ray1.90C/D490-501[»]
    1W50X-ray1.75A43-453[»]
    1W51X-ray2.55A43-453[»]
    1XN2X-ray1.90A/B/C/D58-446[»]
    1XN3X-ray2.00A/B/C/D58-446[»]
    1XS7X-ray2.80D58-446[»]
    1YM2X-ray2.05A/B/C48-447[»]
    1YM4X-ray2.25A/B/C48-453[»]
    2B8LX-ray1.70A43-446[»]
    2B8VX-ray1.80A43-446[»]
    2F3EX-ray2.11A/B/C48-447[»]
    2F3FX-ray2.30A/B/C48-447[»]
    2FDPX-ray2.50A/B/C59-446[»]
    2G94X-ray1.86A/B/C/D58-446[»]
    2HIZX-ray2.50A/B/C14-453[»]
    2HM1X-ray2.20A57-453[»]
    2IQGX-ray1.70A57-453[»]
    2IRZX-ray1.80A43-446[»]
    2IS0X-ray2.20A43-446[»]
    2NTRX-ray1.80A43-446[»]
    2OAHX-ray1.80A43-446[»]
    2OF0X-ray2.25A45-446[»]
    2OHKX-ray2.20A45-446[»]
    2OHLX-ray2.65A45-446[»]
    2OHMX-ray2.70A45-446[»]
    2OHNX-ray2.15A45-446[»]
    2OHPX-ray2.25A45-446[»]
    2OHQX-ray2.10A45-446[»]
    2OHRX-ray2.25A45-446[»]
    2OHSX-ray2.45A45-446[»]
    2OHTX-ray2.30A45-446[»]
    2OHUX-ray2.35A45-446[»]
    2P4JX-ray2.50A/B/C/D58-446[»]
    2P83X-ray2.50A/B/C14-446[»]
    2P8HX-ray1.80A43-446[»]
    2PH6X-ray2.00A43-446[»]
    2PH8X-ray1.70A43-446[»]
    2Q11X-ray2.40A/B/C59-446[»]
    2Q15X-ray2.40A62-446[»]
    2QK5X-ray2.20A/B55-447[»]
    2QMDX-ray1.65A/B55-447[»]
    2QMFX-ray1.75A/B55-447[»]
    2QMGX-ray1.89A/B55-447[»]
    2QP8X-ray1.50A/B55-447[»]
    2QU2X-ray2.60A46-454[»]
    2QU3X-ray2.00A46-454[»]
    2QZKX-ray1.80A43-446[»]
    2QZLX-ray1.80A43-446[»]
    2VA5X-ray2.75A14-453[»]
    2VA6X-ray2.50A14-453[»]
    2VA7X-ray2.20A14-453[»]
    2VIEX-ray1.90A61-452[»]
    2VIJX-ray1.60A61-452[»]
    2VIYX-ray1.82A61-452[»]
    2VIZX-ray1.60A61-452[»]
    2VJ6X-ray1.80A61-452[»]
    2VJ7X-ray1.60A61-452[»]
    2VJ9X-ray1.60A61-452[»]
    2VKMX-ray2.05A/B/C/D58-446[»]
    2VNMX-ray1.79A61-452[»]
    2VNNX-ray1.87A61-452[»]
    2WEZX-ray1.70A61-452[»]
    2WF0X-ray1.60A61-452[»]
    2WF1X-ray1.60A61-452[»]
    2WF2X-ray1.80A61-452[»]
    2WF3X-ray2.08A61-452[»]
    2WF4X-ray1.80A61-452[»]
    2WJOX-ray2.50A58-460[»]
    2XFIX-ray1.73A61-452[»]
    2XFJX-ray1.80A61-452[»]
    2XFKX-ray1.80A61-452[»]
    2ZDZX-ray2.00A46-454[»]
    2ZE1X-ray2.20A46-454[»]
    2ZHRX-ray2.50A/B45-454[»]
    2ZHSX-ray2.70A45-454[»]
    2ZHTX-ray2.35A45-454[»]
    2ZHUX-ray2.40A45-454[»]
    2ZHVX-ray1.85A45-454[»]
    2ZJHX-ray2.60A43-446[»]
