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Protein

Programmed cell death protein 5

Gene

Pdcd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in the process of apoptosis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 5
Alternative name(s):
TF-1 cell apoptosis-related protein 19
Short name:
Protein TFAR19
Gene namesi
Name:Pdcd5
Synonyms:Tfar19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913538 Pdcd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001215462 – 126Programmed cell death protein 5Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei63N6-acetyllysineBy similarity1
Modified residuei119PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP56812
PaxDbiP56812
PeptideAtlasiP56812
PRIDEiP56812
TopDownProteomicsiP56812

PTM databases

iPTMnetiP56812
PhosphoSitePlusiP56812

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000030417 Expressed in 88 organ(s), highest expression level in female gonad
CleanExiMM_PDCD5
ExpressionAtlasiP56812 baseline and differential
GenevisibleiP56812 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113761

Structurei

3D structure databases

ProteinModelPortaliP56812
SMRiP56812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDCD5 family.Curated

Phylogenomic databases

eggNOGiKOG3431 Eukaryota
COG2118 LUCA
GeneTreeiENSGT00390000011085
HOGENOMiHOG000194121
HOVERGENiHBG053536
InParanoidiP56812
KOiK06875
OMAiRLNTVKM
PhylomeDBiP56812
TreeFamiTF313112

Family and domain databases

Gene3Di1.10.8.140, 1 hit
InterProiView protein in InterPro
IPR002836 PDCD5-like
IPR036883 PDCD5-like_sf
PANTHERiPTHR10840 PTHR10840, 1 hit
PfamiView protein in Pfam
PF01984 dsDNA_bind, 1 hit
PIRSFiPIRSF015730 TFAR19, 1 hit
SUPFAMiSSF46950 SSF46950, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P56812-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEELEALR KQRLAELQAK HGDPGDAAQQ EAKQREAEMR NSILAQVLDQ
60 70 80 90 100
SARARLSNLA LVKPEKTKAV ENYLIQMARY GQLSGKVSEQ GLIEILEKVS
110 120
QQTEKKTTVK FNRRKVMDSD EDDADY
Length:126
Mass (Da):14,275
Last modified:January 23, 2007 - v3
Checksum:i05796820CD5C780B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7Q5D3Z7Q5_MOUSE
Programmed cell death protein 5
Pdcd5
205Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161074 mRNA Translation: AAD45607.1
BC048476 mRNA Translation: AAH48476.1
BC056167 mRNA Translation: AAH56167.1
CCDSiCCDS52203.1
RefSeqiNP_062720.1, NM_019746.4
XP_001478306.1, XM_001478256.5
UniGeneiMm.371609

Genome annotation databases

EnsembliENSMUST00000118501; ENSMUSP00000113761; ENSMUSG00000030417
GeneIDi100042424
56330
KEGGimmu:56330
UCSCiuc009gkf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161074 mRNA Translation: AAD45607.1
BC048476 mRNA Translation: AAH48476.1
BC056167 mRNA Translation: AAH56167.1
CCDSiCCDS52203.1
RefSeqiNP_062720.1, NM_019746.4
XP_001478306.1, XM_001478256.5
UniGeneiMm.371609

3D structure databases

ProteinModelPortaliP56812
SMRiP56812
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113761

PTM databases

iPTMnetiP56812
PhosphoSitePlusiP56812

Proteomic databases

EPDiP56812
PaxDbiP56812
PeptideAtlasiP56812
PRIDEiP56812
TopDownProteomicsiP56812

Protocols and materials databases

DNASUi56330
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118501; ENSMUSP00000113761; ENSMUSG00000030417
GeneIDi100042424
56330
KEGGimmu:56330
UCSCiuc009gkf.1 mouse

Organism-specific databases

CTDi100042424
9141
MGIiMGI:1913538 Pdcd5

Phylogenomic databases

eggNOGiKOG3431 Eukaryota
COG2118 LUCA
GeneTreeiENSGT00390000011085
HOGENOMiHOG000194121
HOVERGENiHBG053536
InParanoidiP56812
KOiK06875
OMAiRLNTVKM
PhylomeDBiP56812
TreeFamiTF313112

Miscellaneous databases

PROiPR:P56812
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030417 Expressed in 88 organ(s), highest expression level in female gonad
CleanExiMM_PDCD5
ExpressionAtlasiP56812 baseline and differential
GenevisibleiP56812 MM

Family and domain databases

Gene3Di1.10.8.140, 1 hit
InterProiView protein in InterPro
IPR002836 PDCD5-like
IPR036883 PDCD5-like_sf
PANTHERiPTHR10840 PTHR10840, 1 hit
PfamiView protein in Pfam
PF01984 dsDNA_bind, 1 hit
PIRSFiPIRSF015730 TFAR19, 1 hit
SUPFAMiSSF46950 SSF46950, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDCD5_MOUSE
AccessioniPrimary (citable) accession number: P56812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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