    2ZJIX-ray2.30A43-446[»]
    2ZJJX-ray2.20A43-446[»]
    2ZJKX-ray3.00A/B/C43-446[»]
    2ZJLX-ray2.10A43-446[»]
    2ZJMX-ray1.90A43-446[»]
    2ZJNX-ray2.70A43-446[»]
    3BRAX-ray2.30A46-454[»]
    3BUFX-ray2.30A46-454[»]
    3BUGX-ray2.50A46-454[»]
    3BUHX-ray2.30A46-454[»]
    3CIBX-ray1.72A/B58-447[»]
    3CICX-ray1.75A/B58-447[»]
    3CIDX-ray1.80A/B58-447[»]
    3CKPX-ray2.30A/B/C43-454[»]
    3CKRX-ray2.70A/B/C43-454[»]
    3DM6X-ray2.60A/B/C42-446[»]
    3DUYX-ray1.97A/B/C48-447[»]
    3DV1X-ray2.10A/B/C48-447[»]
    3DV5X-ray2.10A/B/C48-447[»]
    3EXOX-ray2.10A43-454[»]
    3FKTX-ray1.90A43-446[»]
    3H0BX-ray2.70A/B/C43-446[»]
    3HVGX-ray2.26A/B/C46-453[»]
    3HW1X-ray2.48A/B/C46-453[»]
    3I25X-ray2.10A/B/C42-446[»]
    3IGBX-ray2.24A46-454[»]
    3IN3X-ray2.00A46-454[»]
    3IN4X-ray2.30A46-454[»]
    3INDX-ray2.25A46-454[»]
    3INEX-ray2.00A46-454[»]
    3INFX-ray1.85A46-454[»]
    3INHX-ray1.80A46-454[»]
    3IVHX-ray1.80A57-453[»]
    3IVIX-ray2.20A/B/C57-453[»]
    3IXJX-ray2.20A/B/C59-446[»]
    3IXKX-ray2.50A/B/C42-446[»]
    3K5CX-ray2.12A/B/C48-447[»]
    3K5DX-ray2.90A/B/C48-453[»]
    3K5FX-ray2.25A/B/C48-447[»]
    3K5GX-ray2.00A/B/C48-447[»]
    3KMXX-ray1.70A/B53-447[»]
    3KMYX-ray1.90A/B53-447[»]
    3KN0X-ray1.90A/B53-447[»]
    3KYRX-ray2.60A/B/C42-446[»]
    3L38X-ray2.10A46-454[»]
    3L3AX-ray2.36A46-454[»]
    3L58X-ray1.80A/B41-454[»]
    3L59X-ray2.00A/B41-454[»]
    3L5BX-ray1.80A/B41-454[»]
    3L5CX-ray1.80A/B41-454[»]
    3L5DX-ray1.75A/B41-454[»]
    3L5EX-ray1.53A/B41-454[»]
    3L5FX-ray1.70A/B41-454[»]
    3LHGX-ray2.10A46-454[»]
    3LNKX-ray1.80A/B53-447[»]
    3LPIX-ray2.05A/B14-454[»]
    3LPJX-ray1.79A/B14-454[»]
    3LPKX-ray1.93A/B14-454[»]
    3MSJX-ray1.80A/B/C43-453[»]
    3MSKX-ray2.00A48-453[»]
    3MSLX-ray2.40A48-453[»]
    3N4LX-ray2.70A/B/C57-453[»]
    3NSHX-ray2.20A/B/C57-453[»]
    3OHFX-ray2.10A/B14-454[»]
    3OHHX-ray2.01A/B14-454[»]
    3OOZX-ray1.80A46-454[»]
    3PI5X-ray2.40A/B/C48-447[»]
    3QBHX-ray2.24A/B/C48-447[»]
    3QI1X-ray2.30A57-453[»]
    3R1GX-ray2.80B57-453[»]
    3R2FX-ray2.53A/B/D/E14-454[»]
    3RSVX-ray2.50A43-453[»]
    3RSXX-ray2.48A43-453[»]
    3RTHX-ray2.70A43-453[»]
    3RTMX-ray2.76A43-453[»]
    3RTNX-ray2.70A43-453[»]
    3RU1X-ray2.30A43-453[»]
    3RVIX-ray2.65A43-453[»]
    3S2OX-ray2.60A48-453[»]
    3S7LX-ray2.16A46-454[»]
    3S7MX-ray2.20A46-454[»]
    3SKFX-ray3.00A/B14-454[»]
    3SKGX-ray2.88A/B/D/E14-454[»]
    3TPJX-ray1.61A43-454[»]
    3TPLX-ray2.50A/B/C43-454[»]
    3TPPX-ray1.60A43-454[»]
    3TPRX-ray2.55A43-454[»]
    3U6AX-ray2.20A/B/C58-446[»]
    3UDHX-ray1.70A58-453[»]
    3UDJX-ray1.80A58-453[»]
    3UDKX-ray2.51A58-453[»]
    3UDMX-ray1.94A58-453[»]
    3UDNX-ray2.19A58-453[»]
    3UDPX-ray1.95A58-453[»]
    3UDQX-ray2.73A58-453[»]
    3UDRX-ray1.95A58-453[»]
    3UDYX-ray2.00A58-453[»]
    3UFLX-ray1.90A58-446[»]
    3UQPX-ray1.77A43-454[»]
    3UQRX-ray3.06A/B/C43-454[»]
    3UQUX-ray1.70A43-454[»]
    3UQWX-ray2.20A43-454[»]
    3UQXX-ray1.70A43-454[»]
    3VEUX-ray1.52A48-447[»]
    3VF3X-ray1.48A48-447[»]
    3VG1X-ray1.77A48-447[»]
    3VV6X-ray2.05A43-454[»]
    3VV7X-ray2.10A43-454[»]
    3VV8X-ray2.50A43-454[»]
    3WB4X-ray2.25A43-454[»]
    3WB5X-ray2.50A43-454[»]
    3ZMGX-ray1.74A46-454[»]
    3ZOVX-ray2.10A46-454[»]
    4ACUX-ray1.75A43-453[»]
    4ACXX-ray2.00A43-453[»]
    4AZYX-ray1.79A43-453[»]
    4B00X-ray1.83A43-453[»]
    4B05X-ray1.80A43-453[»]
    4B0QX-ray1.87A62-445[»]
    4B1CX-ray1.95A58-445[»]
    4B1DX-ray1.95A58-445[»]
    4B1EX-ray1.95A58-445[»]
    4B70X-ray1.60A61-445[»]
    4B72X-ray1.60A58-445[»]
    4B77X-ray1.80A58-445[»]
    4B78X-ray1.50A62-445[»]
    4BEKX-ray2.39A46-454[»]
    4BFDX-ray2.30A46-454[»]
    4D83X-ray2.40A/B/C48-447[»]
    4D85X-ray2.65A48-453[»]
    4D88X-ray1.70A48-447[»]
    4D89X-ray1.65A48-447[»]
    4D8CX-ray2.07A/B/C48-447[»]
    4DH6X-ray2.50A43-453[»]
    4DI2X-ray2.00A/B/C43-453[»]
    4DJUX-ray1.80A/B41-454[»]
    4DJVX-ray1.73A/B41-454[»]
    4DJWX-ray1.90A/B41-454[»]
    4DJXX-ray1.50A/B41-454[»]
    4DJYX-ray1.86A/B41-454[»]
    4DPFX-ray1.80A57-446[»]
    4DPIX-ray1.90A57-446[»]
    4DUSX-ray2.50A43-453[»]
    4DV9X-ray2.08A43-454[»]
    4DVFX-ray1.80A/B43-454[»]
    4EWOX-ray1.80A61-446[»]
    4EXGX-ray1.80A61-446[»]
    4FCOX-ray1.76A43-454[»]
    4FGXX-ray1.59A43-454[»]
    4FM7X-ray1.56A58-453[»]
    4FM8X-ray1.90A58-453[»]
    4FRIX-ray2.30A43-453[»]
    4FRJX-ray1.95A43-453[»]
    4FRKX-ray2.10A43-453[»]
    4FRSX-ray1.70A/B53-447[»]
    4FS4X-ray1.74A/B58-447[»]
    4FSEX-ray2.65A/B/D/E14-454[»]
    4FSLX-ray2.50A/B/D/E43-453[»]
    4GIDX-ray2.00A/B/C/D59-446[»]
    4GMIX-ray1.80A57-446[»]
    4H1EX-ray1.90A/B41-454[»]
    4H3FX-ray1.70A/B41-454[»]
    4H3GX-ray1.85A/B41-454[»]
    4H3IX-ray1.96A/B41-454[»]
    4H3JX-ray1.60A/B41-454[»]
    4HA5X-ray1.83A/B41-454[»]
    4HZTX-ray1.80A57-453[»]
    4I0DX-ray1.91A57-453[»]
    4I0EX-ray1.70A57-453[»]
    4I0FX-ray1.80A57-453[»]
    4I0GX-ray1.78A57-453[»]
    4I0HX-ray2.20A/B/C57-453[»]
    4I0IX-ray2.20A/B/C57-453[»]
    4I0JX-ray1.99A57-453[»]
    4I0ZX-ray1.80A57-453[»]
    4I10X-ray2.07A57-453[»]
    4I11X-ray1.89A57-453[»]
    4I12X-ray1.78A57-453[»]
    4I1CX-ray2.00A57-453[»]
    4IVSX-ray2.64A43-454[»]
    4IVTX-ray1.60A43-454[»]
    4J0PX-ray1.97A46-454[»]
    4J0TX-ray2.05A46-454[»]
    4J0VX-ray1.94A46-454[»]
    4J0YX-ray1.77A46-454[»]
    4J0ZX-ray2.13A46-454[»]
    4J17X-ray1.81A46-454[»]
    4J1CX-ray2.01A46-454[»]
    4J1EX-ray1.78A46-454[»]
    4J1FX-ray2.25A46-454[»]
    4J1HX-ray2.20A46-454[»]
    4J1IX-ray2.05A46-454[»]
    4J1KX-ray2.18A46-454[»]
    4JOOX-ray1.80A57-453[»]
    4JP9X-ray1.80A57-453[»]
    4JPCX-ray1.80A57-453[»]
    4JPEX-ray1.80A57-453[»]
    4K8SX-ray2.39A/B/C59-446[»]
    4K9HX-ray2.29A/B/C59-446[»]
    4KE0X-ray2.30A/B/C43-453[»]
    4KE1X-ray1.91A43-453[»]
    4L7GX-ray1.38A57-453[»]
    4L7HX-ray1.85A57-453[»]
    4L7JX-ray1.65A57-453[»]
    4LC7X-ray1.70A57-453[»]
    4LXAX-ray1.95A/B/C48-447[»]
    4LXKX-ray2.05A/B/C48-447[»]
    4LXMX-ray2.30A/B/C48-447[»]
    4N00X-ray1.80A57-453[»]
    4PZWX-ray1.80A57-453[»]
    4PZXX-ray1.80A57-453[»]
    4R5NX-ray1.80A57-453[»]
    4R8YX-ray1.90A/B41-454[»]
    4R91X-ray1.58A/B41-454[»]
    4R92X-ray1.71A/B41-454[»]
    4R93X-ray1.71A/B41-454[»]
    4R95X-ray1.99A/B41-454[»]
    4RCDX-ray1.90A43-453[»]
    4RCEX-ray2.40A43-453[»]
    4RCFX-ray1.78A43-453[»]
    4RRNX-ray1.80A57-453[»]
    4RROX-ray1.80A57-453[»]
    4RRSX-ray1.80A57-453[»]
    4TRWX-ray2.85A/B/C58-447[»]
    4TRYX-ray2.75A/B/C60-447[»]
    4TRZX-ray3.25A/B/C60-447[»]
    4WTUX-ray1.85A43-453[»]
    4WY1X-ray1.98A58-453[»]
    4WY6X-ray2.10A46-454[»]
    4X2LX-ray2.55A46-454[»]
    4X7IX-ray1.77A/B14-454[»]
    4XKXX-ray1.80A43-453[»]
    4XXSX-ray1.86A46-454[»]
    4YBIX-ray1.84A/B14-454[»]
    4ZPEX-ray1.70A43-446[»]
    4ZPFX-ray1.80A43-446[»]
    4ZPGX-ray2.00A43-446[»]
    4ZSMX-ray1.96A/B14-454[»]
    4ZSPX-ray1.91A/B14-454[»]
    4ZSQX-ray2.30A/B14-454[»]
    4ZSRX-ray1.65A/B14-454[»]
    5CLMX-ray2.61A46-446[»]
    5DQCX-ray2.47A/B/C58-447[»]
    5ENKX-ray2.11A14-454[»]
    5ENMX-ray1.98A14-454[»]
    5EZXX-ray1.90A57-446[»]
    5EZZX-ray2.10A57-446[»]
    5F00X-ray1.95A57-446[»]
    5F01X-ray1.52A57-446[»]
    5HD0X-ray1.65A/B41-454[»]
    5HDUX-ray1.58A/B41-454[»]
    5HDVX-ray1.71A/B41-454[»]
    5HDXX-ray1.60A/B41-454[»]
    5HDZX-ray1.49A/B41-454[»]
    5HE4X-ray1.53A/B41-454[»]
    5HE5X-ray1.55A/B41-454[»]
    5HE7X-ray1.71A/B41-454[»]
    5HTZX-ray1.95A/B43-454[»]
    5HU0X-ray1.83A/B43-454[»]
    5HU1X-ray1.50A/B43-454[»]
    5I3VX-ray1.62A43-453[»]
    5I3WX-ray2.15A43-453[»]
    5I3XX-ray1.85A43-453[»]
    5I3YX-ray2.15A43-453[»]
    5IE1X-ray2.30A43-453[»]
    5KQFX-ray1.98A14-454[»]
    5KR8X-ray2.12A14-454[»]
    5MBWX-ray2.95A46-454[»]
    5MCOX-ray2.49A46-454[»]
    5MCQX-ray1.82A46-454[»]
    5MXDX-ray2.52A/B/C22-446[»]
    5T1UX-ray1.78A46-454[»]
    5T1WX-ray2.96A46-454[»]
    5TOLX-ray2.51A43-454[»]
    5UYUX-ray1.90A43-453[»]
    5V0NX-ray2.15A/B/C14-454[»]
    5YGXX-ray2.20A43-454[»]
    5YGYX-ray2.30A43-454[»]
    6BFDX-ray1.62A/B14-454[»]
    6BFEX-ray1.51A/B14-454[»]
    6BFWX-ray1.84A/B14-454[»]
    6BFXX-ray1.99A/B14-454[»]
    6C2IX-ray1.95A43-453[»]
    6DHCX-ray2.85A/B/C14-454[»]
    6DMIX-ray1.90A57-446[»]
    6E3ZX-ray1.94A/B/C22-446[»]
    6EJ2X-ray1.46A1-501[»]
    6EJ3X-ray1.94A1-501[»]
    6EQMX-ray1.35A48-447[»]
    6FGYX-ray1.54A60-453[»]
    6JSEX-ray2.00A43-454[»]
    6JSFX-ray2.30A43-454[»]
    6JSGX-ray2.30A43-454[»]
    6JSNX-ray2.60A43-454[»]
    6JT3X-ray2.40A43-454[»]
    6JT4X-ray2.20A43-454[»]
    6NV7X-ray2.13A/B/C58-447[»]
    6NV9X-ray2.13A/B/C58-447[»]
    6NW3X-ray2.35A/B/C58-447[»]
    6OD6X-ray2.00A/B/C22-446[»]
    6PZ4X-ray1.85A43-453[»]
    6UVPX-ray1.56A/B14-454[»]
    6UVVX-ray1.63A/B14-454[»]
    6UVYX-ray1.71A/B14-454[»]
    6UWPX-ray1.29A/B14-454[»]
    6UWVX-ray1.47A/B14-454[»]
    SMRiP56817
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi117154, 22 interactors
    CORUMiP56817
    DIPiDIP-41388N
    IntActiP56817, 40 interactors
    MINTiP56817
    STRINGi9606.ENSP00000318585

    Chemistry databases

    BindingDBiP56817
    ChEMBLiCHEMBL4822
    DrugBankiDB07573 (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol
    DB07736 (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
    DB07737 (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
    DB07519 (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
    DB07874 (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
    DB07535 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
    DB08749 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
    DB07345 4-(2-aminoethyl)-2-cyclohexylphenol
    DB07346 4-(2-aminoethyl)-2-ethylphenol
    DB07110 4-(4-FLUOROBENZYL)PIPERIDINE
    DB07415 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine
    DB07206 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE
    DB07245 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE
    DB06073 CTS-21166
    DB02378 MMI-175
    DB07734 N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
    DB07019 N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
    DB07735 N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
    DB07738 N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
    DB06930 N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
    DB07089 N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
    DB07175 N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide
    DB07284 N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
    DB07993 N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE
    DB07303 N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
    DB07994 N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE
    DB07281 N~3~-BENZYLPYRIDINE-2,3-DIAMINE
    DB12285 Verubecestat
    DrugCentraliP56817
    GuidetoPHARMACOLOGYi2330

    Protein family/group databases

    MEROPSiA01.004
    TCDBi8.A.32.1.1 the Beta-amyloid cleaving enzyme (bace1) family

    PTM databases

    GlyConnecti71
    72
    iPTMnetiP56817
    PhosphoSitePlusiP56817
    SwissPalmiP56817
    UniCarbKBiP56817

    Polymorphism and mutation databases

    BioMutaiBACE1
    DMDMi296434407

    Proteomic databases

    jPOSTiP56817
    MassIVEiP56817
    PaxDbiP56817
    PeptideAtlasiP56817
    PRIDEiP56817
    ProteomicsDBi19820
    43307
    56947 [P56817-1]
    56948 [P56817-2]
    56949 [P56817-3]
    56950 [P56817-4]

    Protocols and materials databases

    ABCD curated depository of sequenced antibodies

    More...    ABCDi    		P56817

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		4285 867 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		23621

    Genome annotation databases

    EnsembliENST00000313005; ENSP00000318585; ENSG00000186318 [P56817-1]
    ENST00000392937; ENSP00000475405; ENSG00000186318 [P56817-5]
    ENST00000428381; ENSP00000402228; ENSG00000186318 [P56817-4]
    ENST00000445823; ENSP00000403685; ENSG00000186318 [P56817-3]
    ENST00000510630; ENSP00000422461; ENSG00000186318 [P56817-6]
    ENST00000513780; ENSP00000424536; ENSG00000186318 [P56817-2]
    GeneIDi23621
    KEGGihsa:23621
    UCSCiuc001pqw.4 human [P56817-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		23621
    DisGeNETi23621

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		BACE1
    HGNCiHGNC:933 BACE1
    HPAiENSG00000186318 Group enriched (brain, pancreas)
    MIMi604252 gene
    neXtProtiNX_P56817
    OpenTargetsiENSG00000186318
    PharmGKBiPA25232

    Human Unidentified Gene-Encoded large proteins database

    More...    HUGEi    		Search...

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1339 Eukaryota
    ENOG410XNV7 LUCA
    GeneTreeiENSGT00940000157786
    HOGENOMiCLU_039009_0_0_1
    InParanoidiP56817
    KOiK04521
    OMAiELEDCGY
    OrthoDBi429758at2759
    PhylomeDBiP56817
    TreeFamiTF329595

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000160610-MONOMER
    BRENDAi3.4.23.46 2681
    ReactomeiR-HSA-977225 Amyloid fiber formation
    SABIO-RKiP56817
    SIGNORiP56817

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		BACE1 human
    EvolutionaryTraceiP56817

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		Beta-secretase_1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		23621
    PharosiP56817 Tchem

    Protein Ontology

    More...    PROi    		PR:P56817
    RNActiP56817 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000186318 Expressed in C1 segment of cervical spinal cord and 222 other tissues
    ExpressionAtlasiP56817 baseline and differential
    GenevisibleiP56817 HS

    Family and domain databases

    CDDicd05473 beta_secretase_like, 1 hit
    Gene3Di2.40.70.10, 2 hits
    InterProiView protein in InterPro
    IPR001461 Aspartic_peptidase_A1
    IPR001969 Aspartic_peptidase_AS
    IPR009119 BACE
    IPR009120 BACE1
    IPR033874 Memapsin-like
    IPR033121 PEPTIDASE_A1
    IPR021109 Peptidase_aspartic_dom_sf
    PANTHERiPTHR13683 PTHR13683, 1 hit
    PTHR13683:SF245 PTHR13683:SF245, 1 hit
    PfamiView protein in Pfam
    PF00026 Asp, 1 hit
    PRINTSiPR01815 BACEFAMILY
    PR00792 PEPSIN
    SUPFAMiSSF50630 SSF50630, 1 hit
    PROSITEiView protein in PROSITE
    PS00141 ASP_PROTEASE, 1 hit
    PS51767 PEPTIDASE_A1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBACE1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56817
    Secondary accession number(s): A0M8W7
    , B0YIU9, E9PE65, H7BXJ9, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 7, 2017
    Last modified: April 22, 2020
    This is version 219 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again